المؤلفون: Wuyts S; European Molecular Biology Laboratory, Heidelberg, Germany., Alves R; European Molecular Biology Laboratory, Heidelberg, Germany., Zimmermann-Kogadeeva M; European Molecular Biology Laboratory, Heidelberg, Germany., Nishijima S; European Molecular Biology Laboratory, Heidelberg, Germany., Blasche S; European Molecular Biology Laboratory, Heidelberg, Germany.; Medical Research Council Toxicology Unit, Cambridge, UK., Driessen M; European Molecular Biology Laboratory, Heidelberg, Germany., Geyer PE; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany., Hercog R; European Molecular Biology Laboratory, Heidelberg, Germany., Kartal E; European Molecular Biology Laboratory, Heidelberg, Germany., Maier L; European Molecular Biology Laboratory, Heidelberg, Germany., Müller JB; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany., Garcia Santamarina S; European Molecular Biology Laboratory, Heidelberg, Germany., Schmidt TSB; European Molecular Biology Laboratory, Heidelberg, Germany., Sevin DC; Cellzome, GlaxoSmithKline R&D, Heidelberg, Germany., Telzerow A; European Molecular Biology Laboratory, Heidelberg, Germany., Treit PV; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany., Wenzel T; European Molecular Biology Laboratory, Heidelberg, Germany., Typas A; European Molecular Biology Laboratory, Heidelberg, Germany., Patil KR; European Molecular Biology Laboratory, Heidelberg, Germany.; Medical Research Council Toxicology Unit, Cambridge, UK., Mann M; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.; Proteomics Program, NNF Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark., Kuhn M; European Molecular Biology Laboratory, Heidelberg, Germany., Bork P; European Molecular Biology Laboratory, Heidelberg, Germany.; Max Delbrück Centre for Molecular Medicine, Berlin, Germany.; Yonsei Frontier Lab (YFL), Yonsei University, Seoul, South Korea.; Department of Bioinformatics, Biocenter, University of Würzburg, Würzburg, Germany.

المصدر: Molecular systems biology [Mol Syst Biol] 2023 Sep 12; Vol. 19 (9), pp. e11525. Date of Electronic Publication: 2023 Jul 24.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: EMBO Press Country of Publication: England NLM ID: 101235389 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-4292 (Electronic) Linking ISSN: 17444292 NLM ISO Abbreviation: Mol Syst Biol Subsets: MEDLINE

مواضيع طبية MeSH: Multiomics* , Microbiota*/genetics, Humans ; RNA, Ribosomal, 16S/genetics ; Metabolomics/methods ; Bacteria/genetics ; Metagenomics/methods

المؤلفون: Jardi F; Preclinical Sciences & Translational Safety, Janssen Pharmaceutica NV, Beerse, Belgium. fjardi@its.jnj.com., Kelly C; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Teague C; GlaxoSmithKline, Non-Clinical Safety, Ware, UK., Fowler-Williams H; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Sevin DC; Omics Sciences, Genomic Sciences, GlaxoSmithKline, Heidelberg, Germany., Rodrigues D; Department of Toxicogenomics, GROW School for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands., Jo H; Certara UK Limited, Simcyp Division, Sheffield, UK., Ferreira S; Certara UK Limited, Simcyp Division, Sheffield, UK., Herpers B; Crown Bioscience Netherlands, Leiden, The Netherlands., Van Heerden M; Preclinical Sciences & Translational Safety, Janssen Pharmaceutica NV, Beerse, Belgium., de Kok T; Department of Toxicogenomics, GROW School for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands., Pin C; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK., Lynch A; GlaxoSmithKline, Non-Clinical Safety, Ware, UK., Duckworth CA; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., De Jonghe S; Preclinical Sciences & Translational Safety, Janssen Pharmaceutica NV, Beerse, Belgium., Lammens L; Preclinical Sciences & Translational Safety, Janssen Pharmaceutica NV, Beerse, Belgium., Pritchard DM; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.

المصدر: Archives of toxicology [Arch Toxicol] 2023 Jan; Vol. 97 (1), pp. 235-254. Date of Electronic Publication: 2022 Oct 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: Fluorouracil*/toxicity , Apoptosis*, Humans ; Animals ; Mice ; Caspase 3/metabolism ; Diarrhea/chemically induced ; Organoids ; Intestinal Mucosa

المؤلفون: Khan MM; European Molecular Biology Laboratory, Heidelberg, Germany.; Discovery Biology, Cellzome GmbH, GSK, Heidelberg, Germany.; Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany., Poeckel D; Discovery Biology, Cellzome GmbH, GSK, Heidelberg, Germany., Halavatyi A; European Molecular Biology Laboratory, Heidelberg, Germany.; Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany., Zukowska-Kasprzyk J; European Molecular Biology Laboratory, Heidelberg, Germany., Stein F; European Molecular Biology Laboratory, Heidelberg, Germany., Vappiani J; Discovery Biology, Cellzome GmbH, GSK, Heidelberg, Germany., Sevin DC; Discovery Biology, Cellzome GmbH, GSK, Heidelberg, Germany., Tischer C; European Molecular Biology Laboratory, Heidelberg, Germany., Zinn N; Discovery Biology, Cellzome GmbH, GSK, Heidelberg, Germany., Eley JD; Novel Human Genetics Research Unit, GSK, Stevenage, UK., Gudmann NS; Nordic Bioscience, Herlev, Denmark., Muley T; Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.; Biobank Thoraxklinik, University Hospital Heidelberg, Heidelberg, Germany., Winter H; Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.; Biobank Thoraxklinik, University Hospital Heidelberg, Heidelberg, Germany., Fisher AJ; Newcastle University Translational and Clinical Research Institute and Institute of Transplantation, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, UK., Nanthakumar CB; Novel Human Genetics Research Unit, GSK, Stevenage, UK., Bergamini G; Discovery Biology, Cellzome GmbH, GSK, Heidelberg, Germany.; G. Bergamini and R. Pepperkok contributed equally to this article as lead authors and supervised the work., Pepperkok R; European Molecular Biology Laboratory, Heidelberg, Germany pepperko@embl.de.; Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.; G. Bergamini and R. Pepperkok contributed equally to this article as lead authors and supervised the work.

المصدر: The European respiratory journal [Eur Respir J] 2021 Jul 01; Vol. 58 (1). Date of Electronic Publication: 2021 Jul 01 (Print Publication: 2021).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: European Respiratory Society Country of Publication: England NLM ID: 8803460 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1399-3003 (Electronic) Linking ISSN: 09031936 NLM ISO Abbreviation: Eur Respir J Subsets: MEDLINE

مواضيع طبية MeSH: Microscopy* , Pulmonary Fibrosis*/pathology, Fibrosis ; Humans ; Lung/pathology ; Proteomics ; Transforming Growth Factor beta1

المؤلفون: Perrin J; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Werner T; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Kurzawa N; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Rutkowska A; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Childs DD; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Kalxdorf M; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Poeckel D; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Stonehouse E; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Strohmer K; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Heller B; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Thomson DW; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Krause J; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Becher I; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Eberl HC; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Vappiani J; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Sevin DC; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Rau CE; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Franken H; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Huber W; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Faelth-Savitski M; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany., Savitski MM; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. mikhail.savitski@embl.de., Bantscheff M; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany. marcus.x.bantscheff@gsk.com., Bergamini G; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany. giovanna.2.bergamini@gsk.com.

المصدر: Nature biotechnology [Nat Biotechnol] 2020 Mar; Vol. 38 (3), pp. 303-308. Date of Electronic Publication: 2020 Jan 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE

مواضيع طبية MeSH: Blood/*metabolism , Proteome/*chemistry , Proteome/*metabolism , Small Molecule Libraries/*administration & dosage, Animals ; Azepines/administration & dosage ; Azepines/pharmacology ; Hep G2 Cells ; Humans ; Kidney/chemistry ; Kidney/metabolism ; Liver/chemistry ; Liver/metabolism ; Lung/chemistry ; Lung/metabolism ; Male ; Mass Spectrometry ; Mice ; Organ Specificity ; Panobinostat/administration & dosage ; Panobinostat/pharmacology ; Protein Stability ; Rats ; Small Molecule Libraries/pharmacology ; Spleen/chemistry ; Spleen/metabolism ; Testis/chemistry ; Testis/metabolism ; Thermodynamics ; Triazoles/administration & dosage ; Triazoles/pharmacology ; Vemurafenib/administration & dosage ; Vemurafenib/pharmacology