المؤلفون: Shao, Hao, Taguwa, Shuhei, Gilbert, Luke, Shkedi, Arielle, Sannino, Sara, Guerriero, Christopher J, Gale-Day, Zachary J, Young, Zapporah T, Brodsky, Jeffrey L, Weissman, Jonathan, Gestwicki, Jason E, Frydman, Judith

المصدر: Cell Chemical Biology. 29(8)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Breast Cancer, Cancer, Good Health and Well Being, Binding Sites, Endoplasmic Reticulum Chaperone BiP, HSP70 Heat-Shock Proteins, Molecular Chaperones, Protein Domains, Hsp70, allosteric inhibitors, anti-cancer, antivirals, chaperones, chemical biology, subcellular localization, Biochemistry and cell biology, Medicinal and biomolecular chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3m5613rk

المؤلفون: Shkedi, Arielle, Taylor, Isabelle R, Echtenkamp, Frank, Ramkumar, Poornima, Alshalalfa, Mohamed, Rivera-Márquez, Génesis M, Moses, Michael A, Shao, Hao, Karnes, Robert Jeffrey, Neckers, Len, Feng, Felix, Kampmann, Martin, Gestwicki, Jason E

المصدر: Cell Chemical Biology. 29(3)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Urologic Diseases, Clinical Research, Aging, Prostate Cancer, Cancer, Aetiology, 2.1 Biological and endogenous factors, Cell Line, Tumor, HSP70 Heat-Shock Proteins, HSP90 Heat-Shock Proteins, Humans, Male, Molecular Chaperones, Prostatic Neoplasms, Castration-Resistant, Proteostasis, Receptors, Androgen, chaperones, functional genomics, heat shock proteins, mitochondria, prostate cancer, proteostasis, shRNA, Biochemistry and cell biology, Medicinal and biomolecular chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3vc4z3sf

المؤلفون: Arhar, Taylor, Shkedi, Arielle, Nadel, Cory M, Gestwicki, Jason E

المصدر: Journal of Biological Chemistry. 297(5)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Humans, Molecular Chaperones, Protein Binding, Protein Conformation, Protein Folding, chaperone, nuclear magnetic resonance, protein aggregation, protein folding, protein–protein interactions, Chemical Sciences, Medical and Health Sciences, Biochemistry & Molecular Biology, Biological sciences, Biomedical and clinical sciences, Chemical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/39z3j96h

المؤلفون: Shkedi, Arielle, Adkisson, Michael, Schroeder, Andrew, Eckalbar, Walter L, Kuo, Szu-Yu, Neckers, Leonard, Gestwicki, Jason E

المصدر: Journal of Medicinal Chemistry. 64(19)

مصطلحات موضوعية: Urologic Diseases, Cancer, Prostate Cancer, Antineoplastic Agents, Cell Line, Tumor, Cell Survival, HSP70 Heat-Shock Proteins, HSP90 Heat-Shock Proteins, Humans, Male, Prostatic Neoplasms, Proteasome Endopeptidase Complex, Proteostasis, Receptors, Androgen, Sequence Analysis, RNA, Stress, Physiological, Medicinal and Biomolecular Chemistry, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/0md990s0

المؤلفون: Lou, Kevin, Steri, Veronica, Ge, Alex Y, Hwang, Y Christina, Yogodzinski, Christopher H, Shkedi, Arielle R, Choi, Alex LM, Mitchell, Dominique C, Swaney, Danielle L, Hann, Byron, Gordan, John D, Shokat, Kevan M, Gilbert, Luke A

المصدر: Science Signaling. 12(583)

مصطلحات موضوعية: Biotechnology, Genetics, Cancer, Rare Diseases, Digestive Diseases, Lung, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, Animals, Antineoplastic Agents, CRISPR-Cas Systems, Cell Line, Tumor, Cell Proliferation, Cysteine, Female, Genomics, HEK293 Cells, Humans, Lung Neoplasms, Mice, Mice, Nude, Mutation, Neoplasm Transplantation, Oncogenes, Pancreatic Neoplasms, Protein Binding, Proteomics, Proto-Oncogene Proteins p21(ras), Sequence Analysis, RNA, Signal Transduction, Biochemistry and Cell Biology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/9rc1w0v9

المؤلفون: Shkedi, Arielle

مصطلحات موضوعية: Pharmacology, molecular chaperones, prostate cancer, protein homeostasis

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/0413n12z

المؤلفون: Lou, Kevin, Steri, Veronica, Ge, Alex Y., Hwang, Y. Christina, Yogodzinski, Christopher H., Shkedi, Arielle R., Choi, Alex L. M., Mitchell, Dominique C., Swaney, Danielle L., Hann, Byron, Gordan, John D., Shokat, Kevan M., Gilbert, Luke A.

المصدر: Science Signaling; 5/28/2019, Vol. 12 Issue 583, pN.PAG-N.PAG, 1p

مصطلحات موضوعية: FUNCTIONAL genomics, CANCER, CLINICAL trials, THERAPEUTICS, GUANOSINE diphosphate

المؤلفون: Lou, Kevin, Steri, Veronica, Ge, Alex Y., Hwang, Y. Christina, Yogodzinski, Christopher H., Shkedi, Arielle R., Choi, Alex L. M., Mitchell, Dominique C., Swaney, Danielle L., Hann, Byron, Gordan, John D., Shokat, Kevan M., Gilbert, Luke A.

المصدر: Science Signaling; May 2019, Vol. 12 Issue: 583

المؤلفون: Lou K; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Steri V; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.; Preclinical Therapeutics Core, University of California, San Francisco, San Francisco, CA 94158, USA., Ge AY; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.; Department of Urology, University of California, San Francisco, San Francisco, CA 94158, USA., Hwang YC; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.; Department of Medicine and Division of Hematology/Oncology, University of California, San Francisco, San Francisco, CA 94158, USA., Yogodzinski CH; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.; Department of Urology, University of California, San Francisco, San Francisco, CA 94158, USA., Shkedi AR; Institute for Neurodegenerative Diseases and Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94158, USA., Choi ALM; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.; Department of Medicine and Division of Hematology/Oncology, University of California, San Francisco, San Francisco, CA 94158, USA., Mitchell DC; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.; Department of Medicine and Division of Hematology/Oncology, University of California, San Francisco, San Francisco, CA 94158, USA., Swaney DL; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA., Hann B; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.; Preclinical Therapeutics Core, University of California, San Francisco, San Francisco, CA 94158, USA., Gordan JD; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.; Department of Medicine and Division of Hematology/Oncology, University of California, San Francisco, San Francisco, CA 94158, USA., Shokat KM; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA. luke.gilbert@ucsf.edu kevan.shokat@ucsf.edu.; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA., Gilbert LA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA. luke.gilbert@ucsf.edu kevan.shokat@ucsf.edu.; Department of Urology, University of California, San Francisco, San Francisco, CA 94158, USA.; Innovative Genomics Institute, University of California, San Francisco, San Francisco, CA 94158, USA.

المصدر: Science signaling [Sci Signal] 2019 May 28; Vol. 12 (583). Date of Electronic Publication: 2019 May 28.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE

مواضيع طبية MeSH: Lung Neoplasms/*metabolism , Pancreatic Neoplasms/*metabolism , Proto-Oncogene Proteins p21(ras)/*antagonists & inhibitors, Animals ; Antineoplastic Agents/pharmacology ; CRISPR-Cas Systems ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cysteine/genetics ; Female ; Genomics ; HEK293 Cells ; Humans ; Lung Neoplasms/genetics ; Mice ; Mice, Nude ; Mutation ; Neoplasm Transplantation ; Oncogenes ; Pancreatic Neoplasms/genetics ; Protein Binding ; Proteomics ; Proto-Oncogene Proteins p21(ras)/genetics ; Sequence Analysis, RNA ; Signal Transduction/drug effects