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1دورية أكاديمية
المؤلفون: Picavet LW; Center for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., van Vroonhoven ECN; Center for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Scholman RC; Center for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Smits YTH; Center for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Banerjee R; Hubrecht Institute-KNAW and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Oncode Institute, 3584 CX Utrecht, The Netherlands., Besteman SB; Center for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Viveen MC; Center for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., van der Vlist MM; Center for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Oncode Institute, 3584 CX Utrecht, The Netherlands., Tanenbaum ME; Hubrecht Institute-KNAW and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Oncode Institute, 3584 CX Utrecht, The Netherlands.; Department of Bionanoscience, Delft University of Technology, 2600 AA Delft, The Netherlands., Lebbink RJ; Department of Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Vastert SJ; Center for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., van Loosdregt J; Center for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
المصدر: Viruses [Viruses] 2024 May 14; Vol. 16 (5). Date of Electronic Publication: 2024 May 14.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE
مواضيع طبية MeSH: Respiratory Syncytial Virus Infections*/virology , Respiratory Syncytial Virus Infections*/metabolism , Respiratory Syncytial Virus, Human*/genetics , Respiratory Syncytial Virus, Human*/physiology , Adenosine*/analogs & derivatives , Adenosine*/metabolism , Virus Internalization* , CX3C Chemokine Receptor 1*/metabolism , CX3C Chemokine Receptor 1*/genetics, Humans ; Virus Replication ; Methylation ; Down-Regulation ; RNA Splicing Factors/metabolism ; RNA Splicing Factors/genetics ; Epithelial Cells/virology ; Epithelial Cells/metabolism ; Cell Line ; A549 Cells ; RNA, Viral/genetics ; RNA, Viral/metabolism ; Host-Pathogen Interactions ; Nerve Tissue Proteins
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2دورية أكاديمية
المؤلفون: van Vroonhoven ECN; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands., Picavet LW; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands., Scholman RC; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands., Sijbers LJPM; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands., Kievit CRE; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands., van den Dungen NAM; Department of Experimental Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands., Mokry M; Department of Experimental Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands., Evers A; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands., Lebbink RJ; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands., Mocholi E; Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.; Regenerative Medicine Center, University Medical Center Utrecht, Utrecht, the Netherlands., Coffer PJ; Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.; Regenerative Medicine Center, University Medical Center Utrecht, Utrecht, the Netherlands., Calis JJA; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands., Vastert SJ; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Pediatric Rheumatology and Immunology, University Medical Center Utrecht, Utrecht, the Netherlands., van Loosdregt J; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.
المصدر: Journal of leukocyte biology [J Leukoc Biol] 2024 Apr 24. Date of Electronic Publication: 2024 Apr 24.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 8405628 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-3673 (Electronic) Linking ISSN: 07415400 NLM ISO Abbreviation: J Leukoc Biol Subsets: MEDLINE
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3دورية أكاديمية
المؤلفون: Erkens RGA; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., Calis JJA; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., Verwoerd A; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., De Roock S; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., Ter Haar NM; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., Den Engelsman G; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., Van der Veken LT; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., Ernst RF; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., Van Deutekom HWM; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., Pickering A; Harvard Medical School, Boston, Massachusetts., Scholman RC; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., Jansen MHA; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., Swart JF; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., Sinha R; Systemic Juvenile Idiopathic Arthritis Foundation, Cincinnati, Ohio., Roth J; University of Münster, Münster, Germany., Schulert GS; Cincinnati Children's Hospital and University of Cincinnati College of Medicine, Cincinnati, Ohio., Grom AA; Cincinnati Children's Hospital and University of Cincinnati College of Medicine, Cincinnati, Ohio., Van Loosdregt J; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., Vastert SJ; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands.
المصدر: Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2024 Jan; Vol. 76 (1), pp. 119-129. Date of Electronic Publication: 2023 Nov 06.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101623795 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2326-5205 (Electronic) Linking ISSN: 23265191 NLM ISO Abbreviation: Arthritis Rheumatol Subsets: MEDLINE
مواضيع طبية MeSH: Arthritis, Juvenile*/drug therapy , Arthritis, Juvenile*/genetics , Biological Products*/therapeutic use , Eosinophilia*/drug therapy, Humans ; Interleukin 1 Receptor Antagonist Protein/genetics ; Interleukin 1 Receptor Antagonist Protein/therapeutic use ; HLA-DRB1 Chains/genetics ; Prospective Studies ; Receptors, Interleukin-1/therapeutic use
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4دورية أكاديمية
المؤلفون: Peeters JGC; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Boltjes A; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Scholman RC; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Vervoort SJ; Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Coffer PJ; Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Mokry M; Laboratory of Experimental Cardiology, UMC Utrecht, Utrecht University, Utrecht, The Netherlands.; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Vastert SJ; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Department of Pediatric Rheumatology and Immunology, Division of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University Utrecht, The Netherlands., van Wijk F; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., van Loosdregt J; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
المصدر: Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2023 Aug 01; Vol. 62 (8), pp. 2887-2897.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 100883501 Publication Model: Print Cited Medium: Internet ISSN: 1462-0332 (Electronic) Linking ISSN: 14620324 NLM ISO Abbreviation: Rheumatology (Oxford) Subsets: MEDLINE
مواضيع طبية MeSH: Monocytes*/metabolism , Arthritis*/metabolism, Humans ; Epigenesis, Genetic ; Synovial Fluid/metabolism ; Phenotype
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5دورية أكاديمية
المؤلفون: van Vroonhoven ECN; Center for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Picavet LW; Center for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Scholman RC; Center for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., van den Dungen NAM; Department of Experimental Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Mokry M; Department of Experimental Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Evers A; Department of Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Lebbink RJ; Department of Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Calis JJA; Center for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Vastert SJ; Center for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Department of Pediatric Rheumatology and Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., van Loosdregt J; Center for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
المصدر: Biology [Biology (Basel)] 2023 Jul 14; Vol. 12 (7). Date of Electronic Publication: 2023 Jul 14.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101587988 Publication Model: Electronic Cited Medium: Print ISSN: 2079-7737 (Print) Linking ISSN: 20797737 NLM ISO Abbreviation: Biology (Basel) Subsets: PubMed not MEDLINE
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6دورية أكاديميةHuman Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor Tregs.
المؤلفون: Wienke J; Center for Translational Immunology., Brouwers L; Wilhelmina Children's Hospital Birth Center., van der Burg LM; Center for Translational Immunology., Mokry M; Regenerative Medicine Utrecht.; Laboratory of Clinical Chemistry and Hematology, and., Scholman RC; Center for Translational Immunology., Nikkels PG; Department of Pathology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Netherlands., van Rijn BB; Wilhelmina Children's Hospital Birth Center.; Obstetrics and Fetal Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands., van Wijk F; Center for Translational Immunology.
المصدر: JCI insight [JCI Insight] 2020 Sep 17; Vol. 5 (18). Date of Electronic Publication: 2020 Sep 17.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
مواضيع طبية MeSH: Adaptation, Physiological*, Fetus/*metabolism , Lymphocytes, Tumor-Infiltrating/*immunology , Neoplasms/*pathology , Placenta/*metabolism , T-Lymphocytes, Regulatory/*immunology , Uterus/*metabolism, Cesarean Section ; Female ; Fetus/immunology ; Humans ; Lymphocytes, Tumor-Infiltrating/metabolism ; Maternal-Fetal Exchange ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/metabolism ; Placenta/immunology ; Pregnancy ; T-Lymphocytes, Regulatory/metabolism ; Transcriptome ; Uterus/immunology
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7دورية أكاديمية
المؤلفون: Ter Haar NM; University Medical Center Utrecht, Wilhelmina Children's Hospital and Utrecht University, Utrecht, The Netherlands., Tak T; University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands., Mokry M; University Medical Center Utrecht, Wilhelmina Children's Hospital and Utrecht University, Utrecht, The Netherlands., Scholman RC; University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands., Meerding JM; University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands., de Jager W; University Medical Center Utrecht, Wilhelmina Children's Hospital and Utrecht University, Utrecht, The Netherlands., Verwoerd A; University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands., Foell D; University of Muenster, Muenster, Germany., Vogl T; University of Muenster, Muenster, Germany., Roth J; University of Muenster, Muenster, Germany., Leliefeld PHC; University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands., van Loosdregt J; University Medical Center Utrecht, Wilhelmina Children's Hospital and Utrecht University, Utrecht, The Netherlands., Koenderman L; University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands., Vastert SJ; University Medical Center Utrecht, Wilhelmina Children's Hospital and Utrecht University, Utrecht, The Netherlands., de Roock S; University Medical Center Utrecht, Wilhelmina Children's Hospital and Utrecht University, Utrecht, The Netherlands.
المصدر: Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2018 Jun; Vol. 70 (6), pp. 943-956. Date of Electronic Publication: 2018 May 07.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101623795 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2326-5205 (Electronic) Linking ISSN: 23265191 NLM ISO Abbreviation: Arthritis Rheumatol Subsets: MEDLINE
مواضيع طبية MeSH: Antirheumatic Agents/*therapeutic use , Arthritis, Juvenile/*drug therapy , Interleukin 1 Receptor Antagonist Protein/*therapeutic use , Neutrophils/*drug effects , Systemic Inflammatory Response Syndrome/*drug therapy, Arthritis, Juvenile/immunology ; Child ; Female ; Humans ; Male ; Netherlands ; Prospective Studies ; Systemic Inflammatory Response Syndrome/immunology ; Treatment Outcome
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8دورية أكاديمية
المؤلفون: Scholman RC; Department of Pediatric Immunology, University Medical Center Utrecht, Utrecht, The Netherlands; Multiplex Core Facility, Laboratory of Translational Immunology, University Medical center Utrecht, Utrecht, The Netherlands., Giovannone B; Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht, The Netherlands; Multiplex Core Facility, Laboratory of Translational Immunology, University Medical center Utrecht, Utrecht, The Netherlands., Hiddingh S; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands; Multiplex Core Facility, Laboratory of Translational Immunology, University Medical center Utrecht, Utrecht, The Netherlands., Meerding JM; Department of Pediatric Immunology, University Medical Center Utrecht, Utrecht, The Netherlands; Multiplex Core Facility, Laboratory of Translational Immunology, University Medical center Utrecht, Utrecht, The Netherlands., Malvar Fernandez B; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands; Multiplex Core Facility, Laboratory of Translational Immunology, University Medical center Utrecht, Utrecht, The Netherlands., van Dijk MEA; Multiplex Core Facility, Laboratory of Translational Immunology, University Medical center Utrecht, Utrecht, The Netherlands., Tempelman MJ; Multiplex Core Facility, Laboratory of Translational Immunology, University Medical center Utrecht, Utrecht, The Netherlands., Prakken BJ; Department of Pediatric Immunology, University Medical Center Utrecht, Utrecht, The Netherlands; Multiplex Core Facility, Laboratory of Translational Immunology, University Medical center Utrecht, Utrecht, The Netherlands., de Jager W; Department of Pediatric Immunology, University Medical Center Utrecht, Utrecht, The Netherlands; Multiplex Core Facility, Laboratory of Translational Immunology, University Medical center Utrecht, Utrecht, The Netherlands. Electronic address: wjager@umcutrecht.nl.
المصدر: Cytokine [Cytokine] 2018 Jun; Vol. 106, pp. 114-124. Date of Electronic Publication: 2017 Oct 28.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005353 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0023 (Electronic) Linking ISSN: 10434666 NLM ISO Abbreviation: Cytokine Subsets: MEDLINE
مواضيع طبية MeSH: Healthy Volunteers*, Anticoagulants/*pharmacology , Immunoproteins/*metabolism, Adult ; Edetic Acid/pharmacology ; Female ; Freezing ; Heparin/pharmacology ; Humans ; Immunoassay ; Limit of Detection ; Male ; Middle Aged ; Protein Stability ; Reference Standards ; Reproducibility of Results
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9دورية أكاديمية
المؤلفون: Petrelli A; University Medical Center Utrecht, Utrecht, The Netherlands., Wehrens EJ; University Medical Center Utrecht, Utrecht, The Netherlands., Scholman RC; University Medical Center Utrecht, Utrecht, The Netherlands., Prakken BJ; University Medical Center Utrecht, Utrecht, The Netherlands., Vastert SJ; University Medical Center Utrecht, Utrecht, The Netherlands., van Wijk F; University Medical Center Utrecht, Utrecht, The Netherlands.
المصدر: Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2016 Jan; Vol. 68 (1), pp. 229-36.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101623795 Publication Model: Print Cited Medium: Internet ISSN: 2326-5205 (Electronic) Linking ISSN: 23265191 NLM ISO Abbreviation: Arthritis Rheumatol Subsets: MEDLINE
مواضيع طبية MeSH: Arthritis, Juvenile/*immunology , CD8-Positive T-Lymphocytes/*immunology , Cytokines/*immunology , Interferon-gamma/*immunology , Tumor Necrosis Factor-alpha/*immunology, Adolescent ; Antigen-Presenting Cells ; Autoimmune Diseases ; CD4-Positive T-Lymphocytes ; Case-Control Studies ; Cell Proliferation ; Child ; Female ; Flow Cytometry ; Humans ; Inflammation ; Interferon-gamma/antagonists & inhibitors ; Interleukin-10/immunology ; Interleukin-17/immunology ; Interleukin-6/immunology ; Male ; Synovial Fluid/cytology ; T-Lymphocytes, Regulatory ; Tumor Necrosis Factor-alpha/antagonists & inhibitors
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10دورية أكاديميةMethotrexate treatment affects effector but not regulatory T cells in juvenile idiopathic arthritis.
المؤلفون: Bulatović Ćalasan M; Center for Molecular and Cellular Intervention, Department of Pediatric Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands m.bulatovic@umcutrecht.nl., Vastert SJ; Center for Molecular and Cellular Intervention, Department of Pediatric Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands., Scholman RC; Center for Molecular and Cellular Intervention, Department of Pediatric Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands., Verweij F; Center for Molecular and Cellular Intervention, Department of Pediatric Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands., Klein M; Center for Molecular and Cellular Intervention, Department of Pediatric Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands., Wulffraat NM; Center for Molecular and Cellular Intervention, Department of Pediatric Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands., Prakken BJ; Center for Molecular and Cellular Intervention, Department of Pediatric Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands., van Wijk F; Center for Molecular and Cellular Intervention, Department of Pediatric Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands.
المصدر: Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2015 Sep; Vol. 54 (9), pp. 1724-34. Date of Electronic Publication: 2015 Apr 14.
نوع المنشور: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 100883501 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1462-0332 (Electronic) Linking ISSN: 14620324 NLM ISO Abbreviation: Rheumatology (Oxford) Subsets: MEDLINE
مواضيع طبية MeSH: Antirheumatic Agents/*pharmacology , Arthritis, Juvenile/*pathology , Cell Proliferation/*drug effects , Methotrexate/*pharmacology , T-Lymphocyte Subsets/*drug effects , T-Lymphocytes, Regulatory/*drug effects, Adolescent ; Antirheumatic Agents/therapeutic use ; Arthritis, Juvenile/drug therapy ; Arthritis, Juvenile/metabolism ; Cells, Cultured ; Child ; Child, Preschool ; Cytokines/metabolism ; Dose-Response Relationship, Drug ; Female ; Follow-Up Studies ; Humans ; Immunity/drug effects ; Interferon-gamma/blood ; Male ; Methotrexate/therapeutic use ; Phenotype ; Prospective Studies ; T-Lymphocyte Subsets/metabolism ; T-Lymphocyte Subsets/pathology ; T-Lymphocytes, Regulatory/metabolism ; T-Lymphocytes, Regulatory/pathology ; Treatment Outcome