يعرض 1 - 10 نتائج من 29 نتيجة بحث عن '"Sebastian Hayes"', وقت الاستعلام: 1.11s تنقيح النتائج
  1. 1
    دورية أكاديمية
    1433 Targeting peptidyl-prolyl isomerase Pin1 to modulate cancer-associated fibroblast phenotype and TGF-beta signaling

    المؤلفون: Krista Goodman, Emily Corse, Catherine Sabatos-Peyton, Hanna Starobinets, Melvyn Chow, Morgan O’Shea, Doga Tasdemir, Kristin Brown, Sebastian Hayes

    المصدر: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

    مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

    وصف الملف: electronic resource

    Relation: https://doaj.org/toc/2051-1426

    URL الوصول: https://doaj.org/article/3f56b6e078e442b2a2767e4a86b8a8b7

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  2. 2
    دورية أكاديمية
    A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition

    المؤلفون: Christopher E. Mahoney, David Pirman, Victor Chubukov, Taryn Sleger, Sebastian Hayes, Zi Peng Fan, Eric L. Allen, Ying Chen, Lingling Huang, Meina Liu, Yingjia Zhang, Gabrielle McDonald, Rohini Narayanaswamy, Sung Choe, Yue Chen, Stefan Gross, Giovanni Cianchetta, Anil K. Padyana, Stuart Murray, Wei Liu, Kevin M. Marks, Joshua Murtie, Marion Dorsch, Shengfang Jin, Nelamangala Nagaraja, Scott A. Biller, Thomas Roddy, Janeta Popovici-Muller, Gromoslaw A. Smolen

    المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

    مصطلحات موضوعية: Science

    وصف الملف: electronic resource

    Relation: https://doaj.org/toc/2041-1723

    URL الوصول: https://doaj.org/article/27aeab8f4bce40e788924435c21f0b77

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  3. 3
    دورية أكاديمية
    Itaconate confers tolerance to late NLRP3 inflammasome activation

    المؤلفون: Monika Bambouskova, Lucie Potuckova, Tomas Paulenda, Martina Kerndl, Denis A. Mogilenko, Kate Lizotte, Amanda Swain, Sebastian Hayes, Ryan D. Sheldon, Hyeryun Kim, Unnati Kapadnis, Abigail E. Ellis, Christine Isaguirre, Samantha Burdess, Anwesha Laha, Gaya K. Amarasinghe, Victor Chubukov, Thomas P. Roddy, Michael S. Diamond, Russell G. Jones, Donald M. Simons, Maxim N. Artyomov

    المصدر: Cell Reports, Vol 34, Iss 10, Pp 108756- (2021)

    مصطلحات موضوعية: immunometabolism, macrophages, itaconate, inflammasome, innate immunity, Biology (General), QH301-705.5

    وصف الملف: electronic resource

    Relation: http://www.sciencedirect.com/science/article/pii/S2211124721000693; https://doaj.org/toc/2211-1247

    URL الوصول: https://doaj.org/article/dfbaa470a8684ff5a4d62690f4e0c2bb

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  4. 4
    دورية أكاديمية
    Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production

    المؤلفون: Brandon M. Gassaway, Rebecca L. Cardone, Anil K. Padyana, Max C. Petersen, Evan T. Judd, Sebastian Hayes, Shuilong Tong, Karl W. Barber, Maria Apostolidi, Abudukadier Abulizi, Joshua B. Sheetz, Kshitiz, Hans R. Aerni, Stefan Gross, Charles Kung, Varman T. Samuel, Gerald I. Shulman, Richard G. Kibbey, Jesse Rinehart

    المصدر: Cell Reports, Vol 29, Iss 11, Pp 3394-3404.e9 (2019)

    مصطلحات موضوعية: Biology (General), QH301-705.5

    وصف الملف: electronic resource

    Relation: http://www.sciencedirect.com/science/article/pii/S2211124719314809; https://doaj.org/toc/2211-1247

    URL الوصول: https://doaj.org/article/843a5a89bddc469f9d601bd5b6452f15

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  5. 5
    Supplementary Data Table S3 from Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase

    المؤلفون: Danielle B. Ulanet, Kevin M. Marks, Josh Murtie, Scott A. Biller, Jonathan Hurov, Georg Lenz, Lenny Dang, Nelamangala Nagaraja, Zhihua Sui, Sreevalsam Gopinath, Thomas Antony, Sunil K. Panigrahi, K. Satish Reddy, Hosahalli Subramanya, Siva Sanjeeva Rao, Kavitha Nellore, Mark Fletcher, Sebastian Hayes, Alan Mann, Tabea Erdmann, Zi-Peng Fan, Charles Locuson, Sebastien Ronseaux, Lei Jin, Anil K. Padyana, Erin Artin, Mya Steadman, Sung Choe, Rohini Narayanaswamy, Kevin Truskowski, John Coco, Victor Chubukov, Gabrielle McDonald

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b4ca858542c027e4592c9d144d2e2b
    https://doi.org/10.1158/1535-7163.22520980.v1

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  6. 6
    Supplementary Data from Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase

    المؤلفون: Danielle B. Ulanet, Kevin M. Marks, Josh Murtie, Scott A. Biller, Jonathan Hurov, Georg Lenz, Lenny Dang, Nelamangala Nagaraja, Zhihua Sui, Sreevalsam Gopinath, Thomas Antony, Sunil K. Panigrahi, K. Satish Reddy, Hosahalli Subramanya, Siva Sanjeeva Rao, Kavitha Nellore, Mark Fletcher, Sebastian Hayes, Alan Mann, Tabea Erdmann, Zi-Peng Fan, Charles Locuson, Sebastien Ronseaux, Lei Jin, Anil K. Padyana, Erin Artin, Mya Steadman, Sung Choe, Rohini Narayanaswamy, Kevin Truskowski, John Coco, Victor Chubukov, Gabrielle McDonald

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0375725bf558a85632625bf90c45d1f
    https://doi.org/10.1158/1535-7163.22520971

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  7. 7
    Data from Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase

    المؤلفون: Danielle B. Ulanet, Kevin M. Marks, Josh Murtie, Scott A. Biller, Jonathan Hurov, Georg Lenz, Lenny Dang, Nelamangala Nagaraja, Zhihua Sui, Sreevalsam Gopinath, Thomas Antony, Sunil K. Panigrahi, K. Satish Reddy, Hosahalli Subramanya, Siva Sanjeeva Rao, Kavitha Nellore, Mark Fletcher, Sebastian Hayes, Alan Mann, Tabea Erdmann, Zi-Peng Fan, Charles Locuson, Sebastien Ronseaux, Lei Jin, Anil K. Padyana, Erin Artin, Mya Steadman, Sung Choe, Rohini Narayanaswamy, Kevin Truskowski, John Coco, Victor Chubukov, Gabrielle McDonald

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c2082a01fe43de83bde9d3812f1570
    https://doi.org/10.1158/1535-7163.c.6542857

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  8. 8
    A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition

    المؤلفون: Lingling Huang, Kevin Marks, Shengfang Jin, Sung Choe, Scott A. Biller, Joshua Murtie, Gromoslaw A. Smolen, Janeta Popovici-Muller, Eric L. Allen, Rohini Narayanaswamy, Stefan Gross, Yingjia Zhang, Wei Liu, Thomas P. Roddy, Gabrielle McDonald, Nelamangala Nagaraja, Marion Dorsch, Anil K. Padyana, Christopher E. Mahoney, Taryn Sleger, Meina Liu, Yue Chen, Stuart Murray, Victor Chubukov, Sebastian Hayes, Giovanni Cianchetta, Ying Chen, Zi Peng Fan, David Pirman

    المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
    Nature Communications

    مصطلحات موضوعية: 0301 basic medicine, Squalene monooxygenase, Science, Cell, Chemical biology, General Physics and Astronomy, Antineoplastic Agents, 02 engineering and technology, Neuroendocrine tumors, Biology, General Biochemistry, Genetics and Molecular Biology, Article, Gene Expression Regulation, Enzymologic, 03 medical and health sciences, Drug Delivery Systems, Cell Line, Tumor, medicine, Humans, lcsh:Science, Regulation of gene expression, Multidisciplinary, Cancer, General Chemistry, 021001 nanoscience & nanotechnology, medicine.disease, Gene Expression Regulation, Neoplastic, 030104 developmental biology, medicine.anatomical_structure, Cholesterol, Squalene Monooxygenase, Cell culture, Cancer cell, Cancer research, lcsh:Q, Drug Screening Assays, Antitumor, 0210 nano-technology, Gene Deletion

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b9963f98863abf7bfee5a9413bdfc9
    https://doaj.org/article/27aeab8f4bce40e788924435c21f0b77

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  9. 9
    Itaconate confers tolerance to late NLRP3 inflammasome activation

    المؤلفون: Lucie Potuckova, Christine Isaguirre, Ryan D. Sheldon, Monika Bambouskova, Amanda Swain, Hyeryun Kim, Samantha Burdess, Maxim N. Artyomov, Martina Kerndl, Tomas Paulenda, Anwesha Laha, Abigail E. Ellis, Victor Chubukov, Michael S. Diamond, Sebastian Hayes, Unnati Kapadnis, Russell G. Jones, Kate Lizotte, Gaya K. Amarasinghe, Donald M. Simons, Thomas P. Roddy, Denis A. Mogilenko

    المصدر: Cell Reports, Vol 34, Iss 10, Pp 108756-(2021)

    مصطلحات موضوعية: 0301 basic medicine, Lipopolysaccharides, Lipopolysaccharide, Inflammasomes, Interleukin-1beta, immunometabolism, Nitric Oxide Synthase Type II, Endogeny, Pyrin domain, chemistry.chemical_compound, Mice, 0302 clinical medicine, Adenosine Triphosphate, Immunology and Allergy, Receptor, innate immunity, lcsh:QH301-705.5, Mice, Knockout, biology, Caspase 1, Toll-Like Receptors, Intracellular Signaling Peptides and Proteins, Inflammasome, Cell biology, macrophages, Nitric oxide synthase, medicine.drug, Signal Transduction, Programmed cell death, Immunology, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, inflammasome, Sepsis, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Pyroptosis, Animals, Hydro-Lyases, Innate immune system, Succinates, Phosphate-Binding Proteins, Mice, Inbred C57BL, 030104 developmental biology, Poly I-C, chemistry, lcsh:Biology (General), itaconate, biology.protein, 030217 neurology & neurosurgery

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::962db5d46cf52479dac062503bbe2428
    http://www.sciencedirect.com/science/article/pii/S2211124721000693

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  10. 10
    Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase

    المؤلفون: K. Satish Reddy, Scott A. Biller, Kavitha Nellore, Siva Sanjeeva Rao, Anil K. Padyana, Georg Lenz, Thomas Antony, Charles Locuson, Jonathan Hurov, Mya Steadman, Tabea Erdmann, Mark Fletcher, Zi Peng Fan, Kevin Truskowski, Sreevalsam Gopinath, Alan Mann, Danielle Ulanet, Rohini Narayanaswamy, Sebastien Ronseaux, Gabrielle McDonald, Sung Choe, Zhihua Sui, John Coco, Lenny Dang, Kevin Marks, Victor Chubukov, Erin Artin, Sebastian Hayes, Josh Murtie, Lei Jin, Nelamangala Nagaraja, Hosahalli Subramanya, Sunil Kumar Panigrahi

    المصدر: Molecular cancer therapeutics. 19(12)

    مصطلحات موضوعية: 0301 basic medicine, Proteomics, Cancer Research, Oxidoreductases Acting on CH-CH Group Donors, Cell Survival, Chemical biology, Dihydroorotate Dehydrogenase, Antineoplastic Agents, Biology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, In vivo, Cell Line, Tumor, medicine, Extracellular, Humans, Enzyme Inhibitors, Neoplasm Staging, Genomics, medicine.disease, Uridine, Lymphoma, Metabolic pathway, 030104 developmental biology, Pyrimidines, Oncology, chemistry, Cell culture, 030220 oncology & carcinogenesis, Hematologic Neoplasms, Cancer research, Dihydroorotate dehydrogenase, DNA Damage

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4f845cc62e9703a40911be67f90bd8
    https://pubmed.ncbi.nlm.nih.gov/33082276

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