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المؤلفون: Bass AS; Global Discovery Sciences Support, Discovery & Preclinical Sciences, Merck Research Laboratories, 33 Avenue Louis Pasteur, MS: BMB 6-101, Boston, MA 02115, USA. alan.bass@merck.com, Vargas HM, Valentin JP, Kinter LB, Hammond T, Wallis R, Siegl PK, Yamamoto K

المصدر: Journal of pharmacological and toxicological methods [J Pharmacol Toxicol Methods] 2011 Jul-Aug; Vol. 64 (1), pp. 7-15. Date of Electronic Publication: 2011 Jun 12.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 9206091 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-488X (Electronic) Linking ISSN: 10568719 NLM ISO Abbreviation: J Pharmacol Toxicol Methods Subsets: MEDLINE

مواضيع طبية MeSH: Drug-Related Side Effects and Adverse Reactions*, Drug Evaluation, Preclinical/*trends, Animals ; Drug Discovery/methods ; Drug Evaluation, Preclinical/methods ; Humans ; Risk Assessment/methods ; Societies, Pharmaceutical ; Toxicity Tests/trends

المؤلفون: Guth BD; Boehringer Ingelheim Pharma GmbH & Co KG, Department of Drug Discovery Support, D-88397 Biberach an der Riss, Germany. brian.guth@boehringer-ingelheim.com, Bass AS, Briscoe R, Chivers S, Markert M, Siegl PK, Valentin JP

المصدر: Journal of pharmacological and toxicological methods [J Pharmacol Toxicol Methods] 2009 Sep-Oct; Vol. 60 (2), pp. 107-16. Date of Electronic Publication: 2009 May 24.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 9206091 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-488X (Electronic) Linking ISSN: 10568719 NLM ISO Abbreviation: J Pharmacol Toxicol Methods Subsets: MEDLINE

مواضيع طبية MeSH: Drug-Related Side Effects and Adverse Reactions*/*chemically induced, Risk* , Safety*, Electrocardiography/*drug effects , Long QT Syndrome/*chemically induced, Animals ; Heart Rate/drug effects ; Humans ; Toxicity Tests

المؤلفون: Forrest MJ; Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA. mike_forrest@merck.com, Bloomfield D, Briscoe RJ, Brown PN, Cumiskey AM, Ehrhart J, Hershey JC, Keller WJ, Ma X, McPherson HE, Messina E, Peterson LB, Sharif-Rodriguez W, Siegl PK, Sinclair PJ, Sparrow CP, Stevenson AS, Sun SY, Tsai C, Vargas H, Walker M 3rd, West SH, White V, Woltmann RF

المصدر: British journal of pharmacology [Br J Pharmacol] 2008 Aug; Vol. 154 (7), pp. 1465-73. Date of Electronic Publication: 2008 Jun 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0007-1188 (Print) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Blood Pressure/*drug effects , Cholesterol Ester Transfer Proteins/*antagonists & inhibitors , Oxazolidinones/*toxicity , Quinolines/*toxicity, Adrenal Cortex/cytology ; Adrenal Cortex/drug effects ; Aldosterone/blood ; Animals ; Anticholesteremic Agents/toxicity ; Corticosterone/blood ; Dogs ; Drug Evaluation, Preclinical ; Female ; Macaca mulatta ; Male ; Mice ; Mice, Inbred C57BL ; Models, Animal ; Muscle, Smooth, Vascular/drug effects ; Muscle, Smooth, Vascular/metabolism ; Rats ; Rats, Sprague-Dawley ; Species Specificity

المؤلفون: Kinter LB; Safety Assessment U.S., Development, AstraZeneca Pharmaceuticals, Wilmington, DE 19850-5437, USA. lewis.kinter@astrazeneca.com, Siegl PK, Bass AS

المصدر: Journal of pharmacological and toxicological methods [J Pharmacol Toxicol Methods] 2004 May-Jun; Vol. 49 (3), pp. 153-8.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 9206091 Publication Model: Print Cited Medium: Print ISSN: 1056-8719 (Print) Linking ISSN: 10568719 NLM ISO Abbreviation: J Pharmacol Toxicol Methods Subsets: MEDLINE

مواضيع طبية MeSH: Guidelines as Topic* , Ventricular Function*, Drug Evaluation, Preclinical/*standards , Electrocardiography/*drug effects , Long QT Syndrome/*chemically induced, Animals ; Biomarkers ; Humans ; Risk Assessment ; Safety/standards

المؤلفون: Friesen RW; Department of Biology and Medicinal Chemistry, Merck Frosst Centre for Therapeutic Research, P.O. Box 1005, Pointe Claire-Dorval, Quebec, H9R 4P8, Canada. rick_friesen@merck.com, Ducharme Y, Ball RG, Blouin M, Boulet L, Côté B, Frenette R, Girard M, Guay D, Huang Z, Jones TR, Laliberté F, Lynch JJ, Mancini J, Martins E, Masson P, Muise E, Pon DJ, Siegl PK, Styhler A, Tsou NN, Turner MJ, Young RN, Girard Y

المصدر: Journal of medicinal chemistry [J Med Chem] 2003 Jun 05; Vol. 46 (12), pp. 2413-26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Potassium Channels, Voltage-Gated*, 3',5'-Cyclic-AMP Phosphodiesterases/*antagonists & inhibitors , Alcohols/*chemical synthesis , Cyclic N-Oxides/*chemical synthesis , Phosphodiesterase Inhibitors/*chemical synthesis , Potassium Channels/*metabolism , Pyridines/*chemical synthesis, Alcohols/pharmacokinetics ; Alcohols/pharmacology ; Alcohols/toxicity ; Animals ; Bronchoconstriction/drug effects ; Crystallography, X-Ray ; Cyclic N-Oxides/pharmacokinetics ; Cyclic N-Oxides/pharmacology ; Cyclic N-Oxides/toxicity ; Cyclic Nucleotide Phosphodiesterases, Type 4 ; Dogs ; ERG1 Potassium Channel ; Electrocardiography ; Ether-A-Go-Go Potassium Channels ; Guinea Pigs ; Humans ; In Vitro Techniques ; Long QT Syndrome/chemically induced ; Phosphodiesterase Inhibitors/pharmacokinetics ; Phosphodiesterase Inhibitors/pharmacology ; Phosphodiesterase Inhibitors/toxicity ; Protein Binding ; Pyridines/chemistry ; Pyridines/pharmacokinetics ; Pyridines/pharmacology ; Pyridines/toxicity ; Rats ; Saimiri ; Sheep ; Stereoisomerism ; Structure-Activity Relationship ; Tumor Necrosis Factor-alpha/biosynthesis ; Vomiting/chemically induced