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المؤلفون: Nicola Arnold, Julie Christie, Sandra Haberthuer, Roger J. Taylor, Alastair Denholm, Mark Keenan, Julia Hatto, Mark Mercer, Lyndon Nigel Brown, Clive Mccarthy, Neil John Press, Helen Oakman, Andrew R. Tuffnell, Morris Tweed, Alexandre Trifilieff, Robert Cheung, Joseph D. Fullerton, Thomas H. Keller, David Beer, Helene Sahri, Pamela Tranter
المصدر: Journal of Medicinal Chemistry. 58:6747-6752
مصطلحات موضوعية: Drug, Cyclohexanecarboxylic Acids, Vomiting, Nausea, media_common.quotation_subject, Pulmonary disease, Pharmacology, Pulmonary Disease, Chronic Obstructive, Structure-Activity Relationship, Pharmacokinetics, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Dosing, Naphthyridines, PDE4 Inhibitors, media_common, COPD, Dose-Response Relationship, Drug, Chemistry, medicine.disease, Rats, Solubility, Thermodynamics, Molecular Medicine, Phosphodiesterase 4 Inhibitors, medicine.symptom
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2
المؤلفون: Robin Alec Fairhurst, Joseph D. Fullerton, David Andrew Sandham, Heinz E. Moser, Mauro Zurini, Sandra Haberthuer, Darryl Brynley Jones, Mark Dodds, Julia Hatto, Gurdip Bhalay, Colin Howes, Paul Nicklin, Simon J. Watson, David Farr, Reto Naef, Irene Muller, Andrew Dunstan, Nichola J. Arnold, Nicholas James Devereux, Morris Tweed, Angela Glen, Katharine L. Turner, Beate Leuenberger, David Beer, Sylvie Gomez, Ruth Arnold, Thomas H. Keller, Stephen Paul Collingwood, Sarah Craig
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:2376-2379
مصطلحات موضوعية: Male, Clinical Biochemistry, Biological Availability, Pharmaceutical Science, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Erectile Dysfunction, 3',5'-Cyclic-GMP Phosphodiesterases, In vivo, Drug Discovery, Animals, Humans, Protein Isoforms, Structure–activity relationship, Pharmacokinetics, Enzyme Inhibitors, Molecular Biology, Cyclic Nucleotide Phosphodiesterases, Type 5, chemistry.chemical_classification, Organic Chemistry, Biological activity, Xanthine, In vitro, Bioavailability, Enzyme, chemistry, Xanthines, cGMP-specific phosphodiesterase type 5, Molecular Medicine, Cattle, sense organs
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المؤلفون: Helene Sahri, Julie Christie, Neil John Press, Mark Keenan, Sandra Haberthuer, Morris Tweed, Andrew R. Tuffnell, Mark Mercer, Joseph D. Fullerton, John R. Fozard, Thomas H. Keller, Nicola Elaine Press, Lyndon Nigel Brown, Roger J. Taylor, Clive Mccarthy, Julia Hatto, Robert Cheung, Pamela Tranter
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:3081-3085
مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Adenosine A3 Receptor Antagonists, Pharmaceutical Science, Pharmacology, Receptor, Adenosine A2B, Adenosine receptor antagonist, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Aminothiazole, Heterocyclic Compounds, Drug Discovery, medicine, Animals, Rats, Wistar, Receptor, Molecular Biology, ADME, Chemistry, Receptor, Adenosine A3, Organic Chemistry, Antagonist, Receptor antagonist, Adenosine, Adenosine receptor, Adenosine A2 Receptor Antagonists, Rats, Thiazoles, Molecular Medicine, medicine.drug
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المؤلفون: Robin Alec Fairhurst, David Beer, Diana Janus, David Bentley, Lynne Jordan, Claire Hayden, Peter Gedeck, Kirsty Smithies, Sandra Haberthuer, Christine Lewis, Ian N. Bruce, Vahid Alikhani, Bernard Cuenoud, Elke Wissler
المصدر: Bioorganic & Medicinal Chemistry Letters. 14:4705-4710
مصطلحات موضوعية: Time Factors, medicine.drug_class, Stereochemistry, Guinea Pigs, Clinical Biochemistry, Substituent, Pharmaceutical Science, Ether, Carboxamide, In Vitro Techniques, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Residue (chemistry), Formoterol Fumarate, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Albuterol, Adrenergic beta-2 Receptor Agonists, Salmeterol Xinafoate, Molecular Biology, Chemistry, Organic Chemistry, Muscle, Smooth, Stereoisomerism, Adrenergic beta-Agonists, Ethanolamines, Molecular Medicine, Formoterol, Muscle Contraction, medicine.drug
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5
المؤلفون: Gurdip Bhalay, David Beer, Stephen Paul Collingwood, Sarah Craig, Nicholas James Devereux, Rowan Stringer, Sandra Haberthuer, Trevor John Howe, Angela Glen, Katharine L. Turner, Andrew Dunstan, Heinz E. Moser, Ruth Arnold, Mauro Zurini, Sylvie Gomez, Paul Nicklin, Simon J. Watson, Urs Baettig, Reto Naef, David Andrew Sandham, Stephen Jelfs
المصدر: Bioorganic & Medicinal Chemistry Letters. 12:2587-2590
مصطلحات موضوعية: Models, Molecular, Phosphodiesterase Inhibitors, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Isozyme, Chemical synthesis, chemistry.chemical_compound, Drug Discovery, medicine, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Phosphoric Diester Hydrolases, Chemistry, Organic Chemistry, Sulfonamide (medicine), Xanthine, In vitro, Enzyme, Enzyme inhibitor, Xanthines, cGMP-specific phosphodiesterase type 5, biology.protein, Molecular Medicine, medicine.drug
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المؤلفون: Sandra Haberthuer, Trixie Wagner, Lyndon Nigel Brown, Julia Hatto, Nicola Arnold, Clive Mccarthy, Julie Christie, John R. Fozard, Helene Sahri, Helen Oakman, Thomas H. Keller, Roger J. Taylor, Robert Cheung, Mark Keenan, Neil John Press, Joseph D. Fullerton, Andrew R. Tuffnell, Alexandre Trifilieff, John W. Tyler, David Beer, Alastair Denholm, Morris Tweed, Mark Mercer, Pamela Tranter
المصدر: Journal of medicinal chemistry. 55(17)
مصطلحات موضوعية: Models, Molecular, Magnetic Resonance Spectroscopy, Chemistry, Vomiting, Drug Evaluation, Preclinical, Pharmacology, Bioavailability, Rats, Disease Models, Animal, Mice, Phosphodiesterase-4, Pharmacokinetics, Solubility, In vivo, Drug Design, Drug Discovery, Aqueous solubility, Molecular Medicine, Animals, Humans, Phosphodiesterase 4 Inhibitors, Cells, Cultured
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المؤلفون: Deborah Hynx, Claire Ffoulkes-Jones, Gaynor Elizabeth Pilgrim, Sarah Jeffers, Sandra Haberthuer, Elisabeth Schaebulin, John R. Fozard, Thomas H. Keller, Bernard Cuenoud, David Bentley, Katharine L. Turner, Andrew Nicholls, David Beattie, Morris Tweed, Lucy Barker, Sarah Craig, David Beer, Christoph Walker, Paul Kirkham, Rowan Stringer, David Farr, David Andrew Sandham, K D Butler, Colin Howes, Simon J. Watson, Lazzaro Mazzoni, Gillian Spooner, Louise Bidlake, Pamela Tranter, Janet Maas
المصدر: Bioorganicmedicinal chemistry. 12(19)
مصطلحات موضوعية: Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Biological Availability, Thymus Gland, Pharmacology, Biochemistry, Chemical synthesis, Steroid, Cell Line, Structure-Activity Relationship, Glucocorticoid receptor, Receptors, Glucocorticoid, In vivo, Oral administration, Drug Discovery, Eosinophilia, medicine, Structure–activity relationship, Animals, Humans, Molecular Biology, Glucocorticoids, Chemistry, Tumor Necrosis Factor-alpha, Macrophages, Organic Chemistry, Esters, Organ Size, In vitro, Rats, Molecular Medicine, Androstenes, Glucocorticoid, medicine.drug, Protein Binding
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المؤلفون: Angela Glen, Gurdip Bhalay, Sandra Haberthuer, David Beer, Andrew Dunstan, Heinz E. Moser
المصدر: Bioorganicmedicinal chemistry letters. 12(15)
مصطلحات موضوعية: Databases, Factual, Phosphodiesterase Inhibitors, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chloride, Chemical synthesis, Xanthine, chemistry.chemical_compound, Structure-Activity Relationship, 3',5'-Cyclic-GMP Phosphodiesterases, Drug Discovery, medicine, Structure–activity relationship, Organic chemistry, Combinatorial Chemistry Techniques, Molecular Biology, Nuclear Magnetic Resonance, Biomolecular, Cyclic Nucleotide Phosphodiesterases, Type 5, Bicyclic molecule, Phosphoric Diester Hydrolases, Organic Chemistry, chemistry, Molecular Medicine, Surface modification, Indicators and Reagents, Selectivity, Linker, medicine.drug
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