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1
المؤلفون: Manel Ferrer, Elena Calama, Richard S. Roberts, Begoña Hernández, Sara Sevilla, Judit Cabedo, Dolors Vilella, Peter Eichhorn, Amadeu Gavaldà, Miriam Andrés, Jordi Gràcia, Martin D. Lehner, Carla Carcasona, Joan Taltavull, Victor Segarra, Montserrat Miralpeix
المصدر: Journal of medicinal chemistry. 61(6)
مصطلحات موضوعية: 0301 basic medicine, Drug, Lipopolysaccharides, Male, Neutrophils, media_common.quotation_subject, Pharmacology, Crystallography, X-Ray, Rats, Sprague-Dawley, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, In vivo, Drug Discovery, Hydrolase, Administration, Inhalation, Structure–activity relationship, Animals, Naphthyridines, Lung, media_common, chemistry.chemical_classification, Dose-Response Relationship, Drug, Tumor Necrosis Factor-alpha, Rational design, Dry Powder Inhalers, Rats, Dose–response relationship, 030104 developmental biology, Enzyme, chemistry, Structural biology, 030220 oncology & carcinogenesis, Drug Design, Molecular Medicine, Phosphodiesterase 4 Inhibitors
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2
المؤلفون: Laura Vidal, Miriam Andrés, Marta Mir, Pilar Forns, Sara Sevilla, Bernat Vidal, Estrella Lozoya, Cristina Esteve, Mónica Bravo, Manel Ferrer, Paul R. Eastwood, Richard S. Roberts, Jordi Castro, Elena Gómez, Marta Calbet, Pere Vilaseca, Jacob González, Imma Moreno, Silvia Petit, J. A. Alonso, Maria Antonia Buil
المصدر: Bioorganic & Medicinal Chemistry Letters. 24:5127-5133
مصطلحات موضوعية: Steric effects, endocrine system diseases, Stereochemistry, Receptors, Prostaglandin, Clinical Biochemistry, Substituent, Pharmaceutical Science, Acetates, Kinetic energy, Biochemistry, Dissociation (chemistry), Bridged Bicyclo Compounds, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Receptors, Immunologic, Receptor, Crth2 antagonist, Molecular Biology, Bicyclic molecule, Hydrogen bond, Organic Chemistry, nutritional and metabolic diseases, Hydrogen Bonding, Models, Chemical, chemistry, Molecular Medicine, Half-Life
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3
المؤلفون: Cristina Esteve, Jacob González, Pere Vilaseca, Marta Calbet, Imma Moreno, Marta Mir, Richard S. Roberts, Silvia Petit, Elena Gómez, Mónica Bravo, Miriam Zanuy, J. A. Alonso, Manel Ferrer, Sara Sevilla, Laura Vidal, Peter Eichhorn, Miriam Andrés, Paul R. Eastwood, Bernat Vidal
المصدر: Bioorganic & Medicinal Chemistry Letters. 24:5123-5126
مصطلحات موضوعية: Indoles, Stereochemistry, Receptors, Prostaglandin, Clinical Biochemistry, Substituent, Pharmaceutical Science, Acetates, Biochemistry, Dissociation (chemistry), Bridged Bicyclo Compounds, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Humans, Molecule, Rats, Wistar, Receptors, Immunologic, Crth2 antagonist, Molecular Biology, Bicyclic molecule, Chemistry, Organic Chemistry, Rats, Injections, Intravenous, Molecular Medicine, Half-Life
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4
المؤلفون: Richard S. Roberts, Maria Antonia Buil, Manel Ferrer, Marcos Castillo, Miriam Andrés, Mónica Bravo, Martin D. Lehner, Jordi Castro, Sara Sevilla, Peter Eichhorn, Marta Calbet, Imma Moreno
المصدر: European Journal of Medicinal Chemistry. 71:168-184
مصطلحات موضوعية: Pharmacology, Stereochemistry, Receptors, Prostaglandin, Organic Chemistry, Biological activity, General Medicine, Acetates, Pyrazole, In vitro, Structure-Activity Relationship, Acetic acid, chemistry.chemical_compound, chemistry, Biochemistry, In vivo, Drug Discovery, Homologous chromosome, Humans, Pyrazoles, Structure–activity relationship, Molecule, Receptors, Immunologic
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5
المؤلفون: Jordi Serrat, Jordi Gràcia, Judit Cabedo, Lluís Pagès, Dolors Vilella, Martin D. Lehner, Manel Ferrer, Montserrat Miralpeix, Peter Eichhorn, Jordi Castro, Begoña Hernández, Maria Antonia Buil, Victor Segarra, Elena Calama, Sara Sevilla, Carla Carcasona, Miriam Andrés, Joan Taltavull, Imma Moreno, Richard S. Roberts, Amadeu Gavaldà
المصدر: Journal of medicinal chemistry. 59(23)
مصطلحات موضوعية: 0301 basic medicine, Male, Models, Molecular, Pharmacology, Adenylyl cyclase, Rats, Sprague-Dawley, 03 medical and health sciences, Cyclic nucleotide, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Animals, Humans, chemistry.chemical_classification, Cyclic nucleotide phosphodiesterase, Dose-Response Relationship, Drug, Molecular Structure, Biphenyl Compounds, Adenosine receptor, Cyclic Nucleotide Phosphodiesterases, Type 4, Rats, Pyridazines, 030104 developmental biology, Enzyme, chemistry, Biochemistry, Structural biology, Second messenger system, Molecular Medicine, Phosphodiesterase 4 Inhibitors, Intracellular
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6
المؤلفون: Manel Ferrer, Sara Sevilla, Richard S. Roberts
المصدر: Tetrahedron Letters. 54:4821-4825
مصطلحات موضوعية: Phosphodiesterase IV, business.industry, Chemistry, Stereochemistry, Organic Chemistry, Drug Discovery, Modular design, PDE4 Inhibitors, business, Biochemistry, Structural class
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7
المؤلفون: Pere Vilaseca, Marcos Castillo, Bernat Vidal, Cristina Esteve, Richard S. Roberts, Sara Sevilla, Manel Ferrer, Maria Antonia Buil, Jordi Castro, Sara López, Marta Calbet, Laura Vidal, Pilar Forns, Jacob González
المصدر: European journal of medicinal chemistry. 113
مصطلحات موضوعية: Stereochemistry, Kinetics, Receptors, Prostaglandin, Ring (chemistry), Kinetic energy, 01 natural sciences, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Humans, Sulfones, Receptors, Immunologic, Crth2 antagonist, Pharmacology, Bicyclic molecule, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, General Medicine, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Methyl group
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8
المؤلفون: Natalia de la Figuera, Alberto Ortega, Sara Sevilla, Fernando Albericio, Pilar Forns, Montserrat Erra, Joan-Carles Fernàndez, Dolors Fernández-Forner
المصدر: Tetrahedron Letters. 44:6907-6910
مصطلحات موضوعية: chemistry.chemical_classification, fungi, Organic Chemistry, technology, industry, and agriculture, food and beverages, respiratory system, Biochemistry, Amino acid, chemistry.chemical_compound, stomatognathic system, chemistry, Drug Discovery, Trifluoroacetic acid, Organic chemistry, Linker
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9
المؤلفون: Sara Sevilla, Jordi Garcia, Marta Amador, Xavier Ariza
المصدر: Organic Letters. 4:4511-4514
مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Organic Chemistry, Molecular Conformation, Diastereomer, Alpha (ethology), Alkyne, Biochemistry, Catalysis, Molecular conformation, Amino acid, chemistry, Cyclization, Leucine, Serine, Stereoselectivity, Amino Acids, Physical and Theoretical Chemistry, Beta (finance)
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10
المؤلفون: Manel Ferrer, Sara Sevilla, Richard S. Roberts
المصدر: ChemInform. 45
مصطلحات موضوعية: Chemistry, fungi, Condensation, General Medicine, PDE4 Inhibitors, Combinatorial chemistry