يعرض 1 - 10 نتائج من 10 نتيجة بحث عن '"Simon Klaessens"', وقت الاستعلام: 0.85s تنقيح النتائج
  1. 1
    دورية أكاديمية
    Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes

    المؤلفون: Luc Pilotte, Benoit J Van den Eynde, Jingjing Zhu, Christine Sers, Marie Solvay, Pauline Holfelder, Simon Klaessens, Vincent Stroobant, Juliette Lamy, Stefan Naulaerts, Quentin Spillier, Raphaël Frédérick, Etienne De Plaen, Christiane A Opitz

    المصدر: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 6 (2023)

    مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

    وصف الملف: electronic resource

    Relation: https://jitc.bmj.com/content/11/6/e006728.full; https://doaj.org/toc/2051-1426

    URL الوصول: https://doaj.org/article/8b5d6705c624408ca6c9425808c1b3f5

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  2. 2
    دورية أكاديمية
    Systemic tryptophan homeostasis

    المؤلفون: Simon Klaessens, Vincent Stroobant, Etienne De Plaen, Benoit J. Van den Eynde

    المصدر: Frontiers in Molecular Biosciences, Vol 9 (2022)

    مصطلحات موضوعية: tryptophan, TDO (tryptophan 2,3-dioxygenase), IDO1 (indoleamine 2,3-dioxygenase 1), pellagra, hartnup disease, tumor, Biology (General), QH301-705.5

    وصف الملف: electronic resource

    Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2022.897929/full; https://doaj.org/toc/2296-889X

    URL الوصول: https://doaj.org/article/becb4e76f8b64d06a2dc8cae8aaca4f8

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  3. 3
    Supplementary Table 1 and Supplementary Figures 1-5 from Tryptophan 2,3-Dioxygenase Expression Identified in Human Hepatocellular Carcinoma Cells and in Intratumoral Pericytes of Most Cancers

    المؤلفون: Benoit J. Van den Eynde, Etienne Marbaix, Julie Lelotte, Nicolas van Baren, Jean-Christophe Renauld, Marie-Claire Letellier, Simon Klaessens, Marie Solvay, Aurélie Daumerie, Caroline Bouzin, Vincent Stroobant, Tereza Dvorakova, Delia Hoffmann

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e5b11eee0feb91d4c6a59bc085457d
    https://doi.org/10.1158/2326-6066.22543315.v1

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  4. 4
    Data from Tryptophan 2,3-Dioxygenase Expression Identified in Human Hepatocellular Carcinoma Cells and in Intratumoral Pericytes of Most Cancers

    المؤلفون: Benoit J. Van den Eynde, Etienne Marbaix, Julie Lelotte, Nicolas van Baren, Jean-Christophe Renauld, Marie-Claire Letellier, Simon Klaessens, Marie Solvay, Aurélie Daumerie, Caroline Bouzin, Vincent Stroobant, Tereza Dvorakova, Delia Hoffmann

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0534b0fa3056295644db5fc99c26ad
    https://doi.org/10.1158/2326-6066.c.6550213

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  5. 5
    Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes

    المؤلفون: Marie Solvay, Pauline Pfänder, Simon Klaessens, Luc Pilotte, Vincent Stroobant, Juliette Lamy, Stefan Naulaerts, Quentin Spillier, Raphaël Frédérick, Etienne De Plaen, Christine Sers, Christiane A. Opitz, Benoit J. Van den Eynde, Jing-Jing Zhu

    المساهمون: UCL - SSS/DDUV/GECE - Génétique cellulaire, UCL - SSS/LDRI - Louvain Drug Research Institute

    المصدر: Journal for ImmunoTherapy of Cancer, Vol. 11, no. 6, p. e006728 (2023)

    مصطلحات موضوعية: Pharmacology, Cancer Research, Oncology, Immunology, Molecular Medicine, Immunology and Allergy

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb910b1a5937411c7ca8b70616f19263
    https://hdl.handle.net/2078.1/275939

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  6. 6
    Rational design of original fused-cycle selective inhibitors of tryptophan 2,3-dioxygenase

    المؤلفون: Arina Kozlova, Benoît Van den Eynde, Raphaël Frédérick, Simon Klaessens, Léopold Thabault, Caroline Mathieu, Vincent Stroobant, Maxime Liberelle, Luc Pilotte, Julien R. C. Prevost

    المساهمون: UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - SSS/DDUV/GECE - Génétique cellulaire

    المصدر: Journal of Medicinal Chemistry, (2021)

    مصطلحات موضوعية: chemistry.chemical_classification, Kynurenine pathway, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Catabolism, Tryptophan, Rational design, Active site, Triazoles, Tryptophan Oxygenase, Molecular Docking Simulation, Structure-Activity Relationship, Enzyme, Biochemistry, Drug Design, Drug Discovery, Cancer cell, Tumor Cells, Cultured, biology.protein, Humans, Molecular Medicine, Structure–activity relationship, Enzyme Inhibitors

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed66b155772394bcb38fa4f79f3912a7
    https://ora.ox.ac.uk/objects/uuid:e29d5aba-ce71-44d4-83fb-2dea9a0345b2

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  7. 7
    Tryptophanemia is controlled by a tryptophan-sensing mechanism ubiquitinating tryptophan 2,3-dioxygenase

    المؤلفون: Mads Gyrd-Hansen, Delia Hoffmann, Nathalie Vigneron, Etienne De Plaen, Simon Klaessens, Benoît Van den Eynde, Luc Pilotte, Vincent Stroobant

    المساهمون: UCL - SSS/DDUV/GECE - Génétique cellulaire

    المصدر: Proc Natl Acad Sci U S A
    Proceedings of the National Academy of Sciences, Vol. 118, no.23, p. e2022447118 (2021)
    PNAS

    مصطلحات موضوعية: tumor, SCF complexes, Tryptophan 2 3 dioxygenase, tryptophanemia, liver, ubiquitination, Tryptophan 2, CUL1, Mice, Tetramer, Ubiquitin, alpha-methyl-tryptophan, Animals, Homeostasis, Humans, tryptophan, Multidisciplinary, biology, Chemistry, Catabolism, Tryptophan, Ubiquitination, Tryptophanemia, Biological Sciences, Tryptophan Oxygenase, kynurenine, degron, Mice, Inbred C57BL, 3-dioxygenase, proteasome, HEK293 Cells, Biochemistry, cullins, biology.protein, Degron

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9400f07350e89555977a4d8317c1c5a
    https://pubmed.ncbi.nlm.nih.gov/34074763

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  8. 8
    Tryptophan 2,3-dioxygenase expression identified in human hepatocellular carcinoma cells and in intratumoral pericytes of most cancers

    المؤلفون: Aurélie Daumerie, Simon Klaessens, Etienne Marbaix, Vincent Stroobant, Benoît Van den Eynde, Tereza Dvorakova, Caroline Bouzin, Marie-Claire Letellier, Julie Lelotte, Jean-Christophe Renauld, Marie Solvay, Delia Hoffmann, Nicolas van Baren

    المساهمون: UCL - SSS/DDUV - Institut de Duve, UCL - SSS/DDUV/CELL - Biologie cellulaire, UCL - SSS/DDUV/GECE - Génétique cellulaire, UCL - SSS/DDUV/MEXP - Médecine expérimentale, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Service d'anatomie pathologique, UCL - (SLuc) Unité d'oncologie médicale

    المصدر: Cancer immunology research, Vol. 8, no. 1, p. 19-31 (2020)

    مصطلحات موضوعية: Lung Diseases, 0301 basic medicine, Cancer Research, medicine.medical_treatment, Mice, 0302 clinical medicine, Cancer immunotherapy, Neoplasms, GENE-EXPRESSION, biology, INDUCTION, Tryptophan, Antibodies, Monoclonal, Tryptophan Oxygenase, Oncology, Mice, Inbred DBA, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Immunohistochemistry, Antibody, Life Sciences & Biomedicine, ARYL-HYDROCARBON RECEPTOR, medicine.drug_class, Immunology, RAT-LIVER, INHIBITION, Monoclonal antibody, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, Immune system, Cell Line, Tumor, KYNURENINE, Biomarkers, Tumor, medicine, Animals, Humans, SUPPRESSION, Science & Technology, INTERFERON-GAMMA, Cancer, TUMORAL IMMUNE RESISTANCE, medicine.disease, Mice, Inbred C57BL, 030104 developmental biology, Cell culture, Antibody Formation, biology.protein, Cancer research, Neoplasm Grading, Pericytes, INDOLEAMINE 2,3-DIOXYGENASE

    وصف الملف: Print-Electronic

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c5abee8ed6c72659fa34257e4b0fea
    https://ora.ox.ac.uk/objects/uuid:ac3048d5-28b8-4933-982b-6cc7785facb7

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  9. 9
    Correction to 'Rational Design of Original Fused-Cycle Selective Inhibitors of Tryptophan 2,3-Dioxygenase'

    المؤلفون: Benoît Van den Eynde, Julien R. C. Prevost, Arina Kozlova, Luc Pilotte, Maxime Liberelle, Raphaël Frédérick, Simon Klaessens, Caroline Mathieu, Vincent Stroobant, Léopold Thabault

    المصدر: Journal of Medicinal Chemistry. 64:13096-13096

    مصطلحات موضوعية: Stereochemistry, Chemistry, Drug Discovery, Rational design, Molecular Medicine, Tryptophan 2 3 dioxygenase

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::09e0853f7feb319364226d1b157d1196
    https://doi.org/10.1021/acs.jmedchem.1c01455

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  10. 10
    A novel cancer-germline transcript carrying pro-metastatic miR-105 andTET-targeting miR-767 induced by DNA hypomethylation in tumors

    المؤلفون: Axelle Loriot, Aurélie Van Tongelen, Simon Klaessens, Nicolas van Baren, Julie Cannuyer, Charles De Smet, Anabelle Decottignies, Jordi Blanco

    المساهمون: UCL - SSS/DDUV - Institut de Duve

    المصدر: Epigenetics, Vol. 9, no. 8, p. 1163-1171 (2014)
    Epigenetics

    مصطلحات موضوعية: Cancer Research, Biology, Dioxygenases, Mixed Function Oxygenases, Cancer epigenetics, Transcription (biology), Cell Line, Tumor, Neoplasms, Proto-Oncogene Proteins, microRNA, Humans, RNA, Messenger, Epigenetics, Neoplasm Metastasis, Molecular Biology, Gene, Exosomal secretion, DNA methylation, TET genes, cancer-germline or cancer-testis genes, Receptors, GABA-A, Molecular biology, microRNAs, DNA-Binding Proteins, Cancer research, Research Paper, DNA hypomethylation

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b64f69dd6f383a9ecb979af4853def
    https://doi.org/10.4161/epi.29628

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