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المؤلفون: Greszler Stephen N, Searle Xenia B, Eric A. Voight, Marek Buchman, Bo Liu, Gang Zhao

المصدر: The Journal of Organic Chemistry. 85:7620-7632

مصطلحات موضوعية: Chemistry, Stereochemistry, Ligand, Organic Chemistry, Enantioselective synthesis, Cycloaddition

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::db8639b920b98beaa1acbaae661ba9a6
https://doi.org/10.1021/acs.joc.0c00820

المؤلفون: Wenqing Gao, Robert J. Altenbach, Gang Zhao, John R. Koenig, Greszler Stephen N, Searle Xenia B, Gregory A. Gfesser, Hong Yong, Corina Balut, Marc J. C. Scanio, Yihong Fan, Michael R. Schrimpf, Philip R. Kym, Timothy A. Vortherms, Andrew M. Swensen, Bo Liu, Arlene M. Manelli, Ying Jia, Xueqing Wang, Chris Tse, Andrew Bogdan, Ashvani K. Singh

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, 010405 organic chemistry, business.industry, Organic Chemistry, Genetic disorder, medicine.disease, 01 natural sciences, Biochemistry, Cystic fibrosis, Transmembrane protein, 0104 chemical sciences, Cftr gene, 010404 medicinal & biomolecular chemistry, Drug Discovery, Cancer research, Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418648a24d9417696c73d206f53310b2
https://doi.org/10.1021/acsmedchemlett.9b00377

المؤلفون: Searle Xenia B, Wenqing Gao, Andrew M. Swensen, Timothy A. Vortherms, Hong Yong, Clinton Yeung, Corina Balut, Philip R. Kym, Yihong Fan, Ashvani K. Singh, Greszler Stephen N, Kelly E. Desino, Andrew Bogdan, Ying Jia, Chris Tse, Xueqing Wang, Bo Liu

المصدر: Journal of Medicinal Chemistry. 61:1436-1449

مصطلحات موضوعية: 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, Cystic Fibrosis, Cell, Cystic Fibrosis Transmembrane Conductance Regulator, Pharmacology, medicine.disease_cause, Benzoates, Cystic fibrosis, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, 0302 clinical medicine, Drug Discovery, medicine, Animals, Humans, Chromans, Benzoic acid, Gastrointestinal tract, Mutation, biology, Potentiator, medicine.disease, Amides, Cystic fibrosis transmembrane conductance regulator, Rats, 030104 developmental biology, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, Mutant Proteins, Pancreas

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7451d4d615499d205ff8e0f34d896f9a
https://doi.org/10.1021/acs.jmedchem.7b01339

المؤلفون: Zhu, Chang Z., Vortherms, Timothy A., Zhang, Min, Xu, Jun, Swensen, Andrew M., Niforatos, Wende, Neelands, Torben, Milicic, Ivan, Lewis, La Geisha, Zhong, Chengmin, Gauvin, Donna, Mikusa, Joseph, Zhan, Cenchen, Pai, Madhavi, Roderwald, Victoria, Chu, Katharine L., Cole, Emily E., Bespalov, Anton, Searle, Xenia B., McGaraughty, Steve, Bitner, Robert S., Jarvis, Michael F., Bannon, Anthony W., Joshi, Shailen K., Scott, Victoria E., Lee, Chih-Hung

المصدر: In Journal of Pain April 2014 15(4):387-387

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المؤلفون: Rodger F. Henry, Steven A. Buckner, Michael E. Brune, Tracy L. Carr, Sweta P. Katwala, Masaki Nakane, Thomas R. Miller, Arthur A. Hancock, Jorge D. Brioni, Anthony V. Daza, Michael Meyer, John C Cain, William A. Carroll, Robert J. Altenbach, Albert Khilevich, Lynne M. Ireland, Fan Yang, Mark W. Holladay, Meena V. Patel, Rohde Jeffrey J, William H. Bunnelle, Chae H Kang, Timothy A. Esbenshade, Donna M. Gauvin, Teodozyj Kolasa, James P. Sullivan, Karin R. Tietje, Jane Kuk, Pramila Bhatia, Alyssa B. O'Neill, Searle Xenia B, Ivan Milicic, Erol K. Bayburt

المصدر: Journal of Medicinal Chemistry. 47:3220-3235

مصطلحات موضوعية: Male, Agonist, Tetrahydronaphthalenes, Stereochemistry, medicine.drug_class, Alpha (ethology), Blood Pressure, In Vitro Techniques, Naphthalenes, Pharmacology, Chemical synthesis, Radioligand Assay, Structure-Activity Relationship, Dogs, Vas Deferens, Urethra, In vivo, Receptors, Adrenergic, alpha-1, Drug Discovery, medicine, Animals, Receptor, Aorta, Active metabolite, Sulfonamides, Chemistry, Imidazoles, Vas deferens, Muscle, Smooth, Rats, medicine.anatomical_structure, Molecular Medicine, Female, Adrenergic alpha-1 Receptor Agonists, Rabbits, Spleen, Phenylpropanolamine, Muscle Contraction, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5013ae295bf243228c84c7a005bf8f58
https://doi.org/10.1021/jm030551a

المؤلفون: Lance Lee, Wende Niforatos, Searle Xenia B, Jun Xu, Chang Z. Zhu, Andrew M. Swensen, Katharine L. Chu, Michael F. Jarvis, Steve McGaraughty

المصدر: Journal of neurophysiology. 111(2)

مصطلحات موضوعية: Male, Nociception, Physiology, Action Potentials, Stimulation, Pharmacology, Administration, Cutaneous, Rats, Sprague-Dawley, chemistry.chemical_compound, Inhibitory Concentration 50, Leucine, medicine, Animals, Peripheral Nerves, Neurotransmitter, Injections, Spinal, Anesthetics, Neurons, Dose-Response Relationship, Drug, General Neuroscience, medicine.disease, Spinal cord, Calcium Channel Blockers, Rats, medicine.anatomical_structure, Spinal Nerves, chemistry, Receptive field, Hyperalgesia, Neuropathic pain, Neuralgia, medicine.symptom, Neuroscience, Azabicyclo Compounds

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278117f5b83eebd8162e4122c0617176
https://pubmed.ncbi.nlm.nih.gov/24155005