المؤلفون: Wang, XD, Rammes, G, Wolf, M, Scharf, SH, Liebl, C, Baram, TZ, Deussing, JM, Mueller, MB, Schmidt, MV

مصطلحات موضوعية: Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/5jm1q06v

المؤلفون: Wang, XD, Rammes, G, Wolf, M, Scharf, SH, Liebl, C, Baram, TZ, Deussing, JM, Mueller, MB, Schmidt, MV

المصدر: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 20

مصطلحات موضوعية: Psychiatry, Medical and Health Sciences, Psychology and Cognitive Sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/5jm1q06v

المؤلفون: Goto A; Oxford Protein Informatics Group, Department of Statistics, University of Oxford, 24-29 St Giles', Oxford, OX1 3LB, UK., Rodriguez-Esteban R; Roche Innovation Center Basel, Basel, Switzerland., Scharf SH; Roche Innovation Center Basel, Basel, Switzerland., Morris GM; Oxford Protein Informatics Group, Department of Statistics, University of Oxford, 24-29 St Giles', Oxford, OX1 3LB, UK. garrett.morris@stats.ox.ac.uk.

المصدر: Scientific reports [Sci Rep] 2022 Aug 25; Vol. 12 (1), pp. 14476. Date of Electronic Publication: 2022 Aug 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Hepatitis B, Chronic* , COVID-19 Drug Treatment*, Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; DNA, Viral/genetics ; Drug Resistance, Viral/genetics ; Genotype ; Hepatitis B virus/genetics ; Humans ; Mutation ; SARS-CoV-2/genetics

المؤلفون: Berry-Kravis EM; Departments of Pediatrics, Neurological Sciences and Biochemistry, Rush University Medical Center, 1725 West Harrison Street, Suite 718, Chicago, Illinois 60612, USA., Lindemann L; Roche Pharmaceuticals Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland., Jønch AE; Department of Clinical Genetics, Odense University Hospital, Sdr. Boulevard 29, Odense C, Denmark.; Human Genetics, Department of Clinical Research, University of Southern Denmark, J.B. Winsløws Vej 19, 5000 Odense C, Denmark., Apostol G; Formerly at Neuroscience Development, Novartis Pharma AG, Fabrikstrasse 2, 4056 Basel, Switzerland., Bear MF; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, 43 Vassar St, Cambridge, Massachusetts 02139, USA., Carpenter RL; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, 43 Vassar St, Cambridge, Massachusetts 02139, USA., Crawley JN; MIND Institute, University of California Davis School of Medicine, 2825 50th Street, Sacramento, California 95817, USA.; Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, 4625 2nd Avenue, Sacramento, California 95817, USA., Curie A; National Reference Center for Rare Diseases with Intellectual Disability, Hôpital Femme-Mère-Enfant, Hospices Civils de Lyon, Université de Lyon, Institut des Sciences Cognitives, CNRS UMR 5304, Boulevard Pinel 67, 69675 Bron Cedex, France., Des Portes V; National Reference Center for Rare Diseases with Intellectual Disability, Hôpital Femme-Mère-Enfant, Hospices Civils de Lyon, Université de Lyon, Institut des Sciences Cognitives, CNRS UMR 5304, Boulevard Pinel 67, 69675 Bron Cedex, France., Hossain F; Neuroscience Development, Novartis Pharmaceutical Corporation, 1 Health Plaza, East Hanover, New Jersey 07936, USA., Gasparini F; Novartis Institutes for Biomedical Research, Neuroscience Research, Postfach, 4002 Basel, Switzerland., Gomez-Mancilla B; Novartis Institutes for Biomedical Research, Neuroscience Research, Postfach, 4002 Basel, Switzerland.; Department of Neurology & Neurosurgery, McGill University, 845 Sherbrook Street West, Montreal, Quebec H3A 0G4, Canada., Hessl D; MIND Institute, University of California Davis School of Medicine, 2825 50th Street, Sacramento, California 95817, USA.; Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, 4625 2nd Avenue, Sacramento, California 95817, USA., Loth E; Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK., Scharf SH; Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland., Wang PP; Simons Foundation, 160 Fifth Avenue, 7th Floor, New York, New York 10010, USA., Von Raison F; Neuroscience Development, Novartis Pharma AG, Fabrikstrasse 2, 4056 Basel, Switzerland., Hagerman R; MIND Institute, University of California Davis School of Medicine, 2825 50th Street, Sacramento, California 95817, USA.; Department of Pediatrics, University of California Davis Medical Center, 2516 Stockton Boulevard, Sacramento, California 95817, USA., Spooren W; Roche Pharmaceuticals Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland., Jacquemont S; Service de Génétique Médicale, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 46, 1011 Lausanne and University of Lausanne, Switzerland.; CHU Sainte-Justine Research Centre, University of Montreal, 3175 Chemin de la Côte-Sainte-Catherine, Montreal, Quebec H3T 1C5, Canada.

المصدر: Nature reviews. Drug discovery [Nat Rev Drug Discov] 2018 Apr; Vol. 17 (4), pp. 280-299. Date of Electronic Publication: 2017 Dec 08.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124171 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-1784 (Electronic) Linking ISSN: 14741776 NLM ISO Abbreviation: Nat Rev Drug Discov Subsets: MEDLINE

مواضيع طبية MeSH: Fragile X Syndrome/*drug therapy , Neurodevelopmental Disorders/*drug therapy , Neurotransmitter Agents/*pharmacology , Neurotransmitter Agents/*therapeutic use, Animals ; Clinical Trials as Topic ; Drug Development/methods ; Drug Evaluation, Preclinical ; Humans ; Randomized Controlled Trials as Topic

المؤلفون: Pao W; Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland. william.pao@roche.com., Ooi CH; Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland., Birzele F; Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland., Ruefli-Brasse A; Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland., Cannarile MA; Roche Innovation Center Munich, F. Hoffmann-La Roche AG, Munich, Germany., Reis B; Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland., Scharf SH; Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland., Schubert DA; Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland., Hatje K; Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland., Pelletier N; Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland., Spleiss O; Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland., Reed JC; Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland.

المصدر: Cancer discovery [Cancer Discov] 2018 Apr; Vol. 8 (4), pp. 395-402. Date of Electronic Publication: 2018 Mar 15.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Immune System*, Neoplasms/*immunology , Neoplasms/*therapy, Animals ; Humans ; Immunotherapy ; Mice ; Organ Specificity ; Precision Medicine

المؤلفون: Carrillo-Roa T; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany., Labermaier C; Max Planck Institute of Psychiatry, Munich, Germany., Weber P; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany., Herzog DP; Department of Psychiatry and Psychotherapy & German Resilience Center (DRZ), Johannes Gutenberg University Medical Center, Mainz, Germany., Lareau C; Department of Biostatistics, Harvard University, Boston, Massachusetts, United States of America., Santarelli S; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany., Wagner KV; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany., Rex-Haffner M; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany., Harbich D; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany., Scharf SH; Max Planck Institute of Psychiatry, Munich, Germany., Nemeroff CB; Department of Psychiatry and Behavioral Sciences, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, United States of America., Dunlop BW; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, United States of America., Craighead WE; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, United States of America.; Department of Psychology, Emory University, Atlanta, Georgia, United States of America., Mayberg HS; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, United States of America.; Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, United States of America., Schmidt MV; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany., Uhr M; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany., Holsboer F; Max Planck Institute of Psychiatry, Munich, Germany., Sillaber I; Phenoquest AG, Martinsried/Munich, Germany., Binder EB; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, United States of America., Müller MB; Max Planck Institute of Psychiatry, Munich, Germany.; Department of Psychiatry and Psychotherapy & German Resilience Center (DRZ), Johannes Gutenberg University Medical Center, Mainz, Germany.

المصدر: PLoS biology [PLoS Biol] 2017 Dec 28; Vol. 15 (12), pp. e2002690. Date of Electronic Publication: 2017 Dec 28 (Print Publication: 2017).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE

مواضيع طبية MeSH: Antidepressive Agents/*pharmacology , Depressive Disorder, Major/*drug therapy , Paroxetine/*pharmacology , Receptors, Glucocorticoid/*physiology, Animals ; Antidepressive Agents/therapeutic use ; Biomarkers, Pharmacological ; Brain/metabolism ; Corticosterone/blood ; Gene Expression Profiling ; Gene Expression Regulation ; Humans ; Mice ; Mice, Inbred DBA ; Multigene Family ; Paroxetine/metabolism ; Paroxetine/therapeutic use ; Receptors, Glucocorticoid/genetics ; Receptors, Glucocorticoid/metabolism

المؤلفون: Lindemann L; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.) lothar.lindemann@roche.com., Porter RH; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., Scharf SH; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., Kuennecke B; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., Bruns A; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., von Kienlin M; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., Harrison AC; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., Paehler A; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., Funk C; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., Gloge A; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., Schneider M; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., Parrott NJ; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., Polonchuk L; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., Niederhauser U; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., Morairty SR; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., Kilduff TS; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., Vieira E; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., Kolczewski S; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., Wichmann J; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., Hartung T; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., Honer M; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., Borroni E; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., Moreau JL; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., Prinssen E; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., Spooren W; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., Wettstein JG; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.)., Jaeschke G; Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.).

المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2015 Apr; Vol. 353 (1), pp. 213-33. Date of Electronic Publication: 2015 Feb 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Anxiety Agents/*pharmacology , Antidepressive Agents/*pharmacology , Depression/*drug therapy , Imidazoles/*pharmacology , Pyridines/*pharmacology , Receptor, Metabotropic Glutamate 5/*antagonists & inhibitors, Allosteric Regulation ; Animals ; Anti-Anxiety Agents/pharmacokinetics ; Anti-Anxiety Agents/therapeutic use ; Antidepressive Agents/pharmacokinetics ; Antidepressive Agents/therapeutic use ; Biogenic Monoamines/metabolism ; Brain/metabolism ; Cells, Cultured ; Cricetulus ; Depression/metabolism ; Depression/psychology ; Drug Inverse Agonism ; Electroencephalography ; Female ; Imidazoles/pharmacokinetics ; Imidazoles/therapeutic use ; Macaca fascicularis ; Male ; Mice ; Pain/drug therapy ; Pain/physiopathology ; Pyridines/pharmacokinetics ; Pyridines/therapeutic use ; Radioligand Assay ; Rats, Sprague-Dawley ; Rats, Wistar ; Receptor, Metabotropic Glutamate 5/metabolism ; Urinary Bladder, Overactive/drug therapy ; Urinary Bladder, Overactive/physiopathology

المؤلفون: Scharf SH; Roche Pharmaceutical Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Jaeschke G; Roche Pharmaceutical Research and Early Development, Small Molecules Research, Discovery Chemistry, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Wettstein JG; Roche Pharmaceutical Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland., Lindemann L; Roche Pharmaceutical Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland. Electronic address: lothar.lindemann@roche.com.

المصدر: Current opinion in pharmacology [Curr Opin Pharmacol] 2015 Feb; Vol. 20, pp. 124-34. Date of Electronic Publication: 2014 Dec 02.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 100966133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-4973 (Electronic) Linking ISSN: 14714892 NLM ISO Abbreviation: Curr Opin Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Excitatory Amino Acid Antagonists/*pharmacology , Fragile X Syndrome/*drug therapy , Receptor, Metabotropic Glutamate 5/*antagonists & inhibitors, Animals ; Disease Models, Animal ; Excitatory Amino Acid Antagonists/therapeutic use ; Fragile X Syndrome/physiopathology ; Humans ; Imidazoles/pharmacology ; Imidazoles/therapeutic use ; Indoles/pharmacology ; Indoles/therapeutic use ; Mice ; Mice, Knockout ; Molecular Targeted Therapy ; Phenotype ; Pyridines/pharmacology ; Pyridines/therapeutic use

المؤلفون: Masana M; Max Planck Institute of Psychiatry, 80804 Munich, Germany. Electronic address: Merce.Masana@unimedizin-mainz.de., Su YA; Max Planck Institute of Psychiatry, 80804 Munich, Germany; Institute of Mental Health, Peking University, China; Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China., Liebl C; Max Planck Institute of Psychiatry, 80804 Munich, Germany., Wang XD; Max Planck Institute of Psychiatry, 80804 Munich, Germany., Jansen L; Max Planck Institute of Psychiatry, 80804 Munich, Germany., Westerholz S; Max Planck Institute of Psychiatry, 80804 Munich, Germany., Wagner KV; Max Planck Institute of Psychiatry, 80804 Munich, Germany., Labermaier C; Max Planck Institute of Psychiatry, 80804 Munich, Germany., Scharf SH; Max Planck Institute of Psychiatry, 80804 Munich, Germany., Santarelli S; Max Planck Institute of Psychiatry, 80804 Munich, Germany., Hartmann J; Max Planck Institute of Psychiatry, 80804 Munich, Germany., Schmidt MV; Max Planck Institute of Psychiatry, 80804 Munich, Germany., Rein T; Max Planck Institute of Psychiatry, 80804 Munich, Germany., Müller MB; Max Planck Institute of Psychiatry, 80804 Munich, Germany.

المصدر: Psychoneuroendocrinology [Psychoneuroendocrinology] 2014 Oct; Vol. 48, pp. 98-110. Date of Electronic Publication: 2014 Jun 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 7612148 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3360 (Electronic) Linking ISSN: 03064530 NLM ISO Abbreviation: Psychoneuroendocrinology Subsets: MEDLINE

مواضيع طبية MeSH: Behavior, Animal* , Social Behavior*, Mental Disorders/*genetics , Tumor Suppressor Proteins/*physiology, Actins/metabolism ; Animals ; Astrocytes/drug effects ; Astrocytes/metabolism ; Dexamethasone/pharmacology ; Gene Expression Regulation/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Neurons/drug effects ; Neurons/metabolism ; Protein Binding ; Stress, Psychological/genetics ; Stress, Psychological/physiopathology

المؤلفون: Labermaier C; Max Planck Institute of Psychiatry (C.L., C.K., J.H., C.D., A.A, P.W., J.A., C.Q., K.V.W., S.H.S., L.C., R.W-A., J.B., R.L., F.H., M.U., F.H., E.B.B., M.V.S.), 80804 Munich, Germany; Lundbeck Research USA (K.A.J.), Paramus, New Jersey 07652; and Johannes Gutenberg University Medical Center (M.B.M.), 55131 Mainz, Germany., Kohl C, Hartmann J, Devigny C, Altmann A, Weber P, Arloth J, Quast C, Wagner KV, Scharf SH, Czibere L, Widner-Andrä R, Brenndörfer J, Landgraf R, Hausch F, Jones KA, Müller MB, Uhr M, Holsboer F, Binder EB, Schmidt MV

المصدر: Endocrinology [Endocrinology] 2014 Jul; Vol. 155 (7), pp. 2500-10. Date of Electronic Publication: 2014 Apr 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-7170 (Electronic) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: MEDLINE

مواضيع طبية MeSH: Polymorphism, Single Nucleotide*, Genetic Predisposition to Disease/*genetics , Receptors, Corticotropin-Releasing Hormone/*genetics , Stress, Psychological/*genetics, Animals ; Behavior, Animal/drug effects ; Binding, Competitive ; Corticosterone/blood ; Female ; Gene Expression ; Gene Frequency ; Gene-Environment Interaction ; Genotype ; Haplotypes ; Humans ; Hypothalamo-Hypophyseal System/metabolism ; In Situ Hybridization ; Male ; Mice ; Pituitary Gland/metabolism ; Pituitary-Adrenal System/metabolism ; Pyrazoles/pharmacology ; Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors ; Receptors, Corticotropin-Releasing Hormone/metabolism ; Regulatory Sequences, Nucleic Acid/genetics ; Signal Transduction/genetics ; Triazines/pharmacology