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1
المؤلفون: Paul W. Smith, Ian Thomson Forbes, Andrea M. Bradford, Graham Walker, Graham Murkitt, Wyman Paul Adrian, Graeme Irvine Stevenson, Dale James Johnson, Jeannette M. Watson, Steve P. Watson, Adam J. Lucas, Claudette Mookherjee, Fiona Brown, Vincenzo Garzya, Sean Thomas Flynn, Jane Gartlon, Harminder Mudhar
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:5434-5438
مصطلحات موضوعية: Agonist, Indoles, medicine.drug_class, Stereochemistry, education, Clinical Biochemistry, Allosteric regulation, Pharmaceutical Science, Muscarinic Agonists, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Drug Discovery, Muscarinic acetylcholine receptor, medicine, Animals, Molecular Biology, Nootropic Agents, Benzoxazoles, Memory Disorders, Bicyclic molecule, Receptor, Muscarinic M1, Organic Chemistry, Brain, Oxindoles, Rats, chemistry, Lipophilicity, Lactam, Molecular Medicine, Penetrant (biochemical)
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2
المؤلفون: Deirdre M. B. Hickey, Ian Stansfield, Leach Colin Andrew, Caroline M. Whittaker, Ivan Leo Pinto, Stephen A. Smith, Stephen Christopher Martin Fell, Sean Thomas Flynn, Kitty Moores, Helen F. Boyd, Colin J. Theobald, David G. Tew, Roderick A. Porter, Robert John Ife, Kevin J. Milliner, Colin H. Macphee, D. Anthony Rawlings
المصدر: Bioorganic & Medicinal Chemistry Letters. 10:2557-2561
مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Lipoproteins, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Carboxamide, Pyrimidinones, Biochemistry, Chemical synthesis, Phospholipases A, chemistry.chemical_compound, Phospholipase A2, Oral administration, Drug Discovery, medicine, Animals, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Chemistry, Lipoprotein-associated phospholipase A2, Organic Chemistry, Phospholipases A2, Enzyme, Enzyme inhibitor, biology.protein, Lactam, Molecular Medicine, Rabbits
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3
المؤلفون: Martin Jones, Colin J. Theobald, Leach Colin Andrew, Sean Thomas Flynn, Deirdre M. B. Hickey, Ian Stansfield, David G. Tew, Brian Peter Slingsby, Helen F. Boyd, Stephen A. Smith, Kevin J. Milliner, Colin H. Macphee, Robert John Ife, D. Anthony Rawlings
المصدر: Bioorganic & Medicinal Chemistry Letters. 10:395-398
مصطلحات موضوعية: Stereochemistry, High-throughput screening, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Pyrimidinones, Biochemistry, Chemical synthesis, Phospholipases A, Substrate Specificity, Inhibitory Concentration 50, Structure-Activity Relationship, Phospholipase A2, Drug Discovery, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Chemistry, Lipoprotein-associated phospholipase A2, Organic Chemistry, Substrate (chemistry), Phospholipases A2, Enzyme, Enzyme inhibitor, Drug Design, 1-Alkyl-2-acetylglycerophosphocholine Esterase, biology.protein, Molecular Medicine, Selectivity
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4
المؤلفون: Paul W. Smith, Caroline J. Goodacre, Wyman Paul Adrian, Sara A. Coggon, Vong Antonio Kuok Keong, Jeannette M. Watson, William J. Martin, Kirsten L. Searle, Daniel Marcus Bradley, Zining Wu, Peter J. Lovell, Lee A. Dawson, Harrington Frank Peter, David R. Thomas, Roderick A. Porter, Graham Murkitt, Halina T Serafinowska, Sean Thomas Flynn
المصدر: Bioorganicmedicinal chemistry letters. 19(3)
مصطلحات موضوعية: Central Nervous System, Male, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Gerbil, Biochemistry, Rats, Sprague-Dawley, chemistry.chemical_compound, In vivo, Drug Discovery, Talnetant, medicine, Animals, Amines, Molecular Biology, Cerebral Cortex, Chemistry, Organic Chemistry, Quinoline, Antagonist, Brain, Receptors, Neurokinin-3, Rats, Models, Chemical, Area Under Curve, Lipophilicity, Quinolines, Molecular Medicine, Gerbillinae, Ex vivo, medicine.drug
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5
المؤلفون: Laurie J. Gordon, Sean Thomas Flynn, Simon E. Ward, Wyman Paul Adrian, Claire M. Scott, Susan H. Moore, Kevin M. Thewlis, Peter J. Lovell, Peter Eddershaw, Paul W. Smith
المصدر: Bioorganicmedicinal chemistry letters. 19(2)
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Biological Availability, Ligands, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Pharmacokinetics, Drug Discovery, Animals, heterocyclic compounds, Receptor, Molecular Biology, Serotonin transporter, biology, musculoskeletal, neural, and ocular physiology, Organic Chemistry, Quinoline, In vitro, Bioavailability, Rats, nervous system, chemistry, biology.protein, Quinolines, Molecular Medicine, 5-HT1 receptor, Selectivity, Receptors, Serotonin, 5-HT1
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6
المؤلفون: Lee A. Dawson, Wyman Paul Adrian, Howard Robert Marshall, Gary W. Price, Paul W. Smith, Sean Thomas Flynn, Claire M. Scott, Mervyn Thompson, Ron J. King, Michael S. Hadley
المصدر: ChemInform. 37
مصطلحات موضوعية: Intrinsic activity, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Serotonin 5-HT1 Receptor Antagonists, Ligands, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Humans, Selective receptor modulator, Receptor, Molecular Biology, 5-HT receptor, Organic Chemistry, Antagonist, General Medicine, Receptor antagonist, Rats, HYDIA, Piperazine, chemistry, Competitive antagonist, Microsomes, Liver, Molecular Medicine, Serotonin Antagonists, Selectivity
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7
المصدر: Journal of medicinal chemistry. 36(10)
مصطلحات موضوعية: Phosphodiesterase Inhibitors, Pyridines, Isozyme, Amidine, chemistry.chemical_compound, Structure-Activity Relationship, 3',5'-Cyclic-GMP Phosphodiesterases, Drug Discovery, heterocyclic compounds, chemistry.chemical_classification, Bicyclic molecule, Cyclic nucleotide phosphodiesterase, biology, Imidazoles, Phosphodiesterase, musculoskeletal system, Isoenzymes, enzymes and coenzymes (carbohydrates), Enzyme, chemistry, Biochemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, sense organs, PDE10A, circulatory and respiratory physiology