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المؤلفون: Tony Muchamuel, Andrea R. Fan, Dustin McMinn, Simeon Bowers, Christopher J. Kirk, Henry Johnson, Janet L. Anderl, David C. Moebius, Eric Lowe
المصدر: Journal of Medicinal Chemistry. 61:11127-11143
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, biology, Molecular mass, Chemistry, medicine.drug_class, Protein subunit, Active site, Peptide, Pharmacology, Anti-inflammatory, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, In vivo, Cell culture, 030220 oncology & carcinogenesis, Drug Discovery, biology.protein, medicine, Molecular Medicine, Structure–activity relationship
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2
المؤلفون: Henry W B, Johnson, Eric, Lowe, Janet L, Anderl, Andrea, Fan, Tony, Muchamuel, Simeon, Bowers, David C, Moebius, Christopher, Kirk, Dustin L, McMinn
المصدر: Journal of medicinal chemistry. 61(24)
مصطلحات موضوعية: Mice, Inbred BALB C, Proteasome Endopeptidase Complex, Morpholines, Anti-Inflammatory Agents, Non-Steroidal, Arthritis, Experimental, Arthritis, Rheumatoid, Cysteine Endopeptidases, Structure-Activity Relationship, Cell Line, Tumor, Drug Design, Animals, Cytokines, Humans, Administration, Intravenous, Female, Oligopeptides, Proteasome Inhibitors
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3
المؤلفون: Randall L. Halcomb, Amanda Valdiosera, David Y. Jackson, Lawrence Chinn, Jonathan S. Melnick, Migone Thi Sau, Mark R. Flory, Derrick Houser, Edward H. van der Horst, Maureen Fitch-Bruhns, Simeon Bowers, Edward Ha, Jorge Monteon, Jan Willem Theunissen, Gary Probst, Tiffany Wong, Paul W. Sauer, Zoia Levashova, Kristy Venstrom, Abel Bermudez, Sindy Liao-Chan, Christopher R. Behrens
المصدر: Mol Pharm
مصطلحات موضوعية: Male, Antibody-drug conjugate, Immunoconjugates, Lung Neoplasms, Receptor, ErbB-2, Stereochemistry, Blotting, Western, Fluorescent Antibody Technique, Pharmaceutical Science, Antineoplastic Agents, Apoptosis, Fusion Regulatory Protein-1, Mice, SCID, Conjugated system, Article, Rats, Sprague-Dawley, Mice, chemistry.chemical_compound, Mice, Inbred NOD, In vivo, Drug Discovery, Tumor Cells, Cultured, Animals, Humans, Cysteine, Bifunctional, Maleimide, Cell Proliferation, Chemistry, dBm, Antibodies, Monoclonal, Trastuzumab, Flow Cytometry, Xenograft Model Antitumor Assays, Combinatorial chemistry, Rats, body regions, Cross-Linking Reagents, Molecular Medicine, Female, Linker, Conjugate
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المؤلفون: David F. Nakamura, Hing L. Sham, John-Michael Sauer, Dean R. Artis, Lany Ruslim, Ted Yednock, Michael A. Pleiss, Gary Probst, Marc Adler, Minghua Sun, Louis Brogley, Michael S. Dappen, Roy K. Hom, Michel Maillard, Nanhua Yao, Simeon Bowers, Andrei W. Konradi, Jay S. Tung, Raymond A. Ng, Andrea Gailunas, Wes Zmolek, Kevin P. Quinn, Fang Lawrence Y, Varghese John, R. Jeffrey Neitz, Michael P. Bova
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:4674-4679
مصطلحات موضوعية: Models, Molecular, Binding Sites, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Design, Drug Discovery, Ethylamines, Aspartic Acid Endopeptidases, Molecular Medicine, Structure–activity relationship, Chromane, Amyloid Precursor Protein Secretases, Chromans, Enzyme Inhibitors, Selectivity, Molecular Biology, Cells, Cultured
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المؤلفون: John P. Anderson, Dean R. Artis, Hing L. Sham, Roy K. Hom, Michael S. Dappen, Andrei W. Konradi, Simeon Bowers, Hu Pan, Robert A. Galemmo, Marc Adler, Pearl Tanaka, May Lin, Jeanne Baker, Lany Ruslim, Donald J. Fauss, Zhao Ren, Yong L. Zhu, Anh P. Truong, Danny Tam, Marcelle Bergeron, Lee H. Latimer, Paul Beroza, Jacek Jagodzinski, Heather Zhang, Michael P. Bova, George Tonn, Linnea Diep, Ruth Motter, Kent Fitzgerald, Nanhua Yao, Wayman Chan, Jennifer K. Hoffman, R. Jeffrey Neitz, Danielle L. Aubele
المصدر: ChemMedChem. 8:1295-1313
مصطلحات موضوعية: Male, Parkinson's disease, Polo-like kinase, Molecular Dynamics Simulation, Protein Serine-Threonine Kinases, Pharmacology, Biology, Blood–brain barrier, Biochemistry, Rats, Sprague-Dawley, Mice, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Animals, Humans, Protein Isoforms, Phosphorylation, General Pharmacology, Toxicology and Pharmaceutics, Protein Kinase Inhibitors, Alpha-synuclein, Binding Sites, Kinase, Drug discovery, Organic Chemistry, Brain, medicine.disease, Protein Structure, Tertiary, Rats, HEK293 Cells, medicine.anatomical_structure, chemistry, Blood-Brain Barrier, alpha-Synuclein, Molecular Medicine, Female, Half-Life
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المؤلفون: Anna Liao, Gary Probst, Pamela S. Keim, Kang Hu, Roy K. Hom, David A. Quincy, Michael S. Dappen, Grace T. Kwong, Jenifer Smith, Martin L. Neitzel, Ying-zi Xu, Elizabeth F. Brigham, Kevin P. Quinn, Frédérique Bard, Minghua Sun, Jing Wu, John-Michael Sauer, Dora Kholodenko, Hongbin Zhang, William Wallace, Matthew N. Mattson, Patricia Sacayon, Jacek Jagodzinski, Hing L. Sham, Brian T. Peterson, Simeon Bowers, Jennifer Marugg, Guriqbal S. Basi, Lee H. Latimer, Susanna S. Hemphill, Darren B. Dressen, Karina Wong, Kevin Tanaka, Michael P. Bova, Pamela Santiago, Daniel K. Ness, Anh P. Truong, Wes Zmolek, Lany Ruslim, Christopher Willits, Michael K. Lee, Andrei W. Konradi, Xiaocong M. Ye, Lam Nguyen, Chris M. Semko, Ted A. Yednock, Ruth N. Motter, Albert W. Garofalo, Erich Goldbach, Pearl Tanaka, Danielle L. Aubele
المصدر: Journal of Medicinal Chemistry. 56:5261-5274
مصطلحات موضوعية: Trifluoromethyl, biology, Stereochemistry, Quinoline, In vitro, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, biology.protein, medicine, Molecular Medicine, Structure–activity relationship, Chirality (chemistry), Amyloid precursor protein secretase, Semagacestat, medicine.drug
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المؤلفون: Colin Lorentzen, Maurizio Franzini, Anh P. Truong, R. Jeffrey Neitz, Marc Adler, Danielle L. Aubele, Pam Santiago, Hing L. Sham, Albert W. Garofalo, Simeon Bowers, Xiaocong M. Ye, Danny Tam, Kevin P. Quinn, Gary Probst, Zhao Ren, Erich Goldbach
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:71-74
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Protein Serine-Threonine Kinases, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Transfection, Heterocyclic Compounds, 2-Ring, Biochemistry, MAP2K7, Mice, TANK-binding kinase 1, Drug Discovery, Animals, Humans, c-Raf, Kinase activity, Protein Kinase Inhibitors, Molecular Biology, Binding Sites, biology, Cyclin-dependent kinase 4, Chemistry, Organic Chemistry, Cyclin-dependent kinase 2, Amides, Protein kinase R, Protein Structure, Tertiary, nervous system diseases, Molecular Docking Simulation, HEK293 Cells, Mutation, biology.protein, Molecular Medicine, Cyclin-dependent kinase 9, Protein Binding
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المؤلفون: Chris M. Semko, Danielle L. Aubele, Guriqbal S. Basi, Wes Zmolek, Gary Probst, Matthew N. Mattson, Elizabeth F. Brigham, Erich Goldbach, Karina Wong, William A Wallace, John-Michael Sauer, Hing L. Sham, Lan K. Nguyen, Michael P. Bova, Andrei W. Konradi, Albert W. Garofalo, Susanna S. Hemphill, Darren B. Dressen, Kevin P. Quinn, Minghua Sun, Anh P. Truong, Simeon Bowers
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:5791-5794
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Mice, Inbred Strains, Biochemistry, Amyloid beta-Protein Precursor, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Peptide synthesis, Animals, Structure–activity relationship, γ secretase, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Sulfonamides, Amyloid beta-Peptides, Bicyclic molecule, Chemistry, Organic Chemistry, Combinatorial chemistry, Sulfonamide, Design synthesis, Drug Design, Molecular Medicine, Amyloid Precursor Protein Secretases, Selectivity, Heterocyclic Compounds, 3-Ring
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المؤلفون: Roy K. Hom, Hing L. Sham, Kyle Powell, Gary Probst, Irene Griswold-Prenner, Simeon Bowers, Brian T. Peterson, Heather Zhang, Gergely Tóth, Frederique Bard, Jennifer Sealy, Karina Wong, Wayman Chan, May Lin, R. Jeffrey Neitz, Lany Ruslim, Bhushan Samant, David A. Quincy, Anh P. Truong, Robert A. Galemmo, Colin Lorentzen, Zhao Ren, Andrei W. Konradi, Mark Dryer, Wes Zmolek, Ted Yednock, Nanhua Yao, Erich Goldbach, Sarah J Wright, Hu Pan, Kevin P. Quinn, John-Michael Sauer, Dean R. Artis, George Tonn, Linda Chen
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:5521-5527
مصطلحات موضوعية: Models, Molecular, Drug, Metabolite, media_common.quotation_subject, Clinical Biochemistry, Pharmaceutical Science, Chemistry Techniques, Synthetic, Thiophenes, Pharmacology, Crystallography, X-Ray, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, Drug Discovery, medicine, Animals, Structure–activity relationship, Protein Kinase Inhibitors, Molecular Biology, media_common, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Neurodegeneration, JNK Mitogen-Activated Protein Kinases, Brain, Stereoisomerism, medicine.disease, chemistry, Drug Design, Nerve Degeneration, Molecular Medicine, Penetrant (biochemical), Half-Life
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المؤلفون: Hing L. Sham, Gergley Tóth, Karina Wong, Ann Qin, Kyle Powell, David A. Quincy, Andrei W. Konradi, Nanhua Yao, Jennifer Sealy, David Chereau, Lany Ruslim, Gary Probst, Sarah J Wright, May Lin, Ted Yednock, Irene Griswold-Prenner, Wes Zmolek, Kevin P. Quinn, Hu Pan, Roy K. Hom, Simeon Bowers, Colin Lorentzen, Frederique Bard, John P. Anderson, Anh P. Truong, Zhao Ren, Robert A. Galemmo, John-Michael Sauer, Dean R. Artis, David F. Nakamura
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:315-319
مصطلحات موضوعية: Central Nervous System, Stereochemistry, Clinical Biochemistry, Aminopyridines, Pharmaceutical Science, Biochemistry, Mice, Structure-Activity Relationship, Mitogen-Activated Protein Kinase 10, Drug Discovery, medicine, Animals, Humans, Mitogen-Activated Protein Kinase 9, Structure–activity relationship, Computer Simulation, Protein Kinase Inhibitors, Molecular Biology, Binding Sites, biology, Triazines, Kinase, Chemistry, Organic Chemistry, Neurodegeneration, c-jun, Neurotoxicity, Neurodegenerative Diseases, medicine.disease, In vitro, Neuroprotective Agents, Mitogen-activated protein kinase, Microsomes, Liver, biology.protein, Molecular Medicine, Selectivity
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