-
1دورية أكاديمية
المؤلفون: Butler JS; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Chan A; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Costelha S; b Instituto de Investigação e Inovação em Saúde, Universidade do Porto , Porto , Portugal .; c Molecular Neurobiology, IBMC - Institute for Molecular and Cell Biology Porto , Porto , Portugal., Fishman S; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Willoughby JL; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Borland TD; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Milstein S; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Foster DJ; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Gonçalves P; b Instituto de Investigação e Inovação em Saúde, Universidade do Porto , Porto , Portugal .; c Molecular Neurobiology, IBMC - Institute for Molecular and Cell Biology Porto , Porto , Portugal., Chen Q; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Qin J; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Bettencourt BR; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Sah DW; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Alvarez R; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Rajeev KG; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Manoharan M; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Fitzgerald K; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Meyers RE; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Nochur SV; a Alnylam Pharmaceuticals , Cambridge , MA , USA ., Saraiva MJ; b Instituto de Investigação e Inovação em Saúde, Universidade do Porto , Porto , Portugal .; c Molecular Neurobiology, IBMC - Institute for Molecular and Cell Biology Porto , Porto , Portugal., Zimmermann TS; a Alnylam Pharmaceuticals , Cambridge , MA , USA .
المصدر: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis [Amyloid] 2016 Jun; Vol. 23 (2), pp. 109-18. Date of Electronic Publication: 2016 Mar 31.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9433802 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-2818 (Electronic) Linking ISSN: 13506129 NLM ISO Abbreviation: Amyloid Subsets: MEDLINE
مواضيع طبية MeSH: Amyloid Neuropathies, Familial/*therapy , Liver/*metabolism , Prealbumin/*antagonists & inhibitors , RNA, Messenger/*antagonists & inhibitors , RNA, Small Interfering/*administration & dosage, Amyloid Neuropathies, Familial/genetics ; Amyloid Neuropathies, Familial/metabolism ; Amyloid Neuropathies, Familial/pathology ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Benzoxazoles/pharmacology ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Female ; Gene Expression ; Humans ; Liver/pathology ; Macaca fascicularis ; Male ; Mice ; Mice, Transgenic ; Prealbumin/genetics ; Prealbumin/metabolism ; RNA Interference ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/pharmacokinetics
SCR Disease Name: Amyloidosis, Hereditary, Transthyretin-Related
-
2دورية أكاديمية
المؤلفون: Grondin R; Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA., Ge P; Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA., Chen Q; Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA., Sutherland JE; Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA., Zhang Z; Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA., Gash DM; Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA., Stiles DK; Drug Delivery R&D, Neuromodulation, Medtronic Inc., Minneapolis, Minnesota, USA., Stewart GR; Drug Delivery R&D, Neuromodulation, Medtronic Inc., Minneapolis, Minnesota, USA., Sah DW; Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA., Kaemmerer WF; Drug Delivery R&D, Neuromodulation, Medtronic Inc., Minneapolis, Minnesota, USA.
المصدر: Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2015 Jun 30; Vol. 4, pp. e245. Date of Electronic Publication: 2015 Jun 30.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101581621 Publication Model: Electronic Cited Medium: Print ISSN: 2162-2531 (Print) Linking ISSN: 21622531 NLM ISO Abbreviation: Mol Ther Nucleic Acids Subsets: PubMed not MEDLINE
-
3دورية أكاديمية
المؤلفون: Kim, Hyunsook, Kim, Sujeong, Lee, Dayoung, Lee, Dahye, Yoon, Jiyeon, Lee, Hyukjin
المصدر: Journal of Pharmaceutical Investigation (2093-5552); Jul2024, Vol. 54 Issue 4, p415-433, 19p
-
4دورية أكاديمية
المؤلفون: Azur, Romie Angelo G., Olarte, Kevin Christian V., Ybañez, Weand S., Ocampo, Alessandria Maeve M., Bagamasbad, Pia D.
المصدر: PLoS ONE; 5/13/2024, Vol. 19 Issue 5, p1-25, 25p
-
5دورية أكاديمية
المؤلفون: Sehgal A, Chen Q, Gibbings D, Sah DW, Bumcrot D
المصدر: RNA (New York, N.Y.) [RNA] 2014 Feb; Vol. 20 (2), pp. 143-9. Date of Electronic Publication: 2013 Dec 19.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9509184 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-9001 (Electronic) Linking ISSN: 13558382 NLM ISO Abbreviation: RNA Subsets: MEDLINE
مواضيع طبية MeSH: Gene Knockdown Techniques* , RNA Interference*, RNA, Messenger/*blood, Aged ; Animals ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; Gene Expression ; Glypicans/genetics ; Humans ; Liver/metabolism ; Macaca fascicularis ; Male ; Organ Specificity ; RNA, Messenger/genetics ; RNA, Small Interfering/genetics ; Rats ; Rats, Sprague-Dawley ; Species Specificity ; alpha-Fetoproteins/genetics
-
6دورية أكاديمية
المؤلفون: Zhang, ZhileiAff1, Aff2, Hong, DongyangAff1, Aff2, Ma, DingyuanAff1, Aff2, Yang, PeiyingAff1, Aff2, Zhang, JingjingAff1, Aff2, Wang, XinAff1, Aff2, Wang, YanAff1, Aff2, Meng, LuluAff1, Aff2, Wang, YanyunAff1, Aff2, Li, YahongAff1, Aff2, Sun, YunAff1, Aff2, Jiang, TaoAff1, Aff2, Xu, ZhengfengAff1, Aff2
المصدر: Molecular Neurobiology. :1-11
-
7دورية أكاديمية
المؤلفون: Ansari, Mohammad Azam, Tripathi, Takshashila, Venkidasamy, Baskar, Monziani, Alan, Rajakumar, Govindasamy, Alomary, Mohammad N., Alyahya, Sami A., Onimus, Oriane, D’souza, Naomi, Barkat, Md. Abul, Al-Suhaimi, Ebtesam A., Samynathan, Ramkumar, Thiruvengadam, MuthuAff12, IDs1203502303730z_cor13
المصدر: Molecular Neurobiology. 61(5):3042-3089
-
8دورية أكاديمية
المؤلفون: Coelho T; Unidade Clinica de Paramiloidose, Hospital de Santo Antonio, Porto, Portugal. tcoelho@netcabo.pt, Adams D, Silva A, Lozeron P, Hawkins PN, Mant T, Perez J, Chiesa J, Warrington S, Tranter E, Munisamy M, Falzone R, Harrop J, Cehelsky J, Bettencourt BR, Geissler M, Butler JS, Sehgal A, Meyers RE, Chen Q, Borland T, Hutabarat RM, Clausen VA, Alvarez R, Fitzgerald K, Gamba-Vitalo C, Nochur SV, Vaishnaw AK, Sah DW, Gollob JA, Suhr OB
المصدر: The New England journal of medicine [N Engl J Med] 2013 Aug 29; Vol. 369 (9), pp. 819-29.
نوع المنشور: Clinical Trial, Phase I; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE
مواضيع طبية MeSH: Amyloid Neuropathies, Familial/*therapy , Prealbumin/*genetics , RNA, Small Interfering/*therapeutic use, Adolescent ; Adult ; Amyloid Neuropathies, Familial/genetics ; Animals ; Dose-Response Relationship, Drug ; Female ; Humans ; Liposomes ; Macaca fascicularis ; Male ; Nanocapsules ; Prealbumin/metabolism ; RNA, Small Interfering/administration & dosage ; Young Adult
SCR Disease Name: Amyloidosis, Hereditary, Transthyretin-Related
-
9دورية أكاديمية
المؤلفون: Tabernero J; Medical Oncology Department, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain. jtabernero@vhio.net, Shapiro GI, LoRusso PM, Cervantes A, Schwartz GK, Weiss GJ, Paz-Ares L, Cho DC, Infante JR, Alsina M, Gounder MM, Falzone R, Harrop J, White AC, Toudjarska I, Bumcrot D, Meyers RE, Hinkle G, Svrzikapa N, Hutabarat RM, Clausen VA, Cehelsky J, Nochur SV, Gamba-Vitalo C, Vaishnaw AK, Sah DW, Gollob JA, Burris HA 3rd
المصدر: Cancer discovery [Cancer Discov] 2013 Apr; Vol. 3 (4), pp. 406-17. Date of Electronic Publication: 2013 Jan 28.
نوع المنشور: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
مواضيع طبية MeSH: RNA Interference*, Kinesins/*genetics , Liver Neoplasms/*therapy , Nanoparticles/*administration & dosage , RNA, Small Interfering/*administration & dosage , Vascular Endothelial Growth Factor A/*genetics, Adult ; Aged ; Animals ; Cell Line, Tumor ; Cytokines/blood ; Female ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Male ; Mice ; Mice, SCID ; Middle Aged ; RNA, Messenger/metabolism ; Xenograft Model Antitumor Assays
-
10دورية أكاديمية
المؤلفون: Burgess A; Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada. aburgess@sri.utoronto.ca, Huang Y, Querbes W, Sah DW, Hynynen K
المصدر: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2012 Oct 28; Vol. 163 (2), pp. 125-9. Date of Electronic Publication: 2012 Aug 19.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
بيانات الدورية: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE
مواضيع طبية MeSH: Basal Ganglia/*metabolism , Nerve Tissue Proteins/*genetics , RNA, Small Interfering/*administration & dosage, Animals ; Blood-Brain Barrier/metabolism ; Gene Knockdown Techniques ; Genetic Therapy/methods ; Huntingtin Protein ; Magnetic Resonance Imaging/methods ; Mutation ; Rats ; Rats, Wistar ; Sound