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1
المؤلفون: Badry Bursulaya, Yun O. Long, Jaganmohan Anumolu, Matthew McNeill, Sangamesh Badiger, Rina Fong, Michael DiDonato, Mari Manuia, Jie Li, Bender Steven Lee, Jose Juarez, Wenshuo Lu, Gerald Lelais, Daniel E. Mason, Thomas H. Marsilje, John Isbell, Kevin Johnson, Shailaja Kasibhatla, Bei Chen, Glen Spraggon, Pierre-Yves Michellys, Todd Groessl, Robert Epple, Yong Jia, Perry Gordon, Chun Li
المصدر: Journal of Medicinal Chemistry. 59:6671-6689
مصطلحات موضوعية: 0301 basic medicine, Mutation, Chemistry, Drug discovery, Mutant, Pharmacology, medicine.disease_cause, medicine.disease, 03 medical and health sciences, T790M, 030104 developmental biology, 0302 clinical medicine, In vivo, 030220 oncology & carcinogenesis, Drug Discovery, medicine, Molecular Medicine, Structure–activity relationship, Lung cancer, EGFR inhibitors
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2
المؤلفون: Arndt Meyer, Murali Chebrolu, Christine E. Gee, Grit Laue, Markus Fendt, Laura H. Jacobson, Sangamesh Badiger, Samuel Hintermann, Chetan Pandit, Simona Cotesta, Claudia Betschart, Daniel Hoyer, Vinod D. Chaudhari, Dirk Behnke, Trixie Wagner
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:5555-5560
مصطلحات موضوعية: Pyridines, High-throughput screening, Clinical Biochemistry, Dual Orexin Receptor Antagonists, Administration, Oral, Pharmaceutical Science, Pharmacology, Crystallography, X-Ray, Doras, Biochemistry, Mice, Drug Discovery, Animals, Molecular Biology, G protein-coupled receptor, Molecular Structure, biology, Chemistry, Drug discovery, Orexin Receptor Antagonists, Organic Chemistry, biology.organism_classification, Orexin, Pyrazoles, Molecular Medicine, Administration, Intravenous, Protein Binding
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3
المؤلفون: Sunil Kumar Panigrahi, Pramod Kumar Dubey, Arun P. Chandrasekharappa, Sekhar Reddy V.V.V. Manukonda, Sangamesh Badiger
المصدر: Letters in Drug Design & Discovery. 11:444-453
مصطلحات موضوعية: chemistry.chemical_compound, Benzothiazole, chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Organic chemistry
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e37002427cc30709aff6df8e78649e73
https://doi.org/10.2174/15701808113106660076 -
4
المؤلفون: Chetan Pandit, Christine E. Gee, Daniel Hoyer, Vinod D. Chaudhari, Grit Laue, Juergen Wagner, Laura H. Jacobson, Dirk Behnke, Claudia Betschart, Simona Cotesta, Sangamesh Badiger, Samuel Hintermann, Markus Fendt, Silvio Ofner
المصدر: Journal of Medicinal Chemistry. 56:7590-7607
مصطلحات موضوعية: Male, Indoles, Sleep induction, Primary Insomnia, Motor Activity, Pharmacology, Doras, Non-rapid eye movement sleep, Mice, Structure-Activity Relationship, Quinoxalines, Sleep Initiation and Maintenance Disorders, mental disorders, Drug Discovery, medicine, Animals, Spiro Compounds, Sleep Stages, biology, Electromyography, Chemistry, Suvorexant, Electroencephalography, Stereoisomerism, Azepines, Triazoles, biology.organism_classification, Orexin receptor, Mice, Inbred C57BL, Pyrimidines, Molecular Medicine, Orexin Receptor Antagonists, Almorexant, Sleep, medicine.drug
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5
المؤلفون: Sangamesh Badiger, Sunil Kumar Panigrahi, Pramod Kumar Dubey, Sekhar Reddy V.V.V. Manukonda, Arun P. Chandrasekharappa
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:2579-2584
مصطلحات موضوعية: Benzimidazole, Molecular model, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Plasma protein binding, Biochemistry, Molecular Docking Simulation, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Potency, Structure–activity relationship, Enzyme Inhibitors, Binding site, Molecular Biology, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Benzoxazoles, Oxamic Acid, Binding Sites, Organic Chemistry, Benzoxazole, Combinatorial chemistry, Protein Structure, Tertiary, chemistry, Drug Design, Molecular Medicine, Protein Binding
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6
المؤلفون: Gérald, Lelais, Robert, Epple, Thomas H, Marsilje, Yun O, Long, Matthew, McNeill, Bei, Chen, Wenshuo, Lu, Jaganmohan, Anumolu, Sangamesh, Badiger, Badry, Bursulaya, Michael, DiDonato, Rina, Fong, Jose, Juarez, Jie, Li, Mari, Manuia, Daniel E, Mason, Perry, Gordon, Todd, Groessl, Kevin, Johnson, Yong, Jia, Shailaja, Kasibhatla, Chun, Li, John, Isbell, Glen, Spraggon, Steven, Bender, Pierre-Yves, Michellys
المصدر: Journal of medicinal chemistry. 59(14)
مصطلحات موضوعية: Male, Models, Molecular, Mice, Inbred BALB C, Nicotine, Lung Neoplasms, Dose-Response Relationship, Drug, Molecular Conformation, Mice, Nude, Antineoplastic Agents, Neoplasms, Experimental, Crystallography, X-Ray, Rats, ErbB Receptors, Mice, Structure-Activity Relationship, Carcinoma, Non-Small-Cell Lung, Drug Discovery, Mutation, Animals, Humans, Benzimidazoles, Drug Screening Assays, Antitumor, Rats, Wistar, Protein Kinase Inhibitors, Cell Proliferation
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7
المؤلفون: Chakshumathi Ghadiyaram, Lakshmi Narasu Mangamoori, Narasimha Rao Krishnamurthy, Sunil Kumar Panigrahi, Deepankar Manna, Sangamesh Badiger, Pramod Kumar Dubey, M. V V V Sekhar Reddy, Arun P. Chandrasekharappa, Subramanya Hosahalli
المصدر: Protein and peptide letters. 21(1)
مصطلحات موضوعية: Stereochemistry, Allosteric regulation, Protein Data Bank (RCSB PDB), Protein tyrosine phosphatase, Crystallography, X-Ray, Biochemistry, Mice, Structural Biology, Catalytic Domain, Animals, Molecular replacement, Obesity, Cloning, Molecular, Receptor, chemistry.chemical_classification, Mice, Knockout, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Binding Sites, biology, Active site, General Medicine, Enzyme, chemistry, Diabetes Mellitus, Type 2, Cytoplasm, biology.protein, hormones, hormone substitutes, and hormone antagonists
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b8ccdf1cf343b3a234fe62ad76108e
https://pubmed.ncbi.nlm.nih.gov/23964742
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