المؤلفون: Karlberg, T, Collins, R, van den Berg, S, Flores, A, Hammarstrom, M, Hogbom, M, Schiavone, LH, Uppenberg, J

المصدر: Acta crystallographica. Section D, Biological crystallography. 64(Pt 3):279-286

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:116621334

المؤلفون: Hogbom, M, Collins, R, van den Berg, S, Jenvert, RM, Karlberg, T, Kotenyova, T, Flores, A, Hedestam, GBK, Schiavone, LH

المصدر: Journal of molecular biology. 372(1):150-159

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:115889040

المؤلفون: Collins, R, Johansson, AL, Karlberg, T, Markova, N, van den Berg, S, Olesen, K, Hammarstrom, M, Flores, A, Schuler, H, Schiavone, LH, Brzezinski, P, Arner, ESJ, Hogbom, M

المصدر: PloS one. 7(1):e30581

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:124315299

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المؤلفون: Edfeldt K; Structural Genomics Consortium, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden., Edwards AM; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Engkvist O; Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden & Department of Computer Science and Engineering, Chalmers University of Technology, Gothenburg, Sweden., Günther J; Bayer AG Research and Development, Computational Molecular Design, Berlin, Germany., Hartley M; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK., Hulcoop DG; Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.; European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK., Leach AR; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK., Marsden BD; Centre for Medicines Discovery, NDM, University of Oxford, Oxford, UK., Menge A; Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Frankfurt am Main, 60438, Germany & Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Johann Wolfgang Goethe University, Frankfurt am Main, Germany., Misquitta L; National Library of Medicine, National Institutes of Health, Bethesda, MD, USA., Müller S; Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Frankfurt am Main, 60438, Germany & Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Johann Wolfgang Goethe University, Frankfurt am Main, Germany., Owen DR; Pfizer Worldwide Research, Development & Medical, Cambridge, MA, USA., Schütt KT; Pfizer, Worldwide Research, Development and Medical, Machine Learning & Computational Sciences, Berlin, Germany., Skelton N; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, CA, USA., Steffen A; Pfizer, Worldwide Research, Development and Medical, Machine Learning & Computational Sciences, Berlin, Germany., Tropsha A; Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA., Vernet E; Digital Science & Innovation, Novo Nordisk A/S, Maaloev, Denmark., Wang Y; National Library of Medicine, National Institutes of Health, Bethesda, MD, USA., Wellnitz J; Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA., Willson TM; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Clevert DA; Pfizer, Worldwide Research, Development and Medical, Machine Learning & Computational Sciences, Berlin, Germany. Djork-Arne.Clevert@pfizer.com., Haibe-Kains B; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada. benjamin.haibe.kains@utoronto.ca.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. benjamin.haibe.kains@utoronto.ca.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. benjamin.haibe.kains@utoronto.ca.; Vector Institute for Artificial Intelligence, Toronto, ON, Canada. benjamin.haibe.kains@utoronto.ca., Schiavone LH; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden. Lovisa.Holmberg.Schiavone@astrazeneca.com., Schapira M; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada. matthieu.schapira@utoronto.ca.; Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON, Canada. matthieu.schapira@utoronto.ca.

المصدر: Nature communications [Nat Commun] 2024 Jul 05; Vol. 15 (1), pp. 5640. Date of Electronic Publication: 2024 Jul 05.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery*/methods , Machine Learning* , Data Science*/methods, Humans ; Artificial Intelligence ; Information Dissemination/methods ; Data Mining/methods ; Cloud Computing ; Databases, Factual

المؤلفون: Ma T; Department of Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, LA, USA.; Southeast Louisiana Veterans Health Care System, New Orleans, LA, USA., Jin L; Department of Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, LA, USA.; Southeast Louisiana Veterans Health Care System, New Orleans, LA, USA., Bai S; Department of Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, LA, USA., Liu Z; Department of Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, LA, USA., Wang S; Department of Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, LA, USA.; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Urological Department, Peking University Cancer Hospital & Institute, Beijing, China., Shen B; Department of Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, LA, USA.; Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan, Hubei, China., Cho Y; Department of Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, LA, USA.; Southeast Louisiana Veterans Health Care System, New Orleans, LA, USA., Cao S; Department of Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, LA, USA., Sun MJS; Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA, USA., Fazli L; Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, Canada., Zhang D; Department of Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, LA, USA.; Duke University, Durham, NC, USA., Wedderburn C; Department of Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, LA, USA., Zhang DY; Department of Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, LA, USA.; University of Southern California, Los Angeles, CA, USA., Mugon G; Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA, USA., Ungerleider N; Department of Pathology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, LA, USA., Baddoo M; Department of Pathology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, LA, USA., Zhang K; Department of Computer Science, Bioinformatics Facility of Xavier RCMI Center of Cancer Research, Xavier University of Louisiana, New Orleans, LA, USA., Schiavone LH; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Burkhardt BR; Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL, USA., Fan J; Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA, USA., You Z; Department of Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, LA, USA.; Southeast Louisiana Veterans Health Care System, New Orleans, LA, USA., Flemington EK; Department of Pathology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, LA, USA., Dong X; Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, Canada., Dong Y; Department of Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, LA, USA.; Southeast Louisiana Veterans Health Care System, New Orleans, LA, USA.

المصدر: Journal of the National Cancer Institute [J Natl Cancer Inst] 2024 Mar 07; Vol. 116 (3), pp. 421-433.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 7503089 Publication Model: Print Cited Medium: Internet ISSN: 1460-2105 (Electronic) Linking ISSN: 00278874 NLM ISO Abbreviation: J Natl Cancer Inst Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, Androgen*/genetics , Prostatic Neoplasms*/genetics , Prostatic Neoplasms*/metabolism, Male ; Humans ; Feedback ; Transcriptome ; Oncogene Proteins, Fusion/genetics ; Transcriptional Regulator ERG/genetics ; Transcriptional Regulator ERG/metabolism ; Neoplasm Proteins/genetics ; Cytokines/genetics

المؤلفون: Ding M; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden. mei.ding@astrazeneca.com., Malhotra R; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Ottosson T; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Lundqvist M; Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden., Mebrahtu A; Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden., Brengdahl J; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Gehrmann U; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Bäck E; Mechanistic Biology and Profiling, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Ross-Thriepland D; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Isaksson I; Sample Management, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Magnusson B; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Sachsenmeier KF; Translational Medicine, Oncology R&D, AstraZeneca, Boston, USA., Tegel H; Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden., Hober S; Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden., Uhlén M; Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden., Mayr LM; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Davies R; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Rockberg J; Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden., Schiavone LH; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden. lovisa.holmberg.schiavone@astrazeneca.com.

المصدر: Scientific reports [Sci Rep] 2021 Aug 18; Vol. 11 (1), pp. 16767. Date of Electronic Publication: 2021 Aug 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Bone Morphogenetic Proteins/*immunology , Growth Differentiation Factors/*immunology , Immunologic Factors/*immunology , Interferon-alpha/*immunology , Pancreatitis-Associated Proteins/*immunology , T-Lymphocytes, Regulatory/*immunology, Bone Morphogenetic Proteins/genetics ; Growth Differentiation Factors/genetics ; Humans ; Immunologic Factors/genetics ; Interferon-alpha/genetics ; Pancreatitis-Associated Proteins/genetics

المؤلفون: Tegel H; Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden., Dannemeyer M; Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden., Kanje S; Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden., Sivertsson Å; Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden., Berling A; Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden., Svensson AS; Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden., Hober A; Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden., Enstedt H; Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden., Volk AL; Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden., Lundqvist M; Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden., Moradi M; Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden., Afshari D; Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden., Ekblad S; Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden., Xu L; Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden., Westin M; Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden., Bidad F; Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden., Schiavone LH; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Davies R; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Mayr LM; Syncona Investment Ltd, London, UK; ETH Zurich, B-BIOL, Molecular Health Sciences, Zurich, Switzerland., Knight S; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Göpel SO; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceutical R&D, AstraZeneca, Gothenburg, Sweden., Voldborg BG; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Denmark., Edfors F; Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden., Forsström B; Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden., von Feilitzen K; Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden., Zwahlen M; Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden., Rockberg J; Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden., Takanen JO; Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden., Uhlén M; Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Denmark., Hober S; Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, Sweden. Electronic address: sophia@kth.se.

المصدر: New biotechnology [N Biotechnol] 2020 Sep 25; Vol. 58, pp. 45-54. Date of Electronic Publication: 2020 Jun 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101465345 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-4347 (Electronic) Linking ISSN: 18716784 NLM ISO Abbreviation: N Biotechnol Subsets: MEDLINE

مواضيع طبية MeSH: High-Throughput Screening Assays*, Animals ; CHO Cells ; Cricetulus ; DNA/biosynthesis ; DNA/genetics ; HEK293 Cells ; Humans ; Proteomics ; Recombinant Proteins/analysis ; Recombinant Proteins/metabolism

المؤلفون: Jansson AM; From the Reagents and Assay Development Division, Discovery Sciences Department., Csiszar A; the Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria., Maier J; From the Reagents and Assay Development Division, Discovery Sciences Department., Nyström AC; Translational Sciences Division, Cardiovascular and Metabolic Diseases Department, and., Ax E; From the Reagents and Assay Development Division, Discovery Sciences Department., Johansson P; Structure and Biophysics Division, Discovery Sciences Department, AstraZeneca, Pepparedsleden 1, 431 83 Mölndal, Sweden and patrik.johansson@astrazeneca.com., Schiavone LH; From the Reagents and Assay Development Division, Discovery Sciences Department, lovisa.holmberg.schiavone@astrazeneca.com.

المصدر: The Journal of biological chemistry [J Biol Chem] 2017 Sep 15; Vol. 292 (37), pp. 15501-15511. Date of Electronic Publication: 2017 Jul 27.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Models, Molecular*, Cytokines/*metabolism , Neoplasm Proteins/*metabolism, Amino Acid Substitution ; Animals ; Cell Line, Transformed ; Cell Movement ; Crystallography, X-Ray ; Cysteine/chemistry ; Cystine/chemistry ; Cytokines/chemistry ; Cytokines/genetics ; Dimerization ; Humans ; Interleukins/chemistry ; Interleukins/metabolism ; Mice ; Neoplasm Proteins/chemistry ; Neoplasm Proteins/genetics ; Peptide Fragments/chemistry ; Peptide Fragments/genetics ; Peptide Fragments/metabolism ; Point Mutation ; Protein Conformation ; Protein Interaction Domains and Motifs ; Protein Stability ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/metabolism ; Structural Homology, Protein