المؤلفون: Diego Alvarado, Gwenda F Ligon, Jay S Lillquist, Scott B Seibel, Gerald Wallweber, Veronique M Neumeister, David L Rimm, Gerald McMahon, Theresa M LaVallee

المصدر: PLoS ONE, Vol 12, Iss 7, p e0181356 (2017)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC5517012?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/c695b6e9947349e89cb6ca4cd1d6440e

المؤلفون: Diego Alvarado, Marcus Maurer, Richard Gedrich, Scott B. Seibel, Michael B. Murphy, Linda Crew, Joel Goldstein, Andrea Crocker, Laura A. Vitale, Pamela A. Morani, Lawrence J. Thomas, Thomas R. Hawthorne, Tibor Keler, Diane Young, Elizabeth Crowley, Martin Kankam, Margo Heath‐Chiozzi

المصدر: Allergy. 77:2393-2403

مصطلحات موضوعية: Proto-Oncogene Proteins c-kit, Stem Cell Factor, Immunology, Antibodies, Monoclonal, Humans, Immunology and Allergy, Mast Cells, Healthy Volunteers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b83e55af5beb6cbb26e914b5749638d3
https://doi.org/10.1111/all.15262

المؤلفون: Magee Thomas Victor, Thuy-Trinh Nguyen, Joseph A. Abramite, Yue Shen, Jian Lin, Jiri Aubrecht, Fadia Dib-Hajj, Jeremy T. Starr, Alita A. Miller, Matthew Frank Brown, Shawn H. MacVane, Michael D. Huband, Li Zhang, Karl Granskog, Bryan Li, Jinshan Michael Chen, James M. McKim, John P. O'Donnell, Karen L. Leach, Paul C. Wilga, David P. Nicolau, Sandra P. McCurdy, Mark Edward Flanagan, Antonia F. Stepan, Andrew P. Tomaras, Mark C. Noe, Michael Kuhn, Scott B. Seibel, Rebecca Irvine, Jinfeng Xu, David C. Ackley, David R. Luke, Jared L. Crandon, Joel R. Hardink, Andrew Butler

المصدر: Journal of Medicinal Chemistry. 56:5079-5093

مصطلحات موضوعية: Male, medicine.drug_class, Polymyxin, Microbial Sensitivity Tests, medicine.disease_cause, Microbiology, Dogs, Therapeutic index, In vivo, Gram-Negative Bacteria, Drug Discovery, medicine, Animals, Humans, Polymyxins, Cross Infection, biology, Chemistry, Pseudomonas aeruginosa, biology.organism_classification, Antimicrobial, Drug Resistance, Multiple, Anti-Bacterial Agents, Rats, Acinetobacter baumannii, Multiple drug resistance, beta-Alanine, Molecular Medicine, Female, Polymyxin B, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e495f860c984ae946db4940511966812
https://doi.org/10.1021/jm400416u

المؤلفون: Xinjun Hou, Kristin M. Lundy DeMello, Carol F. Petras, Subas M. Sakya, Cheng Hengmiao, Martha L. Minich, Donald W. Mann, Bryson Rast, Burton H. Jaynes, Michelle L. Haven, Scott B. Seibel, Andrei Shavnya, Jin Li

المصدر: Bioorganic & Medicinal Chemistry Letters. 17:1067-1072

مصطلحات موضوعية: Models, Molecular, Nitrile, Molecular model, Pyridines, Stereochemistry, Clinical Biochemistry, Heteroatom, Pharmaceutical Science, In Vitro Techniques, Pyrazole, Biochemistry, Chemical synthesis, Sulfone, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Nitriles, Drug Discovery, Animals, Humans, Structure–activity relationship, heterocyclic compounds, Sulfones, Molecular Biology, Sulfonamides, Binding Sites, Cyclooxygenase 2 Inhibitors, Hydrogen bond, organic chemicals, Organic Chemistry, Hydrogen Bonding, Kinetics, chemistry, Celecoxib, Drug Design, Cyclooxygenase 1, Pyrazoles, Molecular Medicine, Indicators and Reagents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ad9e39836d5513ea4f0aa8a0a1f1a1
https://doi.org/10.1016/j.bmcl.2006.11.026

المؤلفون: Chao Li, Rod Stevens, Jason K. Dutra, Annette M. Silvia, Michelle L. Haven, Scott B. Seibel, Erik L. Nimz, Ziegler Carl B, Kristin M. Lundy DeMello, Robert J. Rafka, Cheng Hengmiao, Martha L. Minich, Jin Li, Nicole L. Kolosko, Carol F. Petras, Subas M. Sakya, Donald W. Mann, Kazuo Ando, K. Kawamura, Carolyn Rose Kilroy, Lisa A. Lund, Burton H. Jaynes, Tomoki Kato

المصدر: Bioorganic & Medicinal Chemistry Letters. 16:2076-2080

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Pyrazole, Biochemistry, Chemical synthesis, Sulfone, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, In vivo, Drug Discovery, Animals, Molecular Biology, Cyclooxygenase 2 Inhibitors, biology, Anti-Inflammatory Agents, Non-Steroidal, Organic Chemistry, In vitro, chemistry, Cyclooxygenase 2, Enzyme inhibitor, Cyclooxygenase 1, biology.protein, Pyrazoles, Molecular Medicine, COX-2 inhibitor, Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096af07029de50fcfe74128b57b3a069
https://doi.org/10.1016/j.bmcl.2006.01.059

المؤلفون: Suzanne H. St. Denis, Michelle L. Haven, Scott B. Seibel, Carol F. Petras, Subas M. Sakya, Lisa A. Lund, Annette M. Silvia, Michael P. Lynch, Bryson Rast, Cheng Hengmiao, Martha L. Minich, Burton H. Jaynes, Kristin M. Lundy DeMello, Donald W. Mann, Andrei Shavnya, Anne Hickman, Ziegler Carl B, David A. Koss, David M. George, Robert J. Rafka, Jin Li

المصدر: Bioorganic & Medicinal Chemistry Letters. 16:288-292

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Heteroatom, Drug Evaluation, Preclinical, Administration, Oral, Pharmaceutical Science, In Vitro Techniques, Biochemistry, Chemical synthesis, Sulfone, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, In vivo, Drug Discovery, Animals, Structure–activity relationship, Molecular Biology, chemistry.chemical_classification, Cyclooxygenase 2 Inhibitors, Molecular Structure, biology, Organic Chemistry, In vitro, Disease Models, Animal, Enzyme, chemistry, Cyclooxygenase 2, Enzyme inhibitor, Cats, biology.protein, Pyrazoles, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f287d246c2a3746f106e9752c3bac59e
https://doi.org/10.1016/j.bmcl.2005.10.006

المؤلفون: Burton H. Jaynes, Michelle L. Haven, Scott B. Seibel, Nicole L. Kolosko, Carolyn Rose Kilroy, Kristin M. Lundy DeMello, Donald W. Mann, Michael P. Lynch, Cheng Hengmiao, Lisa A. Lund, Robert J. Rafka, Jin Li, Carol F. Petras, Subas M. Sakya, Bronk Brian Scott

المصدر: Bioorganic & Medicinal Chemistry. 13:1805-1809

مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Pyridines, Clinical Biochemistry, Pharmaceutical Science, In Vitro Techniques, Pharmacology, Biochemistry, Dogs, Pharmacokinetics, In vivo, Drug Discovery, Animals, Potency, Cyclooxygenase Inhibitors, Molecular Biology, Whole blood, Cyclooxygenase 2 Inhibitors, biology, Chemistry, Organic Chemistry, In vitro, Cyclooxygenase 2, Prostaglandin-Endoperoxide Synthases, Enzyme inhibitor, biology.protein, Pyrazoles, Molecular Medicine, COX-2 inhibitor, Ex vivo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::442d5fd80e9563aadcaab6043c177abd
https://doi.org/10.1016/j.bmc.2004.11.048

المؤلفون: Rhonda M. Crosson, David A. Koss, Michelle L. Haven, Carolyn Rose Kilroy, Martha L. Minich, Robert J. Rafka, Eric L. Nimz, Morton Barry James, Scott B. Seibel, Lisa A. Lund, Carol F. Petras, Kristin M. Lundy DeMello, Chao Li, Annette M. Silvia, Bryson Rast, Kathleen M. Callaghan, Andrei Shavnya, Michael P. Lynch, Subas M. Sakya, Ziegler Carl B, Jin Li, Nicole L. Kolosko, Bronk Brian Scott, Donald W. Mann, Jason K. Dutra, Burton H. Jaynes, Henry Cheng, Glen W. Kirk

المصدر: Bioorganic & Medicinal Chemistry Letters. 14:95-98

مصطلحات موضوعية: Pyridines, Stereochemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Biochemistry, Chemical synthesis, Sulfone, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Oral administration, In vivo, Drug Discovery, Animals, Cyclooxygenase Inhibitors, Molecular Biology, chemistry.chemical_classification, Cyclooxygenase 2 Inhibitors, biology, Chemistry, Organic Chemistry, In vitro, Isoenzymes, Enzyme, Cyclooxygenase 2, Prostaglandin-Endoperoxide Synthases, Enzyme inhibitor, biology.protein, Molecular Medicine, COX-2 inhibitor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f71036c4dab955ec24afc57075467a
https://doi.org/10.1016/j.bmcl.2003.10.004

المؤلفون: Steven M. Finegan, Shigeru F. Hayashi, Arthur E. Girard, J. C. Kane, R.Y. Chandrasekaran, S. A. Kaufman, N. C. Birsner, J.W. Petitpas, B.V. Yang, David A. Whipple, J.P. Lyssikatos, Catherine P. Reese, C.P. MacLelland, Barbara J. Kamicker, B. J. Cronin, S. A. Miller, Joanna Clancy, Susan A. Froshauer, Magee Thomas Victor, B. P. Dirlam, M. A. Lemay, John P. Dirlam, Scott B. Seibel, Wei-Guo Su, Linde Robert Gerald, R. R. Brooks, A. M. Belton, Mark A. Massa, K. T. Sweeney, Martha L. Minich, R. J. Howe, David Austen Perry, Shang-Poa Chang, Nicole L. Kolosko

المصدر: Bioorganic & Medicinal Chemistry Letters. 7:1139-1144

مصطلحات موضوعية: Capreomycin, Clinical Biochemistry, Pharmaceutical Science, medicine.disease_cause, Biochemistry, Microbiology, Drug Discovery, medicine, Pasteurella, Molecular Biology, Antibacterial agent, biology, Chemistry, Organic Chemistry, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, medicine.disease, biology.organism_classification, Combinatorial chemistry, Viomycin, Enterococcus, Staphylococcus aureus, Molecular Medicine, Vancomycin, Pasteurellosis, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c35767df2d0f2186d70412a3ef308451
https://doi.org/10.1016/s0960-894x(97)00186-8

المؤلفون: Arthur E. Girard, J.W. Petitpas, J.P. Lyssikatos, Steven M. Finegan, A.S. Lee, D.P. Larson, John P. Dirlam, Scott B. Seibel, Linde Robert Gerald, C.B. Vu, Shang-Poa Chang, C.P. MacLelland, Joanna Clancy, Shigeru F. Hayashi

المصدر: Bioorganic & Medicinal Chemistry Letters. 7:1145-1148

مصطلحات موضوعية: chemistry.chemical_classification, biology, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, biology.organism_classification, medicine.disease_cause, Biochemistry, Chemical synthesis, Cyclic peptide, Viomycin, Staphylococcus aureus, Drug Discovery, medicine, Molecular Medicine, Pasteurella multocida, Antibacterial activity, Molecular Biology, Escherichia coli, Antibacterial agent, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2a6113bdfa10f31278f2c24379173f92
https://doi.org/10.1016/s0960-894x(97)00187-x