المؤلفون: Junichiro Yuda, Christine Will, Darren C. Phillips, Linu Abraham, Cory Alvey, Abraham Avigdor, Wayne Buck, Lauren Besenhofer, Erwin Boghaert, Dong Cheng, Dan Cojocari, Kelly Doyle, T. Matthew Hansen, Kevin Huang, Eric F. Johnson, Andrew S. Judd, Russell A. Judge, John C. Kalvass, Aaron Kunzer, Lloyd T. Lam, Rachel Li, Ruth L. Martin, Anthony Mastracchio, Mike Mitten, Adam Petrich, Jin Wang, James E. Ward, Haichao Zhang, Xilu Wang, Johannes E. Wolff, Katherine M. Bell-McGuinn, Andrew J. Souers

المصدر: Communications Medicine, Vol 3, Iss 1, Pp 1-14 (2023)

مصطلحات موضوعية: Medicine

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2730-664X

URL الوصول: https://doaj.org/article/a09a2953c50e4da8ad9915dfa149ffac

المؤلفون: Ronen Marmorstein, Clarissa G. Jakob, Kesicki Edward A, Vlasios Manaves, Michael R. Michaelides, Vikram Bhat, Mikkel Algire, Albert Lai, Loren M. Lasko, Hong Liu, Zhiqin Ji, T. Matthew Hansen, Maricel Torrent, Ruth L. Martin, Wei Qiu, Philip A. Cole, Kenneth D. Bromberg, Richard F. Clark

المصدر: Bioorg Med Chem Lett

مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Biological Availability, 01 natural sciences, Biochemistry, Article, chemistry.chemical_compound, Structure-Activity Relationship, Dopamine, Drug Discovery, medicine, Histone acetyltransferase activity, Humans, Spiro Compounds, Enzyme Inhibitors, Molecular Biology, Histone Acetyltransferases, chemistry.chemical_classification, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Hydantoins, Organic Chemistry, Transporter, Histone acetyltransferase, CREB-Binding Protein, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, biology.protein, Molecular Medicine, Serotonin, Lead compound, E1A-Associated p300 Protein, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7576b344a1528891845cb4ea585792
https://pubmed.ncbi.nlm.nih.gov/33631370

المؤلفون: Amanda S. Wilsey, Yevgeniya E. Koshman, Aimee L. Endemann, Sabine Sadilek, Scott W. Mittelstadt, James S. Polakowski, Brandan M. Bird, Jessica Treadway, Ruth L. Martin, Gary Gintant

المصدر: Journal of pharmacological and toxicological methods. 103

مصطلحات موضوعية: Male, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, hERG, Drug Evaluation, Preclinical, Torsades de pointes, 030204 cardiovascular system & hematology, Toxicology, 030226 pharmacology & pharmacy, QT interval, Risk Assessment, 03 medical and health sciences, QRS complex, Electrocardiography, 0302 clinical medicine, Dogs, Heart Rate, Torsades de Pointes, Internal medicine, Heart rate, medicine, Repolarization, Animals, Humans, cardiovascular diseases, Prospective Studies, Pharmacology, Proarrhythmia, biology, business.industry, Models, Cardiovascular, Drug-induced QT prolongation, medicine.disease, Long QT Syndrome, HEK293 Cells, cardiovascular system, Cardiology, biology.protein, business, Anti-Arrhythmia Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b22faf6acdce4244a927e927e6fe257
https://pubmed.ncbi.nlm.nih.gov/32360993

المؤلفون: Ganesh Rajaraman, Leiming Li, Daniel H. Albert, Ruth L. Martin, Terrance J. Magoc, Todd N. Soltwedel, Denise Wilcox, Xiaoli Huang, Chang H. Park, Steven W. Elmore, George S. Sheppard, Charles W. Hutchins, Dachun Liu, Chaohong C. Sun, Guowei Fang, Le Wang, Wenqing Gao, Robert A. Mantei, Rongqi Wang, Emily J. Faivre, Steven D. Fidanze, John K. Pratt, Xiaoyu Lin, Mai H. Bui, Shekman Wong, Scott E. Warder, Jianwei J. Shen, Rohinton P. Edalji, Lisa A. Hasvold, Warren M. Kati, Keith F. McDaniel, Yu Shen

المصدر: Journal of Medicinal Chemistry. 60:8369-8384

مصطلحات موضوعية: 0301 basic medicine, Pyridones, Proton Magnetic Resonance Spectroscopy, Pharmacology, Mass Spectrometry, Mice, Structure-Activity Relationship, 03 medical and health sciences, Pharmacokinetics, In vivo, Cell Line, Tumor, Drug Discovery, Fluorescence Resonance Energy Transfer, Animals, Humans, Structure–activity relationship, Potency, Asparagine, Chromatography, High Pressure Liquid, Sulfonamides, Chemistry, Drug discovery, Proteins, Bromodomain, 030104 developmental biology, Molecular Medicine, Drug metabolism, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e212dfdec3c29433c5f0baac7f9a9a8
https://doi.org/10.1021/acs.jmedchem.7b00746

المؤلفون: Loren M. Lasko, Clarissa G. Jakob, Rohinton P. Edalji, Wei Qiu, Debra Montgomery, Enrico L. Digiammarino, T. Matt Hansen, Roberto M. Risi, Robin Frey, Vlasios Manaves, Bailin Shaw, Mikkel Algire, Paul Hessler, Lloyd T. Lam, Tamar Uziel, Emily Faivre, Debra Ferguson, Fritz G. Buchanan, Ruth L. Martin, Maricel Torrent, Gary G. Chiang, Kannan Karukurichi, J. William Langston, Brian T. Weinert, Chunaram Choudhary, Peter de Vries, Arthur F. Kluge, Michael A. Patane, John H. Van Drie, Ce Wang, David McElligott, Ed Kesicki, Ronen Marmorstein, Chaohong Sun, Philip A. Cole, Saul H. Rosenberg, Michael R. Michaelides, Albert Lai, Kenneth D. Bromberg

المصدر: Nature. 550:128-132

مصطلحات موضوعية: Male, Models, Molecular, 0301 basic medicine, Protein Conformation, Antineoplastic Agents, Mice, SCID, P300-CBP Transcription Factors, Crystallography, X-Ray, Binding, Competitive, Heterocyclic Compounds, 4 or More Rings, Mice, 03 medical and health sciences, Acetyl Coenzyme A, Catalytic Domain, Cell Line, Tumor, Neoplasms, Animals, Humans, Cell Lineage, p300-CBP Transcription Factors, Epigenetics, Enzyme Inhibitors, Cell Proliferation, Histone Acetyltransferases, Regulation of gene expression, Multidisciplinary, biology, Chemistry, Histone acetyltransferase, Xenograft Model Antitumor Assays, Gene Expression Regulation, Neoplastic, Prostatic Neoplasms, Castration-Resistant, 030104 developmental biology, Histone, Receptors, Androgen, Acetylation, Hematologic Neoplasms, Biocatalysis, biology.protein, Cancer research, Histone deacetylase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcdc4d0d1efd86b44451095a833f08b
https://doi.org/10.1038/nature24028

المؤلفون: Bryan F. Cox, Xiaoqin Liu, Gary A. Gintant, James T. Limberis, Gilbert Diaz, Ruth L. Martin, Kathryn Houseman, Zhi Su

المصدر: Life Sciences. 90:607-611

مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, Patch-Clamp Techniques, Purkinje fibers, Voltage clamp, hERG, Acetates, Pharmacology, Tritium, General Biochemistry, Genetics and Molecular Biology, Phenethylamines, medicine, Humans, Terfenadine, cardiovascular diseases, Patch clamp, General Pharmacology, Toxicology and Pharmaceutics, Binding site, Analysis of Variance, Sulfonamides, biology, Chemistry, Sotalol, HEK 293 cells, General Medicine, Ether-A-Go-Go Potassium Channels, HEK293 Cells, medicine.anatomical_structure, biology.protein, Pyrazoles, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef24215cc71f2aa845920e90e5983a84
https://doi.org/10.1016/j.lfs.2012.02.017

المؤلفون: James T. Limberis, Di Zhang, Torben R. Neelands, Richard S. Janis, Diana L. Donnelly-Roberts, Wende Niforatos, Timothy A. Vortherms, Carol S. Surowy, C. Brent Putman, Ruth L. Martin, Michael F. Jarvis, Marian T. Namovic, Rama Thimmapaya, Andrew M. Swensen, Victoria E. Scott

المصدر: Inflammation Research. 60:683-693

مصطلحات موضوعية: Pharmacology, Membrane potential, Calcium metabolism, Patch-Clamp Techniques, Voltage-dependent calcium channel, Chemistry, Calcium channel, Immunology, HEK 293 cells, Calcium Channel Blockers, Cell Line, Membrane Potentials, Electrophysiology, Calcium Channels, N-Type, Biophysics, Extracellular, Animals, Humans, Calcium, Patch clamp, Ion Channel Gating

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a08e3a3b09d01bec446cbdc79a1bd31
https://doi.org/10.1007/s00011-011-0322-9

المؤلفون: Ruth L. Martin, Peter de Vries, Rohinton Edalji, T. Matt Hansen, Mikkel Algire, Fritz G. Buchanan, Wei Qiu, Brian T. Weinert, John H. Van Drie, Debra Ferguson, Kesicki Edward A, Ronen Marmorstein, Enrico L. Digiammarino, Philip A. Cole, Lloyd T. Lam, Chunaram Choudhary, Robin R. Frey, Loren M. Lasko, Roberto M. Risi, Kannan R. Karukurichi, Michael A. Patane, Debra Montgomery, Kenneth D. Bromberg, Bailin Shaw, Michael R. Michaelides, David L. McElligott, Arthur F. Kluge, J. William Langston, Ce Wang, Chaohong Sun, Vlasios Manaves, Emily J. Faivre, Maricel Torrent, Gary G. Chiang, Paul Hessler, Albert Lai, Saul H. Rosenberg, Clarissa G. Jakob, Tamar Uziel

المصدر: Nature. 558:E1-E1

مصطلحات موضوعية: 0301 basic medicine, 03 medical and health sciences, Lineage specific, 030104 developmental biology, 0302 clinical medicine, Multidisciplinary, History, 030220 oncology & carcinogenesis, Interpretation (philosophy), Published Erratum, Cancer therapy, Library science, Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d97c1de2ea9ff83c19ebbdea520398
https://doi.org/10.1038/s41586-018-0111-5

المؤلفون: Roberto M. Risi, Todd M. Hansen, Clarissa G. Jakob, Mikkel Algire, Tamar Uziel, Lloyd T. Lam, Kenneth D. Bromberg, Vlasios Manaves, Loren M. Lasko, Robin R. Frey, Maricel Torrent, Saul H. Rosenberg, Ruth L. Martin, Debra Montgomery, Bailin Shaw, Michael R. Michaelides, Enrico L. Digiammarino, Wei Qiu, Albert Lai, Paul Hessler, Emily Favire, Fritz G. Buchanan, Debra Ferguson

المصدر: Molecular Cancer Therapeutics. 17:LB-A23

مصطلحات موضوعية: Histone Acetyltransferases, Cancer Research, biology, medicine.drug_class, Chemistry, Cancer, Androgen, medicine.disease, Androgen receptor, Prostate cancer, Histone, Oncology, Acetylation, Cancer research, medicine, biology.protein, Epigenetics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::16f9918b04e2fa27f6f2e3b6b4a3f001
https://doi.org/10.1158/1535-7163.targ-17-lb-a23

المؤلفون: Kaitlin E. Browman, Arthur L. Nikkel, Richard Harris, Monika Håkerud, William H. Bunnelle, Paul J. Brackemeyer, David J. Anderson, Jennifer M. Frost, Sabine Halm, Jens Halvard Grønlien, Eva Spies, Liping Pan, Eric A.G. Blomme, Clark A. Briggs, Rosalind J. Helfrich, Ryan M. Fryer, Karla Drescher, Earl J. Gubbins, R. Scott Bitner, Ruth L. Martin, Kennan C. Marsh, Kirsten Thorin-Hagene, Stephani Otte, Peter Curzon, Murali Gopalakrishnan, John Malysz, Michael Meyer, Devalina Law, Gerard B. Fox, Hilde Ween, Dagmar Bury, Karin R. Tietje, Hongyu Xu, Pamela S. Puttfarcken, Angela L. Molesky, Kathy L. Kohlhaas, Holly M. Robb, Jeffrey F. Waring, Richard J. Radek

المصدر: CNS Drug Reviews. 14:65-82

مصطلحات موضوعية: Agonist, alpha7 Nicotinic Acetylcholine Receptor, medicine.drug_class, Hippocampus, Review, Receptors, Nicotinic, Cognition, Physiology (medical), medicine, Animals, Humans, Pyrroles, Pharmacology (medical), Nicotinic Agonists, Pharmacology, Sensory gating, Working memory, medicine.disease, Pyridazines, Psychiatry and Mental health, Neuropsychology and Physiological Psychology, Nicotinic agonist, medicine.anatomical_structure, Memory consolidation, Alzheimer's disease, Psychology, Neuroscience

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a77948a51c5747ec1fd7e59fc278d27f
https://doi.org/10.1111/j.1527-3458.2008.00037.x