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المؤلفون: Scott L. Harbeson, Christopher L. Brummel, Dario Doller, Julie F. Liu, Robert H. Silverman, Roger D. Tung
مصطلحات موضوعية: 0301 basic medicine, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Human studies, Chemistry, Drug discovery, Deuterated drug, 01 natural sciences, Medicinal chemistry, Combinatorial chemistry, 0104 chemical sciences
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ea2fbe425fc282af194b33f639572cfb
https://doi.org/10.1016/bs.armc.2017.08.010 -
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المؤلفون: Lijun Wu, Sunanda Vedananda, Roger D. Tung, Virginia Braman, Scott L. Harbeson, Changfu Cheng
المصدر: Journal of Mass Spectrometry. 48:1019-1031
مصطلحات موضوعية: Chemical structure, Metabolite, virus diseases, Metabolism, Tandem mass spectrometry, Protease inhibitor (biology), Atazanavir, chemistry.chemical_compound, Metabolic pathway, chemistry, Biochemistry, In vivo, medicine, Spectroscopy, medicine.drug
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3
المؤلفون: Lijun Wu, Roger D. Tung, Changfu Cheng, Scott L. Harbeson, Robert E. Zelle, Gary W. Bridson, Richard Gallegos
المصدر: Journal of Mass Spectrometry. 48:640-650
مصطلحات موضوعية: Protease, Chromatography, biology, Metabolite, medicine.medical_treatment, Cytochrome P450, Tandem mass spectrometry, High-performance liquid chromatography, Protease inhibitor (biology), Atazanavir, chemistry.chemical_compound, chemistry, Biochemistry, Structural isomer, medicine, biology.protein, Spectroscopy, medicine.drug
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المؤلفون: Adam J. Morgan, Scott L. Harbeson, Bhaumik A. Pandya, Craig E. Masse
المصدر: Drug Repositioning: Bringing New Life to Shelved Assets and Existing Drugs
مصطلحات موضوعية: Chemistry, Stereochemistry, Yield (chemistry), Site selective, Prodrug, Combinatorial chemistry
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::97579e82a47817037722c37ce5429d3b
https://doi.org/10.1002/9781118274408.ch10 -
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المؤلفون: Craig E. Masse, Adam J. Morgan, Gary W. Bridson, Vinita Uttamsingh, Roger D. Tung, Sophia Nguyen, Scott L. Harbeson
المصدر: Journal of Labelled Compounds and Radiopharmaceuticals. 54:613-624
مصطلحات موضوعية: Human liver, Stereochemistry, Hepatitis C virus, Organic Chemistry, medicine.disease_cause, Biochemistry, In vitro, Analytical Chemistry, chemistry.chemical_compound, chemistry, Pharmacokinetics, Deuterium, Boceprevir, Drug Discovery, Hcv ns3 protease, medicine, Radiology, Nuclear Medicine and imaging, Protease inhibitor (pharmacology), Spectroscopy
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المؤلفون: J. A. Malikayil, Scott L. Harbeson
المصدر: International Journal of Peptide and Protein Research. 39:497-505
مصطلحات موضوعية: chemistry.chemical_classification, Quantitative Biology::Biomolecules, Proton, Stereochemistry, Peptide, Nuclear Overhauser effect, Nuclear magnetic resonance spectroscopy, Dihedral angle, Biochemistry, chemistry.chemical_compound, Molecular dynamics, chemistry, Amide, Two-dimensional nuclear magnetic resonance spectroscopy
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ec4a73d3495451e6c5e550aa408971ea
https://doi.org/10.1111/j.1399-3011.1992.tb00280.x -
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المؤلفون: Gary W. Bridson, Roger D. Tung, Richard Gallegos, Vinita Uttamsingh, David S. Wells, Changfu Cheng, Robert E. Zelle, Julie F. Liu, Philip B. Graham, Scott L. Harbeson
المصدر: The Journal of pharmacology and experimental therapeutics. 354(1)
مصطلحات موضوعية: Neurotransmitter uptake, Pharmacology, Methylenedioxy, chemistry.chemical_compound, Radioligand Assay, Pharmacokinetics, Double-Blind Method, Cytochrome P-450 CYP2D6 Inhibitors, medicine, Animals, Humans, Drug Interactions, 5-HT receptor, Chemistry, Brain, Metabolism, Dextromethorphan, Deuterium, Paroxetine, Rats, Tamoxifen, Cytochrome P-450 CYP2D6, Isotope Labeling, Receptors, Serotonin, Microsome, Microsomes, Liver, Molecular Medicine, Female, Selective Serotonin Reuptake Inhibitors, medicine.drug, Synaptosomes
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4bf7f0aecd4e0c0159fc76ce407e69
https://pubmed.ncbi.nlm.nih.gov/25943764 -
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المؤلفون: Robert B. Perni, Yu-Ping Luong, Scott L. Harbeson, Pravin Chaturvedi, Gurudatt Chandorkar, John A. Thomson, Susan J. Almquist, Yunyi Wei, Randal Byrn, B. Govinda Rao, Gururaj Kalkeri, Kirk Dinehart, Ann D. Kwong, William P. Taylor, Cynthia A. Gates, Roger D. Tung, Kai Lin, Chao Lin, Lawrence F. Courtney, Angela D. Heiser, Caroline Decker, Elaine Kolaczkowski
المصدر: Antimicrobial Agents and Chemotherapy. 50:899-909
مصطلحات موضوعية: Male, Serine Proteinase Inhibitors, Hepatitis C virus, Hepacivirus, medicine.medical_treatment, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Mice, SCID, medicine.disease_cause, Antiviral Agents, Virus, Cell Line, Substrate Specificity, Rats, Sprague-Dawley, Inhibitory Concentration 50, Mice, Dogs, medicine, Animals, Humans, Pharmacology (medical), Replicon, Cells, Cultured, Pharmacology, Serine protease, Binding Sites, Protease, Dose-Response Relationship, Drug, biology, Danoprevir, virus diseases, Hepatitis C, medicine.disease, biology.organism_classification, Virology, digestive system diseases, Rats, Inbred F344, Rats, Infectious Diseases, Area Under Curve, Hepatocytes, biology.protein, RNA, Viral, Oligopeptides, Half-Life
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8312c14c93b23f42d439bf096feffe4
https://doi.org/10.1128/aac.50.3.899-909.2006 -
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المؤلفون: Cynthia A. Gates, John A. Thomson, Kevin M. Cottrell, Yu P. Luong, Scott L. Harbeson, Robert B. Perni, John H. Van Drie, David D. Deininger, Roger D. Tung, Shawn D. Britt, Chao Lin, Janos Pitlik, Luc J. Farmer, John J. Court, Yunyi Wei, John Maxwell, Kai Lin, Bhisetti Govinda Rao, Lawrence F. Courtney, Wayne C. Schairer
المصدر: Letters in Drug Design & Discovery. 2:497-502
مصطلحات موضوعية: NS3, Hepatitis B virus DNA polymerase, Chemistry, Hepatitis C virus, Pharmaceutical Science, medicine.disease_cause, Virology, Hepatitis B virus PRE beta, NS2-3 protease, Drug Discovery, medicine, Molecular Medicine, Proline, Ns3 4a protease
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7d420d4ea1640c769a11c7300ffa8634
https://doi.org/10.2174/157018005774479203 -
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المؤلفون: Kai Lin, Joseph L. Kim, Yu-Ping Luong, Janos Pitlik, Wayne C. Schairer, Chao Lin, Roger D. Tung, Robert B. Perni, John A. Thomson, John Maxwell, Luc J. Farmer, Kevin M. Cottrell, Murcko Mark A, Lawrence F. Courtney, Cynthia A. Gates, John J. Court, John H. Van Drie, David D. Deininger, Wilson Keith P, B. Govinda Rao, Scott L. Harbeson
المصدر: Bioorganic & Medicinal Chemistry Letters. 14:1939-1942
مصطلحات موضوعية: Models, Molecular, Proline, Stereochemistry, Hepatitis C virus, Clinical Biochemistry, Pharmaceutical Science, Peptide, Viral Nonstructural Proteins, medicine.disease_cause, Biochemistry, Structure-Activity Relationship, Viral Proteins, Drug Discovery, medicine, Protease inhibitor (pharmacology), Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Tetrapeptide, Organic Chemistry, Intracellular Signaling Peptides and Proteins, virus diseases, Hepatitis C, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Pharmacophore, Carrier Proteins, Oligopeptides