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المؤلفون: E. de Poel, S. Spelier, M.C. Hagemeijer, P. van Mourik, S.W.F. Suen, A.M. Vonk, J.E. Brunsveld, G.N. Ithakisiou, E. Kruisselbrink, H. Oppelaar, G. Berkers, K.M. de Winter de Groot, S. Heida-Michel, S.R. Jans, H. van Panhuis, M. Bakker, R. van der Meer, J. Roukema, E. Dompeling, E.J.M. Weersink, G.H. Koppelman, A.R. Blaazer, J.E. Muijlwijk-Koezen, C.K. van der Ent, J.M. Beekman
المساهمون: Medical Microbiology and Infection Prevention, AII - Infectious diseases, Pulmonology, Pulmonary Medicine
المصدر: Journal of cystic fibrosis. Elsevier
Journal of Cystic Fibrosis, 22, 548-559
Journal of Cystic Fibrosis, 22, 3, pp. 548-559
Journal of Cystic Fibrosis, 22(3), 548-559. Elsevierمصطلحات موضوعية: Pulmonary and Respiratory Medicine, Genotype, Colforsin, Drug Repositioning, CFTR modulators, Phosphodiesterase 4 Inhibitors/therapeutic use, PDE4 inhibitors, Preclinical, Organoids, All institutes and research themes of the Radboud University Medical Center, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], SDG 3 - Good Health and Well-being, Drug screening, Rare mutations, Mutation, Pediatrics, Perinatology and Child Health, Humans, Cystic Fibrosis Transmembrane Conductance Regulator/genetics, Drug Evaluation, Cystic Fibrosis/drug therapy
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89ec4ff876b41ac455bf427f708ef3b6
https://pure.amc.nl/en/publications/fdaapproved-drug-screening-in-patientderived-organoids-demonstrates-potential-of-drug-repurposing-for-rare-cystic-fibrosis-genotypes(d3d6bd49-ebfc-40f4-ab6c-0e87380d8a5f).html -
2دورية أكاديمية
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3دورية أكاديمية
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4دورية أكاديمية
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5دورية أكاديمية
المؤلفون: Vijftigschild LA; Dept of Pediatric Pulmonology, University Medical Center, Utrecht, The Netherlands Laboratory of Translational Immunology, University Medical Center, Utrecht, The Netherlands These two authors contributed equally to this work., Berkers G; Dept of Pediatric Pulmonology, University Medical Center, Utrecht, The Netherlands These two authors contributed equally to this work., Dekkers JF; Dept of Pediatric Pulmonology, University Medical Center, Utrecht, The Netherlands Laboratory of Translational Immunology, University Medical Center, Utrecht, The Netherlands These two authors contributed equally to this work., Zomer-van Ommen DD; Dept of Pediatric Pulmonology, University Medical Center, Utrecht, The Netherlands Laboratory of Translational Immunology, University Medical Center, Utrecht, The Netherlands These two authors contributed equally to this work., Matthes E; CF Translational Research Centre, Dept of Physiology, McGill University, Montréal, QC, Canada., Kruisselbrink E; Dept of Pediatric Pulmonology, University Medical Center, Utrecht, The Netherlands Laboratory of Translational Immunology, University Medical Center, Utrecht, The Netherlands., Vonk A; Dept of Pediatric Pulmonology, University Medical Center, Utrecht, The Netherlands Laboratory of Translational Immunology, University Medical Center, Utrecht, The Netherlands., Hensen CE; Dept of Pediatric Pulmonology, University Medical Center, Utrecht, The Netherlands., Heida-Michel S; Dept of Pediatric Pulmonology, University Medical Center, Utrecht, The Netherlands., Geerdink M; Dept of Pediatric Pulmonology, University Medical Center, Utrecht, The Netherlands., Janssens HM; Dept of Pediatric Pulmonology, Erasmus Medical Center/Sophia Children's Hospital, Rotterdam, The Netherlands., van de Graaf EA; Dept of Pulmonology, University Medical Center, Utrecht, The Netherlands., Bronsveld I; Dept of Pulmonology, University Medical Center, Utrecht, The Netherlands., de Winter-de Groot KM; Dept of Pediatric Pulmonology, University Medical Center, Utrecht, The Netherlands., Majoor CJ; Dept of Respiratory Medicine, Academic Medical Center, Amsterdam, The Netherlands., Heijerman HG; Dept of Pulmonology and Cystic Fibrosis, Haga Teaching Hospital, The Hague, The Netherlands., de Jonge HR; Dept of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands., Hanrahan JW; CF Translational Research Centre, Dept of Physiology, McGill University, Montréal, QC, Canada., van der Ent CK; Dept of Pediatric Pulmonology, University Medical Center, Utrecht, The Netherlands., Beekman JM; Dept of Pediatric Pulmonology, University Medical Center, Utrecht, The Netherlands Regenerative Medicine Center Utrecht, University Medical Center, Utrecht, The Netherlands jbeekman@umcutrecht.nl.
المصدر: The European respiratory journal [Eur Respir J] 2016 Sep; Vol. 48 (3), pp. 768-79. Date of Electronic Publication: 2016 Jul 28.
نوع المنشور: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: European Respiratory Society Country of Publication: England NLM ID: 8803460 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-3003 (Electronic) Linking ISSN: 09031936 NLM ISO Abbreviation: Eur Respir J Subsets: MEDLINE
مواضيع طبية MeSH: Adrenergic beta-2 Receptor Agonists/*pharmacology , Cystic Fibrosis/*drug therapy , Cystic Fibrosis/*metabolism , Cystic Fibrosis Transmembrane Conductance Regulator/*metabolism, Administration, Oral ; Albuterol/administration & dosage ; Biological Assay ; Bronchi/pathology ; Cell Line ; Cells, Cultured ; Chlorides/chemistry ; Cystic Fibrosis/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Drug Evaluation, Preclinical ; Epithelial Cells/metabolism ; Epithelium/metabolism ; Humans ; Mutation ; Nasal Mucosa/drug effects ; Nasal Mucosa/metabolism ; Organoids ; Pilot Projects ; Respiratory System/metabolism ; Signal Transduction