المؤلفون: Cai M; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; School of Life Sciences, Yunnan University, Kunming 650091, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Bai XL; University of Chinese Academy of Sciences, Beijing 100049, China.; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China., Zang HJ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; School of Life Sciences, Yunnan University, Kunming 650091, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Tang XH; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; School of Life Sciences, Yunnan University, Kunming 650091, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Yan Y; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; State Key Laboratory of Functions and Applications of Medicinal Plants & College of Pharmacy, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang 550014, China., Wan JJ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Peng MY; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; State Key Laboratory of Functions and Applications of Medicinal Plants & College of Pharmacy, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang 550014, China., Liang H; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Liu L; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Guo F; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Zhao PJ; School of Life Sciences, Yunnan University, Kunming 650091, China., Liao X; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China., Di YT; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China., Hao XJ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; State Key Laboratory of Functions and Applications of Medicinal Plants & College of Pharmacy, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang 550014, China.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 11; Vol. 24 (22). Date of Electronic Publication: 2023 Nov 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Parkinson Disease*/drug therapy , Quassins* , Simaroubaceae*/chemistry, Plant Extracts/pharmacology ; Protein Kinases

المؤلفون: Youmbi LM; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.; Department of Biochemistry, Faculty of Science, University of Yaoundé 1, Yaoundé, Cameroon., Makong YSD; Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon., Mbaveng AT; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, University of Mainz, Staudinger Weg 5, 55128, Mainz, Germany., Tankeo SB; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, University of Mainz, Staudinger Weg 5, 55128, Mainz, Germany., Fotso GW; Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, Yaoundé, Cameroon., Ndjakou BL; Department of Chemistry, Higher Teacher Training College, University of Yaoundé 1, Yaounde, Cameroon., Wansi JD; Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon., Beng VP; Department of Biochemistry, Faculty of Science, University of Yaoundé 1, Yaoundé, Cameroon., Sewald N; Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, 33501, Bielefeld, Germany., Ngadjui BT; Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, Yaoundé, Cameroon., Efferth T; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, University of Mainz, Staudinger Weg 5, 55128, Mainz, Germany. efferth@uni-mainz.de., Kuete V; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon. kuetevictor@yahoo.fr.; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, University of Mainz, Staudinger Weg 5, 55128, Mainz, Germany. kuetevictor@yahoo.fr.

المصدر: BMC complementary medicine and therapies [BMC Complement Med Ther] 2023 Feb 15; Vol. 23 (1), pp. 48. Date of Electronic Publication: 2023 Feb 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101761232 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-7671 (Electronic) Linking ISSN: 26627671 NLM ISO Abbreviation: BMC Complement Med Ther Subsets: MEDLINE

مواضيع طبية MeSH: Brucea* , Simaroubaceae* , Adenocarcinoma*/drug therapy , Antineoplastic Agents, Phytogenic*/chemistry , Colonic Neoplasms*/drug therapy, Humans ; Plant Extracts/chemistry ; Methanol ; Reactive Oxygen Species/metabolism ; ATP Binding Cassette Transporter, Subfamily G, Member 2 ; Tumor Suppressor Protein p53 ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; Neoplasm Proteins/metabolism ; Neoplasm Proteins/pharmacology ; Caspases/metabolism

المؤلفون: Jung M; Department of Life Sciences, Gachon University, Seongnam-si, Gyeonggi-do, 13120, South Korea., Kho JW; Department of Life Sciences, Gachon University, Seongnam-si, Gyeonggi-do, 13120, South Korea., Gook DH; Department of Life Sciences, Gachon University, Seongnam-si, Gyeonggi-do, 13120, South Korea., Lee YS; Gyeonggi Agricultural Research and Extension Services, Hwaseong-si, Gyeonggi-do, 18388, South Korea. yslee75@gg.go.kr., Lee DH; Department of Life Sciences, Gachon University, Seongnam-si, Gyeonggi-do, 13120, South Korea. dl343@gachon.ac.kr.

المصدر: Scientific reports [Sci Rep] 2022 Jun 15; Vol. 12 (1), pp. 9972. Date of Electronic Publication: 2022 Jun 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Ailanthus* , Hemiptera* , Simaroubaceae*, Animals ; Female ; Oviposition ; Trees ; United States

المؤلفون: Duan ZK; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China., Zhang ZJ; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China., Dong SH; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China., Wang YX; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China., Song SJ; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China., Huang XX; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: xiaoxiao270@163.com.

المصدر: Phytochemistry [Phytochemistry] 2021 Jul; Vol. 187, pp. 112769. Date of Electronic Publication: 2021 Apr 19.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 0151434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3700 (Electronic) Linking ISSN: 00319422 NLM ISO Abbreviation: Phytochemistry Subsets: MEDLINE

مواضيع طبية MeSH: Quassins*/pharmacology , Simaroubaceae*, Plant Extracts ; Plants ; Structure-Activity Relationship

المؤلفون: Wang XM; Chengdu Institute of Biology,Chinese Academy of Sciences Chengdu 610041,China University of Chinese Academy of Sciences Beijing 100049,China., Tang XH; Kunming Institute of Botany,Chinese Academy of Sciences Kunming 650201,China., Li YY; Kunming Institute of Botany,Chinese Academy of Sciences Kunming 650201,China., Pu XX; Kunming Institute of Botany,Chinese Academy of Sciences Kunming 650201,China., Zhou Y; Chengdu Institute of Biology,Chinese Academy of Sciences Chengdu 610041,China.

المصدر: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2021 Jul; Vol. 46 (14), pp. 3625-3632.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Country of Publication: China NLM ID: 8913656 Publication Model: Print Cited Medium: Print ISSN: 1001-5302 (Print) Linking ISSN: 10015302 NLM ISO Abbreviation: Zhongguo Zhong Yao Za Zhi Subsets: MEDLINE

مواضيع طبية MeSH: Drugs, Chinese Herbal*/pharmacology , Simaroubaceae*, Amyloid Precursor Protein Secretases ; Aspartic Acid Endopeptidases ; Humans ; Metabolomics

المؤلفون: Zewdie KA; Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, 1871, Mekelle, Ethiopia. kalxy2919@gmail.com., Bhoumik D; Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, 1871, Mekelle, Ethiopia., Wondafrash DZ; Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, 1871, Mekelle, Ethiopia., Tuem KB; Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, 1871, Mekelle, Ethiopia.

المصدر: BMC complementary medicine and therapies [BMC Complement Med Ther] 2020 Jun 30; Vol. 20 (1), pp. 201. Date of Electronic Publication: 2020 Jun 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101761232 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-7671 (Electronic) Linking ISSN: 26627671 NLM ISO Abbreviation: BMC Complement Med Ther Subsets: MEDLINE

مواضيع طبية MeSH: Simaroubaceae*, Anti-Bacterial Agents/*pharmacology , Antidiarrheals/*pharmacology , Diarrhea/*drug therapy , Plant Extracts/*pharmacology, Animals ; Disease Models, Animal ; Ethiopia ; Female ; In Vitro Techniques ; Male ; Mice ; Plant Roots

المؤلفون: Almendra RB; Medicinal Plants Research Center (NPPM), Health Sciences Center, Federal University of Piaui, Nossa Senhora de Fátima Avenue, Teresina, PI, 64049-550, Brazil., da Fonseca OC; Medicinal Plants Research Center (NPPM), Health Sciences Center, Federal University of Piaui, Nossa Senhora de Fátima Avenue, Teresina, PI, 64049-550, Brazil., Nunes DB; Medicinal Plants Research Center (NPPM), Health Sciences Center, Federal University of Piaui, Nossa Senhora de Fátima Avenue, Teresina, PI, 64049-550, Brazil., da Silva TIN; Medicinal Plants Research Center (NPPM), Health Sciences Center, Federal University of Piaui, Nossa Senhora de Fátima Avenue, Teresina, PI, 64049-550, Brazil., Oliveira JSSM; Department of Chemistry, Center of Natural Sciences, Federal University of Piaui, Teresina, PI, Brazil., Chaves MH; Department of Chemistry, Center of Natural Sciences, Federal University of Piaui, Teresina, PI, Brazil., de Oliveira AP; Medicinal Plants Research Center (NPPM), Health Sciences Center, Federal University of Piaui, Nossa Senhora de Fátima Avenue, Teresina, PI, 64049-550, Brazil., Dos Santos RF; Medicinal Plants Research Center (NPPM), Health Sciences Center, Federal University of Piaui, Nossa Senhora de Fátima Avenue, Teresina, PI, 64049-550, Brazil., Oliveira RCM; Medicinal Plants Research Center (NPPM), Health Sciences Center, Federal University of Piaui, Nossa Senhora de Fátima Avenue, Teresina, PI, 64049-550, Brazil. menesesoliveira@gmail.com.; Postgraduate Program in Pharmacology, Health Sciences Center, Medicinal Plants Research Center (NPPM), Federal University of Piaui, Universitária Avenue, Teresina, PI, 64049-550, Brazil. menesesoliveira@gmail.com.

المصدر: Digestive diseases and sciences [Dig Dis Sci] 2019 Nov; Vol. 64 (11), pp. 3104-3114. Date of Electronic Publication: 2019 May 24.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 7902782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2568 (Electronic) Linking ISSN: 01632116 NLM ISO Abbreviation: Dig Dis Sci Subsets: MEDLINE

مواضيع طبية MeSH: Simaroubaceae*, Guanylate Cyclase/*metabolism , Ileum/*metabolism , Nitric Oxide Synthase/*metabolism , Parasympatholytics/*pharmacology , Potassium Channels/*metabolism, Animals ; Dose-Response Relationship, Drug ; Ileum/drug effects ; Male ; Muscle Relaxants, Central/isolation & purification ; Muscle Relaxants, Central/pharmacology ; Organ Culture Techniques ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Plant Leaves ; Rats ; Rats, Wistar

المؤلفون: Devecchi MF; Departamento de Botânica, Universidade de São Paulo, Herbário SPF, Rua do Matão 277, São Paulo 05508-900, Brazil. Electronic address: mfdevecchi@usp.br., Thomas WW; Institute of Systematic Botany, New York Botanical Garden, Bronx, NY 10458-5126, USA., Plunkett GM; Cullman Program for Molecular Systematics, New York Botanical Garden, Bronx, NY 10458-5126, USA., Pirani JR; Departamento de Botânica, Universidade de São Paulo, Herbário SPF, Rua do Matão 277, São Paulo 05508-900, Brazil.

المصدر: Molecular phylogenetics and evolution [Mol Phylogenet Evol] 2018 Mar; Vol. 120, pp. 63-82. Date of Electronic Publication: 2017 Dec 05.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 9304400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9513 (Electronic) Linking ISSN: 10557903 NLM ISO Abbreviation: Mol Phylogenet Evol Subsets: MEDLINE

مواضيع طبية MeSH: Phylogeny*, Simaroubaceae/*classification , Simaroubaceae/*genetics, Base Sequence ; Bayes Theorem ; Cell Nucleus/genetics ; Consensus Sequence ; DNA, Plant/genetics ; Geography ; Introns/genetics ; Sequence Analysis, DNA ; Simaroubaceae/anatomy & histology ; Simaroubaceae/ultrastructure ; Species Specificity

المؤلفون: Boeno SI; Laboratório de Ciências Químicas, CCT, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Av. Alberto Lamengo, 2000, Parque Califórnia, 28013-602, Campos dos Goytacazes, RJ, Brazil., Vieira IJC; Laboratório de Ciências Químicas, CCT, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Av. Alberto Lamengo, 2000, Parque Califórnia, 28013-602, Campos dos Goytacazes, RJ, Brazil., Braz-Filho R; Laboratório de Ciências Químicas, CCT, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Av. Alberto Lamengo, 2000, Parque Califórnia, 28013-602, Campos dos Goytacazes, RJ, Brazil., de Souza Passos M; Laboratório de Ciências Químicas, CCT, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Av. Alberto Lamengo, 2000, Parque Califórnia, 28013-602, Campos dos Goytacazes, RJ, Brazil., Curcino Vieira MG; Instituto Federal de Educação, Ciência e Tecnologia, Rua Dr. Siqueira, 273, Parque Dom Bosco, 28030-130, Campos dos Goytacazes, RJ, Brazil., do Nascimento MFA; Faculdade de Farmácia, Departamento de Produtos Farmacêuticos, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Pampulha, 31270-901, Belo Horizonte, MG, Brazil., Gontijo DC; Faculdade de Farmácia, Departamento de Produtos Farmacêuticos, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Pampulha, 31270-901, Belo Horizonte, MG, Brazil., de Oliveira AB; Faculdade de Farmácia, Departamento de Produtos Farmacêuticos, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Pampulha, 31270-901, Belo Horizonte, MG, Brazil. Electronic address: alaidebragaoliveira@gmail.com.

المصدر: Journal of ethnopharmacology [J Ethnopharmacol] 2022 Mar 01; Vol. 285, pp. 114890. Date of Electronic Publication: 2021 Dec 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Alkaloids/*pharmacology , Plant Extracts/*pharmacology , Plant Roots/*chemistry , Simaroubaceae/*chemistry , Squalene/*pharmacology , Triterpenes/*pharmacology, Alkaloids/chemistry ; Antimalarials/chemistry ; Antimalarials/pharmacology ; Molecular Structure ; Phytotherapy ; Plant Extracts/chemistry ; Plasmodium falciparum/drug effects ; Squalene/chemistry ; Triterpenes/chemistry

المؤلفون: Gazoni VF; Área de Farmacologia, Departamento de Ciências Básicas em Saúde, Faculdade de Medicina, Universidade Federal de Mato Grosso (UFMT), 78060-900 Cuiabá, Mato Grosso, Brazil., Balogun SO; Área de Farmacologia, Departamento de Ciências Básicas em Saúde, Faculdade de Medicina, Universidade Federal de Mato Grosso (UFMT), 78060-900 Cuiabá, Mato Grosso, Brazil; Faculdade Noroeste do Mato Grosso - AJES, 78320-000 Juína, Mato Grosso, Brazil., Arunachalam K; Área de Farmacologia, Departamento de Ciências Básicas em Saúde, Faculdade de Medicina, Universidade Federal de Mato Grosso (UFMT), 78060-900 Cuiabá, Mato Grosso, Brazil., Oliveira DM; Área de Farmacologia, Departamento de Ciências Básicas em Saúde, Faculdade de Medicina, Universidade Federal de Mato Grosso (UFMT), 78060-900 Cuiabá, Mato Grosso, Brazil., Filho VC; Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade de Vale do Itajaí, 78020-400 Itajaí, SC, Brazil., Lima SR; Faculdade de Medicina Veterinaria, Universidade Federal de Mato Grosso (UFMT), Av. Fernando Corrêa da Costa, no. 2367, Boa Esperança, 78060-900 Cuiabá, MT, Brazil., Colodel EM; Faculdade de Medicina Veterinaria, Universidade Federal de Mato Grosso (UFMT), Av. Fernando Corrêa da Costa, no. 2367, Boa Esperança, 78060-900 Cuiabá, MT, Brazil., Soares IM; Laboratório de Pesquisa em Produtos Naturais, Faculdade de Medicina, Universidade Federal de Tocantis, 77020-210 Palmas, Tocantins, Brazil., Ascêncio SD; Laboratório de Pesquisa em Produtos Naturais, Faculdade de Medicina, Universidade Federal de Tocantis, 77020-210 Palmas, Tocantins, Brazil., Martins DTO; Área de Farmacologia, Departamento de Ciências Básicas em Saúde, Faculdade de Medicina, Universidade Federal de Mato Grosso (UFMT), 78060-900 Cuiabá, Mato Grosso, Brazil. Electronic address: taba@terra.com.br.

المصدر: Journal of ethnopharmacology [J Ethnopharmacol] 2018 Sep 15; Vol. 223, pp. 122-134. Date of Electronic Publication: 2018 May 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Simaroubaceae*, Anti-Infective Agents/*pharmacology , Anti-Infective Agents/*toxicity , Plant Extracts/*pharmacology , Plant Extracts/*toxicity, Animals ; Bacteria/drug effects ; Bacteria/growth & development ; CHO Cells ; Carbolines/pharmacology ; Carbolines/toxicity ; Cricetulus ; Female ; Fungi/drug effects ; Fungi/growth & development ; Indole Alkaloids/pharmacology ; Indole Alkaloids/toxicity ; Male ; Methanol/chemistry ; Mice ; Microbial Sensitivity Tests ; Micronucleus Tests ; Rhizome/chemistry ; Solvents/chemistry ; Toxicity Tests, Acute