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المؤلفون: David Beattie, Jacobsen John R, Glenmar P. Obedencio, Scott R. Armstrong, Timothy J. Church, Daniel D. Long, Ross G. Vickery, Pamela R. Tsuruda, Pierre-Jean Colson, Christina B. Campbell, Stergiades Ioanna, Miroslav Rapta, Dalziel Sean M, Daisuke Saito, Priscilla Van Dyke, Lan Jiang
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Drug discovery, medicine.drug_class, business.industry, Organic Chemistry, Central nervous system, Antagonist, Physical dependence, Pharmacology, Biochemistry, Axelopran, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Opioid receptor, Drug Discovery, medicine, medicine.symptom, Penetrant (biochemical), Receptor, business, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05eb2998f1bc2f55f8f113199e7df461
https://europepmc.org/articles/PMC6912869/ -
3دورية أكاديمية
المؤلفون: David T Beattie, Scott R Armstrong, Ross G Vickery, Pam eTsuruda, Christina B Campbell, Carrie eRichardson, Julia eMcCullough, Oranee eDaniels, Kathryn eKersey, Yu-Ping eLi, Karl HS Kim
المصدر: Frontiers in Pharmacology, Vol 2 (2011)
مصطلحات موضوعية: Constipation, Serotonin, 5-HT4, prokinetic, TD-8954, Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
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المؤلفون: Ariel M. Wilson, Taner Dogan, Dan Marquess, Agnieszka Dejda, Pedro J. Beltran, Przemyslaw Sapieha, Rachel Juneau, Rathi D. Ryan, Frédérick A. Mallette, Gabrielle Girouard, Scott R. Armstrong, Vera Guber, Christian Beauséjour, Frédérique Pilon, Priyanka Patel, Frederik Fournier, Alexandre Dubrac, Sonali Dasgupta, Manuel Buscarlet, Sergio Crespo-Garcia, Surabhi R. Rao, Shawnta Y. Chaney, Christopher B. Yohn, Robert O’Brien, Gael Cagnone, Jean-Sebastien Joyal, Pamela R. Tsuruda
المصدر: Cell Metabolism. 33:818-832.e7
مصطلحات موضوعية: Male, 0301 basic medicine, Senescence, Flavonols, Physiology, Angiogenesis, bcl-X Protein, Apoptosis, Mice, Transgenic, Bcl-xL, Tacrolimus, Neovascularization, Mice, 03 medical and health sciences, 0302 clinical medicine, Retinal Diseases, Animals, Humans, Medicine, Senolytic, Molecular Biology, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p16, Retina, Neovascularization, Pathologic, biology, business.industry, Endothelial Cells, Cell Biology, Diabetic retinopathy, medicine.disease, 3. Good health, Collagen Type I, alpha 1 Chain, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, biology.protein, Cancer research, Female, medicine.symptom, business, 030217 neurology & neurosurgery, Retinopathy
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724992eebc54ca734985ab51ac6e1db9
https://doi.org/10.1016/j.cmet.2021.01.011 -
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المؤلفون: Jeng-Pyng Shaw, Daniel Marquess, R. Murray McKinnell, Paul R. Fatheree, David Beattie, Scott R. Armstrong, Daniel D. Long, Ross G. Vickery
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:4210-4215
مصطلحات موضوعية: Male, Agonist, Benzimidazole, Intrinsic activity, medicine.drug_class, Stereochemistry, Guinea Pigs, Clinical Biochemistry, Drug Evaluation, Preclinical, Molecular Conformation, Pharmaceutical Science, Pharmacology, Crystallography, X-Ray, Biochemistry, Rats, Sprague-Dawley, Serotonin 5-HT4 Receptor Agonists, chemistry.chemical_compound, Dogs, Piperidines, Drug Discovery, medicine, Animals, Protein Isoforms, Intestinal Mucosa, Receptor, Molecular Biology, 5-HT receptor, Chemistry, Organic Chemistry, In vitro, Rats, Molecular Medicine, Benzimidazoles, Receptors, Serotonin, 5-HT4, Linker, Half-Life
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المؤلفون: Daniel D. Long, Scott R. Armstrong, David Beattie, Carrie Richardson, Sharath S. Hegde, Christina B. Campbell, Ross G. Vickery, Pamela R. Tsuruda
المصدر: Naunyn-Schmiedeberg's Archives of Pharmacology. 386:471-478
مصطلحات موضوعية: Central Nervous System, Male, medicine.drug_class, Narcotic Antagonists, Administration, Oral, Pain, Pharmacology, Naltrexone, Rats, Sprague-Dawley, Mice, Dogs, Piperidines, Oral administration, Opioid receptor, medicine, Alvimopan, Animals, Morphine, Gastric emptying, business.industry, Antagonist, General Medicine, Smooth muscle contraction, Rats, Substance Withdrawal Syndrome, Analgesics, Opioid, Gastrointestinal Tract, Opioid, Benzamides, Female, business, Tropanes, medicine.drug
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المؤلفون: Patrick P.A. Humphrey, J A M Smith, D. Marquess, J. A. Taylor, C. Sandlund, J.-P. Shaw, David Beattie, Scott R. Armstrong
المصدر: Naunyn-Schmiedeberg's Archives of Pharmacology. 378:139-147
مصطلحات موضوعية: Male, Agonist, Indoles, Tegaserod, Intrinsic activity, Colon, medicine.drug_class, Morpholines, Guinea Pigs, Administration, Oral, Pharmacology, Rats, Sprague-Dawley, Contractility, Serotonin 5-HT4 Receptor Agonists, Dogs, Esophagus, In vivo, medicine, Animals, Gastrointestinal Transit, Antrum, Cisapride, Dose-Response Relationship, Drug, Chemistry, Muscle, Smooth, General Medicine, Mosapride, Rats, Serotonin Receptor Agonists, Benzamides, Female, Azabicyclo Compounds, Muscle Contraction, medicine.drug
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المؤلفون: David Beattie, Scott R. Armstrong, Julia L. McCullough
المصدر: Journal of Pharmacological and Toxicological Methods. 53:198-205
مصطلحات موضوعية: Male, medicine.medical_specialty, Indoles, Tegaserod, medicine.drug_class, Morpholines, Toxicology, Rats, Sprague-Dawley, Piboserod, chemistry.chemical_compound, Esophagus, In vivo, Internal medicine, Oxazines, medicine, Animals, Pharmacology, Cisapride, Dose-Response Relationship, Drug, Isoflurane, Drug Synergism, Muscle, Smooth, Bridged Bicyclo Compounds, Heterocyclic, Receptor antagonist, Mosapride, Rats, Serotonin Receptor Agonists, Renzapride, Sonomicrometry, Endocrinology, chemistry, Anesthetics, Inhalation, Benzamides, Benzimidazoles, Receptors, Serotonin, 5-HT4, Serotonin Antagonists, Muscle Contraction, medicine.drug
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المؤلفون: Paul R. Fatheree, Jacqueline A.M. Smith, Patrick P. Humphrey, David Beattie, S. Derek Turner, Seok-Ki Choi, Roland Gendron, Daniel Marquess, Goldblum Adam A, Ross G. Vickery, Jeng Pyng Shaw, Scott R. Armstrong, Daniel D. Long, Lan Jiang, Daniel Genov
المصدر: Bioorganicmedicinal chemistry letters. 22(19)
مصطلحات موضوعية: Agonist, medicine.medical_specialty, medicine.drug_class, Clinical Biochemistry, Guinea Pigs, Pharmaceutical Science, 5-HT4 receptor, Pharmacology, Biochemistry, chemistry.chemical_compound, Serotonin 5-HT4 Receptor Agonists, Structure-Activity Relationship, Pharmacokinetics, In vivo, Internal medicine, Drug Discovery, medicine, Potency, Animals, Humans, Velusetrag, Receptor, Molecular Biology, Molecular Structure, Chemistry, Drug discovery, Organic Chemistry, Rats, Endocrinology, Chronic Disease, Molecular Medicine, Receptors, Serotonin, 5-HT4, Azabicyclo Compounds, Constipation
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المؤلفون: David Beattie, Daniel D. Long, S. Derek Turner, Paul R. Fatheree, Jacqueline A.M. Smith, Scott R. Armstrong, Seok-Ki Choi, Roland Gendron, Jeng Pyng Shaw, Goldblum Adam A, Daniel Marquess, Ross G. Vickery, Patrick P. Humphrey
المصدر: Bioorganicmedicinal chemistry letters. 22(14)
مصطلحات موضوعية: Agonist, Male, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Pharmacology, Biochemistry, Partial agonist, Piperazines, Cell Line, Rats, Sprague-Dawley, Serotonin 5-HT4 Receptor Agonists, Structure-Activity Relationship, In vivo, Heterocyclic Compounds, Drug Discovery, Enzyme-linked receptor, medicine, Potency, Inverse agonist, Animals, Humans, Receptor, Molecular Biology, Molecular Structure, Drug discovery, Chemistry, Organic Chemistry, musculoskeletal system, Rats, Organ Specificity, Molecular Medicine