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1
المؤلفون: Hiroaki Inagaki, Toru Taniguchi, Isao Yasumatsu, Masaki Kiga, Yoshihiro Shibata, Akiko Toyota, Hiroki Shimizu, Takashi Odagiri, Yasuyuki Kaneta, Daichi Baba, Shin Iimura, Kiyono Ueda, Tomoki Imaoka, Maki Seo, Kiyoshi Nakayama
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: 010405 organic chemistry, Kinase, Chemistry, Stereochemistry, Organic Chemistry, FER tyrosine kinase, Chemical modification, 01 natural sciences, Biochemistry, 0104 chemical sciences, Chemical library, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, In vivo, Drug Discovery, Pyridine, Transferase, Tyrosine kinase
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2
المؤلفون: Ken Ichi Yoshida, Isao Yasumatsu, Takeshi Isoyama, Yumi Matsui, Fumie Tanzawa, Yutaka Ikeno, Shin Iimura, Hiroyuki Hanzawa, Takako Nawano, Osamu Ubukata, Hajime Fukano
المصدر: Acta Crystallographica Section F Structural Biology Communications. 74:156-160
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, MAPK/ERK pathway, Protein Conformation, Biophysics, Protein Serine-Threonine Kinases, Crystallography, X-Ray, Biochemistry, Research Communications, 03 medical and health sciences, 0302 clinical medicine, Eukaryotic translation, Structural Biology, Catalytic Domain, Genetics, Humans, Transferase, Amino Acid Sequence, Kinase activity, Protein kinase A, Protein Kinase Inhibitors, Kinase, Chemistry, EIF4E, Intracellular Signaling Peptides and Proteins, Condensed Matter Physics, Cell biology, 030104 developmental biology, 030220 oncology & carcinogenesis, Phosphorylation, Crystallization
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3
المؤلفون: Jean-Marc Lapierre, Cathy O. Bull, Ronald E. Savage, Sudharshan Eathiraj, David Vensel, Sapna Makhija, Eugene Kelleher, Neil Westlund, Jeff Szwaya, Yanbin Liu, Steffi Koerner, Magdi Moussa, Susan Cornell-Kennon, Akihisa Matsuda, Darin Kizer, Nivedita Namdev, Hui Wu, Shin Iimura, Brian Schwartz, Erika Volckova
المصدر: Journal of Medicinal Chemistry. 59:6455-6469
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Allosteric regulation, Administration, Oral, Aminopyridines, AKT1, Antineoplastic Agents, AKT2, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Allosteric Regulation, Drug Discovery, Animals, Humans, Moiety, Protein Kinase Inhibitors, Protein kinase B, Cell Proliferation, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Kinase, Imidazoles, Neoplasms, Experimental, Endometrial Neoplasms, 030104 developmental biology, Enzyme, chemistry, 030220 oncology & carcinogenesis, embryonic structures, Molecular Medicine, Phosphorylation, Female, Drug Screening Assays, Antitumor, Carcinoma, Endometrioid, Proto-Oncogene Proteins c-akt
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4
المؤلفون: Fumihito Muro, Shinji Tanaka, Tomonori Yamasaki, Shin Iimura, Tadashi Toki, Mika Yokoyama, Kaoru Morishita, Hiroki Shimizu, Takanori Yasukochi, Yoshiyuki Yoneda
المصدر: Biological and Pharmaceutical Bulletin. 37:87-95
مصطلحات موضوعية: Male, Down-Regulation, Gene Expression, Pharmaceutical Science, Arthritis, Pharmacology, Heterocyclic Compounds, 2-Ring, Proinflammatory cytokine, Arthritis, Rheumatoid, Mice, NF-KappaB Inhibitor alpha, Downregulation and upregulation, medicine, Animals, Tissue Distribution, Phosphorylation, Kinase activity, Protein Kinase Inhibitors, Mice, Inbred BALB C, Interleukin-6, Tumor Necrosis Factor-alpha, Kinase, Chemistry, NF-kappa B, General Medicine, medicine.disease, Arthritis, Experimental, I-kappa B Kinase, IκBα, Mice, Inbred DBA, Antirheumatic Agents, Benzamides, Immunology, Cytokines, Female, I-kappa B Proteins, Joints, Tumor necrosis factor alpha, Inflammation Mediators, Signal transduction, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64654d27c48e504481fd51a8d942f595
https://doi.org/10.1248/bpb.b13-00628 -
5
المؤلفون: Atsushi Nakayama, Yutaka Iigo, Jun Chiba, Masaki Setoguchi, Yoshiyuki Yoneda, Shin Iimura, Tohru Takashi, Mika Yokoyama, Toshiyuki Watanabe, Misato Aonuma, Gensuke Takayama, Fumihito Muro, Yuuichi Sugimoto, Tomoe Taira, Nobuo Machinaga
المصدر: Bioorganic & Medicinal Chemistry. 21:42-61
مصطلحات موضوعية: Pyrrolidines, Cyclohexanecarboxylic Acids, Stereochemistry, Clinical Biochemistry, Anti-Inflammatory Agents, Administration, Oral, Biological Availability, Pharmaceutical Science, Bronchi, Integrin alpha4beta1, Biochemistry, Pyrrolidine, Cell Line, Mice, chemistry.chemical_compound, In vivo, Drug Discovery, Acetylcholine Chloride, medicine, Animals, Humans, Moiety, Molecular Biology, Mice, Inbred BALB C, Organic Chemistry, Antagonist, Water, Haplorhini, Cyclohexanecarboxylic acid, Human serum albumin, Asthma, Bioavailability, Eosinophils, Solubility, chemistry, Molecular Medicine, Female, medicine.drug
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6
المؤلفون: Tomoe Taira, Misato Aonuma, Tohru Takashi, Mika Yokoyama, Jun Chiba, Toshiyuki Watanabe, Gensuke Takayama, Yuuichi Sugimoto, Yoshiyuki Yoneda, Masaki Setoguchi, Yutaka Iigo, Fumihito Muro, Atsushi Nakayama, Shin Iimura, Nobuo Machinaga
المصدر: Bioorganic & Medicinal Chemistry. 20:1201-1212
مصطلحات موضوعية: Cyclohexanecarboxylic Acids, Stereochemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Bronchi, Integrin alpha4beta1, Bronchoalveolar Lavage, Biochemistry, Cell Line, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, Drug Discovery, medicine, Animals, Humans, Phenyl group, Structure–activity relationship, Molecular Biology, Mice, Inbred BALB C, medicine.diagnostic_test, Organic Chemistry, Antagonist, Cyclohexanecarboxylic acid, Eosinophil, Asthma, In vitro, Eosinophils, Bronchoalveolar lavage, medicine.anatomical_structure, chemistry, Molecular Medicine, Female
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7
المؤلفون: Tadashi Toki, Mika Yokoyama, Kaoru Morishita, Shinji Tanaka, Tomoaki Hamada, Shin Iimura, Tomonori Yamasaki, Takanori Yasukochi, Fumihito Muro, Hiroki Shimizu, Yoshiyuki Yoneda
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:4550-4555
مصطلحات موضوعية: Clinical Biochemistry, Drug Evaluation, Preclinical, Administration, Oral, Pharmaceutical Science, Arthritis, Inflammation, IκB kinase, Pharmacology, Biochemistry, Pyridazine, Mice, chemistry.chemical_compound, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Protein Kinase Inhibitors, Molecular Biology, Tumor Necrosis Factor-alpha, Chemistry, Organic Chemistry, Imidazoles, medicine.disease, Arthritis, Experimental, I-kappa B Kinase, Rats, Pyridazines, Disease Models, Animal, Molecular Medicine, Tumor necrosis factor alpha, medicine.symptom, Collagen-induced arthritis
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8
المؤلفون: Isao Yasumatsu, Tadashi Toki, Shinji Tanaka, Toshihiko Akimoto, Kaoru Morishita, Tomonori Yamasaki, Takanori Yasukochi, Shin Iimura, Hiroki Shimizu
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:5113-5118
مصطلحات موضوعية: Models, Molecular, Molecular model, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Pyridazine, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Structure–activity relationship, Protein Kinase Inhibitors, Molecular Biology, Kinase, Drug discovery, Chemistry, Organic Chemistry, Imidazoles, Hit to lead, I-kappa B Kinase, Pyridazines, Molecular Medicine
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9
المؤلفون: Atsushi Satoh, Masao Tsubokawa, Jun Chiba, Fumito Muro, Nobuo Machinaga, Atsushi Nakayama, Yutaka Iigou, Shin Iimura, Yoshiyuki Yoneda, Gensuke Takayama, Tohru Takashi, Mika Yokoyama, Toshiyuki Watanabe
المصدر: Bioorganic & Medicinal Chemistry. 15:1679-1693
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Integrin alpha4beta1, Pharmacology, Benzoates, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Pharmacokinetics, Oral administration, Drug Discovery, Animals, Pleurisy, Molecular Biology, IC50, Benzoic acid, Inflammation, Organic Chemistry, Antagonist, Biological activity, Rats, Bioavailability, Disease Models, Animal, chemistry, Molecular Medicine
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10
المؤلفون: Tohru Takashi, Mika Yokoyama, Jun Chiba, Fumito Muro, Takao Horiuchi, Yutaka Iigou, Tomomi Ogasawara, Nobuo Machinaga, Atsushi Nakayama, Shin Iimura, Yuichi Ochiai, Gensuke Takayama, Yoshiyuki Yoneda, Yoshimi Takata, Tomoe Taira, Yuichi Sugimoto, Masao Tsubokawa
المصدر: Chemical and Pharmaceutical Bulletin. 54:1515-1529
مصطلحات موضوعية: Male, Cell Membrane Permeability, Pyrrolidines, Stereochemistry, Drug Evaluation, Preclinical, Molecular Conformation, Administration, Oral, Stereoisomerism, Integrin alpha4beta1, Kidney, Benzoates, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Drug Discovery, medicine, Animals, Structure–activity relationship, IC50, Benzoic acid, Mice, Inbred BALB C, Antagonist, VLA-4, General Chemistry, General Medicine, Human serum albumin, Asthma, Pyrrolidinones, Rats, Enzyme Activation, Disease Models, Animal, chemistry, Lipophilicity, Hydroxybenzoate Ethers, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b500c4c2d5a713262c292b29b04d0a
https://doi.org/10.1248/cpb.54.1515