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المؤلفون: John H. Riley, Ian Naya, Neil Barnes, Lee Tombs, Ana R. Sousa, Bernardino Alcázar Navarrete, Sadhana Patel, Gregory J. Feldman, David A. Lipson, Chris Compton
المساهمون: [Feldman, Gregory J.] S Carolina Pharmaceut Res, Spartanburg, SC 29303 USA, [Sousa, Ana R.] GlaxoSmithKline, Resp Res & Dev, Stockley Pk West, Uxbridge, Middx, England, [Lipson, David A.] GlaxoSmithKline, Resp Res & Dev, King Of Prussia, PA USA, [Lipson, David A.] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA, [Tombs, Lee] Precise Approach Ltd, Birmingham, W Midlands, England, [Barnes, Neil] GlaxoSmithKline, Global Resp Franchise, Brentford, Middx, England, [Patel, Sadhana] GlaxoSmithKline, Global Resp Franchise, Brentford, Middx, England, [Compton, Chris] GlaxoSmithKline, Global Resp Franchise, Brentford, Middx, England, [Riley, John H.] GlaxoSmithKline, GlaxoSmithKline Med Res Ctr, Resp Therapy Area Unit, Stevenage, Herts, England, [Naya, Ian] GlaxoSmithKline, Resp Med, Brentford, Middx, England, [Alcazar Navarrete, Bernardino] Hosp Alta Resoluc Loja, Neumol, Granada, Spain, GlaxoSmithKline
المصدر: Advances in Therapy
مصطلحات موضوعية: Male, Quinuclidines, Respimat, Long-acting β2-agonist, law.invention, Pulmonary Disease, Chronic Obstructive, chemistry.chemical_compound, 0302 clinical medicine, Randomized controlled trial, law, Forced Expiratory Volume, Medicine, Pharmacology (medical), Vilanterol, 030212 general & internal medicine, Original Research, education.field_of_study, COPD, Cross-Over Studies, Olodaterol, LAMA, Double-blind, General Medicine, Middle Aged, Dry-powder inhaler, Bronchodilator Agents, Drug Combinations, Treatment Outcome, Anesthesia, Combination, Long-acting beta 2-agonist, Female, Bronchodilation, Safety, Moderate, Population, LABA, Chlorobenzenes, 03 medical and health sciences, Bronchodilators, Double-Blind Method, Administration, Inhalation, Humans, Umeclidinium, Tiotropium Bromide, education, Benzyl Alcohols, Dynamic hyperinflation, Aged, business.industry, Nebulizers and Vaporizers, Tiotropium, medicine.disease, Confidence interval, Benzoxazines, Long-acting muscarinic antagonist, 030228 respiratory system, chemistry, business
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المؤلفون: B. Alcazar Navarrete, Lee Tombs, Ana R. Sousa, David A. Lipson, Ian Naya, Chris Compton, Gregory Feldman, Sadhana Patel
المصدر: Pharmacotherapies for COPD.
مصطلحات موضوعية: medicine.medical_specialty, COPD, education.field_of_study, Vital capacity, Respimat, business.industry, Olodaterol, Population, medicine.disease, Crossover study, chemistry.chemical_compound, chemistry, Internal medicine, medicine, Clinical endpoint, Physical therapy, Vilanterol, business, education
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a76edf414e3141b4a882d984ccded418
https://doi.org/10.1136/thoraxjnl-2017-210983.417 -
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المؤلفون: Andrew Charlton, Stephen J. Medhurst, Laura J. Chambers, Livermore David, Brian Peter Slingsby, Andy Billinton, Lee William Page, Anton D. Michel, Daryl S. Walter, Jon Graham Anthony Steadman, Shilina Roman, Sadhana Patel, Elena Fonfria, Robert Gleave, Stefan Senger, Katharine Laura Collis, Andrew P. Moses, Sue D. Collins, Muna H. Abdi, Paul John Beswick, Clarisse L. Lejeune, David Kenneth Dean, Alexander J. Stevens
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:5080-5084
مصطلحات موضوعية: Models, Molecular, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Amide, Drug Discovery, Purinergic P2 Receptor Antagonists, medicine, Structure–activity relationship, Receptor, Molecular Biology, Drug discovery, Organic Chemistry, Antagonist, Receptor antagonist, Amides, Pyrrolidonecarboxylic Acid, chemistry, Molecular Medicine, Receptors, Purinergic P2X7, Pyroglutamic acid
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المؤلفون: Andy Billinton, Sue Roomans, Stefan Senger, Anton D. Michel, Stephen J. Medhurst, Robert Gleave, Daryl S. Walter, Elena Fonfria, Laura J. Chambers, Andrew P. Moses, Shilina Roman, David Kenneth Dean, Alexander J. Stevens, Paul John Beswick, Sadhana Patel
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:4653-4656
مصطلحات موضوعية: Purinergic P2X Receptor Antagonists, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Analgesic, Administration, Oral, Pain, Pharmaceutical Science, Carboxamide, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Acetamides, Drug Discovery, medicine, Animals, Humans, Molecular Biology, Organic Chemistry, Antagonist, In vitro, Rats, Disease Models, Animal, chemistry, Hyperalgesia, Pyrazoles, Molecular Medicine, Receptors, Purinergic P2X7, medicine.symptom, Lead compound, Acetamide
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المؤلفون: Adrian Hall, Susan H. Brown, Sadhana Patel, Andy Billinton, Gerard Martin Paul Giblin, Alan Naylor, Tiziana Scoccitti, David N. Hurst, Paul Goldsmith, Anita Chowdhury, Pamela J. Theobald
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:2684-2690
مصطلحات موضوعية: Models, Molecular, Indoles, Molecular model, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Computational biology, Scaffold hopping, Biochemistry, Structure-Activity Relationship, In vivo, Drug Discovery, Animals, Humans, Receptors, Prostaglandin E, Receptor, Molecular Biology, Indole test, Molecular Structure, Chemistry, Organic Chemistry, Hydrogen Bonding, Inflammatory pain, Receptors, Prostaglandin E, EP1 Subtype, Rats, Thiazoles, Microsomes, Liver, Molecular Medicine
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المؤلفون: Alyson Fox, Stuart Bevan, Pam Ganju, Jane Barclay, Jakir Hussain Ullah, Anna K. Clark, Marzia Malcangio, Janet Winter, Chuanzheng Song, Frank Buxton, Sadhana Patel, Clive Gentry, Glen Wotherspoon
المصدر: Pain. 130:225-234
مصطلحات موضوعية: Male, Pharmacology, Gene Expression Regulation, Enzymologic, Sciatica, medicine, Animals, RNA, Messenger, Rats, Wistar, Ligation, Oligonucleotide Array Sequence Analysis, Cathepsin S, CATS, business.industry, Macrophages, Nociceptors, Nerve injury, Cathepsins, Sciatic Nerve, Sensory neuron, Rats, Cysteine Endopeptidases, Disease Models, Animal, Anesthesiology and Pain Medicine, Allodynia, medicine.anatomical_structure, Nociception, Neurology, Hyperalgesia, Anesthesia, Chronic Disease, Peripheral nerve injury, Neurology (clinical), medicine.symptom, business
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المؤلفون: Stuart Bevan, Alyson Fox, Adam Kesingland, Clive Gentry, Sadhana Patel
المصدر: Pain. 105:355-362
مصطلحات موضوعية: Male, Pain Threshold, Cyclohexanecarboxylic Acids, Gabapentin, Guinea Pigs, Analgesic, Oxcarbazepine, Acetates, Pharmacology, Lamotrigine, Pressure, medicine, Animals, Amines, Rats, Wistar, gamma-Aminobutyric Acid, Triazines, business.industry, Carbamazepine, Sciatic Nerve, Rats, Anesthesiology and Pain Medicine, Allodynia, Neurology, Hyperalgesia, Touch, Neuropathic pain, Neuralgia, Wounds and Injuries, Anticonvulsants, Neurology (clinical), medicine.symptom, business, medicine.drug
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المؤلفون: Stephen J. Medhurst, Sadhana Patel, Peter McIntyre, Mohanjit Panesar, Katharine Walker, Alyson Fox, Laszlo Urban
المصدر: Journal of Pharmacology and Experimental Therapeutics. 304:56-62
مصطلحات موضوعية: Male, Receptors, Drug, Guinea Pigs, TRPV1, Pharmacology, Guinea pig, Mice, chemistry.chemical_compound, medicine, Animals, Rats, Wistar, Inflammation, Dose-Response Relationship, Drug, Antagonist, Peripheral Nervous System Diseases, Sciatic Nerve, Rats, Mice, Inbred C57BL, Carbamazepine, chemistry, Hyperalgesia, Capsaicin, Anesthesia, Neuropathic pain, Molecular Medicine, Anticonvulsants, Sciatic nerve, medicine.symptom, Capsazepine, Algorithms
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c3ead2f110926964f07a1e17f30733
https://doi.org/10.1124/jpet.102.042010 -
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المؤلفون: Gabriele Dorn, Glen Wotherspoon, Jonathan Hall, Stuart Bevan, Sadhana Patel, Samir Abdel'Al, Pam Ganju, Francois Natt, Janet Winter, Alyson Fox, L. H. Eunson, William Leonard Wishart, Sarah Moffatt, Jane Barclay
المصدر: The Journal of Neuroscience. 22:8139-8147
مصطلحات موضوعية: Male, Freund's Adjuvant, Down-Regulation, Pharmacology, Rats, Sprague-Dawley, Adenosine Triphosphate, Downregulation and upregulation, Animals, Medicine, Neurons, Afferent, RNA, Messenger, Rats, Wistar, ARTICLE, Receptor, Ligation, Injections, Spinal, Pain Measurement, Inflammation, Receptors, Purinergic P2, business.industry, General Neuroscience, Chronic pain, Oligonucleotides, Antisense, Spinal cord, medicine.disease, Pathophysiology, Hindlimb, Rats, body regions, Disease Models, Animal, Protein Subunits, medicine.anatomical_structure, Nociception, Hyperalgesia, Freund's adjuvant, Sciatic Neuropathy, medicine.symptom, business, Neuroscience, Receptors, Purinergic P2X3
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae436a3ba239642b89900eedcdcfa66f
https://doi.org/10.1523/jneurosci.22-18-08139.2002 -
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المؤلفون: Kara McNair, Adam Kesingland, Iain F. James, Clive Gentry, Sadhana Patel, Laszlo Urban, Alyson Fox
المصدر: Pain. 92:91-100
مصطلحات موضوعية: Morpholines, Receptors, Drug, medicine.medical_treatment, Naphthalenes, Pharmacology, Catalepsy, Sciatica, Piperidines, medicine, Animals, Dronabinol, Rats, Wistar, Receptors, Cannabinoid, WIN 55,212-2, Pain Measurement, Analgesics, Cannabinoids, business.industry, Antagonist, Cyclohexanols, medicine.disease, Benzoxazines, Rats, Disease Models, Animal, Anesthesiology and Pain Medicine, Allodynia, Neurology, Hyperalgesia, Anesthesia, Neuropathic pain, Pyrazoles, Neurology (clinical), Cannabinoid, Rimonabant, medicine.symptom, business, Tail flick test, medicine.drug