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1دورية أكاديمية
المؤلفون: Junichiro Yuda, Christine Will, Darren C. Phillips, Linu Abraham, Cory Alvey, Abraham Avigdor, Wayne Buck, Lauren Besenhofer, Erwin Boghaert, Dong Cheng, Dan Cojocari, Kelly Doyle, T. Matthew Hansen, Kevin Huang, Eric F. Johnson, Andrew S. Judd, Russell A. Judge, John C. Kalvass, Aaron Kunzer, Lloyd T. Lam, Rachel Li, Ruth L. Martin, Anthony Mastracchio, Mike Mitten, Adam Petrich, Jin Wang, James E. Ward, Haichao Zhang, Xilu Wang, Johannes E. Wolff, Katherine M. Bell-McGuinn, Andrew J. Souers
المصدر: Communications Medicine, Vol 3, Iss 1, Pp 1-14 (2023)
مصطلحات موضوعية: Medicine
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2730-664X
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2
المؤلفون: Ronen Marmorstein, Clarissa G. Jakob, Kesicki Edward A, Vlasios Manaves, Michael R. Michaelides, Vikram Bhat, Mikkel Algire, Albert Lai, Loren M. Lasko, Hong Liu, Zhiqin Ji, T. Matthew Hansen, Maricel Torrent, Ruth L. Martin, Wei Qiu, Philip A. Cole, Kenneth D. Bromberg, Richard F. Clark
المصدر: Bioorg Med Chem Lett
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Biological Availability, 01 natural sciences, Biochemistry, Article, chemistry.chemical_compound, Structure-Activity Relationship, Dopamine, Drug Discovery, medicine, Histone acetyltransferase activity, Humans, Spiro Compounds, Enzyme Inhibitors, Molecular Biology, Histone Acetyltransferases, chemistry.chemical_classification, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Hydantoins, Organic Chemistry, Transporter, Histone acetyltransferase, CREB-Binding Protein, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, biology.protein, Molecular Medicine, Serotonin, Lead compound, E1A-Associated p300 Protein, medicine.drug
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3
المؤلفون: Amanda S. Wilsey, Yevgeniya E. Koshman, Aimee L. Endemann, Sabine Sadilek, Scott W. Mittelstadt, James S. Polakowski, Brandan M. Bird, Jessica Treadway, Ruth L. Martin, Gary Gintant
المصدر: Journal of pharmacological and toxicological methods. 103
مصطلحات موضوعية: Male, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, hERG, Drug Evaluation, Preclinical, Torsades de pointes, 030204 cardiovascular system & hematology, Toxicology, 030226 pharmacology & pharmacy, QT interval, Risk Assessment, 03 medical and health sciences, QRS complex, Electrocardiography, 0302 clinical medicine, Dogs, Heart Rate, Torsades de Pointes, Internal medicine, Heart rate, medicine, Repolarization, Animals, Humans, cardiovascular diseases, Prospective Studies, Pharmacology, Proarrhythmia, biology, business.industry, Models, Cardiovascular, Drug-induced QT prolongation, medicine.disease, Long QT Syndrome, HEK293 Cells, cardiovascular system, Cardiology, biology.protein, business, Anti-Arrhythmia Agents
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المؤلفون: Ganesh Rajaraman, Leiming Li, Daniel H. Albert, Ruth L. Martin, Terrance J. Magoc, Todd N. Soltwedel, Denise Wilcox, Xiaoli Huang, Chang H. Park, Steven W. Elmore, George S. Sheppard, Charles W. Hutchins, Dachun Liu, Chaohong C. Sun, Guowei Fang, Le Wang, Wenqing Gao, Robert A. Mantei, Rongqi Wang, Emily J. Faivre, Steven D. Fidanze, John K. Pratt, Xiaoyu Lin, Mai H. Bui, Shekman Wong, Scott E. Warder, Jianwei J. Shen, Rohinton P. Edalji, Lisa A. Hasvold, Warren M. Kati, Keith F. McDaniel, Yu Shen
المصدر: Journal of Medicinal Chemistry. 60:8369-8384
مصطلحات موضوعية: 0301 basic medicine, Pyridones, Proton Magnetic Resonance Spectroscopy, Pharmacology, Mass Spectrometry, Mice, Structure-Activity Relationship, 03 medical and health sciences, Pharmacokinetics, In vivo, Cell Line, Tumor, Drug Discovery, Fluorescence Resonance Energy Transfer, Animals, Humans, Structure–activity relationship, Potency, Asparagine, Chromatography, High Pressure Liquid, Sulfonamides, Chemistry, Drug discovery, Proteins, Bromodomain, 030104 developmental biology, Molecular Medicine, Drug metabolism, Half-Life
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المؤلفون: Loren M. Lasko, Clarissa G. Jakob, Rohinton P. Edalji, Wei Qiu, Debra Montgomery, Enrico L. Digiammarino, T. Matt Hansen, Roberto M. Risi, Robin Frey, Vlasios Manaves, Bailin Shaw, Mikkel Algire, Paul Hessler, Lloyd T. Lam, Tamar Uziel, Emily Faivre, Debra Ferguson, Fritz G. Buchanan, Ruth L. Martin, Maricel Torrent, Gary G. Chiang, Kannan Karukurichi, J. William Langston, Brian T. Weinert, Chunaram Choudhary, Peter de Vries, Arthur F. Kluge, Michael A. Patane, John H. Van Drie, Ce Wang, David McElligott, Ed Kesicki, Ronen Marmorstein, Chaohong Sun, Philip A. Cole, Saul H. Rosenberg, Michael R. Michaelides, Albert Lai, Kenneth D. Bromberg
المصدر: Nature. 550:128-132
مصطلحات موضوعية: Male, Models, Molecular, 0301 basic medicine, Protein Conformation, Antineoplastic Agents, Mice, SCID, P300-CBP Transcription Factors, Crystallography, X-Ray, Binding, Competitive, Heterocyclic Compounds, 4 or More Rings, Mice, 03 medical and health sciences, Acetyl Coenzyme A, Catalytic Domain, Cell Line, Tumor, Neoplasms, Animals, Humans, Cell Lineage, p300-CBP Transcription Factors, Epigenetics, Enzyme Inhibitors, Cell Proliferation, Histone Acetyltransferases, Regulation of gene expression, Multidisciplinary, biology, Chemistry, Histone acetyltransferase, Xenograft Model Antitumor Assays, Gene Expression Regulation, Neoplastic, Prostatic Neoplasms, Castration-Resistant, 030104 developmental biology, Histone, Receptors, Androgen, Acetylation, Hematologic Neoplasms, Biocatalysis, biology.protein, Cancer research, Histone deacetylase
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6Characterization of A-935142, a hERG enhancer, in the presence and absence of standard hERG blockers
المؤلفون: Bryan F. Cox, Xiaoqin Liu, Gary A. Gintant, James T. Limberis, Gilbert Diaz, Ruth L. Martin, Kathryn Houseman, Zhi Su
المصدر: Life Sciences. 90:607-611
مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, Patch-Clamp Techniques, Purkinje fibers, Voltage clamp, hERG, Acetates, Pharmacology, Tritium, General Biochemistry, Genetics and Molecular Biology, Phenethylamines, medicine, Humans, Terfenadine, cardiovascular diseases, Patch clamp, General Pharmacology, Toxicology and Pharmaceutics, Binding site, Analysis of Variance, Sulfonamides, biology, Chemistry, Sotalol, HEK 293 cells, General Medicine, Ether-A-Go-Go Potassium Channels, HEK293 Cells, medicine.anatomical_structure, biology.protein, Pyrazoles, medicine.drug
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المؤلفون: James T. Limberis, Di Zhang, Torben R. Neelands, Richard S. Janis, Diana L. Donnelly-Roberts, Wende Niforatos, Timothy A. Vortherms, Carol S. Surowy, C. Brent Putman, Ruth L. Martin, Michael F. Jarvis, Marian T. Namovic, Rama Thimmapaya, Andrew M. Swensen, Victoria E. Scott
المصدر: Inflammation Research. 60:683-693
مصطلحات موضوعية: Pharmacology, Membrane potential, Calcium metabolism, Patch-Clamp Techniques, Voltage-dependent calcium channel, Chemistry, Calcium channel, Immunology, HEK 293 cells, Calcium Channel Blockers, Cell Line, Membrane Potentials, Electrophysiology, Calcium Channels, N-Type, Biophysics, Extracellular, Animals, Humans, Calcium, Patch clamp, Ion Channel Gating
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المؤلفون: Ruth L. Martin, Peter de Vries, Rohinton Edalji, T. Matt Hansen, Mikkel Algire, Fritz G. Buchanan, Wei Qiu, Brian T. Weinert, John H. Van Drie, Debra Ferguson, Kesicki Edward A, Ronen Marmorstein, Enrico L. Digiammarino, Philip A. Cole, Lloyd T. Lam, Chunaram Choudhary, Robin R. Frey, Loren M. Lasko, Roberto M. Risi, Kannan R. Karukurichi, Michael A. Patane, Debra Montgomery, Kenneth D. Bromberg, Bailin Shaw, Michael R. Michaelides, David L. McElligott, Arthur F. Kluge, J. William Langston, Ce Wang, Chaohong Sun, Vlasios Manaves, Emily J. Faivre, Maricel Torrent, Gary G. Chiang, Paul Hessler, Albert Lai, Saul H. Rosenberg, Clarissa G. Jakob, Tamar Uziel
المصدر: Nature. 558:E1-E1
مصطلحات موضوعية: 0301 basic medicine, 03 medical and health sciences, Lineage specific, 030104 developmental biology, 0302 clinical medicine, Multidisciplinary, History, 030220 oncology & carcinogenesis, Interpretation (philosophy), Published Erratum, Cancer therapy, Library science, Article
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المؤلفون: Roberto M. Risi, Todd M. Hansen, Clarissa G. Jakob, Mikkel Algire, Tamar Uziel, Lloyd T. Lam, Kenneth D. Bromberg, Vlasios Manaves, Loren M. Lasko, Robin R. Frey, Maricel Torrent, Saul H. Rosenberg, Ruth L. Martin, Debra Montgomery, Bailin Shaw, Michael R. Michaelides, Enrico L. Digiammarino, Wei Qiu, Albert Lai, Paul Hessler, Emily Favire, Fritz G. Buchanan, Debra Ferguson
المصدر: Molecular Cancer Therapeutics. 17:LB-A23
مصطلحات موضوعية: Histone Acetyltransferases, Cancer Research, biology, medicine.drug_class, Chemistry, Cancer, Androgen, medicine.disease, Androgen receptor, Prostate cancer, Histone, Oncology, Acetylation, Cancer research, medicine, biology.protein, Epigenetics
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::16f9918b04e2fa27f6f2e3b6b4a3f001
https://doi.org/10.1158/1535-7163.targ-17-lb-a23 -
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المؤلفون: Kaitlin E. Browman, Arthur L. Nikkel, Richard Harris, Monika Håkerud, William H. Bunnelle, Paul J. Brackemeyer, David J. Anderson, Jennifer M. Frost, Sabine Halm, Jens Halvard Grønlien, Eva Spies, Liping Pan, Eric A.G. Blomme, Clark A. Briggs, Rosalind J. Helfrich, Ryan M. Fryer, Karla Drescher, Earl J. Gubbins, R. Scott Bitner, Ruth L. Martin, Kennan C. Marsh, Kirsten Thorin-Hagene, Stephani Otte, Peter Curzon, Murali Gopalakrishnan, John Malysz, Michael Meyer, Devalina Law, Gerard B. Fox, Hilde Ween, Dagmar Bury, Karin R. Tietje, Hongyu Xu, Pamela S. Puttfarcken, Angela L. Molesky, Kathy L. Kohlhaas, Holly M. Robb, Jeffrey F. Waring, Richard J. Radek
المصدر: CNS Drug Reviews. 14:65-82
مصطلحات موضوعية: Agonist, alpha7 Nicotinic Acetylcholine Receptor, medicine.drug_class, Hippocampus, Review, Receptors, Nicotinic, Cognition, Physiology (medical), medicine, Animals, Humans, Pyrroles, Pharmacology (medical), Nicotinic Agonists, Pharmacology, Sensory gating, Working memory, medicine.disease, Pyridazines, Psychiatry and Mental health, Neuropsychology and Physiological Psychology, Nicotinic agonist, medicine.anatomical_structure, Memory consolidation, Alzheimer's disease, Psychology, Neuroscience
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a77948a51c5747ec1fd7e59fc278d27f
https://doi.org/10.1111/j.1527-3458.2008.00037.x