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المؤلفون: Santosh Talreja, Hang Chen, Danny Chui, Paul H. Wen, Songli Wang, Jean Danao, Shilpa Sambashivan, Jun Yin, Samir Koirala, Chi-Ming Li, David Tran, Qingwen Cheng, Ning Sun, Ian Foltz
المصدر: Journal of Biological Chemistry. 293:12620-12633
مصطلحات موضوعية: 0301 basic medicine, Myeloid, Microglia, TREM2, medicine.medical_treatment, Neurodegeneration, Cell Biology, Immune receptor, Biology, medicine.disease, Biochemistry, 03 medical and health sciences, 030104 developmental biology, medicine.anatomical_structure, Cytokine, Genetic model, medicine, Cancer research, Molecular Biology, Neuroinflammation
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::69decb1fcf6208c9397856e5993a4837
https://doi.org/10.1074/jbc.ra118.001848 -
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المؤلفون: Ai-Ching Lim, Jean Danao, Nikolai A. Sharkov, Steve Thibault, Songli Wang, Steve Wood, Edoardo Marcora, Santosh Talreja, Eric Bragg, Zhongqi Zhang, Jason Richardson, Ian Foltz, Rob Kegel, Hang Chen, Jodi Bradley, Xiaoshan Min, Shilpa Sambashivan, Zhulun Wang, Athena Sudom
مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, Osteoclasts, Nerve Tissue Proteins, Immune receptor, Crystallography, X-Ray, Ligands, Biochemistry, 03 medical and health sciences, Protein Domains, Alzheimer Disease, medicine, Humans, Editors' Picks, Genetic Predisposition to Disease, Receptors, Immunologic, Receptor, Molecular Biology, Neuroinflammation, Loss function, Membrane Glycoproteins, Microglia, TREM2, Chemistry, Macrophages, Neurodegeneration, Genetic Variation, Cell Biology, Dendritic Cells, medicine.disease, Ligand (biochemistry), Cell biology, 030104 developmental biology, medicine.anatomical_structure, Mutant Proteins
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeef296643aab8b942f16b84784bc212
https://europepmc.org/articles/PMC6093241/ -
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المؤلفون: Qingwen, Cheng, Jean, Danao, Santosh, Talreja, Paul, Wen, Jun, Yin, Ning, Sun, Chi-Ming, Li, Danny, Chui, David, Tran, Samir, Koirala, Hang, Chen, Ian N, Foltz, Songli, Wang, Shilpa, Sambashivan
المصدر: The Journal of biological chemistry. 293(32)
مصطلحات موضوعية: Male, Membrane Glycoproteins, Antibodies, Monoclonal, Brain, High-Throughput Nucleotide Sequencing, Apoptosis, Mice, Transgenic, Molecular Bases of Disease, Mice, Inbred C57BL, Mice, Alzheimer Disease, Cell Movement, Mutation, Animals, Humans, Female, Myeloid Cells, Microglia, Receptors, Immunologic, Biomarkers, Cells, Cultured
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::3fb6d75683f871cfc59a96af475b98f0
https://pubmed.ncbi.nlm.nih.gov/29599291 -
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المؤلفون: Dah-Ren Hwang, Geraldine Hill Della Puppa, Jamie Wong, Essa Hu, Thomas Nixey, Silke Miller, Hang Chen, Jessica Able, Dianna Lester-Zeiner, James J. S. Treanor, Robert Cho, Santosh Talreja, Roxanne Kunz, Jianxia Shi, Ji Ma, David C. Immke, Jennifer R. Allen, Christopher Biorn, Amy Porter, Klaus Michelsen, Shannon Rumfelt, Stephen Hitchcock
المصدر: Journal of Medicinal Chemistry. 55:4776-4787
مصطلحات موضوعية: Male, Phosphodiesterase Inhibitors, Aminopyridines, Striatum, In Vitro Techniques, Tritium, Permeability, Cell Line, Rats, Sprague-Dawley, Dogs, Tandem Mass Spectrometry, In vivo, TRACER, Drug Discovery, Animals, Humans, Tissue Distribution, ATP Binding Cassette Transporter, Subfamily B, Member 1, Radionuclide Imaging, Phosphoric Diester Hydrolases, Drug discovery, Chemistry, Brain, Phosphodiesterase, Stereoisomerism, Surface Plasmon Resonance, Molecular biology, Small molecule, Rats, Pyridazines, Rapid identification, Quinolines, Pyrazoles, Molecular Medicine, PDE10A, Radiopharmaceuticals, Chromatography, Liquid, Protein Binding
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المؤلفون: Hu Ye, Tim Kazules, Ji Ma, Dianna Lester-Zeiner, Essa Hu, Santosh Talreja, Carl Davis, Charlie Glaus, Oliver R. Thiel, Ning Chen, Geraldine Hill Della Puppa, James J. S. Treanor, Shannon Rumfelt, Hui Hannah Dou, Roxanne Kunz, David C. Immke, Jessica Able, Jennifer R. Allen, Silke Miller, Xiaoning Zhao, Hang Chen, Jianxia Shi, Jamie Wong, Toni Williamson, Christopher Biorn, Amy Porter, Klaus Michelsen, Ada Chen
المصدر: The Journal of pharmacology and experimental therapeutics. 352(2)
مصطلحات موضوعية: Male, Fluorine Radioisotopes, Phosphodiesterase Inhibitors, Pharmacology, Mass Spectrometry, Rats, Sprague-Dawley, Radioligand Assay, Species Specificity, medicine, Distribution (pharmacology), Animals, Humans, Tissue Distribution, medicine.diagnostic_test, Molecular Structure, Chemistry, Drug discovery, Phosphoric Diester Hydrolases, Antagonist, Phosphodiesterase, Brain, Stereoisomerism, Surface Plasmon Resonance, Small molecule, Drug development, Positron emission tomography, Positron-Emission Tomography, Pyrazines, Molecular Medicine, Benzimidazoles, Female, PDE10A, Chromatography, Liquid, Papio, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2114c0263395e74897b10174822cf2a
https://pubmed.ncbi.nlm.nih.gov/25502803 -
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المؤلفون: Kaustav Biswas, Ning Chen, Ji Ma, Xiaoning Zhao, Randall W. Hungate, Carl Davis, Jessica Able, Madelyn Cueva, James J. S. Treanor, Matthew P. Bourbeau, Samer Chmait, Paul E. Harrington, Dianna Lester-Zeiner, Roxanne Kunz, Jianxia Shi, Hang Chen, Jennifer R. Allen, Amy Porter, Kristin L. Andrews, Essa Hu, Jean Danao, Santosh Talreja, Thomas Kornecook
المصدر: Journal of medicinal chemistry. 57(15)
مصطلحات موضوعية: Male, Primates, Stereochemistry, Phosphodiesterase Inhibitors, Protein Conformation, Administration, Oral, Biological Availability, Motor Activity, Rats, Sprague-Dawley, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, In vivo, Morpholine, Drug Discovery, Potency, Animals, Humans, Phosphoric Diester Hydrolases, Phosphodiesterase, Brain, Tetrahydropyran, Piperazine, chemistry, Pyrazines, Molecular Medicine, Benzimidazoles, PDE10A, Piperidine, Antipsychotic Agents