-
1
المؤلفون: Magali Mathieu, Jackson Sharon, Guyan Liang, Henry Pauls, Sebastien Maignan, Nieduzak Thaddeus R, Kent W. Neuenschwander, Anthony C. Scotese, Corey R. Hopkins, Dona Cramer, Keith Sides, Jennifer Cairns
المصدر: Bioorganic & Medicinal Chemistry Letters. 14:4819-4823
مصطلحات موضوعية: chemistry.chemical_classification, Serine Proteinase Inhibitors, biology, Serine Endopeptidases, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biological activity, Tryptase, Biochemistry, Chemical synthesis, Mast cell tryptase, Structure-Activity Relationship, Enzyme, chemistry, Enzyme inhibitor, Pyrazines, Drug Discovery, biology.protein, Molecular Medicine, Tryptases, Molecular Biology
-
2
المؤلفون: Alfred P. Spada, Robert J. Leadley, Jonathan S. Mason, Dennis J. Colussi, Ewing William R, Mark H. Perrone, Karen D. Brown, Michael R. Becker, Don D. Cha, Daniel M. Green, Ross Bentley, Henry W. Pauls, Christopher T. Dunwiddie, Jean-Pierre Guilloteau, Y.M. Choi-Sledeski, Sebastien Maignan, Mason Helen J, Vincent E. Manetta, Charles Kasiewski, Valeria Chu, Roderick S. Davis, Suzanne Morgan, Daniel L. Cheney, Jeff Bostwick
المصدر: Journal of Medicinal Chemistry. 42:3557-3571
مصطلحات موضوعية: Models, Molecular, Serine Proteinase Inhibitors, medicine.drug_mechanism_of_action, medicine.drug_class, Factor Xa Inhibitor, Thiophenes, Crystallography, X-Ray, Amidine, Structure-Activity Relationship, chemistry.chemical_compound, Thrombin, In vivo, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Sulfonamides, Molecular Structure, biology, Chemistry, Anticoagulant, Anticoagulants, Stereoisomerism, Thrombosis, Trypsin, Pyrrolidinones, Rats, Biochemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Rabbits, Factor Xa Inhibitors, medicine.drug
-
3
المؤلفون: Jean-Pierre Guilloteau, Qing Zhou-Liu, Vincent Mikol, Christine Clément-Mella, Sebastien Maignan
المصدر: Journal of Molecular Biology. 282:359-368
مصطلحات موضوعية: biology, Stereochemistry, Active site, Integrases, Integrase, Crystallography, chemistry.chemical_compound, Protein structure, chemistry, Structural Biology, biology.protein, A-DNA, DNA Integration, Binding site, Molecular Biology, DNA