المؤلفون: Chen HY; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215, USA., Durmaz YT; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215, USA., Li Y; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215, USA., Sabet AH; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215, USA., Vajdi A; Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Denize T; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Walton E; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Laimon YN; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Doench JG; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Mahadevan NR; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Losman JA; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215, USA.; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA., Barbie DA; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215, USA., Tolstorukov MY; Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Rudin CM; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sen T; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Signoretti S; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Oser MG; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215, USA. Matthew_Oser@dfci.harvard.edu.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. Matthew_Oser@dfci.harvard.edu.

المصدر: Nature communications [Nat Commun] 2022 Aug 25; Vol. 13 (1), pp. 4998. Date of Electronic Publication: 2022 Aug 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Lung Neoplasms*/genetics , Lung Neoplasms*/metabolism , Lung Neoplasms*/pathology , Small Cell Lung Carcinoma*/metabolism , Small Cell Lung Carcinoma*/pathology, Butyrate Response Factor 1/*metabolism, Histone Demethylases/genetics ; Histone Demethylases/metabolism ; Humans ; RNA-Binding Proteins/genetics ; Repressor Proteins/metabolism ; Transcription Factors/metabolism

المؤلفون: Hong D; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Knelson EH; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Li Y; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Durmaz YT; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Gao W; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Walton E; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Vajdi A; Department of Informatics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Thai T; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Sticco-Ivins M; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Sabet AH; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Jones KL; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Schinzel AC; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Bronson RT; Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts., Nguyen QD; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Tolstorukov MY; Department of Informatics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Vivero M; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Signoretti S; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Barbie DA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Oser MG; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. Matthew_Oser@dfci.harvard.edu.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

المصدر: Cancer research [Cancer Res] 2022 Jan 15; Vol. 82 (2), pp. 248-263. Date of Electronic Publication: 2021 Nov 22.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Cell Plasticity/*genetics , Core Binding Factor Alpha 1 Subunit/*metabolism , Lung Neoplasms/*metabolism , Receptor, Notch1/*metabolism , Receptor, Notch2/*metabolism , Signal Transduction/*genetics , Small Cell Lung Carcinoma/*metabolism, Animals ; CRISPR-Cas Systems ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Cell Line, Tumor ; Disease Models, Animal ; Humans ; Loss of Function Mutation ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Mice ; Receptor, Notch1/genetics ; Receptor, Notch2/genetics ; Small Cell Lung Carcinoma/genetics ; Small Cell Lung Carcinoma/pathology ; Transfection

المؤلفون: Koduri V; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Duplaquet L; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Lampson BL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Wang AC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Sabet AH; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Ishoey M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Paulk J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Teng M; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Harris IS; Ludwig Cancer Center, Boston, MA 02115, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA., Endress JE; Ludwig Cancer Center, Boston, MA 02115, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA., Liu X; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Linde Program in Chemical Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Dasilva E; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Linde Program in Chemical Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA., Briggs KJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Doench JG; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Ott CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Zhang T; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Donovan KA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA., Gray NS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Bradner J; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA., Medin JA; Departments of Pediatrics and Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA., Buhrlage SJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Linde Program in Chemical Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Oser MG; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. moser@partners.org william_kaelin@dfci.harvard.edu.; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA., Kaelin WG Jr; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. moser@partners.org william_kaelin@dfci.harvard.edu.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

المصدر: Science advances [Sci Adv] 2021 Feb 05; Vol. 7 (6). Date of Electronic Publication: 2021 Feb 05 (Print Publication: 2021).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

مواضيع طبية MeSH: Oncogene Proteins*/chemistry , Oncogene Proteins*/metabolism , Proteolysis*/drug effects, Adaptor Proteins, Signal Transducing/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Benzylamines ; CRISPR-Cas Systems ; Humans ; Ikaros Transcription Factor/metabolism ; Quinazolines ; Thalidomide/analysis ; Thalidomide/pharmacology ; Transcription Factors

المؤلفون: Oser MG; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Massachusetts 02115, USA., Sabet AH; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA., Gao W; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Massachusetts 02115, USA., Chakraborty AA; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Massachusetts 02115, USA., Schinzel AC; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA., Jennings RB; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Massachusetts 02115, USA., Fonseca R; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA., Bonal DM; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02210, USA., Booker MA; Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA., Flaifel A; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Massachusetts 02115, USA., Novak JS; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Massachusetts 02115, USA., Christensen CL; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA., Zhang H; Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, New York 10016, USA., Herbert ZT; Molecular Biology Core Facilities, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA., Tolstorukov MY; Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA., Buss EJ; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.; Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA., Wong KK; Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, New York 10016, USA., Bronson RT; Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02215., Nguyen QD; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02210, USA., Signoretti S; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Massachusetts 02115, USA., Kaelin WG Jr; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Massachusetts 02115, USA.; Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.

المصدر: Genes & development [Genes Dev] 2019 Dec 01; Vol. 33 (23-24), pp. 1718-1738. Date of Electronic Publication: 2019 Nov 14.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 8711660 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-5477 (Electronic) Linking ISSN: 08909369 NLM ISO Abbreviation: Genes Dev Subsets: MEDLINE

مواضيع طبية MeSH: Cell Differentiation/*genetics , Neuroendocrine Cells/*cytology , Receptors, Notch/*physiology , Retinoblastoma-Binding Protein 2/*metabolism , Signal Transduction/*genetics , Small Cell Lung Carcinoma/*enzymology, Animals ; Basic Helix-Loop-Helix Transcription Factors ; Cell Line ; Cell Transformation, Neoplastic/genetics ; Disease Models, Animal ; Gene Expression Regulation, Neoplastic/genetics ; Histone Demethylases/metabolism ; Humans ; In Vitro Techniques ; Mice ; Neuroendocrine Cells/pathology ; Small Cell Lung Carcinoma/physiopathology

المؤلفون: Salehi N; Department of Interventional Cardiology, Tehran University of Medical Sciences, Tehran, Iran., Samiei N, Pouraliakbar H, Sabet AH, Vakili-Zarch A

المصدر: The heart surgery forum [Heart Surg Forum] 2012 Oct; Vol. 15 (5), pp. E292-3.

نوع المنشور: Case Reports; Journal Article

بيانات الدورية: Publisher: Forum Multimedia Pub Country of Publication: United States NLM ID: 100891112 Publication Model: Print Cited Medium: Internet ISSN: 1522-6662 (Electronic) Linking ISSN: 10983511 NLM ISO Abbreviation: Heart Surg Forum Subsets: MEDLINE

مواضيع طبية MeSH: Imaging, Three-Dimensional*, Coronary Aneurysm/*surgery , Heart Atria/*surgery , Vascular Fistula/*diagnostic imaging , Vascular Fistula/*surgery , Vascular Surgical Procedures/*methods, Adult ; Chest Pain/diagnosis ; Chest Pain/etiology ; Coronary Aneurysm/diagnostic imaging ; Coronary Angiography/methods ; Echocardiography ; Female ; Follow-Up Studies ; Heart Aneurysm/diagnostic imaging ; Heart Aneurysm/surgery ; Heart Atria/diagnostic imaging ; Humans ; Severity of Illness Index ; Tomography, X-Ray Computed/methods ; Treatment Outcome