-
1
المؤلفون: Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d97954935b2f34d5dfe50e66a1f7f5
https://doi.org/10.1158/2159-8290.22531945.v1 -
2
المؤلفون: Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd472a11c8ff29b3f26438ea494ea5d
https://doi.org/10.1158/2159-8290.22531936 -
3
المؤلفون: Samuel F. Bakhoum, Benjamin Izar, Eileen E. Parkes, Alexander N. Shoushtari, Charles Swanton, Olivier Elemento, Jedd D. Wolchok, Simon N. Powell, Neil Vasan, Anusha Kalbasi, Shin-San Michael Su, Nadeem Riaz, Jorge S. Reis-Filho, Hannah Y. Wen, Taha Merghoub, Travis J. Hollmann, Benjamin J. DiPardo, Lee Gottesdiener, Chantal Pauli, Peng Li, Julie-Ann Cavallo, Princesca Dorsaint, Maria Laura Martin, Hao Wei Li, Rohan Bareja, Dhruva Biswas, Ieva Usaite, Kevin Litchfield, Sreeram Vallabhaneni, Johannes C. Melms, Matthew G. Hanna, Jacqueline A. James, Manuel Salto-Tellez, Matthew P. Humphries, Roshan K. Sriram, John Kwon, Sarah E. Bettigole, Walid K. Chatila, Ninjit Dhanota, Mercedes A. Duran, Jun Li
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635ea996437975f580871317155e428c
https://doi.org/10.1158/2159-8290.22540268.v1 -
4
المؤلفون: Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf9f6f1fb6d2a1049263137b504fc3a
https://doi.org/10.1158/2159-8290.22531939 -
5
المؤلفون: Samuel F. Bakhoum, Benjamin Izar, Eileen E. Parkes, Alexander N. Shoushtari, Charles Swanton, Olivier Elemento, Jedd D. Wolchok, Simon N. Powell, Neil Vasan, Anusha Kalbasi, Shin-San Michael Su, Nadeem Riaz, Jorge S. Reis-Filho, Hannah Y. Wen, Taha Merghoub, Travis J. Hollmann, Benjamin J. DiPardo, Lee Gottesdiener, Chantal Pauli, Peng Li, Julie-Ann Cavallo, Princesca Dorsaint, Maria Laura Martin, Hao Wei Li, Rohan Bareja, Dhruva Biswas, Ieva Usaite, Kevin Litchfield, Sreeram Vallabhaneni, Johannes C. Melms, Matthew G. Hanna, Jacqueline A. James, Manuel Salto-Tellez, Matthew P. Humphries, Roshan K. Sriram, John Kwon, Sarah E. Bettigole, Walid K. Chatila, Ninjit Dhanota, Mercedes A. Duran, Jun Li
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af51a233154e60a4e2bb2d77e8270d96
https://doi.org/10.1158/2159-8290.c.6549335 -
6
المؤلفون: Mercedes Duran, Princesca Dorsaint, Julie-Ann Cavallo, Shin-San Michael Su, Dhruva Biswas, Taha Merghoub, Maria Laura Martin, Sreeram Vallabhaneni, Simon N. Powell, Manuel Salto-Tellez, Jedd D. Wolchok, Neil Vasan, Anusha Kalbasi, Nadeem Riaz, Hannah Y Wen, Samuel F. Bakhoum, Jun Li, Benjamin J DiPardo, Jacqueline James, Charles Swanton, Lee S. Gottesdiener, Olivier Elemento, John Kwon, Benjamin Izar, Alexander N. Shoushtari, Rohan Bareja, Hao Wei Li, Matthew G. Hanna, Johannes C. Melms, Ieva Usaite, Kevin Litchfield, Ninjit Dhanota, Matthew P. Humphries, Eileen Parkes, Travis J Hollmann, Roshan K. Sriram, Chantal Pauli, Sarah E Bettigole, Jorge S. Reis-Filho, Peng Li, Walid K. Chatila
المصدر: Li, J, Duran, M A, Dhanota, N, Chatila, W K, Bettigole, S E, Kwon, J, Sriram, R K, Humphries, M P, Salto-Tellez, M, James, J A, Hanna, M G, Melms, J C, Vallabhaneni, S, Litchfield, K, Usaite, I, Biswas, D, Bareja, R, Li, H W, Martin, M L, Dorsaint, P, Cavallo, J-A, Li, P, Pauli, C, Gottesdiener, L, DiPardo, B J, Hollmann, T J, Merghoub, T, Wen, H Y, Reis-Filho, J S, Riaz, N, Su, S-S M, Kalbasi, A, Vasan, N, Powell, S N, Wolchok, J D, Elemento, O, Swanton, C, Shoushtari, A N, Parkes, E E, Izar, B & Bakhoum, S F 2020, ' Metastasis and immune evasion from extracellular cGAMP hydrolysis ', Cancer discovery, vol. Early Online, pp. xx . https://doi.org/10.1158/2159-8290.CD-20-0387
Cancer Discovمصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, Inflammation, Article, Metastasis, Mice, 03 medical and health sciences, 0302 clinical medicine, Immune system, SDG 3 - Good Health and Well-being, Neoplasms, medicine, Extracellular, Animals, Humans, Neoplasm Metastasis, Mice, Inbred BALB C, Innate immune system, Chemistry, Hydrolysis, Immunotherapy, biochemical phenomena, metabolism, and nutrition, medicine.disease, Immune checkpoint, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, bacteria, Tumor Escape, Nucleotides, Cyclic, medicine.symptom
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3a80cefbaee3bdab1ee35690a87c04
https://pure.qub.ac.uk/en/publications/metastasis-and-immune-evasion-from-extracellular-cgamp-hydrolysis(6d7c17ea-11d5-406d-8d68-1f1010b32751).html -
7AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations
المؤلفون: Olivia Bawa, Monika Pilichowska, Paule Opolon, Jeffrey O. Saunders, Fang Wang, Cyril Quivoron, Anil K. Padyana, Zenon D. Konteatis, Kimberly Straley, Erica Tobin, Sophie Broutin, Marion Dorsch, Hua Yang, Byron DeLaBarre, Jeremy Travins, Sung Choe, Yue Chen, Lei Jin, Wentao Wei, Virginie Penard-Lacronique, Raj Nagaraja, Wei Liu, Lenny Dang, Shengfang Jin, Cheng Fang, Lee Silverman, Fan Jiang, Katharine E. Yen, Giovanni Cianchetta, Olivier Bernard, Erin Artin, Muriel D. David, Shin-San Michael Su, Stefan Gross, Francesco G. Salituro, Véronique Saada, Stéphane de Botton, Scott A. Biller, Angelo Paci, Benoit S. Marteyn, Yingxia Xu
المساهمون: Agios Pharmaceuticals, Hématopoïèse normale et pathologique (U1170 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Gustave Roussy (IGR)-Université Paris-Sud - Paris 11 (UP11), Institut Gustave Roussy (IGR), Plateforme d’évaluation préclinique (PFEP), Analyse moléculaire, modélisation et imagerie de la maladie cancéreuse (AMMICa), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Pharmacologie, Département de biologie et pathologie médicales [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Laboratoire de thérapie cellulaire, Département de médecine oncologique [Gustave Roussy], Pathogénie microbienne moléculaire, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Tufts Medical Center, ShangPharma, Viva Biotech Ltd., This work was funded by Agios Pharmaceuticals, Inc., the French National Institute of Health (INSERM-AVIESAN), the National Cancer Institute (INCa-DGOS-Inserm_6043 and INCa 2012-1-RT-09), and the Fondation Association pour la Recherche sur le Cancer (ARC, SL220130607089 Programme Labellisé to V. Penard-Lacronique and S. de Botton). M.D. David is funded by a fellowship from the Institut National du Cancer (INCa-DGOS_5733).
المصدر: Cancer Discovery
Cancer Discovery, American Association for Cancer Research, 2017, 7 (5), pp.478-493. ⟨10.1158/2159-8290.CD-16-1034⟩مصطلحات موضوعية: 0301 basic medicine, Myeloid, IDH1, Cellular differentiation, Myeloid leukemia, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, Enasidenib, medicine.disease, Molecular biology, IDH2, 03 medical and health sciences, Leukemia, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Isocitrate dehydrogenase, Oncology, 030220 oncology & carcinogenesis, medicine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e5319b71d47ef568ebb071e758566cc
https://doi.org/10.1158/2159-8290.cd-16-1034 -
8
المؤلفون: Gajja S. Salomons, Yong Cang, Scott A. Biller, Hua Yang, Josh Powe, Dongwei Zhu, Stefan Gross, Stuart Murray, Kimberly Straley, Samuel V. Agresta, Karen S. Regan, Katharine E. Yen, Yaguang Si, Mya Steadman, Wei Liu, Lenny Dang, Ana Pop, Yue Chen, Erin Artin, Marion Dorsch, Jeremy Travins, Stephanie Santiago, Shengfang Jin, Muriel D. David, Cyril Quivoron, Andrew Kernytsky, Virginie Penard-Lacronique, Lee Silverman, Chenming Lu, Shin San Michael Su, Zhizhong Lin, Erwin E.W. Jansen, Fang Wang, Eduard A. Struys
المساهمون: Laboratory Medicine, Amsterdam Neuroscience - Cellular & Molecular Mechanisms
المصدر: Journal of Inherited Metabolic Disease
Journal of Inherited Metabolic Disease, 39(6), 807-820. Springer Netherlands
Wang, F, Travins, J, Lin, Z, Si, Y, Chen, Y, Powe, J, Murray, S, Zhu, D, Artin, E, Gross, S, Santiago, S, Steadman, M, Kernytsky, A, Straley, K, Lu, C, Pop, A, Struys, E A, Jansen, E E W, Salomons, G S, David, M D, Quivoron, C, Penard-Lacronique, V, Regan, K S, Liu, W, Dang, L, Yang, H, Silverman, L, Agresta, S, Dorsch, M, Biller, S, Yen, K, Cang, Y, Su, S S M & Jin, S 2016, ' A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model ', Journal of Inherited Metabolic Disease, vol. 39, no. 6, pp. 807-820 . https://doi.org/10.1007/s10545-016-9960-yمصطلحات موضوعية: 0301 basic medicine, Mutant, Cardiomyopathy, Locus (genetics), Biology, IDH2, Germline, Small Molecule Libraries, 03 medical and health sciences, Epilepsy, Mice, Genetics, medicine, Animals, Genetics(clinical), Gene, Genetics (clinical), chemistry.chemical_classification, Brain Diseases, Metabolic, Inborn, medicine.disease, Isocitrate Dehydrogenase, Disease Models, Animal, 030104 developmental biology, Enzyme, chemistry, Mutation, Cancer research, Original Article, Cardiomyopathies
-
9
المؤلفون: Yingxia Xu, Shin-San Michael Su, Zhiwei Gu, Scott A. Biller, Charles Kung, Xiaobing Lv, Cheng Fang, Collin Hill, Yaguang Si, Zhiyong Luo, Penelope A. Kosinski, Francesco G. Salituro, Lenny Dang, Huachun Tang, Hua Yang, Lee Silverman, Kendall Johnson, Janeta Popovici-Muller, Gui Yao, Jeff Hixon, Gavin Histen, Stefan Gross, Yue Chen, Byron DeLaBarre, Giovanni Cianchetta
مصطلحات موضوعية: Hemolytic anemia, Erythrocytes, Anemia, Immunology, Allosteric regulation, Pyruvate Kinase, Enzyme Activators, Pharmacology, Biology, Pyruvate Metabolism, Inborn Errors, Biochemistry, Piperazines, 03 medical and health sciences, Mice, 0302 clinical medicine, Red Cells, Iron, and Erythropoiesis, medicine, Animals, Humans, Glycolysis, chemistry.chemical_classification, Sulfonamides, Cell Biology, Hematology, Anemia, Hemolytic, Congenital Nonspherocytic, medicine.disease, Molecular biology, Recombinant Proteins, Tissue Donors, Enzyme Activation, Kinetics, Enzyme, chemistry, 030220 oncology & carcinogenesis, Quinolines, Pyruvate kinase, Ex vivo, 030215 immunology, Pyruvate kinase deficiency
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb277a9c117d8e84c9102a59b1821f1f
https://europepmc.org/articles/PMC5609468/ -
10
المؤلفون: Shin-San Michael Su, Lenny Dang
المصدر: Annual review of biochemistry. 86
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, IDH1, Benzeneacetamides, Gene Expression, Antineoplastic Agents, Biology, Nicotinamide adenine dinucleotide, medicine.disease_cause, Biochemistry, IDH2, Glutarates, Small Molecule Libraries, Translational Research, Biomedical, 03 medical and health sciences, chemistry.chemical_compound, Acetamides, Drug Discovery, medicine, Biomarkers, Tumor, Humans, Epigenetics, Enzyme Inhibitors, Genetics, Mutation, Imidazoles, Myeloid leukemia, Isocitrate Dehydrogenase, Isoenzymes, Leukemia, Myeloid, Acute, 030104 developmental biology, Isocitrate dehydrogenase, chemistry, Benzimidazoles, Carcinogenesis
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128e7195d805bd89b5ade88ff1e701ce
https://pubmed.ncbi.nlm.nih.gov/28375741