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المؤلفون: E. Scott Priestley, Jacques Banville, Daniel Deon, Laurence Dubé, Marc Gagnon, Julia Guy, Philippe Lapointe, Jean-François Lavallée, Alain Martel, Serge Plamondon, Roger Rémillard, Edward Ruediger, François Tremblay, Shana L. Posy, Victor R. Guarino, Jeremy M. Richter, Jianqing Li, Anuradha Gupta, Muthalagu Vetrichelvan, T. J. Balapragalathan, Arvind Mathur, Ji Hua, Mario Callejo, Jocelyne Guay, Chi Shing Sum, Mary Ellen Cvijic, Carol Watson, Pancras Wong, Jing Yang, Michel Bouvier, David A. Gordon, Ruth R. Wexler, Anne Marinier
المصدر: Journal of Medicinal Chemistry. 65:8843-8854
مصطلحات موضوعية: Blood Platelets, Thiazoles, Platelet Aggregation, Morpholines, Drug Discovery, Imidazoles, Thrombin, Humans, Molecular Medicine, Receptor, PAR-1, Receptors, Thrombin, Thrombosis, Benzofurans
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المؤلفون: Nicholas R. Wurtz, James A. Johnson, Andrew Viet, Pravin S. Shirude, Vishweshwaraiah Baligar, Sudhakara Madduri, Daniel L. Cheney, Hyunsoo Park, John A. Lupisella, Mei-Yin Hsu, Mojgan Abousleiman, Michael A. Galella, Darpandeep Aulakh, Elizabeth A. Dierks, Ricardo A. Garcia, Jacek Ostrowski, Ellen K. Kick, Ruth R. Wexler
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Biochemistry
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المؤلفون: Zilun Hu, Doree Sitkoff, Peter W. Glunz, Yan Zou, Cailan Wang, Jodi K. Muckelbauer, Leonard P. Adam, Ruth R. Wexler, Mimi L. Quan
المصدر: SSRN Electronic Journal.
مصطلحات موضوعية: History, Polymers and Plastics, Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Business and International Management, Molecular Biology, Biochemistry, Industrial and Manufacturing Engineering
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41bd0491e080f2db50067a946e1fa19b
https://doi.org/10.2139/ssrn.4379816 -
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المؤلفون: Jeffrey M. Bozarth, Pancras C. Wong, Earl J. Crain, William R. Ewing, Joseph M. Luettgen, David A. Gordon, Ruth R. Wexler, Yiming Wu, Dilger Andrew K
المصدر: Journal of Thrombosis and Haemostasis. 20:399-408
مصطلحات موضوعية: Prothrombin time, Aspirin, medicine.diagnostic_test, Chemistry, Hematology, Pharmacology, Coagulation, In vivo, Bleeding time, Hemostasis, Antithrombotic, medicine, medicine.drug, Partial thromboplastin time
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المؤلفون: Wei Meng, Heather Finlay, Claudia Generaux, Chiuwa E. Luk, Tao Wang, Robert Paul Brigance, Joelle M. Onorato, Peter S. Gargalovic, Ruth R. Wexler, William A. Schumacher, Jeffrey S. Bostwick, Zulan Pi, Karen A. Rossi
المصدر: Journal of Medicinal Chemistry. 64:18102-18113
مصطلحات موضوعية: Agonist, medicine.drug_class, Pyrazole, Pharmacology, In vitro, chemistry.chemical_compound, chemistry, Pharmacokinetics, Pharmacodynamics, Drug Discovery, medicine, Molecular Medicine, Potency, Receptor, Apelin receptor
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المؤلفون: Ruth R. Wexler, Kenneth G. Mann, Leonard M. Milstone, Rodney M. Camire, Jeremy P. Wood, Wolfram Ruf, Robert M. Knabb, Richard C. Becker, Craig M Jackson
المصدر: Journal of Thrombosis and Thrombolysis
مصطلحات موضوعية: Traditional medicine, business.industry, Factor X, MEDLINE, Hematology, Article, Thromboplastin, chemistry.chemical_compound, chemistry, Factor Xa, Medicine, Humans, Blood Coagulation Tests, Anti-coagulants, Cardiology and Cardiovascular Medicine, business
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المؤلفون: Ruth R. Wexler, Robert M. Knabb
المصدر: Journal of Thrombosis and Thrombolysis. 52:403-407
مصطلحات موضوعية: medicine.medical_specialty, Standard of care, medicine.drug_mechanism_of_action, Drug discovery, Basic science, business.industry, Factor Xa Inhibitor, Hematology, medicine, Apixaban, Life saving, Cardiology and Cardiovascular Medicine, Intensive care medicine, business, medicine.drug
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المؤلفون: Jeremy M. Richter, J. Alex Bates, Peter Gargalovic, Joelle M. Onorato, Claudia Generaux, Tao Wang, David A. Gordon, Ruth R. Wexler, Heather J. Finlay
المصدر: Bioorganicmedicinal chemistry letters. 73
مصطلحات موضوعية: Apelin Receptors, Pyridines, Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Animals, Apelin, Molecular Biology, Biochemistry, Rats, Receptors, G-Protein-Coupled
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المؤلفون: Arunachalam Arumugam, Dietmar A. Seiffert, Arvind Mathur, Joanna J. Zheng, Ruth R. Wexler, Jeon Yoon T, Premsai Rai Neithnadka, Earl J. Crain, Paul J. Gilligan, Patrick Y.S. Lam, Yiming Wu, Mahammed Kaspady, Pancras C. Wong, Tianan Fang, Silvi A. Chacko, William R. Ewing, Pabbisetty Kumar Balashanmuga, Zhen Lou, Steven Sheriff, Joseph M. Luettgen, Joseph E. Myers, Wu Yang, Karen A. Rossi, Richard Rampulla, James R. Corte, Amy Lai, Charles G. Clark, Jeffrey M. Bozarth, Yufeng Wang, Sivashankaran Raju
المصدر: Journal of Medicinal Chemistry. 63:7226-7242
مصطلحات موضوعية: Models, Molecular, Proteases, Macrocyclic Compounds, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Pharmacology, Crystallography, X-Ray, 01 natural sciences, Factor XIa, Serine, Structure-Activity Relationship, 03 medical and health sciences, Dogs, Fibrinolytic Agents, Pharmacokinetics, In vivo, Drug Discovery, Antithrombotic, Animals, Humans, Structure–activity relationship, 030304 developmental biology, 0303 health sciences, Chemistry, 0104 chemical sciences, Bioavailability, 010404 medicinal & biomolecular chemistry, Molecular Medicine, Rabbits, Hydrophobic and Hydrophilic Interactions, Linker
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المؤلفون: William A. Schumacher, Yan He, Peter S. Gargalovic, Tao Wang, Joelle M. Onorato, Ruth R. Wexler, James A. Johnson, Zulan Pi, Claudia Generaux, Wei Meng, Heather Finlay, David A. Gordon, Monique Phillips, Jeffrey S. Bostwick
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Agonist, Pyr1, Chemistry, medicine.drug_class, Organic Chemistry, Regulator, Oxadiazole, Endogeny, Pharmacology, Biochemistry, chemistry.chemical_compound, Pharmacodynamics, Drug Discovery, medicine, Receptor, Apelin receptor
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c497839aa78ba246784ea2c27101a0c
https://europepmc.org/articles/PMC8591725/