نتائج البحث - "Shababa T. Masoud"

1

دورية أكاديمية

Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

المؤلفون: Dan Xia, Steve Lianoglou, Thomas Sandmann, Meredith Calvert, Jung H. Suh, Elliot Thomsen, Jason Dugas, Michelle E. Pizzo, Sarah L. DeVos, Timothy K. Earr, Chia-Ching Lin, Sonnet Davis, Connie Ha, Amy Wing-Sze Leung, Hoang Nguyen, Roni Chau, Ernie Yulyaningsih, Isabel Lopez, Hilda Solanoy, Shababa T. Masoud, Chun-chi Liang, Karin Lin, Giuseppe Astarita, Nathalie Khoury, Joy Yu Zuchero, Robert G. Thorne, Kevin Shen, Stephanie Miller, Jorge J. Palop, Dylan Garceau, Michael Sasner, Jennifer D. Whitesell, Julie A. Harris, Selina Hummel, Johannes Gnörich, Karin Wind, Lea Kunze, Artem Zatcepin, Matthias Brendel, Michael Willem, Christian Haass, Daniel Barnett, Till S. Zimmer, Anna G. Orr, Kimberly Scearce-Levie, Joseph W. Lewcock, Gilbert Di Paolo, Pascal E. Sanchez

المصدر: Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-29 (2022)

مصطلحات موضوعية: Neuritic plaques, Vascular amyloid, Neurodegeneration, Astrogliosis, Phagocytic microglia, Lipid dyshomeostasis, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1750-1326

URL الوصول: https://doaj.org/article/9eb417ef38964cb082e476c72c827f5f

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2

LRRK2 Kinase Activity Regulates Parkinson’s Disease-Relevant Lipids at the Lysosome

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::dc13473cd36348881c86cb13ff023e4d
https://doi.org/10.1101/2022.12.19.521070

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Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo

المؤلفون: Ali Salahpour, Reza Nazari, David S. Goldstein, Amy R. Dunn, Nikhil M. Urs, Laura M. Vecchio, Rong Fu, Amy J. Ramsey, Emil Gregersen, Marie Kristel Bermejo, Poul Henning Jensen, Shababa T. Masoud, Patricia Sullivan, Gary W. Miller

المصدر: Journal of Neurochemistry
Vecchio, L M, Sullivan, P, Dunn, A R, Bermejo, M K, Fu, R, Masoud, S T, Gregersen, E, Urs, N M, Nazari, R, Jensen, P H, Ramsey, A, Goldstein, D S, Miller, G W & Salahpour, A 2021, ' Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo ', Journal of Neurochemistry, vol. 158, no. 4, pp. 960-979 . https://doi.org/10.1111/jnc.15432

مصطلحات موضوعية: Male, 0301 basic medicine, Dopamine, Gene Dosage, medicine.disease_cause, Biochemistry, Mice, 0302 clinical medicine, Catecholamines, tyrosine hydroxylase, oxidative stress, Neurons, chemistry.chemical_classification, Molecular Basis of Disease, Chemistry, Parkinson Disease, Methamphetamine, Glutathione, 3. Good health, Female, Original Article, dopamine, medicine.drug, medicine.medical_specialty, Tyrosine 3-Monooxygenase, amphetamine, Mice, Transgenic, 03 medical and health sciences, Cellular and Molecular Neuroscience, Internal medicine, medicine, Humans, Animals, Amphetamine, Reactive oxygen species, Tyrosine hydroxylase, Dopaminergic Neurons, Hydrogen Peroxide, Oxidative Stress, 030104 developmental biology, Endocrinology, DOPAL, Catecholamine, 3,4-Dihydroxyphenylacetic Acid, Central Nervous System Stimulants, Catecholaminergic cell groups, ORIGINAL ARTICLES, 030217 neurology & neurosurgery, Oxidative stress

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f82860774e8f1b29a1ed1ce7f861ff
http://europepmc.org/articles/PMC8376767

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4

Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease

المصدر: Science Translational Medicine. 14

مصطلحات موضوعية: Mice, Mutation, Animals, Humans, Parkinson Disease, General Medicine, Phosphorylation, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Lysosomes

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d447b718b56152fa35afc4ad299bcf
https://doi.org/10.1126/scitranslmed.abj2658

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ETV:SGSH, a brain-penetrant enzyme transport vehicle for SGSH, corrects heparan sulfate accumulation, lysosomal lipid storage and inflammation in MPS IIIA mouse brain

المؤلفون: Shababa T. Masoud, Mohammad Jafarnejad, Hoang Nguyen, Buyankhishig Tsogtbaatar, Yashas Rajendra, Alexander Seay, Elliot R. Thomsen, Kensuke Yamanokuchi, Annie Arguello, Meng Fang, Cathal S. Mahon, Pascal Sanchez, Dolo Diaz, Anna Bakardjiev, Kirk Henne

المصدر: Molecular Genetics and Metabolism. 138:107223

مصطلحات موضوعية: Endocrinology, Endocrinology, Diabetes and Metabolism, Genetics, Molecular Biology, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cf95d87959ec98f4011eeacf9ee0962a
https://doi.org/10.1016/j.ymgme.2022.107223

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6

Fibrillar Aβ causes profound microglial metabolic perturbations in a novel APP knock-in mouse model

مصطلحات موضوعية: Pathogenesis, Transcriptome, medicine.anatomical_structure, Lipid accumulation, Microglia, Parenchyma, Neurodegeneration, medicine, Knock in mouse, Biology, medicine.disease, Vascular amyloid, Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::740621cd30fb1a8feec1aa4ace66f9b6
https://doi.org/10.1101/2021.01.19.426731

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Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits

المساهمون: Institute of Nanoscopy (IoN), RS: M4I - Nanoscopy

المصدر: Molecular Psychiatry, 21(11), 1561-1572. Nature Publishing Group
Molecular psychiatry 21, 1561–1572 (2016). doi:10.1038/mp.2015.194
Molecular Psychiatry

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Dopamine, Dopamine Plasma Membrane Transport Proteins, Mice, Transgenic, Nerve Tissue Proteins, Striatum, Synaptic Transmission, Rats, Sprague-Dawley, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, DISC1, 0302 clinical medicine, Internal medicine, Dopamine receptor D2, medicine, Animals, Homeostasis, Humans, ddc:610, Amphetamine, Molecular Biology, Dopamine transporter, Neurons, Behavior, Animal, biology, Receptors, Dopamine D2, Brain, Rats, Mice, Inbred C57BL, Disease Models, Animal, Psychiatry and Mental health, 030104 developmental biology, Endocrinology, Schizophrenia, biology.protein, Original Article, Psychopharmacology, Rats, Transgenic, Psychology, Neuroscience, 030217 neurology & neurosurgery, medicine.drug