يعرض 1 - 5 نتائج من 5 نتيجة بحث عن '"Sayeh Erfan"', وقت الاستعلام: 1.02s تنقيح النتائج
  1. 1
    SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington's Disease

    المؤلفون: Sabine Schaertl, Celia Dominguez, Douglas Macdonald, Maria Beconi, Marie Li, Stephen Martin Courtney, Ignacio Munoz-Sanjuan, Sayeh Erfan, Richard W Marston, Frederick Arthur Brookfield, Darshan Gunvant Vaidya, Anna Pedret-Dunn, Michael Prime, Laura Reed, Peter Johnson, John Wityak, Siw F. Johnsen

    المصدر: ACS Medicinal Chemistry Letters. 3:1024-1028

    مصطلحات موضوعية: Dipeptide, biology, Tissue transglutaminase, business.industry, Organic Chemistry, Lysine, Pharmacology, medicine.disease, Biochemistry, In vitro, Polar surface area, chemistry.chemical_compound, chemistry, Huntington's disease, Acrylamide, Drug Discovery, biology.protein, medicine, business, ADME

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876741143e5614a16215dc697c0077d5
    https://doi.org/10.1021/ml300241m

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  2. 2
    Discovery and Structure–Activity Relationship of Potent and Selective Covalent Inhibitors of Transglutaminase 2 for Huntington’s Disease

    المؤلفون: Robert K. Y. Cheng, Celia Dominguez, Osamu Ichihara, Douglas Macdonald, Ignacio Munoz-Sanjuan, Mark A. Brooks, Andreas Ebneth, Leticia Toledo-Sherman, Michael Prime, Ian Toogood-Johnson, Sayeh Erfan, John Wityak, Richard W Marston, Frederick Arthur Brookfield, Darshan Gunvant Vaidya, Stephen Martin Courtney, Peter Johnson, Anna Pedret-Dunn, Andreas Scheel, Dirk Winkler, Christopher John Yarnold, Sabine Schaertl, Ole A. Andersen, Shilpa Palan, Maria Beconi, Brunella Felicetti, Siw F. Johnsen, John J. Barker, Jordan J. Palfrey, Ina Sternberger

    المصدر: Journal of Medicinal Chemistry. 55:1021-1046

    مصطلحات موضوعية: Male, Models, Molecular, Cell Membrane Permeability, Pyridines, Tissue transglutaminase, Lysine, In Vitro Techniques, Piperazines, Mice, Structure-Activity Relationship, Huntington's disease, GTP-Binding Proteins, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Protein Glutamine gamma Glutamyltransferase 2, chemistry.chemical_classification, Acrylamides, Sulfonamides, Isopeptide bond, Transglutaminases, biology, medicine.disease, Molecular biology, In vitro, Rats, Glutamine, HEK293 Cells, Huntington Disease, Pyrimidines, Enzyme, Biochemistry, chemistry, Microsomes, Liver, biology.protein, Molecular Medicine, Caco-2 Cells

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58fc19f1a7931a01abe7cc99692b57ab
    https://doi.org/10.1021/jm201310y

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  3. 3
    Distal two-bond versus three-bond electronegative oxo-substituent effect controls the kinetics and thermodynamics of the conversion of a C-nitroso function to the corresponding oxime in the conformationally locked pentofuranose (bicyclo[2.2.1]heptane) system

    المؤلفون: Mansoureh Karimiahmadabadi, Jyoti Chattopadhyaya, Sayeh Erfan, András Földesi

    المصدر: The Journal of organic chemistry. 79(16)

    مصطلحات موضوعية: Bicyclic molecule, Nitroso Compounds, Stereochemistry, Organic Chemistry, Kinetics, Substituent, Molecular Conformation, Oxides, Nitroso, Oxime, Bridged Bicyclo Compounds, Heterocyclic, Chemical kinetics, chemistry.chemical_compound, chemistry, Oximes, Thermodynamics, Isomerization

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0daf13f4c816308b8804d31cf4a7716
    https://pubmed.ncbi.nlm.nih.gov/25051020

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  4. 4
    Steric effects in the tuning of the diastereoselectivity of the intramolecular free-radical cyclization to an olefin as exemplified through the synthesis of a carba-pentofuranose scaffold

    المؤلفون: Jyoti Chattopadhyaya, András Földesi, Sayeh Erfan, Mansoureh Karimiahmadabadi

    المصدر: The Journal of organic chemistry. 77(16)

    مصطلحات موضوعية: Steric effects, Heptane, Olefin fiber, Magnetic Resonance Spectroscopy, Free Radicals, Chemistry, Stereochemistry, Organic Chemistry, Pentoses, Grignard reaction, Diastereomer, Stereoisomerism, Alkenes, Radical cyclization, Heptanes, chemistry.chemical_compound, Cyclization, Intramolecular force, Carbohydrate Conformation, Chirality (chemistry)

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c991d55447cf7bfa396cd70e3f675e
    https://pubmed.ncbi.nlm.nih.gov/22857001

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  5. 5
    Studies on the synthesis of valienamine and 1-epi-valienamine starting from D-glucose or L-sorbose

    المؤلفون: Ian Cumpstey, Riccardo Cribiu, Sayeh Erfan, Sebastian Gehrke

    المصدر: Carbohydrate research. 343(10-11)

    مصطلحات موضوعية: Early introduction, Chemistry, Valienamine, Organic Chemistry, Stereoisomerism, Hexosamines, General Medicine, Metathesis, Sorbose, Biochemistry, Analytical Chemistry, chemistry.chemical_compound, Ring-closing metathesis, Glucose, D-Glucose, Cyclohexenes, Organic chemistry

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1db24f1afba0d5483623664d232c6dc
    https://pubmed.ncbi.nlm.nih.gov/18468588

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