المؤلفون: Ikhar AS; Department of Periodontology and Implant Dentistry, VSPM Dental College and Research Centre, Nagpur, Maharashtra, India., Kolte RA; Department of Periodontology and Implant Dentistry, VSPM Dental College and Research Centre, Nagpur, Maharashtra, India., Kolte AP; Department of Periodontology and Implant Dentistry, VSPM Dental College and Research Centre, Nagpur, Maharashtra, India., Rathi PR; Department of Periodontology and Implant Dentistry, VSPM Dental College and Research Centre, Nagpur, Maharashtra, India., Ghoderao DG; Department of Periodontology and Implant Dentistry, VSPM Dental College and Research Centre, Nagpur, Maharashtra, India., Dahake RN; Department of Oral and Maxillofacial Surgery, VSPM Dental College and Research Centre, Nagpur, Maharashtra, India.

المصدر: Journal of periodontology [J Periodontol] 2024 Jun; Vol. 95 (6), pp. 563-570. Date of Electronic Publication: 2023 Oct 17.

نوع المنشور: Journal Article; Comparative Study

بيانات الدورية: Publisher: American Academy of Periodontology Country of Publication: United States NLM ID: 8000345 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1943-3670 (Electronic) Linking ISSN: 00223492 NLM ISO Abbreviation: J Periodontol Subsets: MEDLINE

مواضيع طبية MeSH: Gingival Crevicular Fluid*/chemistry , Semaphorins*/metabolism , Semaphorins*/analysis , Matrix Metalloproteinase 8*/analysis , Matrix Metalloproteinase 8*/metabolism , Antigens, CD*/analysis , Smoking*, Humans ; Female ; Male ; Adult ; Middle Aged ; Hydrolases/metabolism ; Protein-Arginine Deiminase Type 2 ; Follow-Up Studies ; Periodontitis/therapy ; Periodontitis/metabolism ; Dental Scaling ; Periodontal Index ; Periodontal Pocket/therapy ; Periodontal Pocket/metabolism ; Smokers ; Periodontal Attachment Loss/therapy ; Chronic Periodontitis/therapy ; Chronic Periodontitis/metabolism

المؤلفون: Peng H; Medical School, Southeast University, Nanjing, 210009, China., Yang M; Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical. Sciences, Peking Union Medical College, Beijing, 100730, China., Feng K; Hepatopancreatobiliary Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210009, China., Lv Q; Hepatopancreatobiliary Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210009, China., Zhang Y; Hepatopancreatobiliary Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210009, China. zhangyewei@njmu.edu.cn.

المصدر: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2024 Jul 03; Vol. 9 (1), pp. 169. Date of Electronic Publication: 2024 Jul 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE

مواضيع طبية MeSH: Liver Neoplasms*/genetics , Liver Neoplasms*/pathology , Liver Neoplasms*/metabolism , Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/metabolism , Tumor Microenvironment*/genetics , Semaphorins*/genetics , Semaphorins*/metabolism, Humans ; Integrin beta1/genetics ; Integrin beta1/metabolism ; Mice ; Signal Transduction/genetics ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/pathology ; Neuropilin-1/genetics ; Neuropilin-1/metabolism ; Cell Line, Tumor ; Neoplastic Stem Cells/pathology ; Neoplastic Stem Cells/metabolism ; Animals ; Gene Expression Regulation, Neoplastic/genetics ; Sorafenib/pharmacology ; Cancer-Associated Fibroblasts/metabolism ; Cancer-Associated Fibroblasts/pathology ; Disease Progression

المؤلفون: Cui K; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China., Tang X; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China., Yang B; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China., Fan M; Yale College, Yale University, New Haven, Connecticut, United States., Hu A; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China., Wu P; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China., Yang F; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China., Lin J; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China., Kong H; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China., Lu X; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China., Yu S; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China., Xu Y; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China., Liang X; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.

المصدر: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2024 Jun 03; Vol. 65 (6), pp. 34.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Print Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest Ophthalmol Vis Sci Subsets: MEDLINE

مواضيع طبية MeSH: Choroidal Neovascularization*/metabolism , Choroidal Neovascularization*/genetics , Choroidal Neovascularization*/pathology , Macrophages*/metabolism , rho-Associated Kinases*/metabolism , Mice, Knockout* , Semaphorins*/genetics , Semaphorins*/metabolism , Disease Models, Animal* , Signal Transduction*/physiology , Mice, Inbred C57BL* , rhoA GTP-Binding Protein*/metabolism, Animals ; Mice ; Antigens, CD/metabolism ; Antigens, CD/genetics ; Blotting, Western ; Male ; Fluorescein Angiography

المؤلفون: Yombo DJK; Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States.; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, United States., Ghandikota S; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, United States.; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States., Vemulapalli CP; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States., Singh P; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States., Jegga AG; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, United States.; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States., Hardie WD; Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States.; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, United States., Madala SK; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States.

المصدر: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2024 Jun 01; Vol. 326 (6), pp. C1659-C1668. Date of Electronic Publication: 2024 Apr 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901225 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1563 (Electronic) Linking ISSN: 03636143 NLM ISO Abbreviation: Am J Physiol Cell Physiol Subsets: MEDLINE

مواضيع طبية MeSH: Extracellular Matrix Proteins*/metabolism , Extracellular Matrix Proteins*/genetics , Fibroblasts*/metabolism , Idiopathic Pulmonary Fibrosis*/metabolism , Idiopathic Pulmonary Fibrosis*/pathology , Idiopathic Pulmonary Fibrosis*/genetics , Lung*/metabolism , Lung*/pathology , Neuropilin-1*/metabolism , Neuropilin-1*/genetics , Semaphorins*/metabolism , Semaphorins*/genetics , Transforming Growth Factor beta*/metabolism, Animals ; Female ; Humans ; Male ; Mice ; Middle Aged ; Cells, Cultured ; Extracellular Matrix/metabolism ; Membrane Glycoproteins ; Mice, Inbred C57BL

المؤلفون: Mirza SL; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge CB2 0BB, UK; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK., Upton PD; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge CB2 0BB, UK; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK., Hodgson J; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge CB2 0BB, UK; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK., Gräf S; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge CB2 0BB, UK; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK., Morrell NW; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge CB2 0BB, UK; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK., Dunmore BJ; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge CB2 0BB, UK; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK. Electronic address: bjd28@cam.ac.uk.

المصدر: Vascular pharmacology [Vascul Pharmacol] 2024 Jun; Vol. 155, pp. 107381. Date of Electronic Publication: 2024 May 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 101130615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3649 (Electronic) Linking ISSN: 15371891 NLM ISO Abbreviation: Vascul Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Cell Movement*/drug effects , Semaphorins*/metabolism , Semaphorins*/genetics , Growth Differentiation Factor 2*/genetics , Growth Differentiation Factor 2*/metabolism , Endothelial Cells*/metabolism , Endothelial Cells*/drug effects , Signal Transduction* , Vascular Endothelial Growth Factor A*/metabolism , Vascular Endothelial Growth Factor A*/genetics, Humans ; Smad5 Protein/metabolism ; Smad5 Protein/genetics ; Activin Receptors, Type I/metabolism ; Activin Receptors, Type I/genetics ; Bone Morphogenetic Protein Receptors, Type II/metabolism ; Bone Morphogenetic Protein Receptors, Type II/genetics ; Smad1 Protein/metabolism ; Smad1 Protein/genetics ; Lung/metabolism ; Lung/blood supply ; Neovascularization, Physiologic/drug effects ; Cells, Cultured

المؤلفون: Suzuki M; Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan., Takagi S; Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan.

المصدر: Development, growth & differentiation [Dev Growth Differ] 2024 Jun; Vol. 66 (5), pp. 308-319. Date of Electronic Publication: 2024 May 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Blackwell Publishing on behalf of the Japanese Society of Developmental Biologists Country of Publication: Japan NLM ID: 0356504 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1440-169X (Electronic) Linking ISSN: 00121592 NLM ISO Abbreviation: Dev Growth Differ Subsets: MEDLINE

مواضيع طبية MeSH: Caenorhabditis elegans*/metabolism , Caenorhabditis elegans*/genetics , Semaphorins*/metabolism , Semaphorins*/genetics , Epidermis*/metabolism , Caenorhabditis elegans Proteins*/metabolism , Caenorhabditis elegans Proteins*/genetics, Animals ; Signal Transduction ; Cell Communication ; Epidermal Cells/metabolism ; Epidermal Cells/cytology ; Male

المؤلفون: Verschuren L; TNO Healthy Living & Work, Leiden, The Netherlands. lars.verschuren@tno.nl., Mak AL; Department of Vascular Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands., van Koppen A; TNO Healthy Living & Work, Leiden, The Netherlands., Özsezen S; TNO Healthy Living & Work, Leiden, The Netherlands., Difrancesco S; TNO Healthy Living & Work, Leiden, The Netherlands., Caspers MPM; TNO Healthy Living & Work, Leiden, The Netherlands., Snabel J; TNO Healthy Living & Work, Leiden, The Netherlands., van der Meer D; GenomeScan, Leiden, The Netherlands., van Dijk AM; Department of Vascular Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands., Rashu EB; Gastro Unit, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Nabilou P; Gastro Unit, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Werge MP; Gastro Unit, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., van Son K; Department of Vascular Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands., Kleemann R; TNO Healthy Living & Work, Leiden, The Netherlands., Kiliaan AJ; Department of Medical Imaging, Anatomy, and Radboud Alzheimer Center, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands., Hazebroek EJ; Department of Bariatric Surgery, Vitalys, Rijnstate Hospital, Arnhem, the Netherlands and Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands., Boonstra A; Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Brouwer WP; Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Doukas M; Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Gupta S; Translational Medicine, Bristol Meyers Squibb, Princeton Pike, NJ, USA., Kluft C; Good Biomarker Sciences, Leiden, The Netherlands., Nieuwdorp M; Department of Vascular Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands., Verheij J; Department of Pathology, Amsterdam University Medical Centers, Amsterdam, The Netherlands., Gluud LL; Gastro Unit, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Holleboom AG; Department of Vascular Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands., Tushuizen ME; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Hanemaaijer R; TNO Healthy Living & Work, Leiden, The Netherlands.

المصدر: Nature communications [Nat Commun] 2024 May 29; Vol. 15 (1), pp. 4564. Date of Electronic Publication: 2024 May 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Liver Cirrhosis*/blood , Liver Cirrhosis*/diagnosis , Liver Cirrhosis*/pathology , Biomarkers*/blood , Semaphorins*/blood , Semaphorins*/genetics , Semaphorins*/metabolism, Humans ; Animals ; Male ; Mice ; Female ; Middle Aged ; Fatty Liver/blood ; Fatty Liver/diagnosis ; Fatty Liver/pathology ; Liver/pathology ; Liver/metabolism ; Disease Models, Animal ; Receptors, LDL/genetics ; Receptors, LDL/metabolism ; Transcriptome ; Mice, Knockout ; Adult ; Mice, Inbred C57BL ; Insulin-Like Growth Factor Binding Proteins

المؤلفون: Casden N; Department of Developmental Biology and Cancer Research, The Institute for Medical Research-Israel-Canada, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel., Belzer V; Department of Developmental Biology and Cancer Research, The Institute for Medical Research-Israel-Canada, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel., El Khayari A; Institute of Biological Sciences (ISSB-P), UM6P Faculty of Medical Sciences, Mohammed VI Polytechnic University, Ben-Guerir 43150, Morocco., El Fatimy R; Institute of Biological Sciences (ISSB-P), UM6P Faculty of Medical Sciences, Mohammed VI Polytechnic University, Ben-Guerir 43150, Morocco., Behar O; Department of Developmental Biology and Cancer Research, The Institute for Medical Research-Israel-Canada, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 May 28; Vol. 121 (22), pp. e2400648121. Date of Electronic Publication: 2024 May 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Astrocytes*/metabolism , Mice, Knockout* , Microglia*/metabolism , Microglia*/pathology , Nerve Tissue Proteins*/metabolism , Nerve Tissue Proteins*/genetics , Semaphorins*/metabolism , Semaphorins*/genetics, Animals ; Mice ; Brain Injuries/metabolism ; Brain Injuries/pathology ; Brain Injuries/genetics ; Cell Communication ; Macrophages/metabolism ; Mice, Inbred C57BL

المؤلفون: Bustillo ME; Department of Cell Biology, New York University Grossman School of Medicine, 435 E. 30th Street, New York, NY 10016, USA., Douthit J; Department of Cell Biology, New York University Grossman School of Medicine, 435 E. 30th Street, New York, NY 10016, USA., Astigarraga S; Department of Cell Biology, New York University Grossman School of Medicine, 435 E. 30th Street, New York, NY 10016, USA., Treisman JE; Department of Cell Biology, New York University Grossman School of Medicine, 435 E. 30th Street, New York, NY 10016, USA.

المصدر: Development (Cambridge, England) [Development] 2024 May 15; Vol. 151 (10). Date of Electronic Publication: 2024 May 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Company Of Biologists Limited Country of Publication: England NLM ID: 8701744 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9129 (Electronic) Linking ISSN: 09501991 NLM ISO Abbreviation: Development Subsets: MEDLINE

مواضيع طبية MeSH: Drosophila Proteins*/metabolism , Drosophila Proteins*/genetics , Semaphorins*/metabolism , Semaphorins*/genetics , Nerve Tissue Proteins*/metabolism , Nerve Tissue Proteins*/genetics , Morphogenesis*/genetics , Neuropil*/metabolism , Optic Lobe, Nonmammalian*/metabolism , Optic Lobe, Nonmammalian*/embryology , Receptors, Cell Surface*/metabolism , Receptors, Cell Surface*/genetics, Animals ; Drosophila melanogaster/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/embryology ; Neurons/metabolism ; Drosophila/metabolism ; Drosophila/embryology ; Mutation/genetics

المؤلفون: Chen T; Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei 430022, PR China., Li S; Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei 430022, PR China., Wang L; Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei 430022, PR China. Electronic address: wanglufang1989@163.com.

المصدر: International immunopharmacology [Int Immunopharmacol] 2024 May 10; Vol. 132, pp. 112035. Date of Electronic Publication: 2024 Apr 10.

نوع المنشور: Journal Article; Review; Systematic Review

بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasms*/immunology , Neoplasms*/drug therapy , Neoplasms*/metabolism , Neoplasms*/therapy , Semaphorins*/metabolism , Tumor Microenvironment*, Animals ; Humans ; Neovascularization, Pathologic/immunology ; Signal Transduction