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المؤلفون: Anthony R. Harris, Susan M. Lotarski, Michael Aaron Brodney, Michael Popiolek, Catherine A. Thorn, Stephen Jenkinson, Che Wah Lee, Jennifer E. Davoren, Stefanus J. Steyn, Lei Zhang, Terrence Peter Kenakin, Betty Pettersen, Sarah Grimwood, Damien Webb, Michelle R. Garnsey, Simeon Ramsey, John T. Lazzaro, Steven Victor O'neil, Lisa Nottebaum, Jean-Philippe Fortin, Jeremy R. Edgerton
المصدر: Journal of Medicinal Chemistry. 60:6649-6663
مصطلحات موضوعية: 0301 basic medicine, Agonist, Allosteric modulator, medicine.drug_class, Chemistry, Allosteric regulation, Muscarinic acetylcholine receptor M1, Pharmacology, 03 medical and health sciences, 030104 developmental biology, Drug Discovery, Convulsion, medicine, Molecular Medicine, Cholinergic, Structure–activity relationship, medicine.symptom, Receptor
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المؤلفون: Angela C. Doran, Cheng Chang, Shenping Liu, Butler Todd W, Travis T. Wager, Klaas Schildknegt, Lei Zhang, Michael Marconi, Jianke Li, Scot Richard Mente, Katherine Fisher, Ramalakshmi Yegna Chandrasekaran, Joseph R. Hedde, Sarah Grimwood, Chakrapani Subramanyam, Paul Galatsis
المصدر: ACS Chemical Neuroscience. 8:1995-2004
مصطلحات موضوعية: Male, 0301 basic medicine, Lactams, Physiology, Cognitive Neuroscience, Pharmacology, Biology, Biochemistry, Random Allocation, 03 medical and health sciences, 0302 clinical medicine, In vivo, Chlorocebus aethiops, medicine, Radioligand, Animals, Humans, Nonspecific binding, Molecular Structure, medicine.diagnostic_test, Casein Kinase I, Kinase, Brain, Cell Biology, General Medicine, Ligand (biochemistry), Circadian Rhythm, Mice, Inbred C57BL, 030104 developmental biology, Positron emission tomography, Drug Design, Positron-Emission Tomography, COS Cells, Pet ligand, Casein kinase 1, Radiopharmaceuticals, 030217 neurology & neurosurgery
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المؤلفون: Susan M. Lotarski, Sarah Grimwood, Michael Popiolek, Veronica Reinhart, Jeremy R. Edgerton, Jennifer E. Davoren, Stefanus J. Steyn, John F. Harms, David P. Nguyen
المصدر: Biochemistry. 55:7073-7085
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M1, Pharmacology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, Muscarinic acetylcholine receptor, Muscarinic acetylcholine receptor M5, Muscarinic acetylcholine receptor M4, Inositol, Inositol phosphate, 030217 neurology & neurosurgery
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المؤلفون: Christoffer Bundgaard, Vladimir Stepanov, Stefan Martinsson, Christer Halldin, Nahid Amini, Lars Farde, Sjoerd J. Finnema, Akihiro Takano, Benny Bang-Andersen, Sarah Grimwood, Kai-Chun Yang, Jacob Nielsen
المصدر: European Journal of Nuclear Medicine and Molecular Imaging. 44:308-320
مصطلحات موضوعية: 0301 basic medicine, medicine.diagnostic_test, business.industry, Chemistry, Putamen, Binding potential, Substantia nigra, General Medicine, Striatum, Logan plot, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Nuclear magnetic resonance, Radiology Nuclear Medicine and imaging, Positron emission tomography, Radioligand, medicine, Radiology, Nuclear Medicine and imaging, PDE10A, Nuclear medicine, business, 030217 neurology & neurosurgery
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المؤلفون: Christopher Ryan Butler, Qingyi Yang, Michael Popiolek, Natasha M. Kablaoui, Lei Zhang, Sarah Grimwood, John T. Lazzaro, Rouba Kozak, Damien Webb, Rebecca E. O’Connor, Erik Alphie Lachapelle
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Carbamate, 010405 organic chemistry, Chemistry, medicine.medical_treatment, Organic Chemistry, Key features, 01 natural sciences, Biochemistry, 0104 chemical sciences, Structural homology, 010404 medicinal & biomolecular chemistry, Drug Discovery, Muscarinic acetylcholine receptor, medicine, Cholinergic, Interaction mode, Binding site, Neuroscience
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المؤلفون: Deborah L. Smith, Sarah J. Neal, Lei Zhang, Jeremy R. Edgerton, Jennifer E. Davoren, Sarah Grimwood, John T. Lazzaro, Chewah Lee
المصدر: Molecular Pharmacology. 90:177-187
مصطلحات موضوعية: Male, 0301 basic medicine, Carbachol, Allosteric modulator, Pyridines, Stereochemistry, Allosteric regulation, CHO Cells, Isoindoles, Hippocampus, Rats, Sprague-Dawley, Radioligand Assay, 03 medical and health sciences, Cricetulus, 0302 clinical medicine, Allosteric Regulation, Cricetinae, Muscarinic acetylcholine receptor, medicine, Radioligand, Animals, Humans, Fluorometry, Pharmacology, Membranes, Chemistry, Ligand binding assay, Receptor, Muscarinic M1, N-Methylscopolamine, Acetylcholine, Electrophysiological Phenomena, Kinetics, HEK293 Cells, 030104 developmental biology, Positron-Emission Tomography, Autoradiography, Molecular Medicine, 030217 neurology & neurosurgery, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a4cbb153c3abcd01cb4427f9543370
https://doi.org/10.1124/mol.116.104737 -
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المؤلفون: Edilio Borroni, Christer Halldin, Mohammed Shahid, Jussi Lehto, Mika Scheinin, Lars Farde, Sarah Grimwood, Sjoerd J. Finnema, Jukka Sallinen, Benny Bang-Andersen, Erik H. F. Wong
المصدر: Psychopharmacology
مصطلحات موضوعية: Serotonin, Dopamine, PET imaging, Review, Neurotransmission, Synaptic Transmission, GABA, chemistry.chemical_compound, medicine, Animals, Humans, Neurotransmitter, Pharmacological challenge, Pharmacology, Neurotransmitter Agents, medicine.diagnostic_test, business.industry, Glutamate receptor, Brain, Pet imaging, Non-human primate, Acetylcholine, chemistry, Positron emission tomography, Positron-Emission Tomography, Noradrenaline, Glutamate, business, Neuroscience, medicine.drug
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8
المؤلفون: Jennifer E, Davoren, Michelle, Garnsey, Betty, Pettersen, Michael A, Brodney, Jeremy R, Edgerton, Jean-Philippe, Fortin, Sarah, Grimwood, Anthony R, Harris, Stephen, Jenkinson, Terry, Kenakin, John T, Lazzaro, Che-Wah, Lee, Susan M, Lotarski, Lisa, Nottebaum, Steven V, O'Neil, Michael, Popiolek, Simeon, Ramsey, Stefanus J, Steyn, Catherine A, Thorn, Lei, Zhang, Damien, Webb
المصدر: Journal of medicinal chemistry. 60(15)
مصطلحات موضوعية: Diarrhea, Male, Lactams, Vomiting, Scopolamine, Isoindoles, Structure-Activity Relationship, Dogs, Allosteric Regulation, Piperidines, Seizures, Thiadiazoles, Animals, Humans, Donepezil, Rats, Wistar, Oxazoles, Sulfonamides, Receptor, Muscarinic M1, Mice, Inbred C57BL, Amphetamine, Drug Design, Indans, Microsomes, Liver, Ataxia, Female
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9
المؤلفون: Patrick Robert Verhoest, Susan E. Drozda, Kenneth R. Zasadny, Emily Miller, Lei Zhang, Kari R. Fonseca, Gabriela Barreiro, Patrick Trapa, Michelle Marie Claffey, Julie Cianfrogna, Marc B. Skaddan, Deborah L. Smith, Margaret M. Zaleska, Joshua R. Dunetz, Christopher L. Shaffer, Jessica Mancuso, Isao Sakurada, Gayatri Balan, Jamison B. Tuttle, Lois K. Chenard, Bruce N. Rogers, Matthew R. Reese, Antonia F. Stepan, Paul Galatsis, Brian P. Boscoe, Daniel P. Walker, Sarah Grimwood, Ann S. Wright, John T. Lazzaro, Karen J. Coffman, Laigao Chen
المصدر: Journal of Medicinal Chemistry. 57:861-877
مصطلحات موضوعية: Male, Models, Molecular, Dyskinesia, Drug-Induced, Cell Membrane Permeability, Allosteric modulator, Pyrazine, Stereochemistry, Receptor, Metabotropic Glutamate 5, Allosteric regulation, Administration, Oral, Biological Availability, Pharmacology, Madin Darby Canine Kidney Cells, Antiparkinson Agents, Levodopa, Rats, Sprague-Dawley, Radioligand Assay, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Allosteric Regulation, Pharmacokinetics, Drug Discovery, Animals, Humans, Potency, Hypersensitivity, Delayed, Metabotropic glutamate receptor 5, MPTP, Parkinson Disease, Rats, Macaca fascicularis, HEK293 Cells, chemistry, Regulatory toxicology, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Pyrazines, Microsomes, Liver, Pyrazoles, Molecular Medicine
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المؤلفون: Michael, Popiolek, David P, Nguyen, Veronica, Reinhart, Jeremy R, Edgerton, John, Harms, Susan M, Lotarski, Stefanus J, Steyn, Jennifer E, Davoren, Sarah, Grimwood
المصدر: Biochemistry. 55(51)
مصطلحات موضوعية: Male, Dose-Response Relationship, Drug, Inositol Phosphates, Dopamine Agents, Receptor, Muscarinic M1, Brain, CHO Cells, Motor Activity, Muscarinic Agonists, Hippocampus, Corpus Striatum, Electrophysiological Phenomena, Rats, Sprague-Dawley, Amphetamine, Mice, Cricetulus, Cricetinae, Animals, Humans, Calcium