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1
المؤلفون: Andrew Maynard, Renae M. Crosby, Jill Walker, Maosheng Duan, Janos Botyanszki, Wieslaw M. Kazmierski, Scott Howard Dickerson, Robert Hamatake, Martin Robert Leivers, Christopher Don Roberts, Sam Baskaran, Matthew David Tallant, Rick Grimes
المصدر: Journal of Medicinal Chemistry. 57:2058-2073
مصطلحات موضوعية: Models, Molecular, Magnetic Resonance Spectroscopy, Pyrrolidines, Genotype, Hepatitis C virus, Mutant, Hepacivirus, medicine.disease_cause, Antiviral Agents, Mass Spectrometry, Pyrrolidine, chemistry.chemical_compound, Hepatitis C virus genotype, Drug Discovery, medicine, Humans, Potency, Spiro Compounds, NS5A, virus diseases, RNA, Virology, Molecular biology, digestive system diseases, chemistry, Drug Design, Mutation, RNA, Viral, Molecular Medicine
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2
المؤلفون: Jun Tang, Karen Lackey, Scott Howard Dickerson
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:66-70
مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Thienopyridines, Clinical Biochemistry, Drug Evaluation, Preclinical, Aminopyridines, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, Drug Discovery, Potency, Protein Kinase Inhibitors, Molecular Biology, biology, Chemistry, Kinase, Phenylurea Compounds, Cellular Assay, Organic Chemistry, Raf kinase, Enzyme assay, Drug Design, Knowledge based design, biology.protein, Molecular Medicine, Selectivity, Protein Binding
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3
المؤلفون: Scott Howard Dickerson, James G. Greger, Li Liu, Sylvie Laquerre, Vivian Zhang, Maureen R. Bleam, Stephen Eastman, Kimberly N. Smitheman, Tona M. Gilmer, Ashley M. Hughes
المصدر: Molecular Cancer Therapeutics. 11:909-920
مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Neuroblastoma RAS viral oncogene homolog, Cancer Research, Indoles, MAP Kinase Kinase 1, Apoptosis, Cell Growth Processes, Biology, Small hairpin RNA, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, Oximes, medicine, Humans, Phosphorylation, Vemurafenib, Melanoma, Protein Kinase Inhibitors, Phosphoinositide-3 Kinase Inhibitors, Trametinib, Sulfonamides, Kinase, Cell growth, TOR Serine-Threonine Kinases, Imidazoles, Dabrafenib, Molecular biology, Oncology, Drug Resistance, Neoplasm, V600E, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb36ad3f6b9d5624292c39628e2f3e3
https://doi.org/10.1158/1535-7163.mct-11-0989 -
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المؤلفون: Tara Renae Rheault, Kimberly N. Smitheman, Kimberly G. Petrov, Chao Han, George Adjabeng, Alex G. Waterson, Marc R. Arnone, Alastair J. King, David E. Uehling, Olivia W. Rossanese, Keith R. Hornberger, Scott Howard Dickerson, John Stellwagen, Cynthia M. Rominger, Robert A. Mook
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:4436-4440
مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Stereochemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Catalytic Domain, Drug Discovery, Animals, Thiazole, Protein Kinase Inhibitors, Molecular Biology, chemistry.chemical_classification, Sulfonamides, Binding Sites, Kinase, Chemistry, Organic Chemistry, Fluorine, Rats, Bioavailability, Sulfonamide, Amino Acid Substitution, Microsomes, Liver, Molecular Medicine
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المؤلفون: Chuck Poole, Pierette Banker, Yu Guo, Gregory Schaaf, Tiffany Carpenter, Stephen A. Thomson, Dan Gillie, Curt D. Haffner, John C. Ulrich, Scott Howard Dickerson, Petrov Kimberly, J. Patrick Condreay, Jeff Gobel, Andrew L. Larkin
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:6989-6992
مصطلحات موضوعية: Patch-Clamp Techniques, Nitrile, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Pancreatitis-Associated Proteins, Carboxamide, Biochemistry, Chemical synthesis, Cell Line, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Animals, Humans, Benzothiazoles, Patch clamp, Benzamide, Molecular Biology, Ion channel, Kv1.3 Potassium Channel, Organic Chemistry, Amides, In vitro, Rats, chemistry, Benzamides, Molecular Medicine
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المؤلفون: Kimberly G. Petrov, Thomas R. Caferro, Octerloney B. McDonald, David W. Rusnak, Dana E. Vanderwall, Kelly Horne Donaldson, Tara Renae Rheault, David E. Uehling, Lisa M. Shewchuk, Scott Howard Dickerson, Robert J. Mullin, Michael D. Gaul, Aaron S. Goetz, Glenn M. Spehar, Anne T. Truesdale, Edgar R. Wood
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:817-820
مصطلحات موضوعية: Pyrimidine, Receptor, ErbB-2, Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Antineoplastic Agents, Lapatinib, Biochemistry, Sulfone, Inhibitory Concentration 50, chemistry.chemical_compound, ErbB, Cell Line, Tumor, Drug Discovery, medicine, Humans, Epidermal growth factor receptor, Enzyme Inhibitors, Molecular Biology, Cell Proliferation, biology, Chemistry, Kinase, Organic Chemistry, In vitro, ErbB Receptors, Pyrimidines, Models, Chemical, Enzyme inhibitor, Drug Design, Quinazolines, biology.protein, Molecular Medicine, Drug Screening Assays, Antitumor, medicine.drug
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7
المؤلفون: Erich W. Baum, Brian Wilson, Jason L. Rowand, David E. Uehling, James Michael Salovich, Kelly Anderson, Ganesh S. Moorthy, Stephon C. Smith, M. Anthony Leesnitzer, Robert A. Mook, Kristen Elizabeth Nailor, Kirk L. Stevens, Arthur Groy, Rakesh Kumar, Mui Cheung, Scott Howard Dickerson, Anne M. Hassell, Jingsong Yang, Lisa M. Shewchuk, Roseanne Gerding, Holly Kathleen Emerson, Charity Atkins, Kevin Wayne Kuntz, Peter Sabbatini, Kyle A. Emmitte
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:1004-1008
مصطلحات موضوعية: Pyridines, Chemistry, Pharmaceutical, medicine.medical_treatment, Clinical Biochemistry, Molecular Conformation, Administration, Oral, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Receptor, IGF Type 1, Inhibitory Concentration 50, Mice, Insulin-like growth factor, Growth factor receptor, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Receptor, Molecular Biology, Insulin-like growth factor 1 receptor, Aniline Compounds, biology, Chemistry, Organic Chemistry, Receptor, Insulin, In vitro, Insulin receptor, Models, Chemical, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine
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المؤلفون: David M. Bickett, Francis X. Tavares, Pamela L. Golden, Lauren R. Sheckler, Stephen A. Thomson, Dulce Garrido, Andrew J. Peat, Pierette Banker, James E. Weiel, Steven M. Sparks, Scott Howard Dickerson, Daphne C. Clancy
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:981-985
مصطلحات موضوعية: Threonine, Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, Glycine, Pharmaceutical Science, Ether, Crystallography, X-Ray, Imides, Biochemistry, Serine, Inhibitory Concentration 50, chemistry.chemical_compound, Glycogen phosphorylase, Drug Discovery, Glycosyltransferase, Animals, Humans, ortho-Aminobenzoates, Phosphorylase kinase, Glycogen synthase, Molecular Biology, Cytochrome P-450 CYP2C9, biology, Chemistry, Glycogen Phosphorylase, Organic Chemistry, Rats, Diabetes Mellitus, Type 2, Liver, Models, Chemical, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Aryl Hydrocarbon Hydroxylases
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المؤلفون: Pierette Banker, Daphne C. Clancy, Francis X. Tavares, Pamela L. Golden, Liping Wang, James E. Weiel, Steven M. Sparks, Stephen A. Thomson, Lauren R. Sheckler, Dulce Garrido, Scott Howard Dickerson, Andrew J. Peat, David M. Bickett, H. Luke Carter, Kate A. Dwornik, Robert T. Nolte
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:976-980
مصطلحات موضوعية: Stereochemistry, Chemistry, Pharmaceutical, Carboxylic acid, Clinical Biochemistry, Carboxylic Acids, Glycine, Molecular Conformation, Pharmaceutical Science, Crystallography, X-Ray, Imides, Biochemistry, Inhibitory Concentration 50, chemistry.chemical_compound, Glycogen phosphorylase, Dogs, Drug Discovery, Animals, Humans, ortho-Aminobenzoates, Glycogen synthase, Phosphorylase kinase, Molecular Biology, Cytochrome P-450 CYP2C9, chemistry.chemical_classification, Glycogen, biology, Glycogen Phosphorylase, Organic Chemistry, Rats, Amino acid, Enzyme, Diabetes Mellitus, Type 2, Liver, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Aryl Hydrocarbon Hydroxylases
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المؤلفون: Alex G. Waterson, Hamilton D. Dickson, Edgar R. Wood, Michael J. Reno, Thomas R. Caferro, Douglas M. Sammond, Tara Renae Rheault, Stanley D. Chamberlain, Barry R. Keith, Holly Kathleen Emerson, Jennifer G. Badiang Alberti, Robert D. Hubbard, Robert J. Griffin, David W. Rusnak, Robert J. Mullin, Krystal J. Alligood, David E. Uehling, Stephon C. Smith, Kimberly G. Petrov, Roseanne Gerding, Scott Howard Dickerson, Kirk L. Stevens
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:21-26
مصطلحات موضوعية: Pyrrolidines, Receptor, ErbB-2, Stereochemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Antineoplastic Agents, Biochemistry, Receptor tyrosine kinase, Pyrrolidine, Mice, Structure-Activity Relationship, chemistry.chemical_compound, ErbB, Drug Discovery, Animals, Potency, Moiety, Pharmacokinetics, Proline, Epidermal growth factor receptor, Molecular Biology, chemistry.chemical_classification, biology, Organic Chemistry, ErbB Receptors, Pyrimidines, Enzyme, chemistry, biology.protein, Molecular Medicine