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المؤلفون: Matthew T. Cifone, YongLe He, Rajeswari Basu, Nan Wang, Shabnam Davoodi, Lauren A. Spagnuolo, Yuanyuan Si, Taraneh Daryaee, Craig E. Stivala, Stephen G. Walker, Peter J. Tonge
المصدر: Journal of Medicinal Chemistry. 65:16510-16525
مصطلحات موضوعية: Catalytic Domain, Drug Discovery, Escherichia coli, Molecular Medicine, Enzyme Inhibitors, Acetyl-CoA Carboxylase, Anti-Bacterial Agents
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المؤلفون: Yi-Qian Li, William G. Lannigan, Shabnam Davoodi, Fereidoon Daryaee, Ana Corrionero, Patricia Alfonso, Jose A. Rodriguez-Santamaria, Nan Wang, John D. Haley, Peter J. Tonge
المصدر: Journal of Medicinal Chemistry.
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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3
المؤلفون: Carmela Passaro, Balazs Koscso, Sean Smith, Violet Young, Theresa Ross, Benjamin Primack, Natasha Ly, Patricia Timpug, Shabnam Davoodi, Rachel Burga, Gauri Kulkarni, Scott Lajoie, Meghan Langley, Nirzari Shah, Dexue Sun, Dan Jun Li, Raina Duan, Arman Aksoy, Mithun Khattar, Jeremy Tchaicha, Dhruv Sethi, Jan ter Meulen, Michelle Ols
المصدر: Regular and Young Investigator Award Abstracts.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::abeaefdb3592feda17eb301b997df324
https://doi.org/10.1136/jitc-2022-sitc2022.0369 -
4Correlating Drug–Target Residence Time and Post-antibiotic Effect: Insight into Target Vulnerability
المصدر: ACS Infect Dis
مصطلحات موضوعية: 0301 basic medicine, animal structures, Bacteria, business.industry, 030106 microbiology, Drug target, Antimicrobial pharmacodynamics, Vulnerability, Microbial Sensitivity Tests, Residence time (fluid dynamics), Article, Anti-Bacterial Agents, 03 medical and health sciences, 030104 developmental biology, Infectious Diseases, Drug Development, Environmental health, Medicine, business
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المؤلفون: Thien Anh Le, Sneha Basak, Bernd Engels, Johannes Schiebel, Josef Kehrein, Jonas D. Weinrich, Benjamin Merget, Peter J. Tonge, Caroline Kisker, Christoph A. Sotriffer, S. Eltschkner, Shabnam Davoodi
المصدر: ACS Infect Dis
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Staphylococcus aureus, INHA, Stereochemistry, 030106 microbiology, Substituent, Substrate (chemistry), Context (language use), Mycobacterium tuberculosis, Reductase, Tautomer, Article, Isoenzymes, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Infectious Diseases, Enzyme, Structural biology, chemistry, Isomerism, Enzyme Inhibitors, Oxidoreductases
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المؤلفون: Sandra Eltschkner, Weixuan Yu, Jonathan Merino, Caroline Kisker, James J. Truglio, Eleanor K. H. Allen, Ben Moree, Neil Thivalapill, Shabnam Davoodi, Lauren A. Spagnuolo, Peter J. Tonge, Joshua Salafsky, Richard A. Slayden, Fereidoon Daryaee, Annica Pschibul, Susan E. Knudson
المصدر: Journal of the American Chemical Society. 139:3417-3429
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Time Factors, Stereochemistry, Kinetics, Triazole, Crystallography, X-Ray, Biochemistry, Article, Catalysis, Reaction coordinate, 03 medical and health sciences, chemistry.chemical_compound, Colloid and Surface Chemistry, Humans, Inhibins, Enzyme kinetics, Molecular Structure, Chemistry, INHA, Diphenyl ether, General Chemistry, Triazoles, Combinatorial chemistry, Transition state, 030104 developmental biology, Thermodynamics, Lead compound
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المؤلفون: S. Shah, Caroline Kisker, Pan Pan, Gopal R. Bommineni, Jochen Kuper, Maria Hirschbeck, Annica Pschibul, Nina Liu, Fereidoon Daryaee, Carla Neckles, Junjie Zou, Cheng Tsung Lai, Shabnam Davoodi, Carlos Simmerling, Peter J. Tonge, Cristina Lai
المصدر: Biochemistry. 55:2992-3006
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Protein Conformation, Pyridones, Yersinia pestis, Stereochemistry, 030106 microbiology, Molecular Dynamics Simulation, Reductase, Crystallography, X-Ray, medicine.disease_cause, Biochemistry, Catalysis, Article, Mycobacterium tuberculosis, 03 medical and health sciences, chemistry.chemical_compound, Oxidoreductase, Catalytic Domain, medicine, Enzyme Inhibitors, chemistry.chemical_classification, biology, Phenyl Ethers, Diphenyl ether, NAD, biology.organism_classification, Enoyl-(Acyl-Carrier-Protein) Reductase (NADH), 030104 developmental biology, Enzyme, chemistry, Staphylococcus aureus, Mutation, Mutagenesis, Site-Directed, NAD+ kinase, Crystallization, Protein Binding
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المؤلفون: Gopal R. Bommineni, Weixuan Yu, Jason E. Cummings, Lauren A. Spagnuolo, Carla Neckles, Maria Hirschbeck, Shabnam Davoodi, Sandra Eltschkner, Caroline Kisker, Zhuo Zhang, Richard A. Slayden, Peter J. Tonge, Fereidoon Daryaee
المصدر: Biochemistry. 56(13)
مصطلحات موضوعية: 0301 basic medicine, Burkholderia pseudomallei, Stereochemistry, 030106 microbiology, Kinetics, Colony Count, Microbial, Gene Expression, Microbial Sensitivity Tests, Reductase, Molecular Dynamics Simulation, Crystallography, X-Ray, Biochemistry, Protein Structure, Secondary, Article, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Bacterial Proteins, Oxidoreductase, Structure–activity relationship, Animals, Enzyme Inhibitors, Lung, chemistry.chemical_classification, Mice, Inbred BALB C, Binding Sites, biology, Phenyl Ethers, Diphenyl ether, biology.organism_classification, Enoyl-(Acyl-Carrier-Protein) Reductase (NADH), Receptor–ligand kinetics, Transition state, Anti-Bacterial Agents, 030104 developmental biology, chemistry, Melioidosis, Female, Spleen, Protein Binding