المؤلفون: Ken Hirata, Sungjun Beck, Hong Wang, Tat, Pavla Fajtová, Balachandra Chenna, Daniel C Maneval, Brett L. Hurst, Hsu J, Thomas D. Meek, Ardala Katzfuss, Anthony J. O’Donoghue, Frank M. Raushel, Li Li, Chien-Te K Tseng, Klaudia I. Kocurek, Kostomiris Dh, Aaron F. Carlin, Danielle E. Skinner, Felix W Frueh, Miriam A. Giardini, Jiyun Zhu, Zane W. Taylor, Aleksandra Drelich, Drake M. Mellott, de Siqueira-Neto Jl, Laura Beretta, James H. McKerrow, Alex E. Clark

المصدر: bioRxiv
ACS Chemical Biology
article-version (status) pre
article-version (number) 2

مصطلحات موضوعية: Proteases, K777, Cathepsin L, Phenylalanine, viruses, Microbial Sensitivity Tests, Cysteine Proteinase Inhibitors, spike protein, Biochemistry, Antiviral Agents, Cathepsin B, Piperazines, Article, protease inhibitor, Tosyl Compounds, Protein Domains, Cell Line, Tumor, Chlorocebus aethiops, Animals, Humans, Vero Cells, Cathepsin, Infectivity, biology, Chemistry, SARS-CoV-2, Articles, Biological Sciences, Virus Internalization, Cysteine protease, Molecular biology, Proteolysis, Spike Glycoprotein, Coronavirus, Vero cell, biology.protein, Cysteine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e9f9624831d65f564f679a6c488aa4
https://europepmc.org/articles/PMC7605553/

المؤلفون: McKerrow Jh, Siqueira-Neto Jl, Laura-Isobel McCall, Otrubova K

المصدر: Journal of Pharmaceutics and Drug Development. 4

مصطلحات موضوعية: business.industry, Drug discovery, Medicine, business, Virology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a6e7f08425303e22001d30beb537bac1
https://doi.org/10.15744/2348-9782.4.101

المؤلفون: Siqueira-Neto JL; University of California, San Diego, La Jolla, CA, USA., Wicht KJ; Holistic Drug Discovery and Development (H3D) Centre, University of Cape Town, Rondebosch, South Africa.; South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch, South Africa., Chibale K; Holistic Drug Discovery and Development (H3D) Centre, University of Cape Town, Rondebosch, South Africa.; South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch, South Africa., Burrows JN; Medicines for Malaria Venture, Geneva, Switzerland., Fidock DA; Department of Microbiology and Immunology and Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Winzeler EA; University of California, San Diego, La Jolla, CA, USA. ewinzeler@ucsd.edu.

المصدر: Nature reviews. Drug discovery [Nat Rev Drug Discov] 2024 Sep 13. Date of Electronic Publication: 2024 Sep 13.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124171 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-1784 (Electronic) Linking ISSN: 14741776 NLM ISO Abbreviation: Nat Rev Drug Discov Subsets: MEDLINE

المؤلفون: Siqueira-Neto JL; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States., Lane TR; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States., Bernatchez JA; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States., Calvet Alvarez CM; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States.; Laboratório de Ultraestrutura Celular, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Rio de Janeiro 21040-300, Brazil., Barbosa da Silva E; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States., Giardini MA; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States., Ekins S; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.

المصدر: ACS omega [ACS Omega] 2024 Aug 20; Vol. 9 (35), pp. 37288-37298. Date of Electronic Publication: 2024 Aug 20 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE

المؤلفون: Silva TA; Cellular Ultrastructure Laboratory, Oswaldo Cruz Institute (IOC), FIOCRUZ, Rio de Janeiro 21040-360, RJ, Brazil., Thomas D; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA., Siqueira-Neto JL; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA., Calvet CM; Cellular Ultrastructure Laboratory, Oswaldo Cruz Institute (IOC), FIOCRUZ, Rio de Janeiro 21040-360, RJ, Brazil.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jul 03; Vol. 25 (13). Date of Electronic Publication: 2024 Jul 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Pyridones*/pharmacology , Pyridones*/therapeutic use , Chagas Cardiomyopathy*/drug therapy , Chagas Cardiomyopathy*/parasitology , Chagas Cardiomyopathy*/metabolism , Chagas Cardiomyopathy*/pathology , Fibrosis* , Mice, Inbred C57BL*, Animals ; Mice ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Fibroblasts/parasitology ; Myocardium/pathology ; Myocardium/metabolism ; Collagen/metabolism ; Trypanosoma cruzi/drug effects ; Humans ; Chronic Disease ; Transforming Growth Factor beta/metabolism ; Disease Models, Animal ; p38 Mitogen-Activated Protein Kinases/metabolism ; Male ; Anthracenes

المؤلفون: Xie SC; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3010, Australia., Wang Y; School of Pharmacy, University College London, London, WC1N 1AX, UK., Morton CJ; Biomedical Manufacturing Program, CSIRO, Clayton South, VIC, Australia., Metcalfe RD; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702, USA., Dogovski C; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3010, Australia., Pasaje CFA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Dunn E; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3010, Australia., Luth MR; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA., Kumpornsin K; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Calibr, Division of the Scripps Research Institute, La Jolla, CA, 92037, USA., Istvan ES; Division of Infectious Diseases, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Park JS; Research Institute of Pharmaceutical Sciences and Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea., Fairhurst KJ; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Medical Center, New York, NY, 10032, USA.; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY, 10032, USA., Ketprasit N; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3010, Australia., Yeo T; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Medical Center, New York, NY, 10032, USA.; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY, 10032, USA., Yildirim O; Chemical Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA., Bhebhe MN; School of Chemistry, University of Sydney, Camperdown, NSW, 2006, Australia., Klug DM; School of Pharmacy, University College London, London, WC1N 1AX, UK., Rutledge PJ; School of Chemistry, University of Sydney, Camperdown, NSW, 2006, Australia., Godoy LC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Dey S; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., De Souza ML; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA., Siqueira-Neto JL; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA., Du Y; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3010, Australia., Puhalovich T; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3010, Australia., Amini M; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3010, Australia., Shami G; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3010, Australia., Loesbanluechai D; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Nie S; Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3010, Australia., Williamson N; Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3010, Australia., Jana GP; TCG Lifesciences Private Limited, Salt-Lake Electronics Complex, Kolkata, India., Maity BC; TCG Lifesciences Private Limited, Salt-Lake Electronics Complex, Kolkata, India., Thomson P; School of Chemistry, The University of Edinburgh, Edinburgh, EH9 3JJ, UK., Foley T; School of Chemistry, The University of Edinburgh, Edinburgh, EH9 3JJ, UK., Tan DS; Chemical Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA., Niles JC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Han BW; Research Institute of Pharmaceutical Sciences and Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea., Goldberg DE; Division of Infectious Diseases, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Burrows J; Medicines for Malaria Venture, 20, Route de Pré-Bois, 1215, Geneva 15, Switzerland., Fidock DA; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Medical Center, New York, NY, 10032, USA.; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY, 10032, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, NY, 10032, USA., Lee MCS; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Wellcome Centre for Anti-Infectives Research, Biological Chemistry and Drug Discovery, University of Dundee, Dundee, DD1 4HN, UK., Winzeler EA; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA. ewinzeler@health.ucsd.edu., Griffin MDW; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3010, Australia. mgriffin@unimelb.edu.au., Todd MH; School of Pharmacy, University College London, London, WC1N 1AX, UK. matthew.todd@ucl.ac.uk.; Structural Genomics Consortium, University College London, London, WC1N 1AX, UK. matthew.todd@ucl.ac.uk., Tilley L; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3010, Australia. ltilley@unimelb.edu.au.

المصدر: Nature communications [Nat Commun] 2024 Jan 31; Vol. 15 (1), pp. 937. Date of Electronic Publication: 2024 Jan 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Aspartate-tRNA Ligase*/genetics , Antimalarials*/pharmacology, Animals ; Humans ; Plasmodium falciparum/genetics ; Asparagine/metabolism ; RNA, Transfer, Amino Acyl/metabolism ; Mammals/genetics

المؤلفون: Siqueira-Neto JL; University of California, San Diego, La Jolla, CA, USA., Wicht KJ; Holistic Drug Discovery and Development (H3D) Centre, University of Cape Town, Rondebosch, South Africa.; South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch, South Africa., Chibale K; Holistic Drug Discovery and Development (H3D) Centre, University of Cape Town, Rondebosch, South Africa.; South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch, South Africa., Burrows JN; Medicines for Malaria Venture, Geneva, Switzerland., Fidock DA; Department of Microbiology and Immunology and Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Winzeler EA; University of California, San Diego, La Jolla, CA, USA. ewinzeler@ucsd.edu.

المصدر: Nature reviews. Drug discovery [Nat Rev Drug Discov] 2023 Oct; Vol. 22 (10), pp. 807-826. Date of Electronic Publication: 2023 Aug 31.

نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124171 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-1784 (Electronic) Linking ISSN: 14741776 NLM ISO Abbreviation: Nat Rev Drug Discov Subsets: MEDLINE

مواضيع طبية MeSH: Antimalarials*/pharmacology , Antimalarials*/therapeutic use , Plasmodium*, Animals ; Female ; Humans ; Drug Resistance ; Drug Discovery/methods

المؤلفون: Xie SC; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Wang Y; School of Pharmacy, University College London, London WC1N 1AX, United Kingdom., Morton CJ; Biomedical Manufacturing Program, CSIRO, Clayton South, Australia., Metcalfe RD; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA., Dogovski C; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Pasaje CFA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Dunn E; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Luth MR; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA., Kumpornsin K; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, CB10 1SA, United Kingdom.; Calibr, Division of the Scripps Research Institute, La Jolla, CA 92037, USA., Istvan ES; Division of Infectious Diseases, Department of Medicine, Washington University in St. Louis, USA., Park JS; Research Institute of Pharmaceutical Sciences & Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Fairhurst KJ; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Medical Center, New York, NY 10032, USA.; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA., Ketprasit N; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Yeo T; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Medical Center, New York, NY 10032, USA.; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA., Yildirim O; Chemical Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Bhebhe MN; School of Chemistry, University of Sydney, Camperdown, NSW 2006, Australia., Klug DM; School of Pharmacy, University College London, London WC1N 1AX, United Kingdom., Rutledge PJ; School of Chemistry, University of Sydney, Camperdown, NSW 2006, Australia., Godoy LC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Dey S; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., De Souza ML; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA., Siqueira-Neto JL; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA., Du Y; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Puhalovich T; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Amini M; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Shami G; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Loesbanluechai D; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, CB10 1SA, United Kingdom., Nie S; Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Williamson N; Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Jana GP; TCG Lifesciences Private Limited, Salt-lake Electronics Complex, Kolkata, India., Maity BC; TCG Lifesciences Private Limited, Salt-lake Electronics Complex, Kolkata, India., Thomson P; School of Chemistry, The University of Edinburgh, Edinburgh EH9 3JJ, United Kingdom., Foley T; School of Chemistry, The University of Edinburgh, Edinburgh EH9 3JJ, United Kingdom., Tan DS; Chemical Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Niles JC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Han BW; Research Institute of Pharmaceutical Sciences & Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Goldberg DE; Division of Infectious Diseases, Department of Medicine, Washington University in St. Louis, USA., Burrows J; Medicines for Malaria Venture, 20, Route de Pré-Bois 1215, Geneva 15, Switzerland., Fidock DA; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Medical Center, New York, NY 10032, USA.; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA., Lee MCS; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, CB10 1SA, United Kingdom.; Wellcome Centre for Anti-Infectives Research, Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 4HN, United Kingdom., Winzeler EA; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA., Griffin MDW; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Todd MH; School of Pharmacy, University College London, London WC1N 1AX, United Kingdom.; Structural Genomics Consortium, University College London, London WC1N 1AX, United Kingdom., Tilley L; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia.

المصدر: Research square [Res Sq] 2023 Jul 27. Date of Electronic Publication: 2023 Jul 27.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE

المؤلفون: Maltarollo VG; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, 31270-901, Brazil., da Silva EB; Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0657, USA., Kronenberger T; Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen 72076, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided & Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, 72076, Germany.; Tübingen Center for Academic Drug Discovery, Auf der Morgenstelle 8, Tübingen, 72076, Germany.; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, 70211, Finland., Sena Andrade MM; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, 31270-901, Brazil., de Lima Marques GV; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, 31270-901, Brazil., Cândido Oliveira NJ; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, 31270-901, Brazil., Santos LH; Department of Biochemistry & Immunology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil., Oliveira Rezende Júnior C; Instituto de Química, Universidade Federal de Uberlândia, Uberlândia, Minas Gerais, 38400-902, Brazil.; Instituto de Química, Universidade Estadual de Campinas, Campinas, São Paulo, 13083-970, Brazil., Cassiano Martinho AC; Instituto de Química, Universidade Federal de Uberlândia, Uberlândia, Minas Gerais, 38400-902, Brazil., Skinner D; Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0657, USA., Fajtová P; Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0657, USA.; Institute of Organic Chemistry & Biochemistry, Academy of Sciences of the Czech Republic, Prague, 16610, Czech Republic., M Fernandes TH; Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0657, USA.; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, 90160-093, Brazil.; Pharmaceutical Synthesis Group (PHARSG), Departamento de Produção de Matéria-Prima, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, 90160-093, Brazil., Silveira Dos Santos ED; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, 90160-093, Brazil.; Pharmaceutical Synthesis Group (PHARSG), Departamento de Produção de Matéria-Prima, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, 90160-093, Brazil., Rodrigues Gazolla PA; Grupo de Síntese e Pesquisa de Compostos Bioativos (GSPCB), Departamento de Química, Universidade Federal de Viçosa, Viçosa, Minas Gerais, 36570-900, Brazil., Martins de Souza AP; Grupo de Síntese e Pesquisa de Compostos Bioativos (GSPCB), Departamento de Química, Universidade Federal de Viçosa, Viçosa, Minas Gerais, 36570-900, Brazil., da Silva ML; Grupo de Síntese e Pesquisa de Compostos Bioativos (GSPCB), Departamento de Química, Universidade Federal de Viçosa, Viçosa, Minas Gerais, 36570-900, Brazil., Dos Santos FS; Grupo de Síntese e Pesquisa de Compostos Bioativos (GSPCB), Departamento de Química, Universidade Federal de Viçosa, Viçosa, Minas Gerais, 36570-900, Brazil., Lavorato SN; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, 31270-901, Brazil.; Centro das Ciências Biológicas e da Saúde, Universidade Federal do Oeste da Bahia, Barreiras, Bahia, 47810-047, Brazil., Oliveira Bretas AC; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, 31270-901, Brazil., Carvalho DT; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, 31270-901, Brazil., Franco LL; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, 31270-901, Brazil., Luedtke S; Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0657, USA., Giardini MA; Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0657, USA., Poso A; Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen 72076, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided & Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, 72076, Germany.; Tübingen Center for Academic Drug Discovery, Auf der Morgenstelle 8, Tübingen, 72076, Germany.; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, 70211, Finland., Dias LC; Instituto de Química, Universidade Estadual de Campinas, Campinas, São Paulo, 13083-970, Brazil., Podust LM; Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0657, USA., Alves RJ; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, 31270-901, Brazil., McKerrow J; Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0657, USA., Andrade SF; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, 90160-093, Brazil.; Pharmaceutical Synthesis Group (PHARSG), Departamento de Produção de Matéria-Prima, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, 90160-093, Brazil., Teixeira RR; Grupo de Síntese e Pesquisa de Compostos Bioativos (GSPCB), Departamento de Química, Universidade Federal de Viçosa, Viçosa, Minas Gerais, 36570-900, Brazil., Siqueira-Neto JL; Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0657, USA., O'Donoghue A; Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0657, USA., de Oliveira RB; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, 31270-901, Brazil., Ferreira RS; Department of Biochemistry & Immunology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil.

المصدر: Future medicinal chemistry [Future Med Chem] 2023 Jun; Vol. 15 (11), pp. 959-985. Date of Electronic Publication: 2023 Jul 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Future Science Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: COVID-19* , Thiosemicarbazones*/pharmacology, Humans ; SARS-CoV-2 ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; Molecular Docking Simulation ; Protease Inhibitors/pharmacology ; Protease Inhibitors/chemistry ; Viral Nonstructural Proteins

المؤلفون: Kavouris JA; Department of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University, Boston, Massachusetts, United States of America., McCall LI; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America., Giardini MA; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America., De Muylder G; Department of Pathology, Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America., Thomas D; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America., Garcia-Pérez A; Global Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Cantizani J; Global Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Cotillo I; Global Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Fiandor JM; Global Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., McKerrow JH; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America.; Department of Pathology, Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America., De Oliveira CI; HUPES, Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT) -Salvador, Brazil; Instituto de Investigação em Imunologia (iii-INCT), São Paulo, Brazil., Siqueira-Neto JL; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America.; Department of Pathology, Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America., González S; Global Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Brown LE; Department of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University, Boston, Massachusetts, United States of America., Schaus SE; Department of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University, Boston, Massachusetts, United States of America.

المصدر: Frontiers in tropical diseases [Front Trop Dis] 2023; Vol. 3. Date of Electronic Publication: 2023 Jan 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101779328 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2673-7515 (Electronic) Linking ISSN: 26737515 NLM ISO Abbreviation: Front Trop Dis Subsets: PubMed not MEDLINE