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1
المؤلفون: Andreas Marzinzik, Silvio Ofner, Jean-Michel Rondeau, Wolfgang Jahnke, Chrystelle Henry, S. Lehmann, E. Bourgier, Xavier Pelle, Jonathan Green, J. Constanze D. Hartwieg, Rene Hemmig, Simona Cotesta, Guido Bold, Frédéric Stauffer
المصدر: Angewandte Chemie. 127:14783-14787
مصطلحات موضوعية: General Medicine
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2
المؤلفون: Chetan Pandit, Christine E. Gee, Daniel Hoyer, Vinod D. Chaudhari, Grit Laue, Juergen Wagner, Laura H. Jacobson, Dirk Behnke, Claudia Betschart, Simona Cotesta, Sangamesh Badiger, Samuel Hintermann, Markus Fendt, Silvio Ofner
المصدر: Journal of Medicinal Chemistry. 56:7590-7607
مصطلحات موضوعية: Male, Indoles, Sleep induction, Primary Insomnia, Motor Activity, Pharmacology, Doras, Non-rapid eye movement sleep, Mice, Structure-Activity Relationship, Quinoxalines, Sleep Initiation and Maintenance Disorders, mental disorders, Drug Discovery, medicine, Animals, Spiro Compounds, Sleep Stages, biology, Electromyography, Chemistry, Suvorexant, Electroencephalography, Stereoisomerism, Azepines, Triazoles, biology.organism_classification, Orexin receptor, Mice, Inbred C57BL, Pyrimidines, Molecular Medicine, Orexin Receptor Antagonists, Almorexant, Sleep, medicine.drug
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3
المؤلفون: Stephan Urwyler, Kurt Lingenhoehl, David Carcache, Yves Auberson, Joerg Kallen, Henri Mattes, Silvio Ofner, Markus Schmutz, Ivan-Toma Vranesic, Manuel Koller, David Orain
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:3358-3361
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, AMPA receptor, Pharmacology, Crystallography, X-Ray, Binding, Competitive, Biochemistry, Chemical synthesis, Mice, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Structure–activity relationship, Receptors, AMPA, Receptor, Molecular Biology, Quinazolinones, Sulfonamides, Molecular Structure, Chemistry, Organic Chemistry, Sulfonamide (medicine), Glutamate receptor, Antagonist, Biological activity, Rats, Molecular Medicine, Anticonvulsants, medicine.drug
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4
المؤلفون: Jean-Michel Rondeau, E. Bourgier, Marjo Götte, Johann Zimmermann, Armin Widmer, Steven J. Stout, Andreas Marzinzik, René Amstutz, Wolfgang Jahnke, S. Lehmann, Xavier Pelle, Christelle Henry, Frédéric Stauffer, Silvio Ofner, Simona Cotesta, Guido Bold, Thomas Zoller, J. Fraser Glickman, Thomas P. Roddy, J. Constanze D. Hartwieg
المصدر: ChemMedChem. 10(11)
مصطلحات موضوعية: medicine.medical_treatment, Allosteric regulation, Farnesyl pyrophosphate, Biology, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Allosteric Regulation, Drug Discovery, medicine, Transferase, Structure–activity relationship, Humans, General Pharmacology, Toxicology and Pharmaceutics, Enzyme Inhibitors, Pharmacology, ATP synthase, Dose-Response Relationship, Drug, Molecular Structure, Drug discovery, Organic Chemistry, Geranyltranstransferase, Bisphosphonate, chemistry, biology.protein, Quinolines, Molecular Medicine, Salicylic Acid, Allosteric Site
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5
المؤلفون: Frédéric Stauffer, Jean-Michel Rondeau, Simona Cotesta, Jonathan Green, Rene Hemmig, J. Constanze D. Hartwieg, Guido Bold, Andreas Marzinzik, Xavier Pelle, Silvio Ofner, E. Bourgier, Chrystelle Henry, Wolfgang Jahnke, S. Lehmann
المصدر: Angewandte Chemie (International ed. in English). 54(48)
مصطلحات موضوعية: Chemistry, medicine.medical_treatment, Farnesyl pyrophosphate, Administration, Oral, Biological Availability, Geranyltranstransferase, General Chemistry, Pharmacology, Bisphosphonate, Catalysis, Bone and Bones, Bioavailability, chemistry.chemical_compound, Tissue targeting, Drug Delivery Systems, Drug delivery, medicine, Humans, Enzyme Inhibitors, Site of action, Biological availability
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6
المؤلفون: Niko Schmiedeberg, Gabriele Fendrich, Ralf Glatthar, Henrik Möbitz, André Strauss, Sascha Gutmann, Silvio Ofner, Peter Drückes, Sylvie Antz, Aleksandar Stojanovic, Helmut Sparrer, S. Rieffel, Henri Mattes, Alexandra Hinniger, Troxler Thomas J
المصدر: The Journal of biological chemistry. 290(24)
مصطلحات موضوعية: Models, Molecular, Protein Folding, biology, MAP kinase kinase kinase, Cyclin-dependent kinase 4, Protein Conformation, Cyclin-dependent kinase 2, Cell Biology, Mitogen-activated protein kinase kinase, Crystallography, X-Ray, MAP Kinase Kinase Kinases, Biochemistry, Recombinant Proteins, MAP2K7, TANK-binding kinase 1, Proto-Oncogene Proteins, Protein Structure and Folding, biology.protein, Humans, ASK1, Cyclin-dependent kinase 9, Molecular Biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3e5b0ee5576c7802d57675ce481965
https://pubmed.ncbi.nlm.nih.gov/25918157 -
7
المؤلفون: Ivo Vranesic, Kevin H. McAllister, Peter J. Flor, Fabrizio Gasparini, Rainer Kuhn, Albert Enz, Sandrine Desrayaud, Graeme Bilbe, Silvio Ofner, Rochdi Bouhelal
المصدر: Bioorganicmedicinal chemistry. 22(21)
مصطلحات موضوعية: Male, Dyskinesia, Drug-Induced, Indoles, medicine.drug_class, Pyridines, Receptor, Metabotropic Glutamate 5, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Levodopa, Rats, Sprague-Dawley, chemistry.chemical_compound, Mice, Structure-Activity Relationship, In vivo, mental disorders, Drug Discovery, medicine, Mavoglurant, Animals, Humans, Receptor, Molecular Biology, IC50, Metabotropic glutamate receptor 5, Organic Chemistry, Antagonist, Brain, Hyperthermia, Induced, Receptor antagonist, High-Throughput Screening Assays, Rats, chemistry, Metabotropic glutamate receptor, Molecular Medicine, Half-Life, Protein Binding
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8
المؤلفون: Ivo Vranesic, Markus Fendt, Silvio Ofner, Kaspar Zimmermann, Ralf Glatthar, Grit Laue, Daniel Peterlik, Klemens Kaupmann, Dominik Feuerbach, Christine E. Gee, Rochdi Bouhelal, Peter J. Flor, Herman van der Putten, Christoph Neuhäuser, Nicole Uschold-Schmidt, John F. Cryan
المصدر: The Journal of biological chemistry. 289(16)
مصطلحات موضوعية: Agonist, medicine.drug_class, Long-Term Potentiation, CHO Cells, Biology, Anxiety, Receptors, Metabotropic Glutamate, Biochemistry, Amygdala, Mice, Cricetulus, L Cells, Neurobiology, Cricetinae, medicine, Animals, Fear conditioning, Molecular Biology, Behavior, Animal, Metabotropic glutamate receptor 7, Metabotropic glutamate receptor 6, Long-term potentiation, Cell Biology, Mice, Mutant Strains, Protein Structure, Tertiary, medicine.anatomical_structure, Metabotropic glutamate receptor, Metabotropic glutamate receptor 1, Neuroscience, Stress, Psychological
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d470b156affce7a8cb2c77a1868896
https://pubmed.ncbi.nlm.nih.gov/24596089 -
9
المؤلفون: Silvio Ofner, Dirk Behnke, Edi Schuepbach, Christine E. Gee, Morenike Olorunda, Samuel Hintermann, Markus Fendt, Emmanuelle Briard, Daniel Langenegger, Daniel Hoyer, Grit Laue, Gabrielle E. Callander, Laura H. Jacobson, Claudia Betschart, Simona Cotesta, Dominique Monna
المصدر: Frontiers in Neuroscience
مصطلحات موضوعية: Pharmacology, Filorexant, business.industry, General Neuroscience, orexin receptor antagonists, Suvorexant, Antagonist, Ligand (biochemistry), Orexin receptor, In vivo, kinetics, radioligands, medicine, Original Research Article, dual orexin receptor antagonists, Almorexant, business, Receptor, medicine.drug
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10
المصدر: Bioorganic & Medicinal Chemistry Letters. 6:3029-3034
مصطلحات موضوعية: Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Biochemistry, Ritter reaction, chemistry.chemical_compound, Oral administration, Drug Discovery, Molecular Medicine, NK1 receptor antagonist, sense organs, Receptor, Molecular Biology