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1دورية أكاديمية
المصدر: Molecules, Vol 18, Iss 4, Pp 4487-4509 (2013)
مصطلحات موضوعية: thieno[3,2-d]pyrimidinones, thieno[3,2-d]pyrimidines, quinazolinones, conformationally restricted analogues, enzyme inhibitors, 17b-hydroxysteroid dehydrogenase type 2, osteoporosis, Organic chemistry, QD241-441
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Alessandro Spadaro, Matthias Negri, Sandrine Marchais-Oberwinkler, Emmanuel Bey, Martin Frotscher
المصدر: PLoS ONE, Vol 7, Iss 1, p e29252 (2012)
وصف الملف: electronic resource
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المؤلفون: Rolf W. Hartmann, Chris J. van Koppen, Matthias W. Laschke, Giuseppe Felice Mangiatordi, Ahmed S. Abdelsamie, Martin Frotscher, Orazio Nicolotti, Abdelrahman Mohamed, Angelo Carotti, Arcangela Mazzini, Hanna Drzewiecka, Emanuele M. Gargano, Paweł P. Jagodziński, Sandrine Marchais-Oberwinkler
المساهمون: HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.
المصدر: ACS medicinal chemistry letters
United States
ACS Med Chem Lett
ACS medicinal chemistry letters (2021). doi:10.1021/acsmedchemlett.1c00462
info:cnr-pdr/source/autori:Emanuele M. Gargano, Abdelrahman Mohamed, Ahmed S. Abdelsamie, Giuseppe F. Mangiatordi, Hanna Drzewiecka, Pawe? P. Jagodzi?ski, Arcangela Mazzini, Chris J. van Koppen, Matthias W. Laschke, Orazio Nicolotti, Angelo Carotti, Sandrine Marchais-Oberwinkler, Rolf W. Hartmann, and Martin Frotscher/titolo:17?-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer/doi:10.1021%2Facsmedchemlett.1c00462/rivista:ACS medicinal chemistry letters/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volumeمصطلحات موضوعية: business.industry, Organic Chemistry, Treatment options, medicine.disease, Biochemistry, Docking, respiratory tract diseases, Drug Discovery, Cancer research, Medicine, Non small cell, Hydroxysteroid dehydrogenase, business, Lung cancer, hormones, hormone substitutes, and hormone antagonists
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b72b1eb9a0d3948ea61df325c6e341e
https://hdl.handle.net/10033/623149 -
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المؤلفون: Nicole Bertoletti, Aline Keils, Sandrine Marchais-Oberwinkler, Gerhard Klebe, Andreas Heine, Mohammed J. Badran
المصدر: The Journal of Steroid Biochemistry and Molecular Biology. 189:135-144
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, 17-Hydroxysteroid Dehydrogenases, Protein Conformation, Stereochemistry, Endocrinology, Diabetes and Metabolism, Dimer, Clinical Biochemistry, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Oxidoreductase, Enzyme Stability, Catalytic triad, Humans, Enzyme kinetics, Molecular Biology, chemistry.chemical_classification, biology, Substrate (chemistry), Active site, Cell Biology, Ligand (biochemistry), Amino acid, 030104 developmental biology, Amino Acid Substitution, chemistry, 030220 oncology & carcinogenesis, Mutagenesis, Site-Directed, biology.protein, Molecular Medicine, Protein Multimerization
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المؤلفون: Lorenz Siebenbuerger, Sandrine Marchais-Oberwinkler, Michael D. Menger, Martin Frotscher, Ahmed S. Abdelsamie, Carsten Boerger, Rolf W. Hartmann, Victor Hernandez-Olmos, Claudia Scheuer, Chris J. van Koppen, Matthias W. Laschke
المصدر: Journal of Medicinal Chemistry. 61:10724-10738
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, Pharmacology, 01 natural sciences, Targeted therapy, Estradiol Dehydrogenases, Mice, 03 medical and health sciences, Pharmacokinetics, Drug Discovery, medicine, Animals, Humans, Potency, Tissue Distribution, Enzyme Inhibitors, Hydroxysteroid dehydrogenase, chemistry.chemical_classification, 010405 organic chemistry, Water, In vitro, 0104 chemical sciences, 030104 developmental biology, Enzyme, Solubility, S9 fraction, chemistry, Drug Design, Osteoporosis, Molecular Medicine, Female, Intracellular
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المؤلفون: Pauline Banachowicz, Rolf W. Hartmann, Susanne Maria Weber, Christoph P. Sager, Matthias Negri, Gabriele Möller, Sandrine Marchais-Oberwinkler, Jerzy Adamski
المصدر: The Journal of Steroid Biochemistry and Molecular Biology. 206:105790
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Mutagenesis (molecular biology technique), Dehydrogenase, Molecular Dynamics Simulation, Ligands, Topology, Biochemistry, Catalysis, Estradiol Dehydrogenases, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Humans, Homology modeling, Amino Acids, Enzyme Inhibitors, Site-directed mutagenesis, Molecular Biology, chemistry.chemical_classification, Cell Biology, Ligand (biochemistry), Enzyme structure, Amino acid, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Mutagenesis, Site-Directed, Molecular Medicine, NAD+ kinase
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المؤلفون: Martin Frotscher, Ahmed S. Abdelsamie, Rolf W. Hartmann, Sebastian Müller, Sandrine Marchais-Oberwinkler, Chris J. van Koppen, Matthias W. Laschke, Lorenz Siebenbürger, Mohamed Salah, Ahmed Merabet, Claudia Scheuer, Oliver Zierau, Michael D. Menger, Günter Vollmer
المصدر: Journal of medicinal chemistry. 62(15)
مصطلحات موضوعية: medicine.drug_class, Osteoporosis, Estrogen receptor, Administration, Oral, Pharmacology, 01 natural sciences, Bone resorption, Estradiol Dehydrogenases, 03 medical and health sciences, Mice, Drug Delivery Systems, Drug Discovery, medicine, Animals, Humans, Hydroxysteroid dehydrogenase, Enzyme Inhibitors, Rats, Wistar, IC50, Testosterone, 030304 developmental biology, 0303 health sciences, Bone Density Conservation Agents, Chemistry, medicine.disease, In vitro, 0104 chemical sciences, Rats, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Estrogen, Drug Design, Molecular Medicine, Female
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المؤلفون: Rolf W. Hartmann, Sebastian Müller, Ahmed S. Abdelsamie, Ahmed Merabet, Oliver Zierau, Sophie Pählig, Günter Vollmer, Sandrine Marchais-Oberwinkler, Chris J. van Koppen
المصدر: The Journal of steroid biochemistry and molecular biology. 192
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, 17-Hydroxysteroid Dehydrogenases, medicine.drug_class, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Ovariectomy, Clinical Biochemistry, Osteoporosis, Estrone, Biochemistry, Bone and Bones, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, In vivo, Internal medicine, medicine, Animals, Humans, Tissue Distribution, Enzyme Inhibitors, Rats, Wistar, Molecular Biology, Testosterone, business.industry, Uterus, Hormone replacement therapy (menopause), Cell Biology, Organ Size, medicine.disease, Rats, Disease Models, Animal, 030104 developmental biology, chemistry, Estrogen, 030220 oncology & carcinogenesis, Estradiol benzoate, Molecular Medicine, Female, business, Ex vivo
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المؤلفون: Michael D. Menger, Martin Frotscher, Lorenz Siebenbürger, Matthias W. Laschke, Rolf W. Hartmann, Carsten Börger, Steven C. Herath, Mohamed Salah, Yannik Biskupek, Tim Pohlemann, Ahmed S. Abdelsamie, Claudia Scheuer, Sandrine Marchais-Oberwinkler, Chris J. van Koppen
المصدر: Journal of medicinal chemistry. 62(3)
مصطلحات موضوعية: medicine.medical_specialty, Intracrine, 17-Hydroxysteroid Dehydrogenases, medicine.medical_treatment, Bone healing, 01 natural sciences, Proof of Concept Study, Bone resorption, Targeted therapy, 03 medical and health sciences, Mice, Internal medicine, Drug Discovery, medicine, Animals, Humans, Hydroxysteroid dehydrogenase, Enzyme Inhibitors, Testosterone, 030304 developmental biology, Fracture Healing, 0303 health sciences, Chemistry, Bone fracture, medicine.disease, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Steroid hormone, Endocrinology, Drug Design, Molecular Medicine
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المؤلفون: Jerzy Adamski, Gerhard Klebe, Andreas Heine, Ahmed S. Abdelsamie, Florian Braun, Torsten Steinmetzer, Gabriele Möller, Nicole Bertoletti, Sandrine Marchais-Oberwinkler, Chris J. van Koppen, Mohamed Salah
المصدر: Journal of medicinal chemistry. 59(23)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, 17-Hydroxysteroid Dehydrogenases, Stereochemistry, Crystallography, X-Ray, Cofactor, 03 medical and health sciences, Structure-Activity Relationship, Oxidoreductase, Drug Discovery, Structure–activity relationship, Humans, Hydroxysteroid dehydrogenase, Enzyme Inhibitors, chemistry.chemical_classification, biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Active site, Ligand (biochemistry), 030104 developmental biology, Enzyme, Drug Design, biology.protein, Molecular Medicine, NAD+ kinase