نتائج البحث - "Sing-Yi Wang"

1

Unique Sulfur–Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors

المصدر: Journal of Medicinal Chemistry. 63:1642-1659

مصطلحات موضوعية: Structure-Activity Relationship, Thiazoles, Binding Sites, Molecular Structure, Drug Discovery, Imidazoles, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Molecular Medicine, Enzyme Inhibitors, Crystallography, X-Ray, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4258e7674e4456ad315cdaea64c49e02
https://doi.org/10.1021/acs.jmedchem.9b01549

Find this issue from the American Chemical Society

2

Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors

المؤلفون: Fu Ming Kuo, Chin Yu Lin, Chun Feng Chang, An Siou Li, Hsing Pang Hsieh, Teng Kuang Yeh, Jen Shin Song, Shu Yu Lin, Chun Hwa Chen, Mohane Selvaraj Coumar, Po Chu Kuo, Sing Yi Wang, Mu Chun Li, Wen-Hsing Lin, Chen Ming Yang, Pei Yi Chen, John T.A. Hsu

المصدر: Bioorganic chemistry. 98

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5477e2465975a7f72145a43d0b9932
https://pubmed.ncbi.nlm.nih.gov/32171993

View record from ScienceDirect

3

Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer

المصدر: Journal of medicinal chemistry. 62(22)

مصطلحات موضوعية: Male, Lung Neoplasms, Receptor, ErbB-2, Afatinib, Phases of clinical research, Mice, Nude, Antineoplastic Agents, Crystallography, X-Ray, 01 natural sciences, 03 medical and health sciences, T790M, Structure-Activity Relationship, In vivo, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Osimertinib, Epidermal growth factor receptor, Receptor, Lung cancer, Protein Kinase Inhibitors, 030304 developmental biology, 0303 health sciences, Mice, Inbred ICR, Binding Sites, biology, Chemistry, Exons, medicine.disease, Xenograft Model Antitumor Assays, 0104 chemical sciences, Rats, ErbB Receptors, 010404 medicinal & biomolecular chemistry, Pyrimidines, Drug Resistance, Neoplasm, Drug Design, Mutation, Cancer research, biology.protein, Molecular Medicine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c0a7f2358d5cec8f896161d0fefb55
https://pubmed.ncbi.nlm.nih.gov/31560541

Find this issue from the American Chemical Society

4

Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation

المصدر: Oncotarget

مصطلحات موضوعية: Male, Models, Molecular, 0301 basic medicine, Antineoplastic Agents, acute myeloid leukemia, Rats, Sprague-Dawley, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, aurora kinase, 0302 clinical medicine, Aurora kinase, In vivo, hemic and lymphatic diseases, Cell Line, Tumor, Neoplasms, Drug Discovery, Quinazoline, Animals, Humans, Pharmaceutical sciences, FLT3, Protein Kinase Inhibitors, Aurora Kinase A, Kinase, Rational design, Myeloid leukemia, In vitro, Rats, Leukemia, Myeloid, Acute, 030104 developmental biology, fms-Like Tyrosine Kinase 3, Oncology, chemistry, Drug Design, 030220 oncology & carcinogenesis, Quinazolines, Cancer research, multi-kinase inhibitor, Research Paper, quinazoline

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02a2eb341741edb83e6b9a1de9e85c4
https://doi.org/10.18632/oncotarget.13369

5

Correction to Unique Sulfur–Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors

المصدر: Journal of Medicinal Chemistry. 63:7445-7445

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0154a3670cb148194c67d82c213cc4c4
https://doi.org/10.1021/acs.jmedchem.0c00966

Find this issue from the American Chemical Society

6

Development of Stem-Cell-Mobilizing Agents Targeting CXCR4 Receptor for Peripheral Blood Stem Cell Transplantation and Beyond

المؤلفون: Yi-Yu Ke, Jiing-Jyh Jan, Chen-Tso Tseng, Chen-Lung Huang, Kai-Chia Yeh, Ming-Chen Chou, Chiung-Tong Chen, Szu-Huei Wu, Chia-Jui Lee, Sing-Yi Wang, Lun K. Tsou, Jen-Shin Song, Kak-Shan Shia, Chien-Huang Wu, Po-Chu Kuo, Teng-Kuang Yeh, Hsuan‐Hao Kuan, Mine-Hsine Wu

المصدر: Journal of medicinal chemistry. 61(3)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673e4a8498bb2f6a8a1ac4e555d7c1e3
https://pubmed.ncbi.nlm.nih.gov/29314840

Find this issue from the American Chemical Society

7

Design and Synthesis of Tetrahydropyridothieno[2,3-d]pyrimidine Scaffold Based Epidermal Growth Factor Receptor (EGFR) Kinase Inhibitors: The Role of Side Chain Chirality and Michael Acceptor Group for Maximal Potency

المصدر: Journal of Medicinal Chemistry. 53:7316-7326

مصطلحات موضوعية: Male, Transplantation, Heterologous, Mice, Nude, Antineoplastic Agents, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, T790M, Gefitinib, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Drug Discovery, medicine, Side chain, Animals, Humans, Structure–activity relationship, Epidermal growth factor receptor, biology, Chemistry, Kinase, Stereoisomerism, Orders of magnitude (mass), Rats, respiratory tract diseases, ErbB Receptors, Transplantation, Pyrimidines, Biochemistry, Drug Resistance, Neoplasm, Drug Design, Mutation, Quinazolines, biology.protein, Molecular Medicine, Drug Screening Assays, Antitumor, Heterocyclic Compounds, 3-Ring, Neoplasm Transplantation, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2314351e3bb3abdcd896ccecee8f0760
https://doi.org/10.1021/jm100607r

Find this issue from the American Chemical Society

8

Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: the role of the DFG motif in the design of epidermal growth factor receptor inhibitors

المؤلفون: Mohane Selvaraj Coumar, Hsu Yi Sun, Chih Hsiang Tu, Chun Hwa Chen, Su Ying Wu, Sing Yi Wang, Jian Sung Wu, Prashanth Kumar Amancha, Hui Yi Shiao, Hsing Pang Hsieh, John Tsu An Hsu, Pang Min Liu, Wen-Hsing Lin, Ping-Chiang Lyu, Yu-Sheng Chao, Yi Hui Peng

المصدر: Journal of medicinal chemistry. 56(10)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e369facc64f0a6345cb7ecec09fc1bff
https://pubmed.ncbi.nlm.nih.gov/23611691

Find this issue from the American Chemical Society

9

دورية أكاديمية

Development of Stem-Cell-Mobilizing Agents Targeting CXCR4 Receptor for Peripheral Blood Stem Cell Transplantation and Beyond.

المؤلفون: Chien-Huang Wu, Jen-Shin Song, Hsuan-Hao Kuan, Szu-Huei Wu, Ming-Chen Chou, Jiing-Jyh Jan, Lun K. Tsou, Yi-Yu Ke, Chiung-Tong Chen, Kai-Chia Yeh, Sing-Yi Wang, Teng-Kuang Yeh, Chen-Tso Tseng, Chen-Lung Huang, Mine-Hsine Wu, Po-Chu Kuo, Chia-Jui Lee, Kak-Shan Shia

المصدر: Journal of Medicinal Chemistry; 2/8/2018, Vol. 61 Issue 3, p818-833, 16p

Find this issue from the American Chemical Society

10

دورية أكاديمية

Design and Synthesis of Tetrahydropyridothieno[2,3-d]pyrimidine Scaffold Based Epidermal Growth Factor Receptor (EGFR) Kinase Inhibitors: The Role of Side Chain Chirality and Michael Acceptor Group for Maximal Potency.

المصدر: Journal of Medicinal Chemistry; Oct2010, Vol. 53 Issue 20, p7316-7326, 11p

Find this issue from the American Chemical Society

تنقيح النتائج