يعرض 1 - 10 نتائج من 41 نتيجة بحث عن '"Samuel V. Agresta"', وقت الاستعلام: 1.40s تنقيح النتائج
  1. 1
    Clinical pharmacokinetics and pharmacodynamics of ivosidenib in patients with advanced hematologic malignancies with an IDH1 mutation

    المؤلفون: Samuel V. Agresta, Hua Liu, Ian R Lemieux, Eytan M. Stein, David Dai, Eyal C. Attar, Guowen Liu, Courtney D. DiNardo, Bin Fan, Hua Yang, Stéphane de Botton

    المصدر: Cancer Chemotherapy and Pharmacology. 85:959-968

    مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, IDH1, Maximum Tolerated Dose, Pyridines, CYP3A, Glycine, Antineoplastic Agents, Pharmacology, Toxicology, Drug Administration Schedule, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pharmacokinetics, Humans, Medicine, Pharmacology (medical), Aged, Neoplasm Staging, Dose-Response Relationship, Drug, CYP3A4, business.industry, Cholesterol, Isocitrate Dehydrogenase, Leukemia, Myeloid, Acute, Treatment Outcome, 030104 developmental biology, Isocitrate dehydrogenase, medicine.anatomical_structure, Oncology, chemistry, Hematologic Neoplasms, 030220 oncology & carcinogenesis, Pharmacodynamics, Mutation, Female, Bone marrow, Drug Monitoring, business

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7186949f992d4ceafdba588de9a16aa
    https://doi.org/10.1007/s00280-020-04064-6

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  2. 2
    Safety and activity of ivosidenib in patients with IDH1-mutant advanced cholangiocarcinoma: a phase 1 study

    المؤلفون: Shuchi Sumant Pandya, Ghassan K. Abou-Alfa, Sung Choe, Bin Wu, Elizabeth A. Maher, Filip Janku, Rachna T. Shroff, Muralidhar Beeram, Maeve A. Lowery, Jonathan C. Trent, Antoine Hollebecque, Howard A. Burris, Samuel V. Agresta, Elia Aguado-Fraile, James M. Cleary, Nilofer S. Azad, Lipika Goyal, Camelia Gliser, Lia Gore, Bin Fan, Liewen Jiang, Andrew X. Zhu

    المصدر: The Lancet Gastroenterology & Hepatology. 4:711-720

    مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Pyridines, Nausea, Glycine, Phases of clinical research, Antineoplastic Agents, Gastroenterology, Cholangiocarcinoma, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Progression-free survival, Adverse effect, Aged, Aged, 80 and over, Dose-Response Relationship, Drug, Hepatology, business.industry, Middle Aged, Evaluable Disease, Isocitrate Dehydrogenase, Progression-Free Survival, Bile Duct Neoplasms, Tolerability, Response Evaluation Criteria in Solid Tumors, 030220 oncology & carcinogenesis, Mutation, Vomiting, Female, 030211 gastroenterology & hepatology, medicine.symptom, business

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778c5326d01e16842178c80bc6f8e03b
    https://doi.org/10.1016/s2468-1253(19)30189-x

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  3. 3
    Effect of itraconazole, food, and ethnic origin on the pharmacokinetics of ivosidenib in healthy subjects

    المؤلفون: Hua Yang, Chris Bowden, Jeffrey Zacher, David Dai, Samuel V. Agresta, Apinya Vutikullird, Hua Liu, Guowen Liu, Bin Fan, Chandra Prakash, Salah Nabhan, Denice Hickman

    المصدر: European Journal of Clinical Pharmacology. 75:1099-1108

    مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Pyridines, Itraconazole, Glycine, Cmax, Administration, Oral, Antineoplastic Agents, 030226 pharmacology & pharmacy, Gastroenterology, QT interval, Food-Drug Interactions, 03 medical and health sciences, 0302 clinical medicine, Asian People, Pharmacokinetics, Internal medicine, medicine, Humans, Drug Interactions, Pharmacology (medical), 030212 general & internal medicine, Adverse effect, Pharmacology, Meal, Cross-Over Studies, Dose-Response Relationship, Drug, business.industry, General Medicine, Middle Aged, Drug interaction, Crossover study, Healthy Volunteers, Leukemia, Myeloid, Acute, Long QT Syndrome, Area Under Curve, Cytochrome P-450 CYP3A Inhibitors, Female, business, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d716ee07ac416eff28f76c988d36474f
    https://doi.org/10.1007/s00228-019-02673-6

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  4. 4
    Enasidenib, an inhibitor of mutant IDH2 proteins, induces durable remissions in older patients with newly diagnosed acute myeloid leukemia

    المؤلفون: Eytan M. Stein, Martin S. Tallman, Courtney D. DiNardo, Stéphane de Botton, Kyle J. MacBeth, Wendy L. See, Hagop M. Kantarjian, Alessandra Tosolini, Daniel A. Pollyea, Qiang Xu, Samuel V. Agresta, Anthony S. Stein, Eyal C. Attar, Robert H. Collins, Mark G. Frattini

    المصدر: Leukemia. 33:2575-2584

    مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, medicine.medical_specialty, Myeloid, Maximum Tolerated Dose, Nausea, medicine.medical_treatment, Aminopyridines, Enasidenib, Gene mutation, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Enzyme Inhibitors, Aged, Aged, 80 and over, Chemotherapy, Triazines, business.industry, Remission Induction, Myeloid leukemia, Hematology, Middle Aged, medicine.disease, Hematologic Diseases, Rash, Isocitrate Dehydrogenase, Leukemia, Myeloid, Acute, Leukemia, Treatment Outcome, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Mutation, Female, Mutant Proteins, medicine.symptom, business

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a3e4c0b406ed58363cdfbe066aa265
    https://doi.org/10.1038/s41375-019-0472-2

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  5. 5
    Durable Remissions with Ivosidenib inIDH1-Mutated Relapsed or Refractory AML

    المؤلفون: Courtney D. DiNardo, Hua Liu, Gail J. Roboz, Hongfang Wang, Martha Arellano, Samuel V. Agresta, Vickie Zhang, Ronan T. Swords, Martin S. Tallman, Geoffrey L. Uy, William B. Donnellan, David Dai, Stephanie M. Kapsalis, Christophe Willekens, Jessica K. Altman, James M. Foran, A. Pigneux, Meredith Goldwasser, Sung Choe, Gabriel N. Mannis, Eyal C. Attar, James L. Slack, Amir T. Fathi, Harry P. Erba, Bin Wu, Bin Fan, Robert K. Stuart, S. de Botton, Hagop M. Kantarjian, Richard Stone, Mikkael A. Sekeres, Katharine E. Yen, Hua Yang, Elie Traer, Eytan M. Stein, Robert H. Collins, Alice S. Mims, Daniel A. Pollyea, Anthony S. Stein, Gabrielle T. Prince

    المصدر: New England Journal of Medicine. 378:2386-2398

    مصطلحات موضوعية: Male, 0301 basic medicine, Myeloid, Pyridines, Administration, Oral, Cell Count, Gastroenterology, Hemoglobins, 0302 clinical medicine, Recurrence, hemic and lymphatic diseases, Leukocytosis, Enzyme Inhibitors, Aged, 80 and over, education.field_of_study, Remission Induction, Myeloid leukemia, General Medicine, Middle Aged, Isocitrate Dehydrogenase, Survival Rate, Leukemia, Myeloid, Acute, Leukemia, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Female, medicine.symptom, Adult, medicine.medical_specialty, Adolescent, Population, Glycine, Enasidenib, Young Adult, 03 medical and health sciences, Refractory, Internal medicine, medicine, Humans, education, Survival rate, Aged, Dose-Response Relationship, Drug, business.industry, medicine.disease, 030104 developmental biology, Drug Resistance, Neoplasm, Mutation, business, Follow-Up Studies

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813d58b38d19e9543b4e00255d52453d
    https://doi.org/10.1056/nejmoa1716984

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  6. 6
    Ivosidenib induces deep durable remissions in patients with newly diagnosed IDH1-mutant acute myeloid leukemia

    المؤلفون: Gail J. Roboz, Justin M. Watts, Denice Hickman, Vickie Zhang, Daniel A. Pollyea, Courtney D. DiNardo, Stephanie M. Kapsalis, Hagop M. Kantarjian, Anthony S. Stein, Martha Arellano, Gabrielle T. Prince, Alice S. Mims, Amir T. Fathi, Eytan M. Stein, Hua Liu, Samuel V. Agresta, Katharine E. Yen, Martin S. Tallman, Harry P. Erba, Will Donnellan, David Dai, Stéphane de Botton, Richard Stone, Sung Choe, Bin Fan, Bin Wu, Hongfang Wang, Geoffrey L. Uy, Eyal C. Attar, Jessica K. Altman, Gabriel N. Mannis

    المصدر: Blood. 135(7)

    مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, Myeloid, Blood transfusion, Nausea, Pyridines, medicine.medical_treatment, Immunology, Glycine, Plenary Paper, Biochemistry, Gastroenterology, Translational Research, Biomedical, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Blood Transfusion, Adverse effect, Aged, Aged, 80 and over, business.industry, Remission Induction, Myeloid leukemia, Cell Biology, Hematology, Middle Aged, medicine.disease, Survival Analysis, Isocitrate Dehydrogenase, Discontinuation, Leukemia, Leukemia, Myeloid, Acute, 030104 developmental biology, medicine.anatomical_structure, Treatment Outcome, Hypomethylating agent, 030220 oncology & carcinogenesis, Mutation, Female, medicine.symptom, business

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb9a8e0b4a433f6b3c33a5513df549e
    https://pubmed.ncbi.nlm.nih.gov/31841594

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  7. 7
    A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model

    المؤلفون: Gajja S. Salomons, Yong Cang, Scott A. Biller, Hua Yang, Josh Powe, Dongwei Zhu, Stefan Gross, Stuart Murray, Kimberly Straley, Samuel V. Agresta, Karen S. Regan, Katharine E. Yen, Yaguang Si, Mya Steadman, Wei Liu, Lenny Dang, Ana Pop, Yue Chen, Erin Artin, Marion Dorsch, Jeremy Travins, Stephanie Santiago, Shengfang Jin, Muriel D. David, Cyril Quivoron, Andrew Kernytsky, Virginie Penard-Lacronique, Lee Silverman, Chenming Lu, Shin San Michael Su, Zhizhong Lin, Erwin E.W. Jansen, Fang Wang, Eduard A. Struys

    المساهمون: Laboratory Medicine, Amsterdam Neuroscience - Cellular & Molecular Mechanisms

    المصدر: Journal of Inherited Metabolic Disease
    Journal of Inherited Metabolic Disease, 39(6), 807-820. Springer Netherlands
    Wang, F, Travins, J, Lin, Z, Si, Y, Chen, Y, Powe, J, Murray, S, Zhu, D, Artin, E, Gross, S, Santiago, S, Steadman, M, Kernytsky, A, Straley, K, Lu, C, Pop, A, Struys, E A, Jansen, E E W, Salomons, G S, David, M D, Quivoron, C, Penard-Lacronique, V, Regan, K S, Liu, W, Dang, L, Yang, H, Silverman, L, Agresta, S, Dorsch, M, Biller, S, Yen, K, Cang, Y, Su, S S M & Jin, S 2016, ' A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model ', Journal of Inherited Metabolic Disease, vol. 39, no. 6, pp. 807-820 . https://doi.org/10.1007/s10545-016-9960-y

    مصطلحات موضوعية: 0301 basic medicine, Mutant, Cardiomyopathy, Locus (genetics), Biology, IDH2, Germline, Small Molecule Libraries, 03 medical and health sciences, Epilepsy, Mice, Genetics, medicine, Animals, Genetics(clinical), Gene, Genetics (clinical), chemistry.chemical_classification, Brain Diseases, Metabolic, Inborn, medicine.disease, Isocitrate Dehydrogenase, Disease Models, Animal, 030104 developmental biology, Enzyme, chemistry, Mutation, Cancer research, Original Article, Cardiomyopathies

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e1c78f3a8d7089df8ca5b9da489747d
    http://europepmc.org/articles/PMC5065612

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  8. 8
    Ivosidenib (AG-120) in Patients with IDH1-Mutant Relapsed/Refractory Myelodysplastic Syndrome: Updated Enrollment of a Phase 1 Dose Escalation and Expansion Study

    المؤلفون: Richard Stone, Hongfang Wang, Abdulafeez Oluyadi, Eytan M. Stein, Martin S. Tallman, Samuel V. Agresta, Prapti A. Patel, Stéphane de Botton, Courtney D. DiNardo, Katharine E. Yen, Bin Wu, Thomas Winkler, Eyal C. Attar, Anthony S. Stein, Gabrielle T. Prince, Justin M. Watts, Denice Hickman, Vickie Zhang, Sung Choe, Hagop M. Kantarjian, James M. Foran, Amir T. Fathi, Bin Fan, Hua Liu

    المصدر: Blood. 134:4254-4254

    مصطلحات موضوعية: Oncology, medicine.medical_specialty, IDH1, business.industry, Anemia, education, Immunology, Mutant, Cell Biology, Hematology, medicine.disease, Biochemistry, Internal medicine, Relapsed refractory, medicine, Dose escalation, Vindesine, In patient, business, Adverse effect, health care economics and organizations, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::482e3149a666ab533d276dad23bc1aea
    https://doi.org/10.1182/blood-2019-123946

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  9. 9
    PS1337 IVOSIDENIB (AG-120) INDUCES DURABLE REMISSIONS AND TRANSFUSION INDEPENDENCE IN PATIENTS WITH IDH1-MUTANT RELAPSED/REFRACTORY MYELODYSPLASTIC SYNDROME IN A PHASE 1 DOSE ESCALATION AND EXPANSION STUDY

    المؤلفون: Prapti A. Patel, Anthony S. Stein, Bin Wu, Gabrielle T. Prince, Hagop M. Kantarjian, Richard Stone, S. de Botton, Bin Fan, David Dai, Eytan M. Stein, Courtney Dinardo, Samuel V. Agresta, Katherine Yen, Martin S. Tallman, Hongfang Wang, Justin M. Watts, James M. Foran, Denice Hickman, Vickie Zhang, Amir T. Fathi, Hua Liu, Stephanie M. Kapsalis, Eyal C. Attar, Sung Choe

    المصدر: HemaSphere. 3:610-611

    مصطلحات موضوعية: Oncology, medicine.medical_specialty, IDH1, business.industry, Internal medicine, Mutant, Relapsed refractory, medicine, Dose escalation, Transfusion independence, In patient, Hematology, business

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5c67859183a52e2eb9234c84f94f0669
    https://doi.org/10.1097/01.hs9.0000563628.38037.c3

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  10. 10
    PS1025 IVOSIDENIB (AG-120) INDUCES DURABLE REMISSIONS AND TRANSFUSION INDEPENDENCE IN PATIENTS WITH IDH1-MUTANT NEWLY-DIAGNOSED AML: UPDATED RESULTS FROM A PHASE 1 DOSE ESCALATION AND EXPANSION STUDY

    المؤلفون: Martin S. Tallman, Martha Arellano, Gabriel N. Mannis, Bin Wu, Gail J. Roboz, Stephanie M. Kapsalis, Samuel V. Agresta, Hongfang Wang, Alice S. Mims, Richard Stone, S. de Botton, William B. Donnellan, Amir T. Fathi, Sung Choe, David Dai, Geoffrey L. Uy, Courtney Dinardo, Harry P. Erba, Vickie Zhang, Jessica K. Altman, Hua Liu, Daniel A. Pollyea, Eyal C. Attar, Justin M. Watts, Bin Fan, Denice Hickman, Anthony S. Stein, Gabrielle T. Prince, Eytan M. Stein, Katherine Yen, Hagop M. Kantarjian

    المصدر: HemaSphere. 3:461-462

    مصطلحات موضوعية: Oncology, medicine.medical_specialty, IDH1, business.industry, Internal medicine, Mutant, medicine, Dose escalation, Transfusion independence, In patient, Hematology, Newly diagnosed, business

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::917d1259be544b588267ded9fcbf79b7
    https://doi.org/10.1097/01.hs9.0000562396.68284.e0

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