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1
المؤلفون: John P. Anderson, Dean R. Artis, Hing L. Sham, Roy K. Hom, Michael S. Dappen, Andrei W. Konradi, Simeon Bowers, Hu Pan, Robert A. Galemmo, Marc Adler, Pearl Tanaka, May Lin, Jeanne Baker, Lany Ruslim, Donald J. Fauss, Zhao Ren, Yong L. Zhu, Anh P. Truong, Danny Tam, Marcelle Bergeron, Lee H. Latimer, Paul Beroza, Jacek Jagodzinski, Heather Zhang, Michael P. Bova, George Tonn, Linnea Diep, Ruth Motter, Kent Fitzgerald, Nanhua Yao, Wayman Chan, Jennifer K. Hoffman, R. Jeffrey Neitz, Danielle L. Aubele
المصدر: ChemMedChem. 8:1295-1313
مصطلحات موضوعية: Male, Parkinson's disease, Polo-like kinase, Molecular Dynamics Simulation, Protein Serine-Threonine Kinases, Pharmacology, Biology, Blood–brain barrier, Biochemistry, Rats, Sprague-Dawley, Mice, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Animals, Humans, Protein Isoforms, Phosphorylation, General Pharmacology, Toxicology and Pharmaceutics, Protein Kinase Inhibitors, Alpha-synuclein, Binding Sites, Kinase, Drug discovery, Organic Chemistry, Brain, medicine.disease, Protein Structure, Tertiary, Rats, HEK293 Cells, medicine.anatomical_structure, chemistry, Blood-Brain Barrier, alpha-Synuclein, Molecular Medicine, Female, Half-Life
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2
المؤلفون: Kevin Tanaka, Marcelle Bergeron, Donald J. Fauss, Maria Armanda Viana Rodrigues, Jeanne Baker, Yangli Yang, Pui Seto, Monica You, Linnea Diep, Ruth Motter, Lilibeth Dofiles
المصدر: Journal of Neuroscience Methods. 215:245-257
مصطلحات موضوعية: Male, Parkinson's disease, Tyrosine 3-Monooxygenase, Dopamine, Biotin, Enzyme-Linked Immunosorbent Assay, Neuroprotection, Specimen Handling, Rats, Sprague-Dawley, Pathogenesis, Mice, Intermediate Filament Proteins, Western blot, medicine, Animals, Humans, Chromatography, High Pressure Liquid, biology, Tyrosine hydroxylase, medicine.diagnostic_test, General Neuroscience, Antibodies, Monoclonal, Brain, Parkinson Disease, medicine.disease, Molecular biology, Rats, Mice, Inbred C57BL, Disease Models, Animal, Animals, Newborn, Mutation, Immunology, biology.protein, Synuclein, Female, Antibody, medicine.drug
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3
المؤلفون: Kevin P. Quinn, Marc Adler, Gary Probst, Albert W. Garofalo, Anh P. Truong, Danny Tam, Erich Goldbach, Danielle L. Aubele, Maurizio Franzini, David Chian, Grace Kwong, Xiaocong M. Ye, Zhao Ren, Hing L. Sham, Lany Ruslim, Pearl Tanaka, Elizabeth F. Brigham, Ruth Motter
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:1974-1977
مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Pharmaceutical Science, Mice, Transgenic, Protein Serine-Threonine Kinases, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, MAP3K7, Biochemistry, MAP2K7, Mice, Structure-Activity Relationship, Drug Discovery, Animals, Humans, c-Raf, Kinase activity, Protein Kinase Inhibitors, Molecular Biology, Mice, Knockout, Dose-Response Relationship, Drug, Molecular Structure, biology, Cyclin-dependent kinase 4, Chemistry, Organic Chemistry, Cyclin-dependent kinase 2, Protein kinase R, nervous system diseases, HEK293 Cells, Mutation, Quinolines, biology.protein, Molecular Medicine, Cyclin-dependent kinase 9
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4
المؤلفون: Matthew Jarpe, Frederique Bard, Brian Schlain, Ruth Motter, Ellen Garber, Renee I. Shapiro, Frederick R. Taylor, Ted Yednock, R. Blake Pepinsky, Paula S. Hochman, Tatiana Plavina, Nancy G. Wehner
المصدر: Journal of Pharmaceutical and Biomedical Analysis. 55:168-175
مصطلحات موضوعية: Multiple Sclerosis, medicine.drug_class, Integrin alpha4, Clinical Biochemistry, Immunoglobulin Variable Region, Pharmaceutical Science, Endogeny, Pharmacology, Antibodies, Monoclonal, Humanized, Monoclonal antibody, Protein Refolding, Analytical Chemistry, Rats, Sprague-Dawley, Natalizumab, Crohn Disease, Pharmacokinetics, Limit of Detection, In vivo, Antibodies, Bispecific, Drug Discovery, medicine, Animals, Humans, Technology, Pharmaceutical, Spectroscopy, Immunoassay, Chromatography, biology, Chemistry, Multiple sclerosis, Antibodies, Monoclonal, Reproducibility of Results, medicine.disease, Rats, Immunoglobulin G, Monoclonal, biology.protein, Mutant Proteins, Antibody, Algorithms, medicine.drug
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5
المؤلفون: Elizabeth F. Brigham, Karen S. Chen, Stephen B. Freedman, Ruth Motter, Weiqun Liu, Manuel Buttini, John P. Anderson, Lisa McConlogue, Sukanto Sinha, Kelly Johnson-Wood, Dora Games, Michael K. Lee, Michelle Zeller
المصدر: Journal of Biological Chemistry. 282:26326-26334
مصطلحات موضوعية: Genetically modified mouse, Aging, medicine.medical_specialty, Amyloid beta, Synaptic Membranes, Biochemistry, Amyloid beta-Protein Precursor, Mice, Alzheimer Disease, Internal medicine, mental disorders, Neurites, medicine, Amyloid precursor protein, Animals, Aspartic Acid Endopeptidases, Humans, Molecular Biology, Gene, Gene knockout, Mice, Knockout, chemistry.chemical_classification, biology, Cell Biology, medicine.disease, Enzyme assay, Enzyme Activation, Disease Models, Animal, Enzyme, Endocrinology, chemistry, Immunology, biology.protein, Amyloid Precursor Protein Secretases, Alzheimer's disease
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3db05cead87c83caac2caa1064e167
https://doi.org/10.1074/jbc.m611687200 -
6
المؤلفون: Guiquan Chen, Dione Kobayashi, Robin Barbour, Richard G. M. Morris, Dora Games, Karen S. Chen, Ruth Motter, Stephen J. Martin
المصدر: Chen, G, Chen, K S, Kobayashi, D, Barbour, R, Motter, R, Games, D, Martin, S J & Morris, R G M 2007, ' Active beta-amyloid immunization restores spatial learning in PDAPP mice displaying very low levels of beta-amyloid ', Journal of Neuroscience, vol. 27, no. 10, pp. 2654-62 . https://doi.org/10.1523/JNEUROSCI.3710-06.2007
مصطلحات موضوعية: Male, Genetically modified mouse, medicine.medical_specialty, animal diseases, Monophosphoryl Lipid A, Hippocampus, Mice, Transgenic, Water maze, Hippocampal formation, Active immunization, Antibodies, Amyloid beta-Protein Precursor, Mice, Internal medicine, Task Performance and Analysis, mental disorders, medicine, Amyloid precursor protein, Animals, Humans, Maze Learning, Swimming, Cerebral Cortex, Amyloid beta-Peptides, Behavior, Animal, biology, business.industry, General Neuroscience, Antibody titer, Articles, Peptide Fragments, Endocrinology, Mutation, Immunology, biology.protein, Immunization, Cues, business
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c4b5a6d251c82a2133ae8609c368ac
https://doi.org/10.1523/jneurosci.3710-06.2007 -
7
المؤلفون: Peter Seubert, Ruth Motter, J. Randall Slemmon, Sashi Nadanaciva, Ashley Cook, Florentina Catana, Cory L. Painter
المصدر: Journal of Chromatography B. 846:24-31
مصطلحات موضوعية: Adult, Male, Amyloid beta, Clinical Biochemistry, Enzyme-Linked Immunosorbent Assay, Peptide, Biochemistry, Analytical Chemistry, Pharmacokinetics, Blood plasma, Humans, Distribution (pharmacology), Denaturation (biochemistry), Chromatography, High Pressure Liquid, Whole blood, chemistry.chemical_classification, Amyloid beta-Peptides, Chromatography, biology, Chemistry, Cell Biology, General Medicine, Middle Aged, Blood proteins, biology.protein, Female
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8
المؤلفون: P. Seubert, Kathleen Hoenow, Dora Games, Teresa Guido, Vasquez Nicki J, Ted Yednock, Michael K. Lee, Dora Kholodenko, Catherine Cannon, Robin Barbour, Michael Fox, Kang Hu, Robert Carretto, Minh Nguyen, Ruth Motter, Pearl Tang, Dale Schenk, Celeste Lee, Frederique Bard, Kelly Johnson-Wood, Amanda Reed, Karen Khan
المصدر: Proceedings of the National Academy of Sciences. 100:2023-2028
مصطلحات موضوعية: medicine.drug_class, Molecular Sequence Data, Monoclonal antibody, Epitope, Epitopes, Alzheimer Disease, Antibody Specificity, Amyloid precursor protein, medicine, Humans, Amino Acid Sequence, Amyloid beta-Peptides, Multidisciplinary, biology, P3 peptide, Antibodies, Monoclonal, Biological Sciences, Molecular biology, Isotype, Peptide Fragments, Complement system, Epitope mapping, Immunology, biology.protein, Antibody, Epitope Mapping
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546e4278e4417ccb13a8b57592f18668
https://doi.org/10.1073/pnas.0436286100 -
9
المؤلفون: Teresa M. Cox, Jason P. Brown, Douglas Galasko, Ruth Motter, Gail V.W. Johnson, Peter Seubert
المصدر: Journal of Neurochemistry. 68:430-433
مصطلحات موضوعية: Pathology, medicine.medical_specialty, Immunoprecipitation, Proteolysis, Immunoblotting, Tau protein, Enzyme-Linked Immunosorbent Assay, tau Proteins, Biochemistry, Cellular and Molecular Neuroscience, Degenerative disease, Cerebrospinal fluid, Alzheimer Disease, Reference Values, mental disorders, medicine, Humans, biology, medicine.diagnostic_test, business.industry, medicine.disease, Precipitin, Precipitin Tests, Molecular biology, Peptide Fragments, Cerebrovascular Disorders, biology.protein, Alkaline phosphatase, Alzheimer's disease, business, Peptide Hydrolases
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10
المؤلفون: Ismail Kola, Weiqun Liu, Kjell A. Svensson, Mary E. Shuck, Hartmut Tintrup, Sarah Wright, John A. Wijsman, Karen S. Chen, Lisa McConlogue, Thomas T. Kawabe, John P. Anderson, Kang Hu, Guriqbal Basi, Michael Power, Steven L. Roberds, Karl Kappenman, Dale Schenk, Stephen B. Freedman, Michael Schoor, Normand Frigon, David W. Robertson, Ralf Kuehn, Dora Kate Games, Sukanto Sinha, George Shopp, Kelly Johnson-Wood, Nanette F. Nichols, Michael Jerome Bienkowski, Mike Lee, Gwen Tatsuno, Ruth Motter, Daniel G. Branstetter
المصدر: Human Molecular Genetics. 10:1317-1324
مصطلحات موضوعية: Male, medicine.medical_specialty, Ratón, medicine.disease_cause, Cell Line, Amyloid beta-Protein Precursor, Mice, Degenerative disease, Alzheimer Disease, Culture Techniques, Internal medicine, Endopeptidases, mental disorders, Genetics, medicine, Amyloid precursor protein, Animals, Aspartic Acid Endopeptidases, Enzyme Inhibitors, Molecular Biology, Cells, Cultured, Genetics (clinical), Mice, Knockout, Mutation, Amyloid beta-Peptides, biology, Brain, General Medicine, medicine.disease, Phenotype, Mice, Inbred C57BL, Endocrinology, Knockout mouse, Mice, Inbred CBA, biology.protein, Female, Amyloid Precursor Protein Secretases, Alzheimer's disease, Amyloid precursor protein secretase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62941ba2369e7d9bf17cea82323484d
https://doi.org/10.1093/hmg/10.12.1317
