يعرض 1 - 5 نتائج من 5 نتيجة بحث عن '"Sabine De Breucker"', وقت الاستعلام: 1.38s تنقيح النتائج
  1. 1
    Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy

    المؤلفون: Donald William Ludovici, Gilles Bignan, Carsten Schubert, Erwin Fraiponts, Karine Smans, Norbert Esser, Danielle Peeters, Michael H. Parker, Maxwell D. Cummings, Peter Vermeulen, Lieven Meerpoel, Sabine De Breucker, Tianbao Lu, Luc Van Nuffel, Richard Alexander, Bruce L. Grasberger, James R. Bischoff, Christian Rocaboy, Ron Gilissen, Christophe Meyer, Boudewijn Janssens, Peter J. Connolly

    المصدر: Bioorganic & Medicinal Chemistry Letters. 28:2159-2164

    مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Cell type, Oral treatment, Clinical Biochemistry, Cancer therapy, Pharmaceutical Science, Antineoplastic Agents, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Oral administration, Drug Discovery, medicine, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Cell Proliferation, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Organic Chemistry, Imidazoles, Cancer, Neoplasms, Experimental, medicine.disease, Bioavailability, Fatty Acid Synthase, Type I, Fatty acid synthase, 030104 developmental biology, Drug Design, 030220 oncology & carcinogenesis, Pharmacodynamics, biology.protein, Molecular Medicine, Drug Screening Assays, Antitumor

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd313b43d21d3b1660d7723e4aead6d0
    https://doi.org/10.1016/j.bmcl.2018.05.014

    View record from ScienceDirect
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  2. 2
    Abstract 2023: Complex in vitro and in vivo prostate cancer models for the PREDECT consortium

    المؤلفون: Ian Hickson, Norbert Esser, Malin Åkerfelt, Yolanda T. Chong, Wytske M. van Weerden, Matthias Nees, Ralph Graeser, Suzana Vidic, Varda Rotter, Karine Smans, Ingrid Verberne, Ronald de Hoogt, Ira Kogan-Sakin, Michaël Barbier, Peter King, Yan Stein, Sabine De Breucker

    المصدر: Cancer Research. 74:2023-2023

    مصطلحات موضوعية: Cancer Research, Pathology, medicine.medical_specialty, Matrigel, Stromal cell, business.industry, Cancer, medicine.disease, Metastasis, Prostate cancer, Oncology, Cell culture, LNCaP, Cancer cell, Cancer research, Medicine, business

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d692e5e4908e9e07a2dc90b65560a169
    https://doi.org/10.1158/1538-7445.am2014-2023

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  3. 3
    Abstract 4747: Design and synthesis of a series highly potent and bioavailable FASN KR domain inhibitors for cancer

    المؤلفون: Lieven Meerpoel, Gilles Bignan, Luc Van Nuffel, Peter Vermeulen, Ron Gilissen, Tianbao Lu, Max Cummings, Christophe Meyer, Bruce L. Grasberger, Peter J. Connolly, Michael H. Parker, Erwin Fraiponts, Richard Alexander, Karine Smans, Boudewijn Janssens, Danielle Peeters, Norbert Esser, Donald William Ludovici, Carsten Schubert, James R. Bischoff, Sabine De Breucker

    المصدر: Cancer Research. 74:4747-4747

    مصطلحات موضوعية: chemistry.chemical_classification, Cancer Research, biology, Cell growth, Chemistry, Cancer, Pharmacology, medicine.disease, medicine.disease_cause, Fatty acid synthase, Enzyme, Oncology, Apoptosis, Cancer cell, medicine, biology.protein, Carcinogenesis, IC50

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bbc77f2de582fc793cad2cd350548d6d
    https://doi.org/10.1158/1538-7445.am2014-4747

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  4. 4
    Abstract 801: Sensitivity of cell lines to Fatty Acid Synthase inhibitors depends on the lipid content in the cellular environment

    المؤلفون: Lieven Meerpoel, James R. Bischoff, Carsten Schubert, Boudewijn Janssen, Geert Van Hecke, Erwin Fraiponts, Karine Smans, Luc Van Nuffel, Sabine De Breucker, Tianbao Lu, Michael H. Parker, Danielle Peeters, Yolanda T. Chong, Bruce L. Grasberger, Peter Vermeulen, Christophe Meyer, Ralph Graeser, Gilles Bignan, Suzana Vidic, Norbert Esser, Donald William Ludovici, Ron Gilissen, Peter J. Connolly

    المصدر: Cancer Research. 74:801-801

    مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, biology, Chemistry, Cancer, medicine.disease, Molecular biology, Fatty acid synthase, Endocrinology, Oncology, Growth factor receptor, In vivo, Cell culture, Internal medicine, Cancer cell, LNCaP, medicine, biology.protein, Lipid raft

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1a4a8ba06d36370068648ff2c8bc5179
    https://doi.org/10.1158/1538-7445.am2014-801

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  5. 5
    Abstract 2535: Structure-activity relationships of novel N-benzoyl arylpiperidine and arylazetidine FASN inhibitors

    المؤلفون: Carsten Schubert, Ron Gilissen, Bruce L. Grasberger, Christophe Meyer, Peter J. Connolly, Sabine De Breucker, Luc Van Nuffel, Norbert Esser, James R. Bischoff, Michael H. Parker, Donald William Ludovici, Erwin Fraiponts, Boudewijn Janssens, Danielle Peeters, Karine Smans, Tianbao Lu, Peter Vermeulen, Lieven Meerpoel, Gilles Bignan

    المصدر: Cancer Research. 74:2535-2535

    مصطلحات موضوعية: chemistry.chemical_classification, Cancer Research, biology, In vitro, Palmitic acid, chemistry.chemical_compound, Fatty acid synthase, Enzyme, Oncology, Biochemistry, Biosynthesis, chemistry, In vivo, Cell culture, biology.protein, IC50

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5984cccf305d5033564ca0577f95f99e
    https://doi.org/10.1158/1538-7445.am2014-2535

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