المؤلفون: Lotta Pohjolainen, Sini M. Kinnunen, Samuli Auno, Alexandros Kiriazis, Saana Pohjavaara, Julia Kari-Koskinen, Matej Zore, Mikael Jumppanen, Jari Yli-Kauhaluoma, Virpi Talman, Heikki Ruskoaho, Mika J. Välimäki

المصدر: Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)

مصطلحات موضوعية: Cardiomyocytes, Maturation, Hypertrophy, GATA4, Isoxazole derivatives, Medicine (General), R5-920, Biochemistry, QD415-436

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1757-6512

URL الوصول: https://doaj.org/article/e9849cfeb7e34860b937a7a7a18376a5

المؤلفون: Tony S. Eteläinen, Tommi P. Kilpeläinen, Adele Ignatius, Samuli Auno, Francesca De Lorenzo, Johanna K. Uhari-Väänänen, Ulrika H. Julku, Timo T. Myöhänen

المساهمون: Divisions of Faculty of Pharmacy, PREP in neurodegenerative disorders, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, Research Services, Regenerative Neuroscience

المصدر: Neuropharmacology. 218

مصطلحات موضوعية: Parkinson?s disease, Cell Survival, DOPAMINE TRANSPORTER, Cellular and Molecular Neuroscience, Mice, PROLYL OLIGOPEPTIDASE INHIBITOR, TYROSINE-HYDROXYLASE, Animals, MOTOR BEHAVIOR, SYNUCLEIN, Neurodegeneration, OXIDATIVE STRESS, BRAIN, KYP-2047, Pharmacology, Parkinson Disease, AGGREGATION, Disease Models, Animal, Prolyl oligopeptidase, 317 Pharmacy, Oligomers, alpha-Synuclein, AUTOPHAGY, Endopeptidase K, A53T-?-synuclein, Prolyl Oligopeptidases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d37fd177c4900db144ba2b10c11f9c49
https://pubmed.ncbi.nlm.nih.gov/35964686

المؤلفون: Tony Eteläinen, Samuli Auno, Timo Myöhänen, Tommi Kilpeläinen

المصدر: SSRN Electronic Journal.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::78a82c4179f4813ff05123b7397341e4
https://doi.org/10.2139/ssrn.4022985

المؤلفون: Pyry M. J. Dillemuth, Timo T. Myöhänen, Maija Lahtela-Kakkonen, Henri T. Pätsi, Samuli Auno, Erik A.A. Wallén, Khaled Arja, Tommi Kilpeläinen

المساهمون: Division of Pharmaceutical Chemistry and Technology, PREP in neurodegenerative disorders, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Regenerative pharmacology group, Pharmaceutical Design and Discovery group, Erik Wallen / Principal Investigator

المصدر: ACS Medicinal Chemistry Letters

مصطلحات موضوعية: autophagy, Letter, Stereochemistry, alpha-synuclein, 116 Chemical sciences, Triazole, Oligopeptidase, Pyrazole, 010402 general chemistry, 01 natural sciences, Biochemistry, imidazole, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Imidazole, Tetrazole, KYP-2047, 030304 developmental biology, 0303 health sciences, Organic Chemistry, Endopeptidase, 3. Good health, 0104 chemical sciences, pyrazole, triazole, chemistry, Prolyl oligopeptidase, 317 Pharmacy, Electrophile, ENDOPEPTIDASE, Linker

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2b18fee964d75dc4dbbf9ec8da5bbf
http://hdl.handle.net/10138/336056

المؤلفون: Samuli Auno, Sampo Kurvonen, Poul Henning Jensen, Tommi Kilpeläinen, Lydia Zouzoula, Susanna Norrbacka, Hengjing Cui, Iiris Hovatta, Kalevi Trontti, Timo T. Myöhänen

المساهمون: Division of Pharmacology and Pharmacotherapy, PREP in neurodegenerative disorders, SLEEPWELL Research Program, Department of Psychology and Logopedics, Neuroscience Center, Mind and Matter, Iiris Hovatta / Principal Investigator, Genetics, Faculty of Pharmacy, Regenerative pharmacology group, Drug Research Program, Divisions of Faculty of Pharmacy

المصدر: Journal of Cellular and Molecular Medicine
Cui, H, Kilpeläinen, T, Zouzoula, L, Auno, S, Trontti, K, Kurvonen, S, Norrbacka, S, Hovatta, I, Jensen, P H & Myöhänen, T T 2021, ' Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy ', Journal of Cellular and Molecular Medicine, vol. 25, no. 20, pp. 9634-9646 . https://doi.org/10.1111/jcmm.16910

مصطلحات موضوعية: alpha-synuclein, multiple system atrophy, TOXICITY, DISEASE, chemistry.chemical_compound, 0302 clinical medicine, KYP‐2047, Phosphorylation, PHOSPHORYLATION, KYP-2047, 0303 health sciences, Neurodegeneration, neurodegeneration, PROTEIN PHOSPHATASE 2A, MOUSE MODEL, Transfection, Cell biology, Oligodendroglia, medicine.anatomical_structure, alpha‐synuclein, 317 Pharmacy, PROLINE, alpha-Synuclein, Molecular Medicine, AUTOPHAGY, Original Article, Cellular model, Prolyl Oligopeptidases, Cell Survival, Nerve Tissue Proteins, Protein Aggregation, Pathological, Cell Line, 03 medical and health sciences, Protein Aggregates, SDG 3 - Good Health and Well-being, medicine, Humans, Viability assay, PARKINSONS, 030304 developmental biology, Alpha-synuclein, Synucleinopathies, Autophagy, synucleinopathies, Cell Biology, Original Articles, DEGRADATION, medicine.disease, Oligodendrocyte, chemistry, prolyl oligopeptidase, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126329cf3d916b265e7db63e93e55f8c
https://pubmed.ncbi.nlm.nih.gov/34486218

المؤلفون: Heikki Ruskoaho, Mika J. Välimäki, Samuli Auno, Jari Yli-Kauhaluoma, Ingo B. Aumüller, Virpi Talman, Henri Xhaard, Gustav Boije af Gennäs, Sini Kinnunen, Tanja Bruun, Mikael Jumppanen

المساهمون: Pharmaceutical Design and Discovery group, Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Regenerative pharmacology group, Division of Pharmacology and Pharmacotherapy, Computational Adme, Henri Xhaard / Principal Investigator, Division of Pharmaceutical Biosciences, Jari Yli-Kauhaluoma / Principal Investigator, University Management, Regenerative cardiac pharmacology

المصدر: Journal of Medicinal Chemistry

مصطلحات موضوعية: FIBROBLASTS, endocrine system, medicine.drug_class, Cell Survival, 116 Chemical sciences, REQUIREMENT, Carboxamide, SMALL MOLECULES, 01 natural sciences, Article, Protein–protein interaction, 03 medical and health sciences, Structure-Activity Relationship, Drug Discovery, Chlorocebus aethiops, medicine, Structure–activity relationship, Animals, Viability assay, Rats, Wistar, Transcription factor, Cells, Cultured, 030304 developmental biology, 0303 health sciences, COS cells, Dose-Response Relationship, Drug, Molecular Structure, GATA4, Chemistry, MUTATIONS, DEFECTS, Isoxazoles, respiratory system, Small molecule, 0104 chemical sciences, Cell biology, GATA4 Transcription Factor, Rats, 010404 medicinal & biomolecular chemistry, TRANSCRIPTION FACTORS, 317 Pharmacy, DISCOVERY, embryonic structures, COS Cells, cardiovascular system, Homeobox Protein Nkx-2.5, Molecular Medicine, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed87878294538799b8cdc84144570443
http://europepmc.org/articles/PMC7076710

المؤلفون: Samuli Auno, Anu Vaikkinen, Gianmario Scotti, Petteri Piepponen, Juha-Pekka Hieta, Jaakko Kopra, Markus Haapala, Heikki Räikkönen, Tiina J. Kauppila

المصدر: Journal of the American Society for Mass Spectrometry. 28:1060-1065

مصطلحات موضوعية: Matrix-assisted laser desorption electrospray ionization, Laser ablation, business.industry, Chemistry, Laser ablation electrospray ionization, 010401 analytical chemistry, Far-infrared laser, Analytical chemistry, 02 engineering and technology, 021001 nanoscience & nanotechnology, Laser, 01 natural sciences, Mass spectrometry imaging, 0104 chemical sciences, Atmospheric-pressure laser ionization, law.invention, X-ray laser, Optics, Structural Biology, law, 0210 nano-technology, business, Spectroscopy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e059cd36116ff294f58dd6cf4d00e9f
https://doi.org/10.1007/s13361-016-1578-7

المؤلفون: Gabor Foldes, Gustav Boije af Gennäs, Samuli Auno, Lotta Pohjolainen, Sini Kinnunen, Jari Yli-Kauhaluoma, Virpi Talman, Mikael Jumppanen, S. Tuuli Karhu, Mika J. Välimäki, Heikki Ruskoaho, Robert S. Leigh

المساهمون: Regenerative cardiac pharmacology, Regenerative pharmacology group, Faculty of Pharmacy, Pharmaceutical Design and Discovery group, Division of Pharmacology and Pharmacotherapy, Timo Pyry Juhani Otonkoski / Principal Investigator, Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Jari Yli-Kauhaluoma / Principal Investigator, Medical Research Council (MRC)

المصدر: Archives of Toxicology

مصطلحات موضوعية: 0301 basic medicine, Health, Toxicology and Mutagenesis, Toxicity screening, Stem cells, Toxicology, 0302 clinical medicine, Chlorocebus aethiops, Myocytes, Cardiac, Cells, Cultured, media_common, Cardiomyocytes, Drug discovery, In vitro toxicology, General Medicine, Isoxazole derivatives, 3. Good health, In Vitro Systems, TRANSCRIPTION FACTORS, Drug development, 317 Pharmacy, 030220 oncology & carcinogenesis, High-content screening, COS Cells, Toxicity, Homeobox Protein Nkx-2.5, HEART, Stem cell, Drug, Cell type, Cell Survival, media_common.quotation_subject, CARDIOGENESIS, Induced Pluripotent Stem Cells, Computational biology, Biology, Small Molecule Libraries, Structure-Activity Relationship, 03 medical and health sciences, GATA4, ON-WATER, REGENERATION, Toxicity Tests, Structure-toxicity relationship, Animals, ISOXAZOLES, Fibroblasts, GATA4 Transcription Factor, High-Throughput Screening Assays, Rats, 030104 developmental biology, DNA-DAMAGE, CYCLOADDITIONS, High-content analysis, 1115 Pharmacology And Pharmaceutical Sciences, Structure–toxicity relationship

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82948851bd15a94e2fddbdbd8b3787ca
http://hdl.handle.net/10138/240364

المؤلفون: Henri Xhaard, Samuli Auno, Lari Lehtiö, Yuezhou Zhang, Leo Ghemtio, Gustav Boije af Gennäs, Harikanth Venkannagari, Zulfa Awol, Mikael Jumppanen, Jari Yli-Kauhaluoma, Mirko M. Maksimainen

المساهمون: Faculty of Pharmacy, Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Drug Discovery, Pharmaceutical Design and Discovery group, Division of Pharmaceutical Biosciences, Jari Yli-Kauhaluoma / Principal Investigator, Henri Xhaard / Principal Investigator, Computational Adme

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Adenosine, Clinical Biochemistry, Phosphate isosteres, Pharmaceutical Science, Biochemistry, chemistry.chemical_compound, 0302 clinical medicine, MDO1, Amide, BINDING, Drug Discovery, Moiety, Nucleotide, Enzyme Inhibitors, N-Glycosyl Hydrolases, Macrodomain, chemistry.chemical_classification, Molecular Structure, Mono-ADP-ribosylhydrolase, FAMILY, 317 Pharmacy, 030220 oncology & carcinogenesis, Molecular Medicine, medicine.drug, MACRO DOMAIN, CARCINOMA, PROTEINS, Stereochemistry, LRP16, Adenosine analogs, Phosphates, 03 medical and health sciences, Structure-Activity Relationship, Ribose, medicine, Humans, Adenosine diphosphate ribose, Molecular Biology, Human macrodomain-containing protein 1, RECEPTOR, Dose-Response Relationship, Drug, Ligand, Organic Chemistry, MODEL, 030104 developmental biology, chemistry, CELLS, Linker, Protein Processing, Post-Translational

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a4ef9050e8f6174f78b631bcab2582
http://urn.fi/urn:nbn:fi-fe201902266264

المؤلفون: Antti Mikael Jumppanen, Sini Kinnunen, Mika Juhani Välimäki, Samuli Auno, Gustav Boije af Gennäs, Henri Xhaard, Virpi Talman, Heikki Juhani Ruskoaho, Jari Tapani Yli-Kauhaluoma

المصدر: University of Helsinki

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::14eb09cef4135786bb1c38380162285c
https://researchportal.helsinki.fi/en/publications/a8abbdca-2e6f-4fe8-b688-e7f78b42fcb9