المؤلفون: Powell, Noel A., Hoffman, Jennifer K., Ciske, Fred L., Kaufman, Michael D., Kohrt, Jeffrey T., Quin, John, III, Sheehan, Derek J., Delaney, Amy, Baxi, Sangita M., Catana, Cornel, McConnell, Patrick, Ohren, Jeff, Perrin, Lisa A., Edmunds, Jeremy J.

المصدر: In Bioorganic & Medicinal Chemistry Letters 15 February 2013 23(4):1046-1050

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المؤلفون: Toogood PL; Medicinal Chemistry, Cancer Pharmacology, and Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, Michigan 48105, USA. Peter.toogood2@pfizer.com, Harvey PJ, Repine JT, Sheehan DJ, VanderWel SN, Zhou H, Keller PR, McNamara DJ, Sherry D, Zhu T, Brodfuehrer J, Choi C, Barvian MR, Fry DW

المصدر: Journal of medicinal chemistry [J Med Chem] 2005 Apr 07; Vol. 48 (7), pp. 2388-406.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*chemical synthesis , Cyclin-Dependent Kinases/*antagonists & inhibitors , Piperazines/*chemical synthesis , Proto-Oncogene Proteins/*antagonists & inhibitors , Pyridines/*chemical synthesis , Pyrimidines/*chemical synthesis, Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Biological Availability ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cyclin-Dependent Kinase 4 ; Cyclin-Dependent Kinase 6 ; G1 Phase/drug effects ; Humans ; Male ; Piperazines/chemistry ; Piperazines/pharmacology ; Pyridines/chemistry ; Pyridines/pharmacology ; Pyrimidines/chemistry ; Pyrimidines/pharmacology ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; Thymidine/metabolism