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المؤلفون: John P. Overington, Daniel Domine, Fanny Beltran Escudie, Alexander Roberts, Gerard J. P. van Westen, Serge Christmann-Franck, George Papadatos
المصدر: Journal of Chemical Information and Modeling, 56(9), 1654-1675
Journal of Chemical Information and Modelingمصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Protein Conformation, General Chemical Engineering, Library and Information Sciences, Biology, computer.software_genre, Article, Substrate Specificity, 03 medical and health sciences, 0302 clinical medicine, Protein structure, Kinome, Kinase activity, Protein kinase A, Protein Kinase Inhibitors, Kinase, Drug discovery, Reproducibility of Results, Genomics, General Chemistry, Small molecule, Computer Science Applications, Cancer treatment, 030104 developmental biology, Drug Design, 030220 oncology & carcinogenesis, Data mining, Protein Kinases, computer
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c7fa043270ab809590de16d717965a8
http://hdl.handle.net/1887/133513 -
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المؤلفون: Serge Christmann-Franck, Daniel Cravo, Cele Abad-Zapatero
المصدر: Molecular informatics. 30(2-3)
مصطلحات موضوعية: Structural Biology, Organic Chemistry, Drug Discovery, Molecular Medicine, Computer Science Applications
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المؤلفون: Cele Abad-Zapatero, Cravo Daniel, Serge Christmann-Franck
المصدر: Molecular Informatics. 30:137-144
مصطلحات موضوعية: Structural Biology, Cheminformatics, Drug discovery, Computer science, Organic Chemistry, Drug Discovery, Molecular Medicine, Bioinformatics, Data science, Computer Science Applications
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المؤلفون: Fabien Schmidlin, Sophie Bozec, Franck F. Lepifre, Denis Carniato, Serge Christmann-Franck, Eric Valeur, Caroline Leriche, Didier Roche, Marc Lecomte, Liliane Doare, Christine Charon
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:3682-3685
مصطلحات موضوعية: Drug, Molecular model, medicine.drug_class, Stereochemistry, media_common.quotation_subject, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Structure-Activity Relationship, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Drug Discovery, medicine, Humans, Computer Simulation, Spiro Compounds, Enzyme Inhibitors, Binding site, Molecular Biology, IC50, media_common, chemistry.chemical_classification, Binding Sites, Organic Chemistry, Amides, Enzyme, chemistry, Drug Design, Molecular Medicine, Selectivity
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المؤلفون: Eric Valeur, Marc Lecomte, Christine Charon, Caroline Leriche, Franck F. Lepifre, Liliane Doare, Fabien Schmidlin, Denis Carniato, Serge Christmann-Franck, Didier Roche, Ulrich Graedler, Sophie Bozec
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:2674-2678
مصطلحات موضوعية: Stereochemistry, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Drug design, Carboxamide, Dehydrogenase, Biochemistry, Chemical synthesis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, 11-beta-Hydroxysteroid Dehydrogenase Type 2, 3T3-L1 Cells, Amide, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Drug Discovery, medicine, Animals, Humans, Enzyme Inhibitors, Molecular Biology, IC50, chemistry.chemical_classification, Organic Chemistry, Amides, Rats, Enzyme, chemistry, Molecular Medicine, Lead compound, hormones, hormone substitutes, and hormone antagonists
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المؤلفون: Per Hillertz, Eric Valeur, Christine Charon, Didier Roche, Serge Christmann-Franck, Djordje Musil, Denis Carniato, Liliane Doare, Sophie Bozec, Fabien Schmidlin, Melanie Schultz, Cravo Daniel, Franck F. Lepifre, Marc Lecomte
المصدر: Bioorganicmedicinal chemistry letters. 22(18)
مصطلحات موضوعية: Models, Molecular, Indoles, Pyrrolidines, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Dehydrogenase, Biochemistry, Pyrrolidine, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Drug Discovery, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Potency, Structure–activity relationship, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, 11β hydroxysteroid dehydrogenase, Amides, chemistry, Drug Design, Molecular Medicine, Structure based, Cellular model, Selectivity, hormones, hormone substitutes, and hormone antagonists
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المؤلفون: Serge Christmann-Franck, et al. et al.
المصدر: ChemInform. 40
مصطلحات موضوعية: chemistry.chemical_classification, Chemistry, Stereochemistry, 11β hydroxysteroid dehydrogenase, General Medicine, Bridged compounds
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المساهمون: Laboratoire de Biologie et de Pharmacologie Appliquée (LBPA), École normale supérieure - Cachan (ENS Cachan)-Centre National de la Recherche Scientifique (CNRS), Institut Gustave Roussy (IGR), Biochimie des signaux régulateurs cellulaires et moléculaires (BSRCM), Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)
المصدر: Biochimie
Biochimie, Elsevier, 2007, 89 (4), pp.468-73. ⟨10.1016/j.biochi.2006.10.007⟩
Biochimie, 2007, 89 (4), pp.468-73. ⟨10.1016/j.biochi.2006.10.007⟩مصطلحات موضوعية: Models, Molecular, Pyridoxal, Human dna, Protein Conformation, Stereochemistry, chemical and pharmacologic phenomena, Biology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Protein structure, MESH: Protein Conformation, immune system diseases, medicine, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Candida guilliermondii, Binding site, MESH: Pyridoxal, 030304 developmental biology, 0303 health sciences, Binding Sites, MESH: Humans, Topoisomerase, MESH: DNA Topoisomerases, Type I, Eukaryotic, fungi, General Medicine, Phosphate, Adenosine, 3. Good health, nervous system diseases, DNA Topoisomerases, Type I, chemistry, MESH: Binding Sites, 030220 oncology & carcinogenesis, biology.protein, lipids (amino acids, peptides, and proteins), MESH: Models, Molecular, medicine.drug
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المؤلفون: Serge Christmann-Franck, Serge Fermandjian, P. Arsène Der Garabedian, Rémy Hoffmann, Anne Goupil-Lamy, Olivier Mauffret, Hugues-Olivier Bertrand
المساهمون: Laboratoire de Biologie et de Pharmacologie Appliquée (LBPA), École normale supérieure - Cachan (ENS Cachan)-Centre National de la Recherche Scientifique (CNRS), Accelrys, Biochimie des signaux régulateurs cellulaires et moléculaires (BSRCM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)
المصدر: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2004, 47 (27), pp.6840-53. ⟨10.1021/jm049745w⟩
Journal of Medicinal Chemistry, American Chemical Society, 2004, 47 (27), pp.6840-53. ⟨10.1021/jm049745w⟩مصطلحات موضوعية: Models, Molecular, Molecular model, MESH: Antigens, Neoplasm, MESH: Amino Acid Sequence, 0302 clinical medicine, Protein structure, Drug Discovery, Topoisomerase II Inhibitors, Enzyme Inhibitors, 0303 health sciences, biology, Molecular Structure, Chemistry, 3. Good health, DNA-Binding Proteins, Biochemistry, Enzyme inhibitor, MESH: Enzyme Inhibitors, 030220 oncology & carcinogenesis, Molecular Medicine, medicine.symptom, Pharmacophore, Dimerization, MESH: Models, Molecular, Molecular Sequence Data, MESH: Molecular Structure, MESH: Sequence Alignment, 03 medical and health sciences, Antigens, Neoplasm, medicine, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Amino Acid Sequence, MESH: Templates, Genetic, 030304 developmental biology, MESH: DNA Topoisomerases, Type II, Eukaryotic, Virtual screening, Binding Sites, MESH: Humans, MESH: Molecular Sequence Data, Topoisomerase, Templates, Genetic, DNA Topoisomerases, Type II, Mechanism of action, Structural biology, MESH: Binding Sites, MESH: Dimerization, biology.protein, Sequence Alignment, MESH: DNA-Binding Proteins
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المؤلفون: Leon V. Karabashyan, Serge Christmann-Franck, Jacqueline J. Vermeersch, Serge Fermandjian, Gilles Mirambeau, P. Arsène Der Garabedian
المساهمون: Biochimie des signaux régulateurs cellulaires et moléculaires (BSRCM), Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Laboratoire de Biologie et de Pharmacologie Appliquée (LBPA), École normale supérieure - Cachan (ENS Cachan)-Centre National de la Recherche Scientifique (CNRS), Accelrys, Institute of Molecular Biology, National Academy Science of Armenia, Institut Gustave Roussy (IGR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)
المصدر: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2004, 32 (18), pp.5649-57. ⟨10.1093/nar/gkh897⟩
Nucleic Acids Research, 2004, 32 (18), pp.5649-57. ⟨10.1093/nar/gkh897⟩مصطلحات موضوعية: Models, Molecular, Lysine, Peptide, chemical and pharmacologic phenomena, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, immune system diseases, Genetics, Humans, MESH: Lysine, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Enzyme Inhibitors, Binding site, Pyridoxal phosphate, Pyridoxal, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Binding Sites, MESH: Humans, biology, MESH: Adenosine Diphosphate, Topoisomerase, MESH: DNA Topoisomerases, Type I, Eukaryotic, Active site, Articles, nervous system diseases, Adenosine Diphosphate, Enzyme, DNA Topoisomerases, Type I, chemistry, Biochemistry, MESH: Binding Sites, MESH: Enzyme Inhibitors, Pyridoxal Phosphate, 030220 oncology & carcinogenesis, biology.protein, lipids (amino acids, peptides, and proteins), MESH: Pyridoxal Phosphate, MESH: Models, Molecular
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29a2114da9f7369dc300ce147921422
https://hal.archives-ouvertes.fr/hal-00284752
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