المؤلفون: Ward, K. W., Proksch, J. W., Salyers, K. L., Azzarano, L. M., Morgan, J. A., Roethke, T. J., McSurdy-Freed, J. E., Levy, M. A., Smith, B. R.

المصدر: Xenobiotica; Mar2002, Vol. 32 Issue 3, p221-233, 13p

مصطلحات موضوعية: PROTEIN kinases, AUTOIMMUNE disease treatment, THERAPEUTICS, PHARMACOKINETICS, IMIDAZOLES, CHEMICAL inhibitors

المؤلفون: Miller, W. H., Alberts, D. P., Bhatnagar, P. K., Bondinell, W. E., Callahan, J. F., Calvo, R. R., Cousins, R. D., Erhard, K. F., Heerding, D. A., Keenan, R. M., Kwon, C., Manley, P. J., Newlander, K. A., Ross, S. T., Samanen, J. M., Uzinskas, I. N., Venslavsky, J. W., Yuan, C. C.-K., Haltiwanger, R. C., Gowen, M., Hwang, S.-M., James, I. E., Lark, M. W., Rieman, D. J., Stroup, G. B., Azzarano, L. M., Salyers, K. L., Smith, B. R., Ward, K. W., Johanson, K. O., Huffman, W. F.

المصدر: Journal of Medicinal Chemistry; January 13, 2000, Vol. 43 Issue: 1 p22-26, 5p

المؤلفون: Barr, J., Sipes, I. G., Salyers, K. L.

المصدر: Xenobiotica; May1994, Vol. 24 Issue 5, p389, 0p

مصطلحات موضوعية: METABOLISM, THEOPHYLLINE, XENOBIOTICS

المؤلفون: Ward KW; Preclinical Drug Discovery, Cardiovascular, Urogenitary, and Oncology Centre for Excellence in Drug Discovery, GlaxoSmithKline R&D, King of Prussia, PA 19406, USA. keith_w_ward@gsk.com, Proksch JW, Salyers KL, Azzarano LM, Morgan JA, Roethke TJ, McSurdy-Freed JE, Levy MA, Smith BR

المصدر: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2002 Mar; Vol. 32 (3), pp. 221-33.

نوع المنشور: Clinical Trial; Comparative Study; Journal Article

بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print Cited Medium: Print ISSN: 0049-8254 (Print) Linking ISSN: 00498254 NLM ISO Abbreviation: Xenobiotica Subsets: MEDLINE

مواضيع طبية MeSH: Enzyme Inhibitors/*pharmacokinetics , Imidazoles/*pharmacokinetics , Mitogen-Activated Protein Kinases/*antagonists & inhibitors , Pyridines/*pharmacokinetics, Animals ; Area Under Curve ; Biological Availability ; Blood Proteins/metabolism ; Diffusion ; Dogs ; Half-Life ; Humans ; Macaca fascicularis ; Male ; Protein Binding ; Rats ; Species Specificity ; p38 Mitogen-Activated Protein Kinases

المؤلفون: Ward KW; Preclinical Drug Discovery, Cardiovascular, Urogenitary and Oncology Center for Excellence in Drug Discovery, GlaxoSmithKline, King of Prussia, PA 19406, USA. keith_w_ward@gsk.com, Proksch JW, Azzarano LM, Salyers KL, McSurdy-Freed JE, Molnar TM, Levy MA, Smith BR

المصدر: Pharmaceutical research [Pharm Res] 2001 Sep; Vol. 18 (9), pp. 1336-44.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8406521 Publication Model: Print Cited Medium: Print ISSN: 0724-8741 (Print) Linking ISSN: 07248741 NLM ISO Abbreviation: Pharm Res Subsets: MEDLINE

مواضيع طبية MeSH: Enzyme Inhibitors/*pharmacokinetics , Imidazoles/*pharmacokinetics , Mitogen-Activated Protein Kinases/*antagonists & inhibitors , Pyrimidines/*pharmacokinetics, Administration, Oral ; Animals ; Biological Availability ; Dogs ; Enzyme Inhibitors/administration & dosage ; Imidazoles/administration & dosage ; Injections, Intravenous ; Isomerism ; Macaca fascicularis ; Macaca mulatta ; Male ; Pyrimidines/administration & dosage ; Rats ; Species Specificity ; Substrate Specificity ; p38 Mitogen-Activated Protein Kinases

المؤلفون: Lark MW; Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA., Stroup GB, Dodds RA, Kapadia R, Hoffman SJ, Hwang SM, James IE, Lechowska B, Liang X, Rieman DJ, Salyers KL, Ward K, Smith BR, Miller WH, Huffman WF, Gowen M

المصدر: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research [J Bone Miner Res] 2001 Feb; Vol. 16 (2), pp. 319-27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Bone and Mineral Research Country of Publication: United States NLM ID: 8610640 Publication Model: Print Cited Medium: Print ISSN: 0884-0431 (Print) Linking ISSN: 08840431 NLM ISO Abbreviation: J Bone Miner Res Subsets: MEDLINE

مواضيع طبية MeSH: Bone Resorption/*prevention & control , Osteoclasts/*drug effects , Pyridines/*pharmacology , Receptors, Vitronectin/*antagonists & inhibitors, Animals ; Female ; Osteoclasts/metabolism ; Ovariectomy ; Pyridines/pharmacokinetics ; Rats ; Rats, Sprague-Dawley

المؤلفون: Varaprath S; Dow Corning Corporation, Midland, Michigan, USA. sudarsanan.varaprath@dowcorning.com, Salyers KL, Plotzke KP, Nanavati S

المصدر: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 1999 Nov; Vol. 27 (11), pp. 1267-73.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model: Print Cited Medium: Print ISSN: 0090-9556 (Print) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

مواضيع طبية MeSH: Siloxanes/*metabolism, Animals ; Chromatography, High Pressure Liquid ; Female ; Male ; Mass Spectrometry ; Rats ; Rats, Inbred F344 ; Urine

المؤلفون: Lark MW; Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania, USA. michael__lark1@sbphrd.com, Stroup GB, Hwang SM, James IE, Rieman DJ, Drake FH, Bradbeer JN, Mathur A, Erhard KF, Newlander KA, Ross ST, Salyers KL, Smith BR, Miller WH, Huffman WF, Gowen M

المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 1999 Nov; Vol. 291 (2), pp. 612-7.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print Cited Medium: Print ISSN: 0022-3565 (Print) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

مواضيع طبية MeSH: Acetates/*pharmacology , Aminopyridines/*pharmacology , Bone Resorption/*prevention & control , Cell Adhesion/*drug effects , Platelet Aggregation/*drug effects , Receptors, Vitronectin/*antagonists & inhibitors, Acetates/chemical synthesis ; Acetates/pharmacokinetics ; Administration, Oral ; Aminopyridines/chemical synthesis ; Aminopyridines/pharmacokinetics ; Animals ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Female ; Humans ; In Vitro Techniques ; Infusions, Intravenous ; Integrins/metabolism ; Osteoporosis/prevention & control ; Ovariectomy ; Parathyroidectomy ; Protein Binding ; Rats ; Thyroidectomy ; Time Factors

المؤلفون: Ward KW; Department of Drug Metabolism and Pharmacokinetics, SmithKline Beecham Pharmaceuticals R&D, King of Prussia, Pennsylvania 19406, USA. Keith_W_Ward@sbphrd.com, Azzarano LM, Bondinell WE, Cousins RD, Huffman WF, Jakas DR, Keenan RM, Ku TW, Lundberg D, Miller WH, Mumaw JA, Newlander KA, Pirhalla JL, Roethke TJ, Salyers KL, Souder PR, Stelman GJ, Smith BR

المصدر: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 1999 Nov; Vol. 27 (11), pp. 1232-41.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model: Print Cited Medium: Print ISSN: 0090-9556 (Print) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

مواضيع طبية MeSH: Acetates/*pharmacokinetics , Aminopyridines/*pharmacokinetics , Receptors, Vitronectin/*antagonists & inhibitors, Animals ; Chromatography, High Pressure Liquid ; Dogs ; Macaca fascicularis ; Male ; Mass Spectrometry ; Mice ; Rats ; Rats, Sprague-Dawley ; Species Specificity

المؤلفون: Varaprath S; Dow Corning Corporation, Midland, Michigan 48686, USA., Salyers KL, Plotzke KP, Nanavati S

المصدر: Analytical biochemistry [Anal Biochem] 1998 Feb 01; Vol. 256 (1), pp. 14-22.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0370535 Publication Model: Print Cited Medium: Print ISSN: 0003-2697 (Print) Linking ISSN: 00032697 NLM ISO Abbreviation: Anal Biochem Subsets: MEDLINE

مواضيع طبية MeSH: Siloxanes/*isolation & purification, Animals ; Chromatography, High Pressure Liquid ; Evaluation Studies as Topic ; Furans ; Gas Chromatography-Mass Spectrometry ; Male ; Rats ; Rats, Inbred F344 ; Siloxanes/metabolism ; Siloxanes/pharmacokinetics ; Solvents ; Tissue Distribution