المؤلفون: Dirk Roymans, Sarhad S Alnajjar, Michael B Battles, Panchan Sitthicharoenchai, Polina Furmanova-Hollenstein, Peter Rigaux, Joke Van den Berg, Leen Kwanten, Marcia Van Ginderen, Nick Verheyen, Luc Vranckx, Steffen Jaensch, Eric Arnoult, Richard Voorzaat, Jack M. Gallup, Alejandro Larios-Mora, Marjolein Crabbe, Dymphy Huntjens, Pierre Raboisson, Johannes P. Langedijk, Mark R. Ackermann, Jason S McLellan, Sandrine Vendeville, Anil Koul

المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/a53af0caadf64c108081ce0c70f541ee

المؤلفون: Grosse S; Janssen Research & Development, Janssen Pharmaceutica NV, 2340 Beerse, Belgium., Cooymans L; Janssen Research & Development, Janssen Pharmaceutica NV, 2340 Beerse, Belgium., Embrechts W; Janssen Research & Development, Janssen Pharmaceutica NV, 2340 Beerse, Belgium., McGowan D; Aligos, Gaston Geenslaan 1, 3001 Leuven, Belgium., Jacoby E; Janssen Research & Development, Janssen Pharmaceutica NV, 2340 Beerse, Belgium., Stoops B; Janssen Research & Development, Janssen Pharmaceutica NV, 2340 Beerse, Belgium., Gupta K; Neuron23 Inc. 343 Oyster Point Blvd, South San Francisco, California 94080, United States., Ackermann M; LambCure LLC, Corvallis, Oregon 97232, United States., Alnajjar S; Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7AL, U.K., Guillemont J; NovAlix, 27106 Val-de-Reuil, France., Jin Z; Janssen Pharmaceutica NV, Brisbane, California 94005, United States., Kesteleyn B; Janssen Research & Development, Janssen Pharmaceutica NV, 2340 Beerse, Belgium., Matcha K; Janssen Research & Development, Janssen Pharmaceutica NV, 2340 Beerse, Belgium., Sriboonyapirat P; LambCure LLC, Corvallis, Oregon 97232, United States., Truong A; Neuron23 Inc. 343 Oyster Point Blvd, South San Francisco, California 94080, United States., Van Den Berg J; Janssen Research & Development, Janssen Pharmaceutica NV, 2340 Beerse, Belgium., Yu X; Janssen Pharmaceutica NV, Spring House, Pennsylvania 19477 United States., Herschke F; Janssen Research & Development, Janssen Pharmaceutica NV, 2340 Beerse, Belgium., Roymans D; DNS Life Sciences Consulting, Brandhoefstraat 63, 2300 Turnhout, Belgium., Raboisson P; Galapagos, General De Wittelaan L112, A3, 2800 Mechelen, Belgium., Rigaux P; Janssen Research & Development, Janssen Pharmaceutica NV, 2340 Beerse, Belgium., Jonckers THM; Janssen Research & Development, Janssen Pharmaceutica NV, 2340 Beerse, Belgium.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Aug 22; Vol. 67 (16), pp. 13723-13736. Date of Electronic Publication: 2024 Aug 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry , Antiviral Agents*/chemical synthesis , Pyridines*/pharmacology , Pyridines*/chemistry , Pyridines*/chemical synthesis, Animals ; Humans ; Mice ; Respiratory Syncytial Virus Infections/drug therapy ; Respiratory Syncytial Virus Infections/virology ; Structure-Activity Relationship ; Sheep ; Drug Discovery ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/chemical synthesis ; Respiratory Syncytial Virus, Human/drug effects ; Respiratory Syncytial Viruses/drug effects

المؤلفون: Bonneux B; Laboratory for Microbiology, Parasitology and Hygiene, University of Antwerp, Universiteitsbaan 1, 2610 Wilrijk, Belgium; Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium., Shareef A; Department of Virology, Immunology & Microbiology, National Emerging Infectious Diseases Laboratories, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA., Tcherniuk S; Unité de Virologie et Immunologie Moléculaires (VIM, UMR892), INRAE, Université Paris-Saclay, 78352 Jouy-en-Josas, France., Anson B; Janssen Research & Development LLC, Spring House (PA 19477) And Brisbane (CA 94005), USA., de Bruyn S; Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium., Verheyen N; Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium., Thys K; Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium., Conceição-Neto N; Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium., Van Ginderen M; Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium., Kwanten L; Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium., Ysebaert N; Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium., Vranckx L; Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium., Peeters E; Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium., Lanckacker E; Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium., Gallup JM; Iowa State University, Ames, IA 50011, USA., Sitthicharoenchai P; Iowa State University, Ames, IA 50011, USA., Alnajjar S; Iowa State University, Ames, IA 50011, USA., Ackermann MR; Iowa State University, Ames, IA 50011, USA., Adhikary S; Janssen Research & Development LLC, Spring House (PA 19477) And Brisbane (CA 94005), USA., Bhaumik A; Janssen Research & Development LLC, Spring House (PA 19477) And Brisbane (CA 94005), USA., Patrick A; Janssen Research & Development LLC, Spring House (PA 19477) And Brisbane (CA 94005), USA., Fung A; Janssen Research & Development LLC, Spring House (PA 19477) And Brisbane (CA 94005), USA., Sutto-Ortiz P; AFMB, Aix-Marseille University, CNRS UMR 7257, 163 Avenue de Luminy, Marseille, France., Decroly E; AFMB, Aix-Marseille University, CNRS UMR 7257, 163 Avenue de Luminy, Marseille, France., Mason SW; Janssen Research & Development LLC, Spring House (PA 19477) And Brisbane (CA 94005), USA., Lançois D; Janssen France, 27106 Val de Reuil, France., Deval J; Janssen Research & Development LLC, Spring House (PA 19477) And Brisbane (CA 94005), USA., Jin Z; Janssen Research & Development LLC, Spring House (PA 19477) And Brisbane (CA 94005), USA., Eléouët JF; Unité de Virologie et Immunologie Moléculaires (VIM, UMR892), INRAE, Université Paris-Saclay, 78352 Jouy-en-Josas, France., Fearns R; Department of Virology, Immunology & Microbiology, National Emerging Infectious Diseases Laboratories, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA., Koul A; Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium. Electronic address: akoul@its.jnj.com., Roymans D; Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium., Rigaux P; Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium., Herschke F; Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium. Electronic address: fherschk@its.jnj.com.

المصدر: Antiviral research [Antiviral Res] 2024 Jul; Vol. 227, pp. 105907. Date of Electronic Publication: 2024 May 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8109699 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9096 (Electronic) Linking ISSN: 01663542 NLM ISO Abbreviation: Antiviral Res Subsets: MEDLINE

مواضيع طبية MeSH: Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry , Respiratory Syncytial Virus Infections*/drug therapy , Respiratory Syncytial Virus Infections*/virology , Virus Replication*/drug effects , Respiratory Syncytial Virus, Human*/drug effects, Animals ; Humans ; Sheep ; Drug Resistance, Viral ; Viral Proteins/antagonists & inhibitors ; Viral Proteins/metabolism ; Viral Proteins/genetics ; Lung/virology

المؤلفون: McSweeney MD; Inhalon Biopharma, Research Triangle Park, NC, 27707, USA., Alnajjar S; Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7AL, UK., Schaefer AM; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina-Chapel Hill, Chapel Hill, NC, 27599, USA., Richardson Z; Inhalon Biopharma, Research Triangle Park, NC, 27707, USA., Wolf W; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina-Chapel Hill, Chapel Hill, NC, 27599, USA., Stewart I; RTI International, Research Triangle Park, NC, 27709, USA., Sriboonyapirat P; Oregon State University, Corvallis, Oregon, 97331, USA., McCallen J; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina-Chapel Hill, Chapel Hill, NC, 27599, USA., Farmer E; Inhalon Biopharma, Research Triangle Park, NC, 27707, USA., Nzati B; Inhalon Biopharma, Research Triangle Park, NC, 27707, USA., Lord S; Inhalon Biopharma, Research Triangle Park, NC, 27707, USA., Farrer B; Inhalon Biopharma, Research Triangle Park, NC, 27707, USA., Moench TR; Inhalon Biopharma, Research Triangle Park, NC, 27707, USA., Kumar PA; Department of Anesthesiology, School of Medicine, University of North Carolina, Chapel Hill, NC, 27599, USA.; Outcomes Research Consortium, Cleveland, OH, 44195, USA., Arora H; Department of Anesthesiology, University of Mississippi Medical Center, Jackson, MS, 39216, USA., Pickles RJ; Department of Microbiology & Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Hickey AJ; RTI International, Research Triangle Park, NC, 27709, USA., Ackermann M; USDA/ARS-National Animal Disease Center, Ames, IA, 50010, USA., Lai SK; Inhalon Biopharma, Research Triangle Park, NC, 27707, USA.; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina-Chapel Hill, Chapel Hill, NC, 27599, USA.; Department of Microbiology & Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

المصدر: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Mar; Vol. 11 (12), pp. e2306729. Date of Electronic Publication: 2024 Jan 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal*/therapeutic use , Respiratory Syncytial Virus Infections*/drug therapy, Humans ; Infant ; Child ; Animals ; Sheep ; Mice ; Aged ; Palivizumab/therapeutic use ; Respiratory Syncytial Viruses ; Lung

المؤلفون: Alnajjar S; Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, Iowa, United States of America.; Department of Veterinary Pathology, College of Veterinary Medicine, Baghdad University, Baghdad, Iraq.; Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, United States of America., Sitthicharoenchai P; Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, Iowa, United States of America., Gallup J; Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, Iowa, United States of America., Ackermann M; Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, United States of America., Verhoeven D; Department of Veterinary Microbiology and Preventative Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa, United States of America.

المصدر: PloS one [PLoS One] 2021 Mar 11; Vol. 16 (3), pp. e0235026. Date of Electronic Publication: 2021 Mar 11 (Print Publication: 2021).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Pneumococcal Infections/*pathology , Respiratory Syncytial Virus Infections/*pathology , Streptococcus pneumoniae/*isolation & purification, Animals ; Animals, Newborn ; Bronchoalveolar Lavage Fluid/microbiology ; Bronchoalveolar Lavage Fluid/virology ; Cytokines/metabolism ; Disease Models, Animal ; Lung/microbiology ; Lung/pathology ; Lung/virology ; Lymphocytes/cytology ; Lymphocytes/immunology ; Neutrophils/cytology ; Neutrophils/immunology ; Peroxidase/metabolism ; Pneumococcal Infections/complications ; Pneumococcal Infections/epidemiology ; Pneumococcal Infections/microbiology ; RNA, Viral/metabolism ; Respiratory Syncytial Virus Infections/complications ; Respiratory Syncytial Virus Infections/epidemiology ; Respiratory Syncytial Viruses/genetics ; Respiratory Syncytial Viruses/isolation & purification ; Serogroup ; Sheep ; Streptococcus pneumoniae/genetics

المؤلفون: Sitthicharoenchai P; Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA., Alnajjar S; Department of Veterinary Pathology, College of Veterinary Medicine, University of Baghdad, Baghdad, Iraq.; LambCure LLC, Corvallis, OR, USA., Ackermann MR; LambCure LLC, Corvallis, OR, USA. sarhad@lambcure.com.; Department of Biomedical Sciences and Oregon Veterinary Diagnostic Laboratory, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA. sarhad@lambcure.com.

المصدر: Cell and tissue research [Cell Tissue Res] 2020 May; Vol. 380 (2), pp. 313-324. Date of Electronic Publication: 2020 Apr 29.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417625 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0878 (Electronic) Linking ISSN: 0302766X NLM ISO Abbreviation: Cell Tissue Res Subsets: MEDLINE

مواضيع طبية MeSH: Respiratory Syncytial Virus Infections/*diagnosis, Animals ; Animals, Newborn ; Disease Models, Animal ; Humans