لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

المؤلفون: Kimura T; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan.; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan., Hirai S; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan.; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan., Kujirai T; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan., Fujita R; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan., Ogasawara M; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan., Ehara H; RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan., Sekine SI; RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan., Takizawa Y; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan., Kurumizaka H; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan.; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.; RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan.

المصدر: Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2024 Sep; Vol. 29 (9), pp. 769-781. Date of Electronic Publication: 2024 Jul 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Blackwell Science Ltd Country of Publication: England NLM ID: 9607379 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2443 (Electronic) Linking ISSN: 13569597 NLM ISO Abbreviation: Genes Cells Subsets: MEDLINE

مواضيع طبية MeSH: Nucleosomes*/metabolism , Nucleosomes*/ultrastructure , Nucleosomes*/genetics , Histones*/metabolism , Histones*/genetics , Cryoelectron Microscopy*/methods , Mutation* , Neoplasms*/genetics , Neoplasms*/metabolism, Humans ; RNA Polymerase II/metabolism ; RNA Polymerase II/genetics ; DNA/metabolism ; DNA/genetics ; DNA/chemistry

المؤلفون: Liu Y; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210 People's Republic of China., Wang R; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210 People's Republic of China., Chen Q; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210 People's Republic of China., Chang Y; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210 People's Republic of China., Chen Q; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210 People's Republic of China., Fukumoto K; Institute for Protein Research, Osaka University, Osaka 565-0871, Japan.; RIKEN Center for Biosystems Dynamics Research, Yokohama 230-0045, Japan., Wang B; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210 People's Republic of China., Yu J; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210 People's Republic of China., Luo C; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210 People's Republic of China., Ma J; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210 People's Republic of China., Chen X; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210 People's Republic of China.; Zhejiang Provincial Key Laboratory of Pancreatic Disease Hangzhou, Zhejiang University School of Medicine First Affiliated Hospital, Zhejiang 310009, People's Republic of China., Murayama Y; RIKEN Center for Biosystems Dynamics Research, Yokohama 230-0045, Japan., Umeda K; Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan., Kodera N; Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan., Harada Y; Institute for Protein Research, Osaka University, Osaka 565-0871, Japan., Sekine SI; RIKEN Center for Biosystems Dynamics Research, Yokohama 230-0045, Japan., Li J; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210 People's Republic of China.; Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, People's Republic of China., Tadakuma H; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210 People's Republic of China.; Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, People's Republic of China.

المصدر: Nano letters [Nano Lett] 2024 Jul 10; Vol. 24 (27), pp. 8410-8417. Date of Electronic Publication: 2024 Jun 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101088070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-6992 (Electronic) Linking ISSN: 15306984 NLM ISO Abbreviation: Nano Lett Subsets: MEDLINE

مواضيع طبية MeSH: DNA*/chemistry , Nanotechnology*/methods, Animals ; Mice ; Nanostructures/chemistry ; Nanoparticles/chemistry ; RNA, Small Interfering/chemistry ; RNA, Small Interfering/genetics ; RNA, Messenger/genetics ; RNA, Messenger/chemistry ; Gene Expression Regulation ; Organ Specificity ; Nucleic Acid Conformation ; Lipids/chemistry

المؤلفون: Ohyama T; Laboratory for Advanced NMR Application and Development, Center for Biosystems Dynamics Research, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Kanagawa, Japan.; School of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Kanagawa, Japan., Osawa T; Laboratory for Transcription Structural Biology, Center for Biosystems Dynamics Research, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Kanagawa, Japan., Sekine SI; Laboratory for Transcription Structural Biology, Center for Biosystems Dynamics Research, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Kanagawa, Japan., Ishii Y; Laboratory for Advanced NMR Application and Development, Center for Biosystems Dynamics Research, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Kanagawa, Japan.; School of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Kanagawa, Japan.

المصدر: JACS Au [JACS Au] 2024 Mar 20; Vol. 4 (4), pp. 1323-1333. Date of Electronic Publication: 2024 Mar 20 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101775714 Publication Model: eCollection Cited Medium: Internet ISSN: 2691-3704 (Electronic) Linking ISSN: 26913704 NLM ISO Abbreviation: JACS Au Subsets: PubMed not MEDLINE

المؤلفون: Sekine SI; Laboratory for Transcription Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan. Electronic address: shunichi.sekine@riken.jp., Ehara H; Laboratory for Transcription Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan., Kujirai T; Laboratory for Transcription Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan., Kurumizaka H; Laboratory for Transcription Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. Electronic address: kurumizaka@iqb.u-tokyo.ac.jp.

المصدر: Trends in cell biology [Trends Cell Biol] 2024 Mar; Vol. 34 (3), pp. 211-224. Date of Electronic Publication: 2023 Aug 16.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Science Publishers Country of Publication: England NLM ID: 9200566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3088 (Electronic) Linking ISSN: 09628924 NLM ISO Abbreviation: Trends Cell Biol Subsets: MEDLINE

مواضيع طبية MeSH: Chromatin*/genetics , Nucleosomes*/genetics, Humans ; Transcription, Genetic ; DNA ; RNA Polymerase II/genetics ; RNA Polymerase II/metabolism ; Chromatin Assembly and Disassembly

المؤلفون: Bunch H; Department of Applied Biosciences, Kyungpook National University, Daegu, 41566, Republic of Korea. heeyounbunch@gmail.com.; School of Applied Biosciences, College of Agriculture & Life Sciences, Kyungpook National University, Daegu, 41566, Republic of Korea. heeyounbunch@gmail.com., Kim D; School of Applied Biosciences, College of Agriculture & Life Sciences, Kyungpook National University, Daegu, 41566, Republic of Korea.; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea., Naganuma M; Laboratory for Transcription Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Japan., Nakagawa R; RIKEN BDR Laboratory for Phyloinformatics, Hyogo, 650-0047, Japan., Cong A; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, 55905, USA., Jeong J; Department of Applied Biosciences, Kyungpook National University, Daegu, 41566, Republic of Korea., Ehara H; Laboratory for Transcription Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Japan., Vu H; Department of Biology Education, Kyungpook National University, Daegu, 41566, Republic of Korea., Chang JH; Department of Biology Education, Kyungpook National University, Daegu, 41566, Republic of Korea., Schellenberg MJ; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, 55905, USA., Sekine SI; Laboratory for Transcription Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Japan.

المصدر: Nature communications [Nat Commun] 2023 Dec 14; Vol. 14 (1), pp. 8341. Date of Electronic Publication: 2023 Dec 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Genes, Immediate-Early* , Mitogen-Activated Protein Kinase 1*/metabolism, Humans ; DNA/metabolism ; DNA Topoisomerases, Type II/genetics ; DNA Topoisomerases, Type II/metabolism ; Etoposide ; Phosphorylation ; Transcriptional Activation

المؤلفون: Akatsu M; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo, Tokyo, Japan; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo, Tokyo, Japan., Ehara H; Laboratory for Transcription Structural Biology, RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan., Kujirai T; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo, Tokyo, Japan; Laboratory for Transcription Structural Biology, RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan., Fujita R; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo, Tokyo, Japan., Ito T; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo, Tokyo, Japan., Osumi K; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo, Tokyo, Japan., Ogasawara M; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo, Tokyo, Japan., Takizawa Y; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo, Tokyo, Japan., Sekine SI; Laboratory for Transcription Structural Biology, RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan. Electronic address: shunichi.sekine@riken.jp., Kurumizaka H; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo, Tokyo, Japan; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo, Tokyo, Japan; Laboratory for Transcription Structural Biology, RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan. Electronic address: kurumizaka@iqb.u-tokyo.ac.jp.

المصدر: The Journal of biological chemistry [J Biol Chem] 2023 Dec; Vol. 299 (12), pp. 105477. Date of Electronic Publication: 2023 Nov 17.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Histones*/metabolism , Nucleosomes* , RNA Polymerase II*/metabolism, Chromatin ; Cryoelectron Microscopy ; DNA/metabolism ; Transcriptional Elongation Factors/metabolism

المؤلفون: Hirai S; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan., Kujirai T; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan., Akatsu M; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan., Ogasawara M; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan., Ehara H; Laboratory for Transcription Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan., Sekine SI; Laboratory for Transcription Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan., Ohkawa Y; Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi, Fukuoka 812-0054, Japan., Takizawa Y; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan., Kurumizaka H; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.; Laboratory for Transcription Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.

المصدر: Journal of biochemistry [J Biochem] 2023 Nov 30; Vol. 174 (6), pp. 549-559.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0376600 Publication Model: Print Cited Medium: Internet ISSN: 1756-2651 (Electronic) Linking ISSN: 0021924X NLM ISO Abbreviation: J Biochem Subsets: MEDLINE

مواضيع طبية MeSH: Histones*/genetics , Nucleosomes*, Humans ; Cryoelectron Microscopy ; DNA/chemistry ; RNA Polymerase II/metabolism

المؤلفون: Oishi T; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan., Hatazawa S; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan., Kujirai T; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.; Laboratory for Transcription Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan., Kato J; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan., Kobayashi Y; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan., Ogasawara M; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan., Akatsu M; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan., Ehara H; Laboratory for Transcription Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan., Sekine SI; Laboratory for Transcription Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan., Hayashi G; Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan., Takizawa Y; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan., Kurumizaka H; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.; Laboratory for Transcription Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.

المصدر: Nucleic acids research [Nucleic Acids Res] 2023 Oct 27; Vol. 51 (19), pp. 10364-10374.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

مواضيع طبية MeSH: Histones*/genetics , Histones*/metabolism , Nucleosomes*/genetics, RNA Polymerase II/genetics ; Acetylation ; Chromatin

المؤلفون: Osawa T; Laboratory for Transcription Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan., Aoki M; Laboratory for Transcription Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan., Ehara H; Laboratory for Transcription Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan., Sekine SI; Laboratory for Transcription Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan. Electronic address: shunichi.sekine@riken.jp.

المصدر: Molecular cell [Mol Cell] 2023 Aug 03; Vol. 83 (15), pp. 2781-2791.e4. Date of Electronic Publication: 2023 Jul 20.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

مواضيع طبية MeSH: Dengue Virus*/genetics, Animals ; Humans ; Cryoelectron Microscopy ; Binding Sites ; RNA-Dependent RNA Polymerase/metabolism ; RNA Caps ; Viral Nonstructural Proteins/genetics ; Viral Nonstructural Proteins/metabolism ; Virus Replication ; RNA, Viral/metabolism