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1
المؤلفون: Steven D. Shapiro, Walker T. McGraw, J. Travis, M. J. Janusz, M. Hare, S. L. Durham, Jan Potempa, Robert N. Pike
المصدر: Inflammation Research. 48:280-288
مصطلحات موضوعية: Blotting, Western, Molecular Sequence Data, Immunology, Matrix metallopeptidase 12, Matrix metalloproteinase, Cell Line, Mice, Matrix Metalloproteinase 12, medicine, Animals, Macrophage, Zymography, Amino Acid Sequence, Pharmacology, Metalloproteinase, biology, Macrophages, Cartilage, Metalloendopeptidases, Molecular biology, Elastin, Cell Transformation, Neoplastic, medicine.anatomical_structure, Proteoglycan, Connective Tissue, Cell culture, Culture Media, Conditioned, biology.protein, Electrophoresis, Polyacrylamide Gel, Proteoglycans
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2
المؤلفون: Herman Schreuder, William A. Metz, R.V. Hoffman, Robert J. Cregge, Farr Robert A, Koehl Jack Roger, Hwa-Ok Kim, Norton P. Peet, Shyam Sunder, S L Durham, M J Janusz, C M Hare, Chantal Tardif, J.T. Pelton, Shujaath Mehdi, S.L. Gallion
المصدر: Journal of Medicinal Chemistry. 41:2461-2480
مصطلحات موضوعية: Lung Diseases, Models, Molecular, Serine Proteinase Inhibitors, Ketone, Proline, Neutrophils, Swine, Stereochemistry, Molecular Conformation, Administration, Oral, Hemorrhage, Tripeptide, Crystallography, X-Ray, Chemical synthesis, Structure-Activity Relationship, Cricetinae, Drug Discovery, Animals, Humans, Pancreatic elastase, chemistry.chemical_classification, Fluorocarbons, Binding Sites, Pancreatic Elastase, biology, Chemistry, Elastase, Active site, Ketones, Isoquinolines, Haloketone, Crystallography, Enzyme inhibitor, Drug Design, biology.protein, Azetidines, Molecular Medicine, Leukocyte Elastase, Oligopeptides
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3
المؤلفون: Michael R. Angelastro, Joseph P. Burkhart, M J Janusz, Chen Tm, Edward W. Huber, Koehl, Baugh Le, S L Durham, Philippe Bey, C M Hare
المصدر: Journal of Medicinal Chemistry. 37:4538-4553
مصطلحات موضوعية: Stereochemistry, Molecular Sequence Data, Administration, Oral, Hamster, Hemorrhage, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Oral administration, In vivo, Cricetinae, Drug Discovery, Animals, Humans, Amino Acid Sequence, Chromatography, High Pressure Liquid, Dipeptide, Pancreatic Elastase, biology, Elastase, Ketones, Rats, chemistry, Enzyme inhibitor, Lipophilicity, biology.protein, Molecular Medicine, Leukocyte Elastase
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4
المؤلفون: S. L. Durham, M. J. Janusz
المصدر: Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 46(12)
مصطلحات موضوعية: Cartilage, Articular, medicine.medical_specialty, Pathology, Serine Proteinase Inhibitors, medicine.medical_treatment, Morpholines, Immunology, Type II collagen, Arthritis, Pharmacology, Pannus Formation, Internal medicine, Medicine, Animals, Intradermal injection, Fluorocarbons, biology, business.industry, Cartilage, medicine.disease, Arthritis, Experimental, Rheumatology, Hindlimb, Rats, medicine.anatomical_structure, Rats, Inbred Lew, Neutrophil elastase, biology.protein, Female, Collagen, business, Leukocyte Elastase, Adjuvant, Oligopeptides
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5
المؤلفون: M J Janusz, C M Hare, S L Durham, R. D. Woessner
المصدر: Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 46
مصطلحات موضوعية: Pharmacology, Transcription, Genetic, Chemistry, Immunology, Pharmacology toxicology, Chondrosarcoma, Bone Neoplasms, Transfection, Matrix metalloproteinase, medicine.disease, Molecular biology, Dexamethasone, medicine, Tumor Cells, Cultured, Humans, Matrix Metalloproteinase 3, Promoter Regions, Genetic, Interleukin-1
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6
المؤلفون: M J, Janusz, S L, Durham, C M, Hare, J L, Geary, A K, Mandagere, J C, Poole, T N, Thompson, D, Xu, M R, Anagelastro, J P, Burkhart
المصدر: The Journal of pharmacology and experimental therapeutics. 275(3)
مصطلحات موضوعية: Male, Serine Proteinase Inhibitors, Mesocricetus, Pancreatic Elastase, Molecular Sequence Data, Administration, Oral, Hemorrhage, In Vitro Techniques, Rats, Rats, Sprague-Dawley, Jejunum, Intestinal Absorption, Liver, Cricetinae, Animals, Humans, Amino Acid Sequence, Leukocyte Elastase, Lung
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::cf1898d5eb8573125ad5dfe4ff28ace7
https://pubmed.ncbi.nlm.nih.gov/8531086 -
7
المؤلفون: Sunder S, Koehl, Joseph P. Burkhart, M J Janusz, Edward W. Huber, S L Durham, Shujaath Mehdi, William A. Metz, Michael R. Angelastro, Shum Pw
المصدر: Journal of medicinal chemistry. 38(2)
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Stereochemistry, Neutrophils, Acetates, Chemical synthesis, In vivo, Cricetinae, Drug Discovery, Animals, Humans, Prodrugs, Protease Inhibitors, biology, Pancreatic Elastase, Chemistry, Elastase, Stereoisomerism, Prodrug, Ketones, In vitro, Enzyme inhibitor, biology.protein, Molecular Medicine, Epimer, Stereoselectivity, Leukocyte Elastase
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8
المؤلفون: S L, Durham, C M, Hare, M R, Angelastro, J P, Burkhart, J R, Koehl, A L, Marquart, S, Mehdi, N P, Peet, M J, Janusz
المصدر: The Journal of pharmacology and experimental therapeutics. 270(1)
مصطلحات موضوعية: Lung Diseases, Male, Fluorocarbons, Dose-Response Relationship, Drug, Mesocricetus, Pancreatic Elastase, Drug Administration Routes, Morpholines, Molecular Sequence Data, Administration, Oral, Hemorrhage, Sensitivity and Specificity, Cricetinae, Animals, Humans, Amino Acid Sequence, Leukocyte Elastase, Oligopeptides
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::b9f658e622a2fd267e9a7c1b4161277b
https://pubmed.ncbi.nlm.nih.gov/8035315 -
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المؤلفون: S L, Durham, J F, Hoke, T M, Chen
المصدر: Drug metabolism and disposition: the biological fate of chemicals. 21(3)
مصطلحات موضوعية: Adult, Aminocaproates, Male, Feces, Administration, Oral, Humans, Anticonvulsants, Middle Aged, Biotransformation, Chromatography, High Pressure Liquid, Mass Spectrometry, Vigabatrin, Chromatography, Liquid
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::cd569cbcb17e8a6ed7604da0204d8e1d
https://pubmed.ncbi.nlm.nih.gov/8100505