يعرض 1 - 7 نتائج من 7 نتيجة بحث عن '"Siva Prasad, Putlur"', وقت الاستعلام: 1.22s تنقيح النتائج
  1. 1
    Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain

    المؤلفون: Guanglin Luo, Ling Chen, Walter A. Kostich, Brian Hamman, Jason Allen, Amy Easton, Clotilde Bourin, Michael Gulianello, Jonathan Lippy, Susheel Nara, Sreenivasulu Naidu Pattipati, Kumaran Dandapani, Manoj Dokania, Pradeep Vattikundala, Vivek Sharma, Saravanan Elavazhagan, Manoj Kumar Verma, Manish Lal Das, Santosh Wagh, Anand Balakrishnan, Benjamin M. Johnson, Kenneth S. Santone, George Thalody, Rex Denton, Hariharan Saminathan, Vinay K. Holenarsipur, Anoop Kumar, Abhijith Rao, Siva Prasad Putlur, Sarat Kumar Sarvasiddhi, Ganesh Shankar, Justin V. Louis, Manjunath Ramarao, Charles M. Conway, Yu-Wen Li, Rick Pieschl, Yuan Tian, Yang Hong, Linda Bristow, Charles F. Albright, Joanne J. Bronson, John E. Macor, Carolyn D. Dzierba

    المصدر: Journal of Medicinal Chemistry. 65:4534-4564

    مصطلحات موضوعية: Mice, Structure-Activity Relationship, Spinal Cord, Anesthetics, General, Drug Discovery, Animals, Neuralgia, Molecular Medicine, Protein Kinase Inhibitors, Ethers, Rats

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf11be6e3846cab6b37f029b5b93a8d
    https://doi.org/10.1021/acs.jmedchem.1c02132

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  2. 2
    Discovery of (S)-1-((2′,6-Bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain

    المؤلفون: Guanglin Luo, Ling Chen, Walter A. Kostich, Brian Hamman, Jason Allen, Amy Easton, Clotilde Bourin, Michael Gulianello, Jonathan Lippy, Susheel Nara, Tarun Kumar Maishal, Kamalraj Thiyagarajan, Prasadrao Jalagam, Sreenivasulu Naidu Pattipati, Kumaran Dandapani, Manoj Dokania, Pradeep Vattikundala, Vivek Sharma, Saravanan Elavazhagan, Manoj Kumar Verma, Manish Lal Das, Santosh Wagh, Anand Balakrishnan, Benjamin M. Johnson, Kenneth S. Santone, George Thalody, Rex Denton, Hariharan Saminathan, Vinay K. Holenarsipur, Anoop Kumar, Abhijith Rao, Siva Prasad Putlur, Sarat Kumar Sarvasiddhi, Ganesh Shankar, Justin V. Louis, Manjunath Ramarao, Charles M. Conway, Yu-Wen Li, Rick Pieschl, Yuan Tian, Yang Hong, Jonathan Ditta, Arvind Mathur, Jianqing Li, Daniel Smith, Joseph Pawluczyk, Dawn Sun, Shiuhang Yip, Dauh-Rurng Wu, Muthalagu Vetrichelvan, Anuradha Gupta, Alan Wilson, Suma Gopinathan, Suman Wason, Linda Bristow, Charles F. Albright, Joanne J. Bronson, John E. Macor, Carolyn D. Dzierba

    المصدر: Journal of Medicinal Chemistry. 65:4457-4480

    مصطلحات موضوعية: Drug Discovery, Molecular Medicine

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::38224dcaf3d9ea2fabc4ac6df4a42a84
    https://doi.org/10.1021/acs.jmedchem.1c02131

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  3. 3
    Discovery of (

    المؤلفون: Guanglin, Luo, Ling, Chen, Walter A, Kostich, Brian, Hamman, Jason, Allen, Amy, Easton, Clotilde, Bourin, Michael, Gulianello, Jonathan, Lippy, Susheel, Nara, Tarun Kumar, Maishal, Kamalraj, Thiyagarajan, Prasadrao, Jalagam, Sreenivasulu Naidu, Pattipati, Kumaran, Dandapani, Manoj, Dokania, Pradeep, Vattikundala, Vivek, Sharma, Saravanan, Elavazhagan, Manoj Kumar, Verma, Manish Lal, Das, Santosh, Wagh, Anand, Balakrishnan, Benjamin M, Johnson, Kenneth S, Santone, George, Thalody, Rex, Denton, Hariharan, Saminathan, Vinay K, Holenarsipur, Anoop, Kumar, Abhijith, Rao, Siva Prasad, Putlur, Sarat Kumar, Sarvasiddhi, Ganesh, Shankar, Justin V, Louis, Manjunath, Ramarao, Charles M, Conway, Yu-Wen, Li, Rick, Pieschl, Yuan, Tian, Yang, Hong, Jonathan, Ditta, Arvind, Mathur, Jianqing, Li, Daniel, Smith, Joseph, Pawluczyk, Dawn, Sun, Shiuhang, Yip, Dauh-Rurng, Wu, Muthalagu, Vetrichelvan, Anuradha, Gupta, Alan, Wilson, Suma, Gopinathan, Suman, Wason, Linda, Bristow, Charles F, Albright, Joanne J, Bronson, John E, Macor, Carolyn D, Dzierba

    المصدر: Journal of medicinal chemistry. 65(6)

    مصطلحات موضوعية: Mice, Spinal Cord, Animals, Brain, Neuralgia, Amines, Protein Kinase Inhibitors, Rats

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::1e41976413f9c4afd18a0630ac9bd2a0
    https://pubmed.ncbi.nlm.nih.gov/35257579

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  4. 4
    Selective IKur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide

    المؤلفون: Siva Prasad Putlur, Navnath Dnyanoba Yadav, Heather Finlay, Richard Rampulla, Kommuri Umamaheshwar Reddy, Ajay Saxena, Anjaneya Chimalakonda, Jayakumar Sankara Warrier, James A. Johnson, Ruth R. Wexler, Abhisek Banerjee, Dasthagiri Beldona, Sandhya Mandlekar, Dezhi Xing, Ashok Kumar Adisechen, John Lloyd, Anuradha Gupta, MaryLee Conder, Prashantha Gunaga, Umasankar Mandal, Nagendra Rajugowda, Ramya Jayaram, Somanadham Mummadi, Duraimurugan Kumaraguru, Harinath Sale, Naveen Kumar Dhondi, James Hennan, Arun Kumar Gupta, Paul Levesque, Arvind Mathur, Veena Subray

    المصدر: Journal of Medicinal Chemistry. 60:3795-3803

    مصطلحات موضوعية: 0301 basic medicine, biology, Stereochemistry, hERG, Potassium channel blocker, 030204 cardiovascular system & hematology, Prodrug, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Sodium channel blocker, chemistry, In vivo, Drug Discovery, medicine, biology.protein, Quinazoline, Molecular Medicine, Structure–activity relationship, Lead compound, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0360d2e30d7725ffb9d58c1f2c109d94
    https://doi.org/10.1021/acs.jmedchem.6b01889

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  5. 5
    Electrophilicity of Pyridazine-3-carbonitrile, Pyrimidine-2-carbonitrile, and Pyridine-carbonitrile Derivatives: A Chemical Model To Describe the Formation of Thiazoline Derivatives in Human Liver Microsomes

    المؤلفون: Siva Prasad Putlur, Kumaravel Selvakumar, Deepak Ahire, Ramesh Kumar Sistla, Santosh Wagh, Sarmistha Sinha, Benjamin M. Johnson, Janet Caceres Cortes, Sandhya Mandlekar, Dibakar Mullick

    المصدر: Chemical Research in Toxicology. 27:2052-2061

    مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Nitrile, Pyrimidine, Pyridines, Stereochemistry, Toxicology, Pyridazine, chemistry.chemical_compound, Tandem Mass Spectrometry, Nitriles, Humans, Reactivity (chemistry), biology, Thiazoline, Active site, General Medicine, Pyridazines, Thiazoles, Pyrimidines, Models, Chemical, chemistry, Covalent bond, Microsomes, Liver, biology.protein, Spectrophotometry, Ultraviolet, Chromatography, Liquid, Cysteine

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc87228a5847a5117763b060e545fd2
    https://doi.org/10.1021/tx500256j

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  6. 6
    Selective I

    المؤلفون: Prashantha, Gunaga, John, Lloyd, Somanadham, Mummadi, Abhisek, Banerjee, Naveen Kumar, Dhondi, James, Hennan, Veena, Subray, Ramya, Jayaram, Nagendra, Rajugowda, Kommuri, Umamaheshwar Reddy, Duraimurugan, Kumaraguru, Umasankar, Mandal, Dasthagiri, Beldona, Ashok Kumar, Adisechen, Navnath, Yadav, Jayakumar, Warrier, James A, Johnson, Harinath, Sale, Siva Prasad, Putlur, Ajay, Saxena, Anjaneya, Chimalakonda, Sandhya, Mandlekar, MaryLee, Conder, Dezhi, Xing, Arun Kumar, Gupta, Anuradha, Gupta, Richard, Rampulla, Arvind, Mathur, Paul, Levesque, Ruth R, Wexler, Heather J, Finlay

    المصدر: Journal of medicinal chemistry. 60(9)

    مصطلحات موضوعية: Structure-Activity Relationship, Sulfonamides, Dogs, Proton Magnetic Resonance Spectroscopy, Atrial Fibrillation, Potassium Channel Blockers, Quinazolines, Animals, Rabbits, Carbon-13 Magnetic Resonance Spectroscopy, Mass Spectrometry, Sodium Channel Blockers

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::c2f58bc0896c8f18234c0aaf3b7d84e6
    https://pubmed.ncbi.nlm.nih.gov/28418664

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  7. 7
    Practical and economical implementation of online H/D exchange in LC-MS

    المؤلفون: Santosh Wagh, Ravi P. Shah, Sandhya Mandlekar, Amit Garg, Saranjit Singh, Vineet Kumar, Sridhar Desikan, Venugopala Rao, Siva Prasad Putlur

    المصدر: Analytical chemistry. 85(22)

    مصطلحات موضوعية: inorganic chemicals, Analyte, Spectrometry, Mass, Electrospray Ionization, Hydrogen, Analytical chemistry, chemistry.chemical_element, Urinalysis, Online Systems, Analytical Chemistry, Lactones, Plasma, Liquid chromatography–mass spectrometry, Animals, Humans, Metabolomics, Pravastatin, Syringe driver, Chromatography, Chemistry, Elution, Loratadine, Deuterium, Rats, Microsomes, Liver, Chromatography, Liquid

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbade18b6c9c2c85276d0200b0322c80
    https://pubmed.ncbi.nlm.nih.gov/24117319

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