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1دورية أكاديمية
المؤلفون: Butler JS; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Chan A; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Costelha S; b Instituto de Investigação e Inovação em Saúde, Universidade do Porto , Porto , Portugal .; c Molecular Neurobiology, IBMC - Institute for Molecular and Cell Biology Porto , Porto , Portugal., Fishman S; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Willoughby JL; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Borland TD; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Milstein S; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Foster DJ; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Gonçalves P; b Instituto de Investigação e Inovação em Saúde, Universidade do Porto , Porto , Portugal .; c Molecular Neurobiology, IBMC - Institute for Molecular and Cell Biology Porto , Porto , Portugal., Chen Q; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Qin J; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Bettencourt BR; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Sah DW; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Alvarez R; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Rajeev KG; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Manoharan M; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Fitzgerald K; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Meyers RE; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Nochur SV; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Saraiva MJ; b Instituto de Investigação e Inovação em Saúde, Universidade do Porto , Porto , Portugal .; c Molecular Neurobiology, IBMC - Institute for Molecular and Cell Biology Porto , Porto , Portugal., Zimmermann TS; a Alnylam Pharmaceuticals , Cambridge , MA , USA .
المصدر: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis [Amyloid] 2016 Jun; Vol. 23 (2), pp. 109-18. Date of Electronic Publication: 2016 Mar 31.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9433802 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-2818 (Electronic) Linking ISSN: 13506129 NLM ISO Abbreviation: Amyloid Subsets: MEDLINE
مواضيع طبية MeSH: Amyloid Neuropathies, Familial/*therapy , Liver/*metabolism , Prealbumin/*antagonists & inhibitors , RNA, Messenger/*antagonists & inhibitors , RNA, Small Interfering/*administration & dosage, Amyloid Neuropathies, Familial/genetics ; Amyloid Neuropathies, Familial/metabolism ; Amyloid Neuropathies, Familial/pathology ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Benzoxazoles/pharmacology ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Female ; Gene Expression ; Humans ; Liver/pathology ; Macaca fascicularis ; Male ; Mice ; Mice, Transgenic ; Prealbumin/genetics ; Prealbumin/metabolism ; RNA Interference ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/pharmacokinetics
SCR Disease Name: Amyloidosis, Hereditary, Transthyretin-Related
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2دورية أكاديمية
المؤلفون: Grondin R; Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA., Ge P; Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA., Chen Q; Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA., Sutherland JE; Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA., Zhang Z; Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA., Gash DM; Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA., Stiles DK; Drug Delivery R&D, Neuromodulation, Medtronic Inc., Minneapolis, Minnesota, USA., Stewart GR; Drug Delivery R&D, Neuromodulation, Medtronic Inc., Minneapolis, Minnesota, USA., Sah DW; Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA., Kaemmerer WF; Drug Delivery R&D, Neuromodulation, Medtronic Inc., Minneapolis, Minnesota, USA.
المصدر: Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2015 Jun 30; Vol. 4, pp. e245. Date of Electronic Publication: 2015 Jun 30.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101581621 Publication Model: Electronic Cited Medium: Print ISSN: 2162-2531 (Print) Linking ISSN: 21622531 NLM ISO Abbreviation: Mol Ther Nucleic Acids Subsets: PubMed not MEDLINE
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3دورية أكاديمية
المؤلفون: Sehgal A, Chen Q, Gibbings D, Sah DW, Bumcrot D
المصدر: RNA (New York, N.Y.) [RNA] 2014 Feb; Vol. 20 (2), pp. 143-9. Date of Electronic Publication: 2013 Dec 19.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9509184 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-9001 (Electronic) Linking ISSN: 13558382 NLM ISO Abbreviation: RNA Subsets: MEDLINE
مواضيع طبية MeSH: Gene Knockdown Techniques* , RNA Interference*, RNA, Messenger/*blood, Aged ; Animals ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; Gene Expression ; Glypicans/genetics ; Humans ; Liver/metabolism ; Macaca fascicularis ; Male ; Organ Specificity ; RNA, Messenger/genetics ; RNA, Small Interfering/genetics ; Rats ; Rats, Sprague-Dawley ; Species Specificity ; alpha-Fetoproteins/genetics
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4دورية أكاديمية
المؤلفون: Coelho T; Unidade Clinica de Paramiloidose, Hospital de Santo Antonio, Porto, Portugal. tcoelho@netcabo.pt, Adams D, Silva A, Lozeron P, Hawkins PN, Mant T, Perez J, Chiesa J, Warrington S, Tranter E, Munisamy M, Falzone R, Harrop J, Cehelsky J, Bettencourt BR, Geissler M, Butler JS, Sehgal A, Meyers RE, Chen Q, Borland T, Hutabarat RM, Clausen VA, Alvarez R, Fitzgerald K, Gamba-Vitalo C, Nochur SV, Vaishnaw AK, Sah DW, Gollob JA, Suhr OB
المصدر: The New England journal of medicine [N Engl J Med] 2013 Aug 29; Vol. 369 (9), pp. 819-29.
نوع المنشور: Clinical Trial, Phase I; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE
مواضيع طبية MeSH: Amyloid Neuropathies, Familial/*therapy , Prealbumin/*genetics , RNA, Small Interfering/*therapeutic use, Adolescent ; Adult ; Amyloid Neuropathies, Familial/genetics ; Animals ; Dose-Response Relationship, Drug ; Female ; Humans ; Liposomes ; Macaca fascicularis ; Male ; Nanocapsules ; Prealbumin/metabolism ; RNA, Small Interfering/administration & dosage ; Young Adult
SCR Disease Name: Amyloidosis, Hereditary, Transthyretin-Related
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5دورية أكاديمية
المؤلفون: Tabernero J; Medical Oncology Department, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain. jtabernero@vhio.net, Shapiro GI, LoRusso PM, Cervantes A, Schwartz GK, Weiss GJ, Paz-Ares L, Cho DC, Infante JR, Alsina M, Gounder MM, Falzone R, Harrop J, White AC, Toudjarska I, Bumcrot D, Meyers RE, Hinkle G, Svrzikapa N, Hutabarat RM, Clausen VA, Cehelsky J, Nochur SV, Gamba-Vitalo C, Vaishnaw AK, Sah DW, Gollob JA, Burris HA 3rd
المصدر: Cancer discovery [Cancer Discov] 2013 Apr; Vol. 3 (4), pp. 406-17. Date of Electronic Publication: 2013 Jan 28.
نوع المنشور: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
مواضيع طبية MeSH: RNA Interference*, Kinesins/*genetics , Liver Neoplasms/*therapy , Nanoparticles/*administration & dosage , RNA, Small Interfering/*administration & dosage , Vascular Endothelial Growth Factor A/*genetics, Adult ; Aged ; Animals ; Cell Line, Tumor ; Cytokines/blood ; Female ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Male ; Mice ; Mice, SCID ; Middle Aged ; RNA, Messenger/metabolism ; Xenograft Model Antitumor Assays
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6دورية أكاديمية
المؤلفون: Burgess A; Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada. aburgess@sri.utoronto.ca, Huang Y, Querbes W, Sah DW, Hynynen K
المصدر: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2012 Oct 28; Vol. 163 (2), pp. 125-9. Date of Electronic Publication: 2012 Aug 19.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
بيانات الدورية: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE
مواضيع طبية MeSH: Basal Ganglia/*metabolism , Nerve Tissue Proteins/*genetics , RNA, Small Interfering/*administration & dosage, Animals ; Blood-Brain Barrier/metabolism ; Gene Knockdown Techniques ; Genetic Therapy/methods ; Huntingtin Protein ; Magnetic Resonance Imaging/methods ; Mutation ; Rats ; Rats, Wistar ; Sound
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7دورية أكاديمية
المؤلفون: Bonavia R; Ludwig Institute for Cancer Research, University of California, La Jolla, CA, USA., Inda MM, Vandenberg S, Cheng SY, Nagane M, Hadwiger P, Tan P, Sah DW, Cavenee WK, Furnari FB
المصدر: Oncogene [Oncogene] 2012 Sep 06; Vol. 31 (36), pp. 4054-66. Date of Electronic Publication: 2011 Dec 05.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
مواضيع طبية MeSH: Glioblastoma/*blood supply , Interleukin-8/*metabolism , NF-kappa B/*metabolism , Neovascularization, Pathologic/*metabolism, Animals ; CCAAT-Enhancer-Binding Proteins/metabolism ; Cell Line, Tumor ; Cell Proliferation ; ErbB Receptors ; Female ; Gene Expression Regulation, Neoplastic ; Glioblastoma/pathology ; Human Umbilical Vein Endothelial Cells/physiology ; Humans ; Interleukin-8/genetics ; JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors ; JNK Mitogen-Activated Protein Kinases/metabolism ; MAP Kinase Signaling System ; Mice ; Mice, Nude ; NF-kappa B/antagonists & inhibitors ; Neoplasm Transplantation ; Neoplastic Stem Cells/metabolism ; Nitriles/pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation ; Protein Kinase Inhibitors/pharmacology ; Protein Processing, Post-Translational ; Response Elements ; Sulfones/pharmacology ; Transcription Factor AP-1/metabolism ; Transcriptional Activation ; Tumor Burden ; ras Proteins/metabolism
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8دورية أكاديمية
المؤلفون: Nakayama T; Alnylam Pharmaceuticals, Inc., Cambridge, MA 02142, USA. tnakayama@verizon.net, Butler JS, Sehgal A, Severgnini M, Racie T, Sharman J, Ding F, Morskaya SS, Brodsky J, Tchangov L, Kosovrasti V, Meys M, Nechev L, Wang G, Peng CG, Fang Y, Maier M, Rajeev KG, Li R, Hettinger J, Barros S, Clausen V, Zhang X, Wang Q, Hutabarat R, Dokholyan NV, Wolfrum C, Manoharan M, Kotelianski V, Stoffel M, Sah DW
المصدر: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2012 Aug; Vol. 20 (8), pp. 1582-9. Date of Electronic Publication: 2012 Jun 05.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
مواضيع طبية MeSH: Lipoproteins/*administration & dosage , Lipoproteins/*chemistry , RNA, Small Interfering/*administration & dosage, Animals ; Apolipoprotein A-I/administration & dosage ; Apolipoprotein A-I/chemistry ; Apolipoproteins E/administration & dosage ; Apolipoproteins E/chemistry ; Lipoproteins, HDL/administration & dosage ; Lipoproteins, HDL/chemistry ; Lipoproteins, LDL/administration & dosage ; Lipoproteins, LDL/chemistry ; Male ; Mice ; Mice, Inbred C57BL ; RNA Interference/physiology ; RNA, Small Interfering/genetics
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9دورية أكاديمية
المؤلفون: Hayashi Y; Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan., Mori Y, Higashi T, Motoyama K, Jono H, Sah DW, Ando Y, Arima H
المصدر: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis [Amyloid] 2012 Jun; Vol. 19 Suppl 1, pp. 47-9. Date of Electronic Publication: 2012 Apr 21.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9433802 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-2818 (Electronic) Linking ISSN: 13506129 NLM ISO Abbreviation: Amyloid Subsets: MEDLINE
مواضيع طبية MeSH: Amyloid Neuropathies, Familial/*therapy , Dendrimers/*chemistry , Hepatocytes/*metabolism , Prealbumin/*genetics , RNA, Small Interfering/*genetics , alpha-Cyclodextrins/*chemistry, Animals ; Humans ; RNA Interference
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10دورية أكاديمية
المؤلفون: Stiles DK; Medtronic Neuromodulation, Medtronic, Minneapolis, MN 55432, USA., Zhang Z, Ge P, Nelson B, Grondin R, Ai Y, Hardy P, Nelson PT, Guzaev AP, Butt MT, Charisse K, Kosovrasti V, Tchangov L, Meys M, Maier M, Nechev L, Manoharan M, Kaemmerer WF, Gwost D, Stewart GR, Gash DM, Sah DW
المصدر: Experimental neurology [Exp Neurol] 2012 Jan; Vol. 233 (1), pp. 463-71. Date of Electronic Publication: 2011 Nov 19.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2430 (Electronic) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE
مواضيع طبية MeSH: Convection*, Corpus Striatum/*metabolism , Gene Expression Regulation/*drug effects , Nerve Tissue Proteins/*genetics , Nerve Tissue Proteins/*metabolism , Nuclear Proteins/*genetics , Nuclear Proteins/*metabolism , RNA, Small Interfering/*administration & dosage, Analysis of Variance ; Animals ; Carbon Isotopes/metabolism ; Corpus Striatum/diagnostic imaging ; Dose-Response Relationship, Drug ; Female ; Gene Expression Regulation/genetics ; Gene Expression Regulation/physiology ; Gene Transfer Techniques ; Humans ; Huntingtin Protein ; Macaca mulatta ; RNA, Messenger/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Radionuclide Imaging ; Time Factors